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PE20141060A1 - Inmunoglobulinas de dominio variable dual biespecificas de il-1 alfa y beta y su uso - Google Patents

Inmunoglobulinas de dominio variable dual biespecificas de il-1 alfa y beta y su uso

Info

Publication number
PE20141060A1
PE20141060A1 PE2013001458A PE2013001458A PE20141060A1 PE 20141060 A1 PE20141060 A1 PE 20141060A1 PE 2013001458 A PE2013001458 A PE 2013001458A PE 2013001458 A PE2013001458 A PE 2013001458A PE 20141060 A1 PE20141060 A1 PE 20141060A1
Authority
PE
Peru
Prior art keywords
alpha
binding protein
variable domain
heavy
beta
Prior art date
Application number
PE2013001458A
Other languages
English (en)
Inventor
Chengbin Wu
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45771877&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141060(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PE20141060A1 publication Critical patent/PE20141060A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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Abstract

SE REFIERE A UNA PROTEINA DE ENLACE, CARACTERIZADA PORQUE CONTIENE UNA CADENA POLIPEPTIDA, QUE COMPRENDE VD1-(X1)n -VD2-C-(X2)n, EN DONDE; VD1 ES UN PRIMER DOMINIO VARIABLE DE CADENA PESADA Y LIGERA, VD2 ES UN SEGUNDO DOMINIO VARIABLE DE CADENA PESADA Y LIGERA, C ES UN DOMINIO CONSTANTE DE CADENA PESADA, X1 ES UN ENLAZANTE CON LA CONDICION QUE NO SEA CH1, X2 ES UNA REGION FC, Y n ES 0-1, EN DONDE LA PROTEINA DE ENLACE ES CAPAZ DE ENLAZAR UN PAR DE ANTIGENOS SELECCIONADOS DEL GRUPO QUE CONSISTE DE IL-1 ALFA , IL-1 BETA, ENTRE OTROS. SE FORMA UN CONJUGADO DE PROTEINA DE ENLACE QUE ADICIONALMENTE COMPRENDE UNA MOLECULA DE INMUNOADHESION, UN AGENTE DE FORMACION DE IMAGENES, QUE SE SELECCIONA DEL GRUPO UNA ENZIMA, BIOTINA, ENTRE OTRAS, UN AGENTE TERAPEUTICO Y UN AGENTE CITOTOXICO.SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA, SIENDO UTIL PARA TRATAMIENTOS DE ARTRITIS REUMATOIDE, OSTEOPOROSIS, ENTRE OTRAS.
PE2013001458A 2010-12-21 2011-12-20 Inmunoglobulinas de dominio variable dual biespecificas de il-1 alfa y beta y su uso PE20141060A1 (es)

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