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Application filed by Pfizer Prod IncfiledCriticalPfizer Prod Inc
Publication of CR7747ApublicationCriticalpatent/CR7747A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms
(AREA)
Abstract
Se describen nuevos compuestos de isotiazol e isoxazol, incluyendo derivados de los mismos, intermedios para prepararlos, composiciones farmaceuticas que los contienen y su uso medicinal. Los componenetes de la presente invencion son potentes inhibidores de la ruta de senalizacion del factor de crecimiento transformador ("TGF"). Son utiles en el tratamiento de diversas patologias relacionadas con TGF icluyendo por ejemplo, cancer, y enfermedades fibroticas.New compounds of isothiazole and isoxazole, including derivatives thereof, intermediates for preparing them, pharmaceutical compositions containing them and their medicinal use are described. The components of the present invention are potent inhibitors of the signaling path of transforming growth factor ("TGF"). They are useful in the treatment of various pathologies related to TGF including, for example, cancer, and fibrotic diseases.
CR7747A2002-09-182005-03-16
NEW COMPOUNDS DERIVED FROM ISOXAZOL AS INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF)
CR7747A
(en)