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Application filed by Pfizer Prod IncfiledCriticalPfizer Prod Inc
Priority to CR7748ApriorityCriticalpatent/CR7748A/en
Publication of CR7748ApublicationCriticalpatent/CR7748A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Se describen nuevos compuestos de pirazol, incluyendo sus derivados, intermedios para su preparacion, composiciones farmaceuticas que contienen y su uso medicinal. Los compuestos de la presente invencion son inhibidores potentes de la ruta se senalizacion del factor del crecimiento trasformante ("TGF)-B. Son de utilidad en el tratamiento de diversos estados de enfermedad relacionados con TGF incluyendo, por ejemplo cancer y enfermedades fibroticas.New pyrazole compounds are described, including their derivatives, intermediates for their preparation, pharmaceutical compositions containing and their medicinal use. The compounds of the present invention are potent inhibitors of the signaling pathway of the transforming growth factor ("TGF) -B. They are useful in the treatment of various disease states related to TGF including, for example cancer and fibrotic diseases.
CR7748A2005-03-162005-03-16
NEW PIRAZOL COMPOUNDS AS INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF)
CR7748A
(en)
DERIVED FROM THE 1, 3, 5-TRIAZINA-2, 4-DIAMINAS-6-SUBSTITUTED-N-SUBSTITUTED AND PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, COMPOSITIONS AND APPLICATIONS.
Aryl-isoxasol-imidazole derived compounds; preparation procedure; pharmaceutical composition containing them; and use in the preparation of useful drugs in the treatment of cognitive disorders and Alzheimer's-related diseases.
Compounds derived from pyrazole-pyridinone; preparation process of said compounds; pharmaceutical composition that includes them; and its use to treat inflammation, paget disease, osteoarthritis, Alzheimer's, among other diseases.