CS231182B2 - Processing method of 2-guanidine-4-imidazolythissole - Google Patents

Processing method of 2-guanidine-4-imidazolythissole Download PDF

Info

Publication number: CS231182B2
Authority: CS; Czechoslovakia
Prior art keywords: formula; compound; pharmaceutically acceptable; compounds; acceptable acid
Prior art date: 1980-10-14

Application number

CS817500A

Other languages

Czech (cs)

English (en)

Other versions

CS750081A2 (en

Inventor

John L Lamattina

Christopher A Lipinski

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-10-14

Filing date

1981-10-13

Publication date

1984-10-15

1981-10-13 Application filed by Pfizer filed Critical Pfizer

1982-10-20 Priority to CS827450A priority Critical patent/CS235968B2/cs

1982-10-20 Priority to CS827452A priority patent/CS235970B2/cs

1982-10-20 Priority to CS827451A priority patent/CS235969B2/cs

1984-02-13 Publication of CS750081A2 publication Critical patent/CS750081A2/cs

1984-10-15 Publication of CS231182B2 publication Critical patent/CS231182B2/cs

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CS817500A 1980-10-14 1981-10-13 Processing method of 2-guanidine-4-imidazolythissole CS231182B2 (en)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
CS827450A CS235968B2 (cs)	1980-10-14	1982-10-20	Způsob výroby 2-guanidino-4-imidazolylthiazolů
CS827452A CS235970B2 (cs)	1980-10-14	1982-10-20	Způsob výroby 2-guanidino-4-triazolylthiazolů
CS827451A CS235969B2 (cs)	1980-10-14	1982-10-20	Způsob výroby 2-guanidino-4-thiazolylthiazolů

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19623180A	1980-10-14	1980-10-14
US06/293,574 US4374843A (en)	1980-10-14	1981-08-20	2-Guanidino-4-heteroarylthiazoles

Publications (2)

Publication Number	Publication Date
CS750081A2 CS750081A2 (en)	1984-02-13
CS231182B2 true CS231182B2 (en)	1984-10-15

Family

ID=26891753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS817500A CS231182B2 (en)	1980-10-14	1981-10-13	Processing method of 2-guanidine-4-imidazolythissole

Country Status (28)

Country	Link
US (1)	US4374843A (de)
EP (1)	EP0050458B1 (de)
KR (1)	KR850001858B1 (de)
AR (3)	AR228674A1 (de)
AT (1)	ATE11048T1 (de)
AU (2)	AU530589B2 (de)
CA (1)	CA1156239A (de)
CS (1)	CS231182B2 (de)
DD (4)	DD207913A5 (de)
DE (1)	DE3168067D1 (de)
DK (1)	DK453181A (de)
ES (4)	ES8301978A1 (de)
FI (1)	FI75821C (de)
GR (1)	GR75098B (de)
HK (1)	HK52387A (de)
HU (2)	HU191895B (de)
IE (1)	IE51642B1 (de)
IL (1)	IL64035A (de)
KE (1)	KE3707A (de)
MY (1)	MY8700512A (de)
NO (1)	NO159654C (de)
NZ (1)	NZ198629A (de)
PH (3)	PH17562A (de)
PL (3)	PL135331B1 (de)
PT (1)	PT73817B (de)
SG (1)	SG23487G (de)
SU (1)	SU1153829A3 (de)
YU (4)	YU42434B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4482723A (en) *	1983-04-11	1984-11-13	Pfizer Inc.	Process for preparation of 4-acetyl-2-substituted-imidazoles
US4435396A (en) *	1982-05-10	1984-03-06	Pfizer Inc.	Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor
AU542287B2 (en) *	1982-06-17	1985-02-14	Toyama Chemical Co. Ltd.	Process for producing 2-(2-aminothiazol-4-yl) glyoxylic acid derivative, it:s salt and intermediates therefor
EP0156644A1 (de) *	1984-04-02	1985-10-02	Pfizer Inc.	Verfahren und Zwischenprodukte für 4-Acetylimidazole
US4560690A (en) *	1984-04-30	1985-12-24	Pfizer Inc.	2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
US4591595A (en) *	1984-10-11	1986-05-27	Pfizer Inc.	2-guanidino-4-(2-methyl-4-imidazolyl)thiazoles in the treatment of rheumatoid arthritis
US4632993A (en) *	1984-10-11	1986-12-30	Pfizer Inc.	Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide
US4567179A (en) *	1984-10-11	1986-01-28	Pfizer, Inc.	Antiinflammatory salts of piroxicam
WO1986003203A1 (en) *	1984-11-22	1986-06-05	Yoshitomi Pharmaceutical Industries, Ltd.	Thienylthiazole derivatives
US4814341A (en) *	1986-08-26	1989-03-21	Reiter Lawrence A	2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
ES2031514T3 (es) *	1986-08-29	1992-12-16	Pfizer Inc.	2-guanidino-4-ariltiazoles para el tratamiento de ulceras pepticas.
DE3750023T2 (de) *	1986-10-29	1994-09-29	Pfizer, Inc., New York, N.Y.	Verfahren zur Herstellung von 2-(1-Pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)Thiazol und dessen kristallinisches Dihydrochlorid-Trihydrat.
IL95548A0 (en) *	1989-09-15	1991-06-30	Fujisawa Pharmaceutical Co	Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
CA2105981A1 (en) *	1991-03-13	1992-09-14	Hisashi Takasugi	Thiazole derivatives
SI0928793T1 (en) *	1998-01-02	2002-10-31	F. Hoffmann-La Roche Ag	Thiazole derivatives
WO2007023822A1 (ja) *	2005-08-23	2007-03-01	Ube Industries, Ltd.	１－置換－５－アシルイミダゾール化合物の製法
EP2832731A4 (de)	2012-03-27	2015-08-19	Shionogi & Co	Aromatische heterocyclische fünfgliedrige ringderivate mit trpv4-hemmwirkung
EP4196793A1 (de)	2020-08-11	2023-06-21	Université de Strasbourg	Auf lebermakrophagen abzielende h2-blocker zur prävention und behandlung von lebererkrankungen und krebs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1516777A (fr) *	1966-08-02	1968-02-05	Innothera Lab Sa	Dérivés du thiazole ainsi que de la thiazolo [4,5-d] pyridazine et leur préparation
US3519637A (en) *	1966-12-06	1970-07-07	Hoffmann La Roche	1-(4-thiazolylmethyl)nitroimidazole derivatives
BE758146A (fr) *	1969-10-29	1971-04-28	Smith Kline French Lab	Derives de l'amidine
US3950353A (en) *	1971-03-09	1976-04-13	Smith Kline & French Laboratories Limited	Pharmacologically active thiourea and urea compounds
HU168776B (de) *	1973-11-09	1976-07-28
DE2614189A1 (de) *	1976-04-02	1977-10-20	Hoechst Ag	Therapeutisch wirksame ureido- und semicarbazido-derivate des tiazols und verfahren zu ihrer herstellung
ZA782129B (en) *	1977-04-20	1979-03-28	Ici Ltd	Hertocyclic derivatives
US4315009A (en) *	1978-01-18	1982-02-09	Imperial Chemical Industries Limited	Antisecretory guanidine derivatives and pharmaceutical compositions containing them
DE3069889D1 (en) *	1979-01-18	1985-02-14	Ici Plc	Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4220654A (en) *	1979-06-04	1980-09-02	Merck & Co., Inc.	Cyclic imidazole cyanoguanidines
AU518569B2 (en) *	1979-08-07	1981-10-08	Farmos-Yhtyma Oy	4-benzyl- and 4-benzoyl imidazole derivatives

1981
- 1981-08-20 US US06/293,574 patent/US4374843A/en not_active Expired - Fee Related
- 1981-10-12 AT AT81304724T patent/ATE11048T1/de not_active IP Right Cessation
- 1981-10-12 IE IE2384/81A patent/IE51642B1/en unknown
- 1981-10-12 DE DE8181304724T patent/DE3168067D1/de not_active Expired
- 1981-10-12 IL IL64035A patent/IL64035A/xx unknown
- 1981-10-12 EP EP81304724A patent/EP0050458B1/de not_active Expired
- 1981-10-13 FI FI813177A patent/FI75821C/fi not_active IP Right Cessation
- 1981-10-13 AU AU76287/81A patent/AU530589B2/en not_active Ceased
- 1981-10-13 NO NO813442A patent/NO159654C/no unknown
- 1981-10-13 PH PH26341A patent/PH17562A/en unknown
- 1981-10-13 SU SU813344744A patent/SU1153829A3/ru active
- 1981-10-13 YU YU2464/81A patent/YU42434B/xx unknown
- 1981-10-13 HU HU833918A patent/HU191895B/hu not_active IP Right Cessation
- 1981-10-13 GR GR66268A patent/GR75098B/el unknown
- 1981-10-13 NZ NZ198629A patent/NZ198629A/en unknown
- 1981-10-13 CS CS817500A patent/CS231182B2/cs unknown
- 1981-10-13 KR KR1019810003857A patent/KR850001858B1/ko active
- 1981-10-13 DK DK453181A patent/DK453181A/da not_active Application Discontinuation
- 1981-10-13 HU HU812951A patent/HU186788B/hu not_active IP Right Cessation
- 1981-10-13 ES ES506216A patent/ES8301978A1/es not_active Expired
- 1981-10-13 CA CA000387744A patent/CA1156239A/en not_active Expired
- 1981-10-14 PL PL1981241644A patent/PL135331B1/pl unknown
- 1981-10-14 DD DD81248822A patent/DD207913A5/de not_active IP Right Cessation
- 1981-10-14 PT PT73817A patent/PT73817B/pt unknown
- 1981-10-14 PL PL1981233430A patent/PL134491B1/pl unknown
- 1981-10-14 PL PL1981241643A patent/PL133712B1/pl unknown
- 1981-10-14 DD DD81248821A patent/DD207719A5/de not_active IP Right Cessation
- 1981-10-14 DD DD81234080A patent/DD202293A5/de not_active IP Right Cessation
- 1981-10-14 DD DD81248820A patent/DD207718A5/de not_active IP Right Cessation
1982
- 1982-08-20 ES ES515158A patent/ES515158A0/es active Granted
- 1982-08-20 ES ES515157A patent/ES515157A0/es active Granted
- 1982-08-20 ES ES515159A patent/ES8306751A1/es not_active Expired
- 1982-08-27 AR AR290462A patent/AR228674A1/es active
- 1982-08-27 AR AR290463A patent/AR228675A1/es active
- 1982-08-27 AR AR290461A patent/AR229703A1/es active
1983
- 1983-04-06 PH PH28740A patent/PH18467A/en unknown
- 1983-04-06 PH PH28741A patent/PH17856A/en unknown
- 1983-05-12 YU YU1053/83A patent/YU42078B/xx unknown
- 1983-05-12 YU YU1052/83A patent/YU42077B/xx unknown
- 1983-05-12 YU YU1051/83A patent/YU42076B/xx unknown
1984
- 1984-08-17 AU AU32062/84A patent/AU548992B2/en not_active Ceased
1987
- 1987-03-09 SG SG234/87A patent/SG23487G/en unknown
- 1987-03-20 KE KE3707A patent/KE3707A/xx unknown
- 1987-07-09 HK HK523/87A patent/HK52387A/xx unknown
- 1987-12-30 MY MY512/87A patent/MY8700512A/xx unknown

Also Published As

Publication number	Publication date
AU3206284A (en)	1984-11-29
FI75821B (fi)	1988-04-29
PL233430A1 (en)	1983-11-21
DK453181A (da)	1982-04-15
GR75098B (de)	1984-07-13
MY8700512A (en)	1987-12-31
PH18467A (en)	1985-07-18
SU1153829A3 (ru)	1985-04-30
SG23487G (en)	1987-07-10
YU105183A (en)	1983-10-31
PL134491B1 (en)	1985-08-31
PL241644A1 (en)	1983-11-21
IE51642B1 (en)	1987-01-21
ES506216A0 (es)	1982-12-16
ES515159A0 (es)	1983-06-01
DE3168067D1 (en)	1985-02-14
US4374843A (en)	1983-02-22
AR228675A1 (es)	1983-03-30
IE812384L (en)	1982-04-14
PL133712B1 (en)	1985-06-29
FI813177L (fi)	1982-04-15
AU548992B2 (en)	1986-01-09
IL64035A0 (en)	1982-01-31
YU42078B (en)	1988-04-30
YU42076B (en)	1988-04-30
YU42077B (en)	1988-04-30
KR830007638A (ko)	1983-11-04
NO159654C (no)	1989-01-25
EP0050458A3 (en)	1982-09-01
EP0050458A2 (de)	1982-04-28
NZ198629A (en)	1985-02-28
DD207719A5 (de)	1984-03-14
YU246481A (en)	1983-10-31
PT73817B (en)	1983-11-07
ES8306751A1 (es)	1983-06-01
ES8306749A1 (es)	1983-06-01
AR228674A1 (es)	1983-03-30
AU7628781A (en)	1982-04-22
PH17856A (en)	1985-01-09
FI75821C (fi)	1988-08-08
CA1156239A (en)	1983-11-01
AU530589B2 (en)	1983-07-21
NO159654B (no)	1988-10-17
DD207718A5 (de)	1984-03-14
ES8306750A1 (es)	1983-06-01
DD202293A5 (de)	1983-09-07
YU105383A (en)	1983-10-31
PT73817A (en)	1981-11-01
KE3707A (en)	1987-04-03
YU105283A (en)	1983-10-31
EP0050458B1 (de)	1985-01-02
ES515158A0 (es)	1983-06-01
HU191895B (en)	1987-04-28
HK52387A (en)	1987-07-17
PL135331B1 (en)	1985-10-31
KR850001858B1 (ko)	1985-12-28
AR229703A1 (es)	1983-10-31
HU186788B (en)	1985-09-30
YU42434B (en)	1988-08-31
ES8301978A1 (es)	1982-12-16
PH17562A (en)	1984-10-01
DD207913A5 (de)	1984-03-21
ATE11048T1 (de)	1985-01-15
ES515157A0 (es)	1983-06-01
CS750081A2 (en)	1984-02-13
NO813442L (no)	1982-04-15
PL241643A1 (en)	1983-11-21
IL64035A (en)	1986-01-31

Publication	Publication Date	Title
CS231182B2 (en)	1984-10-15	Processing method of 2-guanidine-4-imidazolythissole
SU1375127A3 (ru)	1988-02-15	Способ получени производных 1,2-диаминоциклобутен-3,4-диона или их хлоргидратов
SU1380614A3 (ru)	1988-03-07	Способ получени производных арилтиазолов или их хлористоводородных или бромистоводородных солей
CA2806051C (en)	2017-02-14	Cyclic n,n'-diarylthioureas and n,n'-diarylureas - androgen receptor antagonists, anticancer agent, method for preparation and use thereof
ZA200605307B (en)	2007-11-28	Polymorphic Forms of a Gabaa agonist
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