CO6321243A2 - Derivados de n-fenil-imidazo[1,2-alfa]piridin2-2carboxamidas, su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de n-fenil-imidazo[1,2-alfa]piridin2-2carboxamidas, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- CO6321243A2 CO6321243A2 CO10080881A CO10080881A CO6321243A2 CO 6321243 A2 CO6321243 A2 CO 6321243A2 CO 10080881 A CO10080881 A CO 10080881A CO 10080881 A CO10080881 A CO 10080881A CO 6321243 A2 CO6321243 A2 CO 6321243A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- alkoxy
- halogen
- alkyl
- phenyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 8
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 229910003827 NRaRb Inorganic materials 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- -1 hydroxy, amino Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004666 alkoxyiminoalkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1.- Compuestos de fórmula (I)X representa un grupo fenilo sustituido con un ciano, un alcoxi(C1-C6)carbonilo, un alcoxi(C1-C6) sustituido con uno o varios halógenos o alquilo(C1-C6) sustituido con uno o varios halógenos estando el fenilo opcionalmente sustituido una segunda vez con un halógeno;R1 representa un átomo de hidrógeno, un halógeno, un grupo alcoxi (C1-C6), un grupo alquilo (C1-C6), un grupo NRaRb;pudiendo estar los grupos alquilo y alcoxi sustituidos opcionalmente con uno o varios halógeno, hidroxi, amino ogrupo alcoxi(C1-C6),R2 representa uno de los siguientes grupos:° un átomo de hidrógeno,° un grupo alquilo(C1-C6) opcionalmente sustituido con uno o varios grupos elegidos independientemente uno de otros entre un hidroxi, un halógeno, un amino, un grupo NRaRb, un grupo alcoxi(C1-C6), un grupo fenilo,° un grupo alcoxi(C1-C6) opcionalmente sustituido con uno o varios grupos elegidos independientemente uno de otros entre hidroxi, halógeno, amino, grupo NRaRb,° un grupo alquenilo(C2-C6):° un grupo alquinilo(C2-C6);° un grupo -CO-R5,° un grupo -CO-NR5R7° un grupo -CO-O-R8,° un grupo -NR9-CO-R10,° un grupo -NR11R12,° un grupo N=ClHNRaRb,° un átomo de halógeno° un grupo ciano, nitro, hidroxiiminoalquilo, alcoxiiminoalquilo,° un grupo alquiltio(C1-C6),un grupo alquil(C1-C6)sulfinilo,° un grupo alquil(C1-C6)sulfonilo,un grupo ((alquil(C1-C6))s)sililetinilo,° un grupo -SO2-NR9R10,un grupo fenilo opcionalmente sustituido con uno o varios grupos elegidos independientemente uno de otros entre los átomos o grupos siguientes : halógeno, alcoxi(C1-C6), ciano; NRaRb, -CO-R5, -CO-NR6R7, -CO-O-R8, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800002A FR2925900B1 (fr) | 2008-01-02 | 2008-01-02 | DERIVES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6321243A2 true CO6321243A2 (es) | 2011-09-20 |
Family
ID=39691313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10080881A CO6321243A2 (es) | 2008-01-02 | 2010-07-02 | Derivados de n-fenil-imidazo[1,2-alfa]piridin2-2carboxamidas, su preparacion y su aplicacion en terapeutica |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20100317685A1 (es) |
| EP (1) | EP2225241B1 (es) |
| JP (1) | JP2011508758A (es) |
| KR (1) | KR20100099245A (es) |
| CN (1) | CN101910176A (es) |
| AR (1) | AR070071A1 (es) |
| AT (1) | ATE524468T1 (es) |
| AU (1) | AU2008351926A1 (es) |
| BR (1) | BRPI0821674A2 (es) |
| CA (1) | CA2710943A1 (es) |
| CL (1) | CL2008003926A1 (es) |
| CO (1) | CO6321243A2 (es) |
| EA (1) | EA201070816A1 (es) |
| FR (1) | FR2925900B1 (es) |
| IL (1) | IL206668A0 (es) |
| MA (1) | MA32060B1 (es) |
| MX (1) | MX2010007348A (es) |
| TW (1) | TW200942539A (es) |
| UY (1) | UY31586A1 (es) |
