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CS190480B2 - Method of producing novel derivatives of 1-/4-piperidinyl/-1,3-dihydro-2h-benzimidazol-2-one - Google Patents

Method of producing novel derivatives of 1-/4-piperidinyl/-1,3-dihydro-2h-benzimidazol-2-one

Info

Publication number
CS190480B2
CS190480B2 CS753693A CS369375A CS190480B2 CS 190480 B2 CS190480 B2 CS 190480B2 CS 753693 A CS753693 A CS 753693A CS 369375 A CS369375 A CS 369375A CS 190480 B2 CS190480 B2 CS 190480B2
Authority
CS
Czechoslovakia
Prior art keywords
benzimidazol
piperidinyl
dihydro
novel derivatives
producing novel
Prior art date
Application number
CS753693A
Other languages
Czech (cs)
English (en)
Inventor
Paul A J Janssen
Heertum Albert H M Van
Jan Vandenberk
Der Aa Marcel J M C Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CS190480B2 publication Critical patent/CS190480B2/cs

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • G01N21/766Chemiluminescence; Bioluminescence of gases
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/10Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using catalysis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/17Nitrogen containing
    • Y10T436/173845Amine and quaternary ammonium
    • Y10T436/175383Ammonia
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/17Nitrogen containing
    • Y10T436/177692Oxides of nitrogen
    • Y10T436/178459Only nitrogen dioxide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
CS753693A 1974-06-21 1975-05-27 Method of producing novel derivatives of 1-/4-piperidinyl/-1,3-dihydro-2h-benzimidazol-2-one CS190480B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/481,594 US3989707A (en) 1974-06-21 1974-06-21 Benzimidazolinone derivatives

Publications (1)

Publication Number Publication Date
CS190480B2 true CS190480B2 (en) 1979-05-31

Family

ID=23912586

Family Applications (1)

Application Number Title Priority Date Filing Date
CS753693A CS190480B2 (en) 1974-06-21 1975-05-27 Method of producing novel derivatives of 1-/4-piperidinyl/-1,3-dihydro-2h-benzimidazol-2-one

Country Status (25)

Country Link
US (1) US3989707A (fr)
JP (1) JPS5840553B2 (fr)
AT (1) AT345833B (fr)
AU (1) AU500910B2 (fr)
BE (1) BE830403A (fr)
CA (1) CA1053235A (fr)
CH (1) CH615173A5 (fr)
CS (1) CS190480B2 (fr)
DE (1) DE2527261C2 (fr)
DK (1) DK141751B (fr)
ES (1) ES438714A1 (fr)
FI (1) FI59589C (fr)
FR (1) FR2275210A1 (fr)
GB (1) GB1505173A (fr)
HU (1) HU170435B (fr)
IE (1) IE41383B1 (fr)
IL (1) IL47529A (fr)
NL (1) NL180587C (fr)
NO (1) NO142400C (fr)
PH (1) PH13604A (fr)
PL (1) PL98220B1 (fr)
SE (2) SE416298B (fr)
SU (1) SU585811A3 (fr)
YU (1) YU159475A (fr)
ZA (1) ZA753968B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4066772A (en) * 1975-07-21 1978-01-03 Janssen Pharmaceutica N.V. 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
NZ181256A (en) * 1975-07-21 1978-04-28 Janssen Pharmaceutica Nv 1-(w-benzazol-11-ylalkyl)-piperidine derivatives and pharmaceutical compositions containing certain of these derivatives
US4076821A (en) * 1976-02-27 1978-02-28 Yoshitomi Pharmaceutical Industries, Ltd. 4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
MA19091A1 (fr) * 1980-03-10 1981-10-01 Janssen Pharmaceutica Nv Nouveaux derives de i-(4-aryl-cyclohexyl)piperidine .
US4777265A (en) * 1986-03-11 1988-10-11 Basf Aktiengesellschaft Preparation of acrylates and methacrylates
DE4107857A1 (de) * 1991-03-12 1992-09-17 Thomae Gmbh Dr K Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
AU2388697A (en) 1996-04-19 1997-11-12 Neurosearch A/S 1-(4-piperidyl)-benzimidazoles having neurotrophic activity
DE69826278T2 (de) * 1997-05-30 2005-11-10 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazol-derivate
WO2000031061A1 (fr) * 1998-11-20 2000-06-02 Banyu Pharmaceutical Co., Ltd. Derives de 2-oxo-imidazole
EP1196391A1 (fr) * 1999-07-21 2002-04-17 Fujisawa Pharmaceutical Co., Ltd. Derives de benzimidazolone et leur utilisation comme inhibiteurs de la phosphodiesterase
EP1451173A4 (fr) * 2001-11-01 2005-10-26 Icagen Inc Piperidines
EP1937670A1 (fr) * 2005-09-30 2008-07-02 Glaxo Group Limited Benzimidazolones exerçant une activite au niveau du recepteur m1
ES2391107T3 (es) * 2005-09-30 2012-11-21 Glaxo Group Limited Compuestos que tienen actividad en el receptor M1 y sus usos en medicina
KR20130091791A (ko) * 2005-09-30 2013-08-19 글락소 그룹 리미티드 M1 수용체에서 활성을 갖는 화합물 및 그의 의약적 용도
GB0605784D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
EP1997381A1 (fr) * 2007-06-01 2008-12-03 Commissariat à l'Energie Atomique Utilisation d'un composant ayant une activité inhibitrice de synthase de monogalactosyldiacylglycerol en tant qu'herbicide ou algicide, compositions herbicides et algicides
GB0718415D0 (en) * 2007-09-20 2007-10-31 Glaxo Group Ltd Compounds
MX2012001875A (es) * 2009-08-12 2012-07-20 Janssen Pharmaceutica Nv Proceso para la preparación de inhibidores de la catepsina s.
US20240287019A1 (en) * 2021-06-07 2024-08-29 Kinki University T-type calcium channel blocker

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (fr) * 1962-06-13
US3161645A (en) * 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
BE659364A (fr) * 1964-02-05
US3799932A (en) * 1970-03-20 1974-03-26 Sumitomo Chemical Co Gamma-piperidinobutyrophenones
JPS5511671B2 (fr) * 1971-08-26 1980-03-26

Also Published As

Publication number Publication date
ES438714A1 (es) 1977-07-01
IE41383B1 (en) 1979-12-19
ATA476175A (de) 1978-02-15
FR2275210A1 (fr) 1976-01-16
NO142400C (no) 1980-08-13
NO142400B (no) 1980-05-05
SU585811A3 (ru) 1977-12-25
NL7507368A (nl) 1975-12-23
ZA753968B (en) 1977-01-26
JPS5113780A (fr) 1976-02-03
NL180587C (nl) 1987-03-16
DK281975A (fr) 1975-12-22
PL98220B1 (pl) 1978-04-29
SE7507026L (sv) 1975-12-22
AU8113875A (en) 1976-11-18
US3989707A (en) 1976-11-02
FR2275210B1 (fr) 1978-12-22
DK141751B (da) 1980-06-09
PH13604A (en) 1980-08-05
DK141751C (fr) 1980-11-03
IL47529A0 (en) 1975-08-31
AT345833B (de) 1978-10-10
DE2527261A1 (de) 1976-01-08
GB1505173A (en) 1978-03-30
SE7601636L (sv) 1976-02-13
CA1053235A (fr) 1979-04-24
JPS5840553B2 (ja) 1983-09-06
NO751735L (fr) 1975-12-23
AU500910B2 (en) 1979-06-07
IL47529A (en) 1978-10-31
DE2527261C2 (de) 1986-09-04
SE416298B (sv) 1980-12-15
IE41383L (en) 1975-12-21
YU159475A (en) 1982-02-28
FI59589B (fi) 1981-05-29
NL180587B (nl) 1986-10-16
BE830403A (nl) 1975-12-19
FI751462A (fr) 1975-12-22
FI59589C (fi) 1981-09-10
CH615173A5 (fr) 1980-01-15
SE415298B (sv) 1980-09-22
HU170435B (fr) 1977-06-28

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