CO6290755A2 - Derivados de azetidinas su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de azetidinas su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- CO6290755A2 CO6290755A2 CO10073795A CO10073795A CO6290755A2 CO 6290755 A2 CO6290755 A2 CO 6290755A2 CO 10073795 A CO10073795 A CO 10073795A CO 10073795 A CO10073795 A CO 10073795A CO 6290755 A2 CO6290755 A2 CO 6290755A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl group
- alkyl
- group
- optionally substituted
- hydrogen atom
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 150000001539 azetidines Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 1
- FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical compound C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 abstract 1
- YHIIJNLSGULWAA-UHFFFAOYSA-N 1,4-thiazinane 1-oxide Chemical compound O=S1CCNCC1 YHIIJNLSGULWAA-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 1
- -1 halo (C1-C6) alkyl Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Psychiatry (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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Abstract
La presente invención tiene por objeto los compuestos que responden a la fórmula (I) en la que: R representa un grupo alquilo(C1-C6), haloalquilo(C1-C6); R' representa un grupo NR4R5, OR8; A y B, si están presentes, representan independientemente uno del otro, uno o dos átomos de carbono, estando estos átomos de carbono sustituidos con uno o varios hidrógenos, grupos alquilo(C1-C6); estando el o los grupos alquilo(C1-C6) opcionalmente sustituidos; A+B representan como máximo dos carbonos; R1 representa un átomo de hidrógeno o un grupo alquilo(C1-C6); R2 y R3 representan, independientemente entre sí, un átomo de hidrógeno, un grupo alquilo (C1-C6); estando el grupo alquilo(C1-C6) opcionalmente sustituido; R4 y R5 representan independientemente el uno del otro, un átomo de hidrógeno, un grupo alquilo(C1-C6), o forman, con el átomo de nitrógeno al que están unidos, un heterociclo de tipo azetidina, pirrolidina, piperidina, azepán, piperacina, homopiperacina, morfolina, tiomorfolina, tiomorfolina S-óxido, tiomorfolina S-dióxido, estando este heterociclo sustituido opcionalmente con un grupo alquilo(C1-C6);representado R6 y R7 cada uno un grupo fenilo, opcionalmente sustituido; Y representa un átomo de hidrógeno, un halógeno, un grupo alquilo(C1-C6), haloalquilo(C1-C6), alcoxi(C1-C6), haloalcoxi(C1-C6), alquilo(C1-C6)S(O)p o ciano; R8 es un átomo de hidrógeno, un grupo alquilo(C1-C6), un grupo haloalquilo(C1-C6), un grupo alilo, un grupo fenilalquilo(C1-C6), estando el grupo fenilo opcionalmente sustituido con 1 ó 2 grupos O-metilo; p representa un número entero elegido entre 0, 1 ó 2; en el estado de base o de sal de adición a un ácido o a una base. Procedimiento de preparación y aplicación en terapéutica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0708830A FR2925051B1 (fr) | 2007-12-18 | 2007-12-18 | Derives d'azetidines,leur preparation et leur application en therapeutique |
| FR0802492A FR2930941B1 (fr) | 2008-05-06 | 2008-05-06 | Derives d'azetidines, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6290755A2 true CO6290755A2 (es) | 2011-06-20 |
Family
ID=40935338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10073795A CO6290755A2 (es) | 2007-12-18 | 2010-06-18 | Derivados de azetidinas su preparacion y su aplicacion en terapeutica |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8445478B2 (es) |
| EP (1) | EP2234966B1 (es) |
| JP (1) | JP5460614B2 (es) |
| KR (1) | KR20100098563A (es) |
| CN (1) | CN101945852B (es) |
| AR (1) | AR069700A1 (es) |
| AU (1) | AU2008351943B2 (es) |
| BR (1) | BRPI0822054A2 (es) |
| CA (1) | CA2709863A1 (es) |
| CL (1) | CL2008003780A1 (es) |
| CO (1) | CO6290755A2 (es) |
| CY (1) | CY1114991T1 (es) |
| DK (1) | DK2234966T3 (es) |
| EA (1) | EA019315B1 (es) |
| ES (1) | ES2439258T3 (es) |
| HR (1) | HRP20131168T1 (es) |
| IL (1) | IL206420A (es) |
| MA (1) | MA32019B1 (es) |
| PA (1) | PA8808101A1 (es) |
| PE (1) | PE20091270A1 (es) |
| PL (1) | PL2234966T3 (es) |
| PT (1) | PT2234966E (es) |
| SI (1) | SI2234966T1 (es) |
| TW (1) | TW200930360A (es) |
| UY (1) | UY31548A1 (es) |
| WO (1) | WO2009106708A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| FR2946650B1 (fr) * | 2009-06-16 | 2011-08-19 | Sanofi Aventis | Esters derives d'azetidines, leur preparation et leur application en therapeutique. |
| WO2012031220A2 (en) | 2010-09-03 | 2012-03-08 | University Of Florida Research Foundation, Inc. | Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use |
| GB201321601D0 (en) * | 2013-12-06 | 2014-01-22 | Canbex Therapeutics Ltd | Modulator |
| US11003343B2 (en) * | 2014-01-06 | 2021-05-11 | Lett.rs LLC | Electronic personal signature generation and distribution for personal communication |
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| CA2399791A1 (en) * | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases |
| FR2805817B1 (fr) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation |
| FR2814678B1 (fr) * | 2000-10-04 | 2002-12-20 | Aventis Pharma Sa | Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite |
| BR0313041A (pt) * | 2002-07-29 | 2005-06-21 | Hoffmann La Roche | Compostos; composições farmacêuticas; método para o tratamento e/ou profilaxia de doenças que estão associadas à modulação dos receptores de cb1; e uso de compostos |
| EP1620395B1 (en) * | 2003-05-01 | 2009-12-30 | Vernalis Research Limited | Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders |
| PE20071092A1 (es) * | 2005-12-08 | 2007-12-10 | Aventis Pharma Inc | Composicion farmaceutica que comprende un antagonista de cb1 y un agente antisicotico |
| AU2007226673A1 (en) * | 2006-03-10 | 2007-09-20 | Jenrin Discovery | Cannabinoid receptor antagonists/inverse agonists useful for treating obesity |
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- 2008-12-16 WO PCT/FR2008/001748 patent/WO2009106708A2/fr active Application Filing
- 2008-12-16 EP EP08872952.0A patent/EP2234966B1/fr active Active
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