CO6361956A2 - Nuevos derivados de benzotiadiazepinas, su procedimiento de preparación y composiciones farmaceúticas que los contienen - Google Patents
Nuevos derivados de benzotiadiazepinas, su procedimiento de preparación y composiciones farmaceúticas que los contienenInfo
- Publication number
- CO6361956A2 CO6361956A2 CO11121546A CO11121546A CO6361956A2 CO 6361956 A2 CO6361956 A2 CO 6361956A2 CO 11121546 A CO11121546 A CO 11121546A CO 11121546 A CO11121546 A CO 11121546A CO 6361956 A2 CO6361956 A2 CO 6361956A2
- Authority
- CO
- Colombia
- Prior art keywords
- benzotiadiazepinas
- pharmaceutical compositions
- compositions containing
- substituted
- preparation procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos de fórmula (I)en la queR1 y R2, idénticos o diferentes, representan cada uno un átomo de hidrógeno o de halógeno, o un grupo alquilo, alcoxi, alquiltio, acilo, alcoxicarbonilo, carboxi, hidroxi, hidroxialquilo, ciano, nitro, amino, aminocarbonilo sustituido o no, aminosulfonilo, alquilsulfonilaminoalquilo, N-hidroxicarboximidamida o benciloxi, R3 representa un átomo de hidrógeno o un grupo alquilo, cicloalquilo o cioalquilalquilo, R4 representa un átomo de hidrógeno o un grupo alquilo sustituido o no Medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0901300A FR2943342B1 (fr) | 2009-03-20 | 2009-03-20 | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6361956A2 true CO6361956A2 (es) | 2012-01-20 |
Family
ID=40863576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO11121546A CO6361956A2 (es) | 2009-03-20 | 2011-09-19 | Nuevos derivados de benzotiadiazepinas, su procedimiento de preparación y composiciones farmaceúticas que los contienen |
Country Status (45)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102725290B (zh) | 2009-07-27 | 2016-03-09 | 吉利德科学股份有限公司 | 作为离子通道调节剂的稠合杂环化合物 |
| CA2802288C (en) | 2010-07-02 | 2018-08-21 | Gilead Sciences, Inc. | Triazolopyridinone compounds as ion channel modulators |
| BR112013002250B1 (pt) | 2010-08-10 | 2020-10-27 | Takeda Pharmaceutical Company Limited | composto, composição farmacêutica, e, uso de um composto |
| EP3400944B1 (en) | 2010-11-04 | 2020-07-15 | Albireo AB | Ibat inhibitors for the treatment of liver diseases |
| MX361350B (es) | 2011-05-10 | 2018-12-04 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como moduladores del canal de sodio. |
| AU2015224425B2 (en) * | 2011-07-01 | 2017-02-09 | Gilead Sciences, Inc. | Fused benzoxazepinones as ion channel modulators |
| NO3175985T3 (es) | 2011-07-01 | 2018-04-28 | ||
| TWI549944B (zh) * | 2011-07-01 | 2016-09-21 | 吉李德科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| JP6134654B2 (ja) | 2012-02-08 | 2017-05-24 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| EP3921028B1 (en) | 2019-02-06 | 2022-11-09 | Albireo AB | Benzothiadiazepine compounds and their use as bile acid modulators |
| CN114761079B (zh) | 2019-12-04 | 2024-05-28 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| CN111620838A (zh) * | 2020-05-16 | 2020-09-04 | 西安都创医药科技有限公司 | 一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用 |
| CN111518055A (zh) * | 2020-05-16 | 2020-08-11 | 西安都创医药科技有限公司 | 一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用 |
| CN111548325A (zh) * | 2020-05-16 | 2020-08-18 | 西安都创医药科技有限公司 | 一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用 |
| CN111574475B (zh) * | 2020-06-03 | 2022-09-20 | 西安都创医药科技有限公司 | 卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用 |
| JP2024500309A (ja) | 2020-12-04 | 2024-01-09 | アルビレオ エービー | ベンゾチア（ジ）アゼピン化合物および胆汁酸モジュレータとしてのその使用 |
| CN115368363B (zh) * | 2021-05-17 | 2024-02-20 | 中山大学 | 一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用 |
| WO2024240249A1 (zh) * | 2023-05-25 | 2024-11-28 | 正大天晴药业集团股份有限公司 | 一种苯并噻二氮卓化合物及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993021170A1 (fr) * | 1992-04-15 | 1993-10-28 | Rhone-Poulenc Rorer S.A. | Derives d'acide 3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxyde-3-carboxylique, leur preparation et les medicaments les contenant |