| WO (1) | WO2009106748A2 (es) |
| ZA (1) | ZA201004641B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2903108B1 (fr) * | 2006-07-03 | 2008-08-29 | Sanofi Aventis Sa | Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique. |
| FR2925906B1 (fr) * | 2008-01-02 | 2010-08-20 | Sanofi Aventis | COMPOSES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| FR2950344B1 (fr) * | 2009-09-18 | 2011-11-25 | Sanofi Aventis | Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2638161B1 (fr) * | 1988-10-24 | 1991-01-11 | Centre Nat Rech Scient | Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| CA2545711A1 (en) * | 2003-11-13 | 2005-06-02 | Ambit Biosciences Corporation | Urea derivatives as kinase modulators |
| UY29300A1 (es) * | 2004-12-22 | 2006-07-31 | Astrazeneca Ab | Compuestos quimicos |
| FR2903107B1 (fr) * | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2903108B1 (fr) * | 2006-07-03 | 2008-08-29 | Sanofi Aventis Sa | Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique. |
| FR2925906B1 (fr) * | 2008-01-02 | 2010-08-20 | Sanofi Aventis | COMPOSES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
-
2008
- 2008-01-02 FR FR0800002A patent/FR2925900B1/fr not_active Expired - Fee Related
- 2008-12-30 UY UY31586A patent/UY31586A1/es not_active Application Discontinuation
- 2008-12-30 CL CL2008003926A patent/CL2008003926A1/es unknown
- 2008-12-30 AR ARP080105776A patent/AR070071A1/es unknown
- 2008-12-31 CA CA2710943A patent/CA2710943A1/fr not_active Abandoned
- 2008-12-31 MX MX2010007348A patent/MX2010007348A/es active IP Right Grant
- 2008-12-31 JP JP2010541082A patent/JP2011508758A/ja not_active Withdrawn
- 2008-12-31 EA EA201070816A patent/EA201070816A1/ru unknown
- 2008-12-31 WO PCT/FR2008/001833 patent/WO2009106748A2/fr active Application Filing
- 2008-12-31 AU AU2008351926A patent/AU2008351926A1/en not_active Abandoned
- 2008-12-31 KR KR1020107014641A patent/KR20100099245A/ko not_active Application Discontinuation
- 2008-12-31 EP EP08872826A patent/EP2225241B1/fr active Active
- 2008-12-31 CN CN200880123840XA patent/CN101910176A/zh active Pending
- 2008-12-31 BR BRPI0821674-6A patent/BRPI0821674A2/pt not_active IP Right Cessation
- 2008-12-31 AT AT08872826T patent/ATE524468T1/de not_active IP Right Cessation
- 2008-12-31 TW TW097151693A patent/TW200942539A/zh unknown
-
2010
- 2010-06-28 IL IL206668A patent/IL206668A0/en unknown
- 2010-07-01 US US12/828,369 patent/US20100317685A1/en not_active Abandoned
- 2010-07-01 ZA ZA2010/04641A patent/ZA201004641B/en unknown
- 2010-07-02 CO CO10080881A patent/CO6321243A2/es not_active Application Discontinuation
- 2010-08-02 MA MA33058A patent/MA32060B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2008003926A1 (es) | 2010-02-12 |
| US20100317685A1 (en) | 2010-12-16 |
| EP2225241B1 (fr) | 2011-09-14 |
| JP2011508758A (ja) | 2011-03-17 |
| ATE524468T1 (de) | 2011-09-15 |
| BRPI0821674A2 (pt) | 2015-06-16 |
| TW200942539A (en) | 2009-10-16 |
| IL206668A0 (en) | 2010-12-30 |
| EA201070816A1 (ru) | 2010-12-30 |
| AR070071A1 (es) | 2010-03-10 |
| MA32060B1 (fr) | 2011-02-01 |
| FR2925900B1 (fr) | 2011-03-04 |
| UY31586A1 (es) | 2009-08-03 |
| CA2710943A1 (fr) | 2009-09-03 |
| WO2009106748A3 (fr) | 2009-12-30 |
| MX2010007348A (es) | 2010-08-18 |
| KR20100099245A (ko) | 2010-09-10 |
| WO2009106748A2 (fr) | 2009-09-03 |
| ZA201004641B (en) | 2011-09-28 |
| EP2225241A2 (fr) | 2010-09-08 |
| AU2008351926A1 (en) | 2009-09-03 |
| CN101910176A (zh) | 2010-12-08 |
| FR2925900A1 (fr) | 2009-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |