[go: up one dir, main page]

CU20150175A7 - Compuestos inhibidores de la mps-1 quinasa, y las composiciones farmacéuticas y combinaciones farmacéuticas que los contienen - Google Patents

Compuestos inhibidores de la mps-1 quinasa, y las composiciones farmacéuticas y combinaciones farmacéuticas que los contienen

Info

Publication number
CU20150175A7
CU20150175A7 CUP2015000175A CU20150175A CU20150175A7 CU 20150175 A7 CU20150175 A7 CU 20150175A7 CU P2015000175 A CUP2015000175 A CU P2015000175A CU 20150175 A CU20150175 A CU 20150175A CU 20150175 A7 CU20150175 A7 CU 20150175A7
Authority
CU
Cuba
Prior art keywords
mps
pharmaceutical
combinations containing
quinasa
pharmaceutical compositions
Prior art date
Application number
CUP2015000175A
Other languages
English (en)
Inventor
Dr Volker Schulze
Dr Hartmut Schirok
Dr Dirk Kosemund
Dr Hans Briem
Dr Benjamin Bader
Dr Ulf Bömer
Dr Antje Margret Wengner
Dr Gerhard Siemeister
Dr Philip Lienau
Dr Detlef Stöckigt
Dr Ulrich Lücking
Dr Andreas Schall
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50897594&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20150175(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CU20150175A7 publication Critical patent/CU20150175A7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La invención se refiere a los inhibidores de Mps-1 quinasa de fórmula (I) y a las composiciones farmacéuticas y combinaciones farmacéuticas que los contienen. Estos compuestos presentan propiedades sorprendentes y ventajosas y representan un nuevo enfoque para el tratamiento de los trastornos proliferativos entre los cuales se incluyen los tumores sólidos tales como carcinomas y sarcomas, las leucemias, los linfomas malignos y otras enfermedades relacionadas con una proliferación celular descontrolada.
CUP2015000175A 2013-06-10 2015-12-10 Compuestos inhibidores de la mps-1 quinasa, y las composiciones farmacéuticas y combinaciones farmacéuticas que los contienen CU20150175A7 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13171171 2013-06-10
EP13198899 2013-12-20
PCT/EP2014/061530 WO2014198594A1 (en) 2013-06-10 2014-06-04 Novel compounds for the treatment of cancer

Publications (1)

Publication Number Publication Date
CU20150175A7 true CU20150175A7 (es) 2016-05-30

Family

ID=50897594

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2015000175A CU20150175A7 (es) 2013-06-10 2015-12-10 Compuestos inhibidores de la mps-1 quinasa, y las composiciones farmacéuticas y combinaciones farmacéuticas que los contienen

Country Status (25)

Country Link
US (1) US20160207928A1 (es)
EP (1) EP3008061A1 (es)
JP (1) JP2016521737A (es)
KR (1) KR20160019426A (es)
CN (1) CN105246891A (es)
AU (1) AU2014280395A1 (es)
BR (1) BR112015030774A2 (es)
CA (1) CA2914668A1 (es)
CL (1) CL2015003584A1 (es)
CR (1) CR20150653A (es)
CU (1) CU20150175A7 (es)
DO (1) DOP2015000298A (es)
EA (1) EA201501175A1 (es)
HK (1) HK1219737A1 (es)
IL (1) IL242546A0 (es)
MX (1) MX2015017011A (es)
NI (1) NI201500175A (es)
PE (1) PE20160747A1 (es)
PH (1) PH12015502747A1 (es)
SG (1) SG11201509351UA (es)
SV (1) SV2015005126A (es)
TN (1) TN2015000542A1 (es)
TW (1) TW201529560A (es)
UY (1) UY35602A (es)
WO (1) WO2014198594A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3008062B1 (en) * 2013-06-11 2017-04-05 Bayer Pharma Aktiengesellschaft Prodrug derivatives of substituted triazolopyridines
SI3580220T1 (sl) 2017-02-13 2022-01-31 Bristol-Myers Squibb Company Aminotriazolopiridini kot kinazni inhibitorji
EP3704118B1 (en) 2017-10-30 2022-01-12 Bristol-Myers Squibb Company Aminoimidazopyridazines as kinase inhibitors
CN109045036B (zh) * 2018-07-19 2020-10-02 中山大学 [1,2,4]三唑并[4,3-b]哒嗪衍生物在制备抗肿瘤药物中的应用
CN111393405B (zh) * 2019-01-02 2022-11-25 中国科学院上海药物研究所 一类含氟取代的苯并噻吩类化合物及其药物组合物及应用
JP7680955B2 (ja) 2019-01-11 2025-05-21 ネイジス ファーマシューティカルズ インコーポレイテッド ロイコトリエン合成阻害剤
AR123793A1 (es) 2020-10-19 2023-01-11 Bristol Myers Squibb Co Compuestos de triazolopiridinilo como inhibidores de quinasas

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2444403A1 (en) * 2008-04-18 2012-04-25 Shionogi Co., Ltd. Heterocyclic compound having inhibitory activity on PI3K
AR071523A1 (es) * 2008-04-30 2010-06-23 Merck Serono Sa Compuestos biciclicos fusionados, un proceso para su preparacion, el compuesto para ser utilizado como medicamento en el tratamiento y profilaxis de enfermedades, una composicion farmaceutica y un conjunto que comprende paquetes separados del compuesto y de un ingrediente activo del medicamento
WO2010007100A1 (en) * 2008-07-15 2010-01-21 Cellzome Ltd 7-substituted amino triazoles as pi3k inhibitors
JP2011529086A (ja) * 2008-07-24 2011-12-01 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド Ａｄ病変を同定するために有用な造影剤
TWI453207B (zh) * 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
WO2011110575A1 (en) * 2010-03-11 2011-09-15 Glaxo Group Limited Derivatives of 2-[2-(benzo- or pyrido-) thiazolylamino]-6-aminopyridine, useful in the treatment of respiratoric, allergic or inflammatory diseases
AR081960A1 (es) * 2010-06-22 2012-10-31 Fovea Pharmaceuticals Sa Compuestos heterociclicos, su preparacion y su aplicacion terapeutica
WO2012080230A1 (en) * 2010-12-17 2012-06-21 Bayer Pharma Aktiengesellschaft 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
JP5951750B2 (ja) * 2011-04-06 2016-07-13 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 置換イミダゾピリジン類およびその中間体
EP2699575B1 (en) * 2011-04-21 2015-03-25 Bayer Intellectual Property GmbH Triazolopyridines
WO2012160029A1 (en) * 2011-05-23 2012-11-29 Bayer Intellectual Property Gmbh Substituted triazolopyridines
US20150051202A1 (en) * 2012-03-07 2015-02-19 Merck Patent Gmbh Triazolopyrazine derivatives

Also Published As

Publication number Publication date
TN2015000542A1 (en) 2017-04-06
BR112015030774A2 (pt) 2017-07-25
TW201529560A (zh) 2015-08-01
US20160207928A1 (en) 2016-07-21
NI201500175A (es) 2016-01-06
CR20150653A (es) 2016-03-04
SV2015005126A (es) 2017-01-30
UY35602A (es) 2015-01-30
PH12015502747A1 (en) 2016-03-14
DOP2015000298A (es) 2016-03-15
CN105246891A (zh) 2016-01-13
PE20160747A1 (es) 2016-08-25
KR20160019426A (ko) 2016-02-19
CL2015003584A1 (es) 2016-06-24
HK1219737A1 (zh) 2017-04-13
SG11201509351UA (en) 2015-12-30
CA2914668A1 (en) 2014-12-18
EP3008061A1 (en) 2016-04-20
MX2015017011A (es) 2016-04-25
JP2016521737A (ja) 2016-07-25
IL242546A0 (en) 2016-02-01
EA201501175A1 (ru) 2016-10-31
WO2014198594A1 (en) 2014-12-18
AU2014280395A1 (en) 2015-12-17

Similar Documents

Publication Publication Date Title
CU20150175A7 (es) Compuestos inhibidores de la mps-1 quinasa, y las composiciones farmacéuticas y combinaciones farmacéuticas que los contienen
CO2019000386A2 (es) Compuestos heterocíclicos como inmunomoduladores
CU20170029A7 (es) Indazoles sustituidos con bencilo en calidad de inhibidores de bub1, útiles para el tratamiento o profilaxis de una enfermedad hiperproliferativa y/o un trastorno que responde a la inducción de la muerte celular, un procedimiento para la preparación de estos compuestos, y compuestos intermediarios
CL2018001685A1 (es) Compuestos heterociclicos como inmuno moduladores.
SV2018005794A (es) Derivados de carbonucleósidos sustituidos útiles como agentes antineoplásicos
GT201700189A (es) Derivados de nucleósidos sustituidos útiles como agentes antineoplásicos
PH12018502102A1 (en) Pyrrolotriazine compounds as tam inhibitors
CU20160162A7 (es) Derivados de pirrolidina-2,5-diona,para usar como inhibidores ido1 y composiciones farmacéuticas que los contienen
ECSP18049420A (es) Composiciones novedosas, usos y métodos para hacerlas
MX2016014308A (es) Compuestos y composiciones como agonistas del receptor tipo toll 7.
EA201691302A1 (ru) Новые гетероциклические соединения
PH12016501898A1 (en) Quinoxaline derivatives useful as fgfr kinase modulators
MX392461B (es) Moduladores de receptores estrogénicos
MX2015012427A (es) Compuestos de morfolinona de acido heteroarilo como inhibidores mdm2 para el tratamiento de cancer.
DOP2015000270A (es) Potenciador de inhibidores del homólogo de zeste
CU20170015A7 (es) Compuesto de (pirazolilamino) pirimidinil biciclo (3.2.1)oct-8-il
MX2016015565A (es) Ciertos inhibidores de la proteina quinasa.
PE20151594A1 (es) Inhibidores de indolamina 2-3 dioxigenasa
CL2017001511A1 (es) Derivados de piperidina como inhibidores de hdac1/2.
UY36654A (es) Azabenzimidazoles con propiedades moduladoras del receptor ampa y composiciones farmacéuticas que los contienen
CL2012002753A1 (es) Uso de compuestos derivados de anilinopirimidina sustituida con sulfoximina, inhibidores de pan-cdk, para tratar tumores tales como carcinomas de mama, pancreas, riñon, melanomas malignos, entre otros.
MY176521A (en) Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising the same and use thereof
MX2018004868A (es) Derivados de la pirrolidina.
CR20190028A (es) Compuestos heterocíclicos como inmunomoduladores
CR20150593A (es) Potenciador de inhibidores del homólogo de zeste