CS101391A2 - 3,5-disubstituted 2-isoxazolines and isoxazoles, method of their production, these compounds containing agents and their application - Google Patents
3,5-disubstituted 2-isoxazolines and isoxazoles, method of their production, these compounds containing agents and their applicationInfo
- Publication number
- CS101391A2 CS101391A2 CS911013A CS101391A CS101391A2 CS 101391 A2 CS101391 A2 CS 101391A2 CS 911013 A CS911013 A CS 911013A CS 101391 A CS101391 A CS 101391A CS 101391 A2 CS101391 A2 CS 101391A2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- isoxazolines
- isoxazoles
- disubstituted
- production
- application
- Prior art date
Links
- -1 3,5-disubstituted 2-isoxazolines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 150000002545 isoxazoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4011880 | 1990-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS101391A2 true CS101391A2 (en) | 1991-11-12 |
Family
ID=6404301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS911013A CS101391A2 (en) | 1990-04-12 | 1991-04-10 | 3,5-disubstituted 2-isoxazolines and isoxazoles, method of their production, these compounds containing agents and their application |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5273989A (fi) |
| EP (1) | EP0451790A1 (fi) |
| JP (1) | JPH04234857A (fi) |
| KR (1) | KR910018363A (fi) |
| CN (1) | CN1055537A (fi) |
| AU (1) | AU7428591A (fi) |
| BR (1) | BR9101475A (fi) |
| CA (1) | CA2040219A1 (fi) |
| CS (1) | CS101391A2 (fi) |
| FI (1) | FI911718A (fi) |
| HU (1) | HU911183D0 (fi) |
| IE (1) | IE911235A1 (fi) |
| IL (1) | IL97821A0 (fi) |
| NO (1) | NO911432L (fi) |
| PT (1) | PT97329A (fi) |
| ZA (1) | ZA912701B (fi) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994020475A1 (en) * | 1993-03-02 | 1994-09-15 | Fujisawa Pharmaceutical Co., Ltd. | Isoxazole derivative |
| CA2177375A1 (en) * | 1993-11-26 | 1995-06-01 | Edward F. Kleinman | 3-aryl-2-isoxazolines as antiinflammatory agents |
| HUT76784A (en) * | 1993-11-26 | 1997-11-28 | Pfizer | Antiinflammatory isoxazoline compounds and pharmaceutical compositions containing them |
| US5767118A (en) * | 1994-10-26 | 1998-06-16 | Merck & Co., Inc. | 4-Heterocyclic peperidines promote release of growth hormone |
| FR2752163B1 (fr) * | 1996-08-12 | 1998-10-30 | Pf Medicament | Utilisation de l'efaroxan pour la fabricaton de medicament destine au traitement de la maladie de huntington |
| KR19990011062A (ko) * | 1997-07-21 | 1999-02-18 | 손욱 | 이소옥사졸리딘 고리 함유 액정화합물 및 이를 포함하고 있는 액정 조성물 |
| US6319937B1 (en) * | 1998-11-18 | 2001-11-20 | Dupont Pharmaceuticals Company | Isoxazoline fibrinogen receptor antagonists |
| MXPA02002578A (es) | 1999-09-08 | 2002-10-23 | Guilford Pharm Inc | Compuestos de union a ciclofilina no peptidicos, y su uso. |
| US6656971B2 (en) | 2001-01-25 | 2003-12-02 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
| AU2003221322A1 (en) * | 2002-03-07 | 2003-09-16 | Sds Biotech K.K. | Substituted isoxazole alkylamine derivative and agri- and horticultural fungicide |
| JP4767850B2 (ja) * | 2003-08-20 | 2011-09-07 | エミスフィアー テクノロジーズ インコーポレイテッド | グルカゴン様ペプチド（ｇｌｐ）−１化合物またはメラノコルチン４受容体（ｍｃ４）アゴニストペプチドの経口デリバリーのための化合物、方法および製剤 |
| ES2286679T3 (es) * | 2003-08-20 | 2007-12-01 | Eli Lilly And Company | Compuestos, procedimientos y formulaciones para la liberacion oral de un compuesto de peptido de tipo glucagon (glp)-1 o un peptido agonist a del receptor de melanocortina 4 (mc4). |
| CA2587224A1 (en) * | 2004-11-19 | 2006-05-26 | Plant Bioscience Limited | Microcin b17 analogs and methods for their preparation and use |
| WO2008150487A2 (en) * | 2007-05-31 | 2008-12-11 | Texas Tech University | Synthesis of half esters |
| US8765735B2 (en) * | 2009-05-18 | 2014-07-01 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| US8927551B2 (en) * | 2009-05-18 | 2015-01-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| US9149465B2 (en) * | 2009-05-18 | 2015-10-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| KR20180003534A (ko) * | 2015-02-27 | 2018-01-09 | 오피 바이오 팩토리 컴퍼니, 리미티드 | 카케로마이신 및 그의 유도체 제조방법 |
| MY199931A (en) * | 2016-11-08 | 2023-11-29 | Bristol Myers Squibb Co | 3-substituted propionic acids as alpha v integrin inhibitors |
| CN111333590B (zh) * | 2018-12-18 | 2022-05-17 | 沈阳中化农药化工研发有限公司 | 一种异恶唑烷盐酸盐的制备方法 |
| CN113149926B (zh) * | 2021-04-30 | 2023-05-26 | 华侨大学 | 一种3,5-二取代异恶唑衍生物的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA826165A (en) * | 1969-10-28 | Gagneux Andre | Process for the production of an isoxazole derivative | |
| US3152139A (en) * | 1961-10-17 | 1964-10-06 | Geigy Chem Corp | Certain aminoisoxazolone derivatives |
| CH450423A (de) * | 1965-06-03 | 1968-01-31 | Geigy Ag J R | Verfahren zur Herstellung von 3-Hydroxy-5-aminomethyl-isoxazol |
| DK150615C (da) * | 1982-10-26 | 1987-11-09 | Cheminova As | Fremgangsmaade til fremstilling af substituerede 3-isoxazololer |
| CA1261335A (en) * | 1984-08-29 | 1989-09-26 | Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee | Ethylenediamine monoamide derivatives |
| US4985428A (en) * | 1987-05-20 | 1991-01-15 | Zambon Group S.P.A. | Isoxazoles with nootropic activity |
| DE3736113A1 (de) * | 1987-10-26 | 1989-05-03 | Hoechst Ag | Arzneimittel, darin enthaltene phosphorhaltige 2-isoxazoline und isoxazole, sowie herstellungsverfahren fuer diese heterocyclischen verbindungen |
| DE3914969A1 (de) * | 1989-05-02 | 1990-11-08 | Schering Ag | 5-substituierte 3-arylisoxazol-derivate, deren herstellung und verwendung als schaedlingsbekaempfungsmittel |
| JP2786683B2 (ja) * | 1989-08-15 | 1998-08-13 | 三共株式会社 | グリコール誘導体およびその用途 |
-
1991
- 1991-04-09 EP EP91105614A patent/EP0451790A1/de not_active Withdrawn
- 1991-04-10 CS CS911013A patent/CS101391A2/cs unknown
- 1991-04-10 IL IL97821A patent/IL97821A0/xx unknown
- 1991-04-10 FI FI911718A patent/FI911718A/fi unknown
- 1991-04-10 KR KR1019910005696A patent/KR910018363A/ko not_active Application Discontinuation
- 1991-04-10 US US07/683,068 patent/US5273989A/en not_active Expired - Fee Related
- 1991-04-11 CA CA002040219A patent/CA2040219A1/en not_active Abandoned
- 1991-04-11 ZA ZA912701A patent/ZA912701B/xx unknown
- 1991-04-11 HU HU911183A patent/HU911183D0/hu unknown
- 1991-04-11 AU AU74285/91A patent/AU7428591A/en not_active Abandoned
- 1991-04-11 NO NO91911432A patent/NO911432L/no unknown
- 1991-04-11 JP JP3105156A patent/JPH04234857A/ja active Pending
- 1991-04-11 IE IE123591A patent/IE911235A1/en unknown
- 1991-04-11 PT PT97329A patent/PT97329A/pt not_active Application Discontinuation
- 1991-04-11 CN CN91102287A patent/CN1055537A/zh active Pending
- 1991-04-11 BR BR919101475A patent/BR9101475A/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5273989A (en) | 1993-12-28 |
| NO911432D0 (no) | 1991-04-11 |
| EP0451790A1 (de) | 1991-10-16 |
| NO911432L (no) | 1991-10-14 |
| IE911235A1 (en) | 1991-10-23 |
| HU911183D0 (en) | 1991-10-28 |
| BR9101475A (pt) | 1991-11-26 |
| CN1055537A (zh) | 1991-10-23 |
| KR910018363A (ko) | 1991-11-30 |
| IL97821A0 (en) | 1992-06-21 |
| JPH04234857A (ja) | 1992-08-24 |
| CA2040219A1 (en) | 1991-10-13 |
| AU7428591A (en) | 1991-10-17 |
| PT97329A (pt) | 1992-01-31 |
| ZA912701B (en) | 1991-12-24 |
| FI911718A0 (fi) | 1991-04-10 |
| FI911718A (fi) | 1991-10-13 |
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