| JP2002503657A (ja) * | 1998-02-11 | 2002-02-05 | デュポン ファーマシューティカルズ カンパニー | メタロプロテイナーゼ阻害剤としての新規な環式スルホンアミド誘導体 |
| NZ506251A (en) * | 1998-02-18 | 2003-01-31 | Neurosearch As | Benzothiadiazine and benzothiadiazepine derivatives and their use as positive AMPA receptor modulators |
| US6156746A (en) * | 1998-08-25 | 2000-12-05 | Bristol-Myers Squibb Company | 1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents |
| GB0209467D0 (en) * | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| DE10300973A1 (de) * | 2003-01-14 | 2004-07-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Carbonsäuren und deren Ester, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| FR2877338B1 (fr) * | 2004-11-03 | 2007-01-26 | Servier Lab | Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2879201B1 (fr) * | 2004-12-10 | 2007-02-16 | Servier Lab | Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2009
- 2009-03-20 FR FR0901300A patent/FR2943342B1/fr not_active Expired - Fee Related
-
2010
- 2010-03-02 JO JO201077A patent/JO2780B1/en active
- 2010-03-03 AU AU2010200815A patent/AU2010200815B2/en not_active Ceased
- 2010-03-04 UY UY0001032475A patent/UY32475A/es unknown
- 2010-03-11 TW TW099107121A patent/TWI388326B/zh not_active IP Right Cessation
- 2010-03-17 CA CA2696705A patent/CA2696705C/fr not_active Expired - Fee Related
- 2010-03-17 ZA ZA2010/01905A patent/ZA201001905B/en unknown
- 2010-03-17 SA SA110310217A patent/SA110310217B1/ar unknown
- 2010-03-18 MX MX2011009638A patent/MX2011009638A/es active IP Right Grant
- 2010-03-18 PL PL10290141T patent/PL2246339T3/pl unknown
- 2010-03-18 PT PT10290141T patent/PT2246339E/pt unknown
- 2010-03-18 BR BRPI1009200A patent/BRPI1009200A2/pt not_active IP Right Cessation
- 2010-03-18 NZ NZ595082A patent/NZ595082A/en not_active IP Right Cessation
- 2010-03-18 SI SI201030006T patent/SI2246339T1/sl unknown
- 2010-03-18 RS RS20110385A patent/RS51919B/en unknown
- 2010-03-18 KR KR1020117024772A patent/KR101431504B1/ko not_active Expired - Fee Related
- 2010-03-18 ES ES10290141T patent/ES2368691T3/es active Active
- 2010-03-18 AP AP2011005935A patent/AP3050A/xx active
- 2010-03-18 SG SG2011064367A patent/SG174274A1/en unknown
- 2010-03-18 EA EA201101334A patent/EA020259B1/ru not_active IP Right Cessation
- 2010-03-18 GE GEAP201012414A patent/GEP20135862B/en unknown
- 2010-03-18 CN CN201080012931.3A patent/CN102361860B/zh not_active Expired - Fee Related
- 2010-03-18 MY MYPI2011004188A patent/MY154001A/en unknown
- 2010-03-18 JP JP2012500288A patent/JP5437473B2/ja not_active Expired - Fee Related
- 2010-03-18 WO PCT/FR2010/000227 patent/WO2010106249A1/fr active Application Filing
- 2010-03-18 MA MA34178A patent/MA33131B1/fr unknown
- 2010-03-18 PE PE2011001589A patent/PE20120113A1/es not_active Application Discontinuation
- 2010-03-18 DK DK10290141.0T patent/DK2246339T3/da active
- 2010-03-18 UA UAA201112094A patent/UA100477C2/uk unknown
- 2010-03-18 EP EP10290141A patent/EP2246339B1/fr active Active
- 2010-03-18 AT AT10290141T patent/ATE513822T1/de active
- 2010-03-19 AR ARP100100881A patent/AR075892A1/es unknown
- 2010-03-19 US US12/661,598 patent/US8236790B2/en not_active Expired - Fee Related
-
2011
- 2011-08-31 HR HR20110626T patent/HRP20110626T1/hr unknown
- 2011-09-07 CU CU2011000169A patent/CU24030B1/es active IP Right Grant
- 2011-09-07 IL IL215016A patent/IL215016A/en not_active IP Right Cessation
- 2011-09-08 CY CY20111100869T patent/CY1111807T1/el unknown
- 2011-09-12 CR CR20110484A patent/CR20110484A/es unknown
- 2011-09-13 NI NI201100169A patent/NI201100169A/es unknown
- 2011-09-15 CL CL2011002287A patent/CL2011002287A1/es unknown
- 2011-09-19 EC EC2011011340A patent/ECSP11011340A/es unknown
- 2011-09-19 TN TN2011000469A patent/TN2011000469A1/fr unknown
- 2011-09-19 CO CO11121546A patent/CO6361956A2/es active IP Right Grant
- 2011-09-20 HN HN2011002458A patent/HN2011002458A/es unknown
-
2012
- 2012-08-21 HK HK12108187.2A patent/HK1167404A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |