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CO6280485A2 - Inhibidores de 11-beta hidroxiesteroide deshidrogenasa tipo i de triazolopiridina - Google Patents

Inhibidores de 11-beta hidroxiesteroide deshidrogenasa tipo i de triazolopiridina

Info

Publication number
CO6280485A2
CO6280485A2 CO10035487A CO10035487A CO6280485A2 CO 6280485 A2 CO6280485 A2 CO 6280485A2 CO 10035487 A CO10035487 A CO 10035487A CO 10035487 A CO10035487 A CO 10035487A CO 6280485 A2 CO6280485 A2 CO 6280485A2
Authority
CO
Colombia
Prior art keywords
alkyl
haloalkyl
cycloalkyl
nr9so2r9a
nr9cor9a
Prior art date
Application number
CO10035487A
Other languages
English (en)
Inventor
Jun Li
James Li
Michael Galella
Chenkou Wei
Reginald O Cann
Laxma Kolla
Rajendra P Deshpande
Xinhua Qian
Jie Li
Haixia Wang
Lawrence J Kennedy
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40523804&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6280485(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CO6280485A2 publication Critical patent/CO6280485A2/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
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  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1.- Un compuesto de fórmula Isus enantiómeros, diastereoisómeros o sales, en la que:O es L, Laa o Lee;X es C e Y es N; oX es N e Y es C;G es R4, R4aa o R4ee;L es -alquenil-(W1)n, -cicloalquil-(W1)n o -alquil-(W2)n; Laa es -alquenil-(W1)n o -alquil-(W2aa)n;Lee es -alquenil-(W1ee)n, -cicloalquil-(W1)n o -alquil-(W2ee)n; n es 1 a 3;W1, cada vez que aparece, es independientemente halógeno, -OH, -CN, -CO2R6, -CONR8R8a, -OCONR8R8a, -SO2NR8R8a, -SOR6, -SO2R6, NR9SO2R9a, -NR9CO2R9a, -NR9COR9a, aquilo, cicloalquilo, haloalquilo, alcoxi, ariloxi, haloalcoxi, alquiltio, ariltio, arilsulfonilo, alquilamino, amino, aminoalquilo, arilamino o heteroarilamino;W1ee es independientemente halógeno, -OH, -CN, -CO2R6, -CONR8R8a, -OCONR8R8a, -SO2NR8R8a, -SOR6, -SO2R6, -NR9SO2R9a, NR9CO2R9a, -NR9COR9a, cicloalquilo, alquilo, haloalquilo, alcoxi, ariloxi, haloalcoxi, alquiltio, ariltio, arilsulfonilo, alquilamino, amino, aminoalquilo, arilamino o heteroarilamino;W2 es independientemente halógeno, -OH, -CO2H, -CN, -CO2R6, -CONR8R8a, -OCOR6, OCONR8R8a, -SO2NR8R8a, -SO-alquilo, -SO2-alquilo, -NR9SO2R9a, -NR9CO2R9a, -NR9COR9a, cicloalquilo, alquilo, haloalquilo, alcoxi, alquenilo, haloalcoxi, alquiltio, alquilamino, amino o aminoalquilo;W2aa es independientemente halógeno, -OH, -CN, -CO2H, -CO2R6, -CONR8R8a, -OCOR6, -OCONR8R8a, -SO2NR8R8a, -SO-alquilo, -SO2-alquilo, -NR9SO2R9a, -NR9CO2R9a, -NR9COR9a, cicloalquilo, alquilo, haloalquilo, alquenilo, haloalcoxi, alquiltio, amino, aminoalquilo; ...
CO10035487A 2007-10-01 2010-03-25 Inhibidores de 11-beta hidroxiesteroide deshidrogenasa tipo i de triazolopiridina CO6280485A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97650607P 2007-10-01 2007-10-01
US12/206,801 US8119658B2 (en) 2007-10-01 2008-09-09 Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors

Publications (1)

Publication Number Publication Date
CO6280485A2 true CO6280485A2 (es) 2011-05-20

Family

ID=40523804

Family Applications (1)

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CO10035487A CO6280485A2 (es) 2007-10-01 2010-03-25 Inhibidores de 11-beta hidroxiesteroide deshidrogenasa tipo i de triazolopiridina

Country Status (20)

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US (2) US8119658B2 (es)
EP (1) EP2205598A1 (es)
JP (1) JP5611044B2 (es)
KR (1) KR20100085081A (es)
CN (1) CN101883772B (es)
AR (1) AR068601A1 (es)
AU (1) AU2008309101B2 (es)
BR (1) BRPI0817656A2 (es)
CA (1) CA2701355A1 (es)
CL (1) CL2008002916A1 (es)
CO (1) CO6280485A2 (es)
EA (2) EA019706B1 (es)
IL (1) IL204799A (es)
MX (1) MX2010003565A (es)
NZ (1) NZ584386A (es)
PE (2) PE20091219A1 (es)
SG (1) SG190638A1 (es)
TW (1) TW200916470A (es)
WO (1) WO2009045753A1 (es)
ZA (1) ZA201002043B (es)

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