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CO6251284A2 - Derivados de 4-(2-amino -1-hidroxietil)fenol como agonistas del receptor adrenergico beta 2 - Google Patents

Derivados de 4-(2-amino -1-hidroxietil)fenol como agonistas del receptor adrenergico beta 2

Info

Publication number
CO6251284A2
CO6251284A2 CO10105924A CO10105924A CO6251284A2 CO 6251284 A2 CO6251284 A2 CO 6251284A2 CO 10105924 A CO10105924 A CO 10105924A CO 10105924 A CO10105924 A CO 10105924A CO 6251284 A2 CO6251284 A2 CO 6251284A2
Authority
CO
Colombia
Prior art keywords
group
attached
groups
monocyclic
aryl
Prior art date
Application number
CO10105924A
Other languages
English (en)
Inventor
Duran Carlos Puig
Crespo Maria Isabel Crespo
Quinones Maria Prat
Feu Laia Sole
Crespo Daniel Perez
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of CO6251284A2 publication Critical patent/CO6251284A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)

Abstract

La presente invención proporciona un compuesto de la fórmula (I):en donde: R1 es un grupo seleccionado de -CH2OH, -NHCOH y R2 es un átomo de hidrógeno; o R1 junto con R2 forman el grupo -NHC(O)CH=CH-, en donde el átomo de nitrógeno está unido al átomo de carbono del anillo de fenilo al que está unido R1 y el átomo de carbono está unido al átomo de carbono del anillo de fenilo al que está unido R2 R3a y R3b se seleccionan independientemente del grupo que consiste en átomos de hidrógeno y grupos alquilo C1-4n es un número entero seleccionado de 0 a 6, R4 se selecciona del grupo que consiste en un grupo cicloalquilo C3-10 monocíclico o policíclico opcionalmente sustituido, un grupo arilo C5-10 monocíclico opcionalmente sustituido y un grupo metilo que está sustituido con uno o más sustituyentes seleccionados de grupos arilo C5-10 y ariloxi C5-10, en donde los grupos cicloalquilo C3-10 monocíclicos o policíclicos y los grupos arilo C5-10 monocíclicos independientemente están opcionalmente sustituidos con uno o más sustituyentes seleccionados de átomos de halógeno, grupos alquilo C1-4, alcoxi C1-4, arilo C5-10 y ariloxi C5-10, o una sal o solvato o estereoisómero del mismo farmacéuticamente aceptables.
CO10105924A 2008-02-28 2010-08-27 Derivados de 4-(2-amino -1-hidroxietil)fenol como agonistas del receptor adrenergico beta 2 CO6251284A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08382008A EP2096105A1 (en) 2008-02-28 2008-02-28 Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor

Publications (1)

Publication Number Publication Date
CO6251284A2 true CO6251284A2 (es) 2011-02-21

Family

ID=39645317

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10105924A CO6251284A2 (es) 2008-02-28 2010-08-27 Derivados de 4-(2-amino -1-hidroxietil)fenol como agonistas del receptor adrenergico beta 2

Country Status (15)

Country Link
US (1) US20110028442A1 (es)
EP (2) EP2096105A1 (es)
JP (1) JP2011517316A (es)
KR (1) KR20100138886A (es)
CN (1) CN101939291A (es)
AU (1) AU2009218688A1 (es)
CA (1) CA2716397A1 (es)
CO (1) CO6251284A2 (es)
EC (1) ECSP10010431A (es)
IL (1) IL206236A0 (es)
MX (1) MX2010008864A (es)
NZ (1) NZ586049A (es)
RU (1) RU2010139571A (es)
WO (1) WO2009106351A1 (es)
ZA (1) ZA201004009B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
ES2296516B1 (es) * 2006-04-27 2009-04-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
ES2306595B1 (es) * 2007-02-09 2009-09-11 Laboratorios Almirall S.A. Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
ES2320961B1 (es) * 2007-11-28 2010-03-17 Laboratorios Almirall, S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2.
UY32297A (es) 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
MA38260B1 (fr) 2012-12-18 2018-04-30 Almirall Sa Nouveaux dérivés de cyclohexyl et quinuclidinyl carbamate ayant une activité d'agoniste adrénergique beta2 et une activité d'antagoniste muscarinique m3
CZ306252B6 (cs) * 2013-03-15 2016-10-26 Zentiva, K.S. Způsob přípravy 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-chinolin-2-onu (indacaterolu)

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Also Published As

Publication number Publication date
EP2254860A1 (en) 2010-12-01
US20110028442A1 (en) 2011-02-03
JP2011517316A (ja) 2011-06-02
NZ586049A (en) 2011-07-29
RU2010139571A (ru) 2012-04-10
ECSP10010431A (es) 2010-09-30
IL206236A0 (en) 2010-12-30
CA2716397A1 (en) 2009-09-03
WO2009106351A1 (en) 2009-09-03
EP2096105A1 (en) 2009-09-02
AU2009218688A1 (en) 2009-09-03
MX2010008864A (es) 2010-09-07
KR20100138886A (ko) 2010-12-31
CN101939291A (zh) 2011-01-05
ZA201004009B (en) 2011-02-23

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