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CO6400231A2 - Proteínas de unión a il-1 - Google Patents

Proteínas de unión a il-1

Info

Publication number
CO6400231A2
CO6400231A2 CO11085495A CO11085495A CO6400231A2 CO 6400231 A2 CO6400231 A2 CO 6400231A2 CO 11085495 A CO11085495 A CO 11085495A CO 11085495 A CO11085495 A CO 11085495A CO 6400231 A2 CO6400231 A2 CO 6400231A2
Authority
CO
Colombia
Prior art keywords
antibodies
activity
antibody
proteins
union
Prior art date
Application number
CO11085495A
Other languages
English (en)
Inventor
Chung-Ming Hsieh
Chengbin Wu
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of CO6400231A2 publication Critical patent/CO6400231A2/es

Links

Classifications

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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Abstract

La presente invención abarca proteínas de unión a IL-1a. Específicamente, la invención se relaciona con anticuerpos que son anticuerpos quiméricos, de CDR injertada y humanizados. Los anticuerpos de la invención tienen alta afinidad por IL-1a y neutralizan la actividad de IL-1a. Un anticuerpo de la invención puede ser un anticuerpo de longitud total o una porción de unión a antígeno del mismo. También se provee el método para preparar y el método para usar los anticuerpos de la invención. Los anticuerpos, o porciones de anticuerpo de la invención son útiles para detectar una IL-1a y para inhibir la actividad de IL-1a, p.e., en un sujeto humano que sufre de un trastorno en el cual la actividad de IL-1a es perjudicial.
CO11085495A 2009-01-29 2011-07-08 Proteínas de unión a il-1 CO6400231A2 (es)

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CL2011001834A1 (es) 2012-03-09
DOP2011000232A (es) 2011-09-15
EP2391652A2 (en) 2011-12-07
UA102722C2 (en) 2013-08-12
RU2011135768A (ru) 2013-03-10
KR20110110349A (ko) 2011-10-06
IL214341A0 (en) 2011-09-27
CN102369217A (zh) 2012-03-07
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NZ593905A (en) 2013-03-28
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AU2010208637A1 (en) 2011-08-04
US20100221179A1 (en) 2010-09-02
MX2011007987A (es) 2011-08-17
ECSP11011239A (es) 2011-08-31
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US8383778B2 (en) 2013-02-26
BRPI1007371A2 (pt) 2018-03-27

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