CO6331306A2 - Derivados de n-heterociclico-imidazo[1,2alfa]piridina-2-carboxamidas su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de n-heterociclico-imidazo[1,2alfa]piridina-2-carboxamidas su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- CO6331306A2 CO6331306A2 CO10080861A CO10080861A CO6331306A2 CO 6331306 A2 CO6331306 A2 CO 6331306A2 CO 10080861 A CO10080861 A CO 10080861A CO 10080861 A CO10080861 A CO 10080861A CO 6331306 A2 CO6331306 A2 CO 6331306A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- alkyl
- alkoxy
- halogen
- optionally substituted
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 5
- 229910003827 NRaRb Inorganic materials 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- -1 hydroxy, amino Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004666 alkoxyiminoalkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- IBAHLNWTOIHLKE-UHFFFAOYSA-N cyano cyanate Chemical compound N#COC#N IBAHLNWTOIHLKE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1.- Compuestos de fórmula (I)en la que:X representa un grupo heterocíclico sustituido opcionalmente con uno o varios grupos elegidos independientemente los unos de los otros entre los átomos o grupos siguientes: halógeno, alcoxi(C1-C6), alquilo(C1-C6), ciano, óxido, COOR8, pudiendo estar los grupos alquilo y alcoxi sustituidos opcionalmente con uno o varios átomos de halógeno;R1 representa un átomo de hidrógeno, un átomo de halógeno, un grupo alcoxi(C1-C6), un grupo alquilo(C2-C6), un grupo NRaRb; pudiendo estar los grupos alquilo y alcoxi sustituidos opcionalmente con uno o varios halógeno, hidroxi, amino o grupo alcoxi(C1-C6);R2 representa uno de los grupos siguientes:un átomo de hidrógeno, un grupo alquilo(C1-C6) sustituido opcionalmente con uno o varios grupos elegidos independientemente los unos de los otros entre un hidroxi, un halógeno, un amino, un grupo NRaRb, un grupo alcoxi(C1-C6), un grupo fenilo un grupo alcoxi(C1-C6) sustituido opcionalmente con uno o varios grupos elegidos independientemente los unos de los otros entre un hidroxi, un halógeno, amino, grupo NRaRb,° un grupo alquenilo(C2-C6),° un grupo alquinilo(C2-C6),° un grupo -CO-R5° un grupo -CO-NR6R7° un grupo -CO-O-R8° un grupo -NR9CO-R10° un grupo -NR11R12,° un grupo -N=CH-NRaRb,° un átomo de halógeno,° un grupo ciano, nitro, hidroxiiminoalquilo, alcoxiiminoalquilo° un grupo alquil(C1-C6)tio,° un grupo alquil(C1-C6)sulfinilo,° un grupo alquil(C1-C6)sulfonilo,° un grupo ((alquil(C1-C6))3)sililetinilo,° un grupo -SO2-NR9R10, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800003A FR2925901B1 (fr) | 2008-01-02 | 2008-01-02 | DERIVES DE N-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6331306A2 true CO6331306A2 (es) | 2011-10-20 |
Family
ID=39712153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10080861A CO6331306A2 (es) | 2008-01-02 | 2010-07-02 | Derivados de n-heterociclico-imidazo[1,2alfa]piridina-2-carboxamidas su preparacion y su aplicacion en terapeutica |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20100317673A1 (es) |
| EP (1) | EP2225242A2 (es) |
| JP (1) | JP2011509250A (es) |
| KR (1) | KR20100099244A (es) |
| CN (1) | CN101910172A (es) |
| AR (1) | AR070072A1 (es) |
| AU (1) | AU2008351927A1 (es) |
| BR (1) | BRPI0821992A2 (es) |
| CA (1) | CA2710860A1 (es) |
| CL (1) | CL2008003933A1 (es) |
| CO (1) | CO6331306A2 (es) |
| EA (1) | EA201070813A1 (es) |
| FR (1) | FR2925901B1 (es) |
| IL (1) | IL206671A0 (es) |
| MA (1) | MA32059B1 (es) |
| MX (1) | MX2010007349A (es) |
| TW (1) | TW200934777A (es) |
| UY (2) | UY3816Q (es) |
| WO (1) | WO2009106749A2 (es) |
| ZA (1) | ZA201004643B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2903108B1 (fr) * | 2006-07-03 | 2008-08-29 | Sanofi Aventis Sa | Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique. |
| BR112013014854B1 (pt) | 2010-12-13 | 2020-12-08 | Array Biopharma | compostos de n-(1h-indazol-4-il)imidazo[1,2-a]piridina-3- carboxamida substituídos como inibidores de tirosina quinase de receptor tipo iii, seu processo de produção e composição farmacêutica |
| WO2012147890A1 (ja) * | 2011-04-27 | 2012-11-01 | 持田製薬株式会社 | 新規アゾール誘導体 |
| JP6284490B2 (ja) * | 2012-12-28 | 2018-02-28 | 株式会社新日本科学 | イミダゾピリジン誘導体を有効成分として含むｏｃｔ３活性阻害剤又はｏｃｔ３検出剤 |
| WO2020201773A1 (en) * | 2019-04-05 | 2020-10-08 | Storm Therapeutics Ltd | Mettl3 inhibitory compounds |
| US20230391770A1 (en) * | 2020-10-06 | 2023-12-07 | Storm Therapeutics Limited | Mettl3 inhibitory compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260303A (en) * | 1991-03-07 | 1993-11-09 | G. D. Searle & Co. | Imidazopyridines as serotonergic 5-HT3 antagonists |
| US7544803B2 (en) * | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| FR2903107B1 (fr) * | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| JP5358962B2 (ja) * | 2007-02-06 | 2013-12-04 | 住友化学株式会社 | 組成物及び該組成物を用いてなる発光素子 |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
-
2008
- 2008-01-02 FR FR0800003A patent/FR2925901B1/fr not_active Expired - Fee Related
- 2008-06-12 UY UY3816F patent/UY3816Q/es not_active IP Right Cessation
- 2008-12-30 UY UY31587A patent/UY31587A1/es not_active Application Discontinuation
- 2008-12-30 CL CL2008003933A patent/CL2008003933A1/es unknown
- 2008-12-30 AR ARP080105777A patent/AR070072A1/es unknown
- 2008-12-31 AU AU2008351927A patent/AU2008351927A1/en not_active Abandoned
- 2008-12-31 MX MX2010007349A patent/MX2010007349A/es not_active Application Discontinuation
- 2008-12-31 CN CN2008801238170A patent/CN101910172A/zh active Pending
- 2008-12-31 BR BRPI0821992-3A patent/BRPI0821992A2/pt not_active IP Right Cessation
- 2008-12-31 EA EA201070813A patent/EA201070813A1/ru unknown
- 2008-12-31 JP JP2010541083A patent/JP2011509250A/ja not_active Withdrawn
- 2008-12-31 KR KR1020107014639A patent/KR20100099244A/ko not_active Withdrawn
- 2008-12-31 TW TW097151676A patent/TW200934777A/zh unknown
- 2008-12-31 CA CA2710860A patent/CA2710860A1/fr not_active Abandoned
- 2008-12-31 EP EP08872909A patent/EP2225242A2/fr not_active Withdrawn
- 2008-12-31 WO PCT/FR2008/001834 patent/WO2009106749A2/fr active Application Filing
-
2010
- 2010-06-28 IL IL206671A patent/IL206671A0/en unknown
- 2010-07-01 US US12/828,370 patent/US20100317673A1/en not_active Abandoned
- 2010-07-01 ZA ZA2010/04643A patent/ZA201004643B/en unknown
- 2010-07-02 CO CO10080861A patent/CO6331306A2/es not_active Application Discontinuation
- 2010-08-02 MA MA33057A patent/MA32059B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100099244A (ko) | 2010-09-10 |
| UY3816Q (es) | 2008-09-30 |
| US20100317673A1 (en) | 2010-12-16 |
| CA2710860A1 (fr) | 2009-09-03 |
| UY31587A1 (es) | 2009-08-03 |
| FR2925901B1 (fr) | 2011-03-04 |
| JP2011509250A (ja) | 2011-03-24 |
| WO2009106749A2 (fr) | 2009-09-03 |
| WO2009106749A3 (fr) | 2010-05-06 |
| BRPI0821992A2 (pt) | 2015-06-23 |
| MX2010007349A (es) | 2010-08-18 |
| TW200934777A (en) | 2009-08-16 |
| EA201070813A1 (ru) | 2010-12-30 |
| EP2225242A2 (fr) | 2010-09-08 |
| CN101910172A (zh) | 2010-12-08 |
| AU2008351927A1 (en) | 2009-09-03 |
| CL2008003933A1 (es) | 2010-02-12 |
| IL206671A0 (en) | 2010-12-30 |
| ZA201004643B (en) | 2011-09-28 |
| FR2925901A1 (fr) | 2009-07-03 |
| MA32059B1 (fr) | 2011-02-01 |
| AR070072A1 (es) | 2010-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |