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CO6210726A2 - Derivados de isoquinolona sustituidos con cicloalquilamina - Google Patents

Derivados de isoquinolona sustituidos con cicloalquilamina

Info

Publication number
CO6210726A2
CO6210726A2 CO09062108A CO09062108A CO6210726A2 CO 6210726 A2 CO6210726 A2 CO 6210726A2 CO 09062108 A CO09062108 A CO 09062108A CO 09062108 A CO09062108 A CO 09062108A CO 6210726 A2 CO6210726 A2 CO 6210726A2
Authority
CO
Colombia
Prior art keywords
alkyl
alkylene
cicloalquilamina
halogen
derivatives substituted
Prior art date
Application number
CO09062108A
Other languages
English (en)
Inventor
Oliver Plettenburg
Armin Hofmeister
Katrin Lorenz
Joachin Brendel
Matthias Lohn
John Weston
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38565513&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6210726(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CO6210726A2 publication Critical patent/CO6210726A2/es

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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

1.- Un compuesto de la fórmula (I)o de la fórmula (I')en la queR2 es H, halógeno o alquilo (C1-C6); R3 es H, halógeno, alquilo (C1-C6), alquileno (C1-C6)-R', OH, O-R", NH2, NHR", NR"R" o NH-C(O)-R", R4 es H, halógeno, hidroxi, CN, alquilo (C1-C6), R´, alquileno (C1-C6)-R'; R5 es H, halógeno, CN, NO2, alquilo (C1-C6), alquenilo (C2-C6), R´, alquileno (C1-C6)-arilo (C6-C10), alquenileno (C1-C6)-arilo(C6-C10), alquileno (C1-C6)-heterociclilo (C5-C10),CH(OH)-alquilo (C1-C6), NH2, NH-R', NH-SO2H, NH-SO2-aIquilo (C1-C6), NH-SO2-R', NH-C(O)-alquilo ((C1-C6), NH-C(O)-R´, C(O)N[alquilo (C1-C6)]2, C(O)OH, o C(O)O-alquilo (C1-C6); R6 y R6' son independientemente entre sí H, R´, alquilo (C1-C8), alquileno (C1-C6)R', alquileno (C1-C6)-O-alquilo (C1-C6), alquileno (C1-C6)-O-R´, alquileno (C1-C6)-CH[R']2, alquileno (C1-C6)-C(O)-R', alquileno (C1-C6)-C(O)NH2, alquileno (C1-C6)-C(O)NH-R', alquileno (C1-C6)-C(O)NH-alquilo (C1-C6), alquileno (C1-C6)-C(O)N[alquilo (C1-C6)]2, alquileno (C1-C6)-C(O)N[R']2; alquileno (C1-C6)-C(O)O-alquilo (C1-C6), C(O)O-alquilo (C1-C6), C(O)OR', C(O)-alquilo (C1-C6), C(O)R', C(O)NH-alquilo (C1-C6), C(O)NHR', C(O)N[alquil (C1-C6)]R', C(O)N[alquilo (C1-C6)]2, C(O)-alquileno (C1-C6)-R', C(O)O-alquileno (C1-C6)-R', o R6 y R6', junto con el átomo de N al que están unidos, forman un grupo heterociclilo (C5-C10);R7 es H, halógeno, CN, NO2, alquilo (C1-C6),O-alquilo (C1-C6), alquenilo (C2-C6), R´, ...
CO09062108A 2006-12-27 2009-06-16 Derivados de isoquinolona sustituidos con cicloalquilamina CO6210726A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06026899 2006-12-27

Publications (1)

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CO6210726A2 true CO6210726A2 (es) 2010-10-20

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US (1) US8742116B2 (es)
EP (1) EP2125745B1 (es)
JP (1) JP5405314B2 (es)
KR (1) KR101474228B1 (es)
CN (1) CN101595094B (es)
AR (1) AR064492A1 (es)
AU (1) AU2007338407B2 (es)
BR (1) BRPI0722064A2 (es)
CA (1) CA2673917C (es)
CL (1) CL2007003821A1 (es)
CO (1) CO6210726A2 (es)
CR (1) CR10813A (es)
DO (1) DOP2009000164A (es)
EC (1) ECSP099467A (es)
ES (1) ES2625266T3 (es)
GT (1) GT200900179A (es)
HK (1) HK1139390A1 (es)
IL (1) IL199540A (es)
MA (1) MA31075B1 (es)
MX (1) MX2009005966A (es)
MY (1) MY155009A (es)
NI (1) NI200900108A (es)
NO (1) NO20092422L (es)
NZ (1) NZ577980A (es)
RU (1) RU2457203C2 (es)
SV (1) SV2009003318A (es)
TN (1) TN2009000269A1 (es)
TW (1) TWI434689B (es)
UY (1) UY30843A1 (es)
WO (1) WO2008077551A1 (es)
ZA (1) ZA200903551B (es)

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