CO6190523A2 - Nuevos derivados de aminopirimidina como inhibidores de plk1 - Google Patents
Nuevos derivados de aminopirimidina como inhibidores de plk1Info
- Publication number
- CO6190523A2 CO6190523A2 CO09048000A CO09048000A CO6190523A2 CO 6190523 A2 CO6190523 A2 CO 6190523A2 CO 09048000 A CO09048000 A CO 09048000A CO 09048000 A CO09048000 A CO 09048000A CO 6190523 A2 CO6190523 A2 CO 6190523A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- lower alkyl
- substituted
- alkyl group
- different
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
1.- Un compuesto de Fórmula (I):o una sal farmacéuticamente aceptable o éster del mismo, donde: cada uno de R1 y R2, que pueden ser iguales o diferentes, es un átomo de hidrógeno; un átomo de halógeno; un grupo alquilo inferior que tiene de uno a dos átomos de carbono, que puede estar sustituido con de uno a tres átomos de flúor; o un grupo ciclopropilo; uno de R3 y R4 es un átomo de hidrógeno, mientras que el otro de R3 y R4 es: a) un grupo alquilo inferior sustituido con NRaRb, donde cada uno de Ra y Rb, que pueden ser iguales o diferentes, es un átomo de hidrógeno, un grupo alquilo inferior, un grupo bencilo, o un grupo cicloalquilo que tiene de tres a seis átomos de carbono, donde el grupo cicloalquilo puede estar sustituido con uno o más sustituyentes, que pueden ser iguales o diferentes, seleccionados entre los siguientes 1) a 3): un grupo alquilo inferior; 2) un sustituyente seleccionado entre el ; y 3) un grupo alquilo inferior sustituido con uno o más sustituyentes seleccionados entre el ; y el grupo cicloalquilo puede incluir un enlace insaturado; b) un grupo heterocíclico alifático de 4 a 6 miembros seleccionado entre un grupo azetidinilo, un grupo pirrolidinilo, un grupo piperidinilo, y un grupo piperazinilo; c) un grupo alquilo inferior sustituido con un grupo heterocíclico alifático de 4 a 6 miembros seleccionado entre un grupo azetidinilo, un grupo pirrolidinilo, un grupo piperidinilo, y un grupo piperazinilo, d) un grupo heterocíclico aromático de 5 ó 6 miembros seleccionado entre un grupo pirrolilo, un grupo imidazolilo, un grupo pirazolilo, un grupo piridilo, un grupo pirazinilo, y un grupo pirimidinilo; o ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006356575 | 2006-12-28 | ||
| JP2007265783 | 2007-10-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6190523A2 true CO6190523A2 (es) | 2010-08-19 |
Family
ID=39588592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09048000A CO6190523A2 (es) | 2006-12-28 | 2009-05-12 | Nuevos derivados de aminopirimidina como inhibidores de plk1 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7977336B2 (es) |
| EP (2) | EP2116543A4 (es) |
| JP (1) | JPWO2008081914A1 (es) |
| KR (1) | KR101481388B1 (es) |
| CN (1) | CN101573361B (es) |
| AR (1) | AR064619A1 (es) |
| AU (1) | AU2007340530B2 (es) |
| BR (1) | BRPI0718966B8 (es) |
| CA (1) | CA2668738A1 (es) |
| CL (1) | CL2007003758A1 (es) |
| CO (1) | CO6190523A2 (es) |
| CR (1) | CR10784A (es) |
| EC (1) | ECSP099324A (es) |
| GT (1) | GT200900124A (es) |
| IL (1) | IL198675A0 (es) |
| MA (1) | MA31109B1 (es) |
| MX (1) | MX2009004920A (es) |
| NO (1) | NO20092770L (es) |
| NZ (1) | NZ577273A (es) |
| PE (1) | PE20081845A1 (es) |
| RU (1) | RU2458062C2 (es) |
| SV (1) | SV2009003258A (es) |
| TW (1) | TW200835485A (es) |
| WO (2) | WO2008081910A1 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009006706A (es) | 2006-12-22 | 2009-07-02 | Astex Therapeutics Ltd | Compuestos heterociclicos biciclicos como inhibidores del receptor del factor de crecimiento de fibroblastos. |
| WO2008078100A2 (en) | 2006-12-22 | 2008-07-03 | Astex Therapeutics Limited | Tricyclic amine derivatives as protein tyrosine kinase inhibitors |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| WO2010013633A1 (ja) * | 2008-07-31 | 2010-02-04 | 萬有製薬株式会社 | 細胞のｒｂステイタス及びｐｌｋ１阻害剤に対する感受性を予測する方法 |
| JP4489132B2 (ja) * | 2008-08-22 | 2010-06-23 | 株式会社東芝 | 磁気記録媒体の製造方法 |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| US8445674B2 (en) | 2009-10-21 | 2013-05-21 | Hoffmann-La Roche Inc | Heterocyclyl compounds |
| AU2010311511B2 (en) | 2009-10-30 | 2014-07-17 | Janssen Pharmaceutica Nv | Imidazo[1,2-b]pyridazine derivatives and their use as PDE10 inhibitors |
| UY33213A (es) | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| EP2463289A1 (en) | 2010-11-26 | 2012-06-13 | Almirall, S.A. | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors |
| CA2838645C (en) | 2011-06-27 | 2020-03-10 | Janssen Pharmaceutica Nv | 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives |
| EP2554544A1 (en) | 2011-08-01 | 2013-02-06 | Almirall, S.A. | Pyridin-2(1h)-one derivatives as jak inhibitors |
| SG11201400989TA (en) | 2011-09-27 | 2014-04-28 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| WO2014001314A1 (en) | 2012-06-26 | 2014-01-03 | Janssen Pharmaceutica Nv | Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
| CA2875057C (en) | 2012-07-09 | 2021-07-13 | Janssen Pharmaceutica Nv | Imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyrazine compounds and their use as inhibitors of the phosphodiesterase 10 enzyme |
| ES2668861T3 (es) | 2012-07-31 | 2018-05-22 | Crown Bioscience, Inc. (Taicang) | Marcadores histológicos para identificar pacientes con carcinoma de pulmón de células no pequeñas para el tratamiento con un fármaco anti EGFR |
| WO2014046617A1 (en) * | 2012-09-19 | 2014-03-27 | Agency For Science, Technology And Research | Compositions and methods for treating cancer |
| JP6559228B2 (ja) | 2014-09-17 | 2019-08-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肥満症及び糖尿病の治療に有用なテトラヒドロイソキノリン誘導体及び医薬組成物 |
| EP3997088A4 (en) * | 2019-07-10 | 2022-12-28 | Aucentra Therapeutics Pty Ltd | DERIVATIVES OF 4-(IMIDAZO[L,2-A]PYRIDIN-3-YL)-N-(PYRIDINYL)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS |
| BR112022001158A2 (pt) | 2019-07-24 | 2022-05-17 | Merck Patent Gmbh | Derivados de 4-(imidazo[1,2-a]piridin-3-il)-pirimidina |
| CN112592318B (zh) * | 2020-12-12 | 2022-05-03 | 贵州医科大学 | 2-(4-甲氨酰基)苯胺基-4-氨基嘧啶衍生物及应用 |
| CN119318874A (zh) * | 2024-12-18 | 2025-01-17 | 淄博凯美可工贸有限公司 | 一种节能型复合脱硫剂的制备方法 |
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| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5223608A (en) | 1987-08-28 | 1993-06-29 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| FI95708C (fi) | 1988-10-31 | 1996-03-11 | Eisai Co Ltd | Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi |
| JPH045029A (ja) | 1990-04-23 | 1992-01-09 | Bridgestone Corp | 空気入りタイヤ |
| ES2137932T3 (es) | 1990-09-28 | 2000-01-01 | Smithkline Beecham Corp | Procedimiento para la preparacion de analogos de camptotecina solubles en agua, asi como los compuestos 10-hidroxi-11-alcoxi-6-camptotecina. |
| US5191082A (en) | 1990-12-20 | 1993-03-02 | North Carolina State University | Camptothecin intermediate and method of making camptothecin intermediates |
| US5200524A (en) | 1990-12-20 | 1993-04-06 | North Carolina State University | Camptothecin intermediates and method of making same |
| US5247089A (en) | 1990-12-20 | 1993-09-21 | North Carolina State University | Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs |
| US5243050A (en) | 1990-12-20 | 1993-09-07 | North Carolina State University | Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs |
| US5162532A (en) | 1990-12-20 | 1992-11-10 | North Carolina State University | Intermediates and method of making camptothecin and camptothecin analogs |
| EP1167384B1 (en) | 1992-10-28 | 2006-12-13 | Genentech, Inc. | HVEGF Receptor as Vascular endothelial cell growth factor antagonists |
| JP3025602B2 (ja) | 1993-05-21 | 2000-03-27 | デビオファーム エス．アー． | 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法 |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
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| JP3154399B2 (ja) | 1996-07-04 | 2001-04-09 | デビオファーム エス．アー． | 白金化合物の製造方法 |
| DE60018037T2 (de) * | 1999-11-10 | 2006-01-12 | Ortho-Mcneil Pharmaceutical, Inc. | Substituierte 2-aryl-3-(heteroaryl)-imidazo[1,2-alpha]pyrimidine und ihren verwandten arzneimittel und verfahren |
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| CA2450555A1 (en) | 2001-06-25 | 2003-01-03 | Merck & Co., Inc. | (pyrimidyl)(phenyl)substituted fused heteroaryl p38 inhibiting and pkg kinase inhibiting compounds |
| CA2455181C (en) | 2001-08-01 | 2010-04-06 | Merck & Co., Inc. | Benzimidazo[4,5-f]isoquinolinone derivatives |
| UA80296C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Imidazolopyridines and methods of making and using the same |
| JPWO2004043936A1 (ja) | 2002-11-14 | 2006-03-09 | 協和醗酵工業株式会社 | Ｐｌｋ阻害剤 |
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| AU2005278292B2 (en) * | 2004-08-31 | 2011-09-08 | Msd K.K. | Novel substituted imidazole derivatives |
-
2007
- 2007-12-18 US US12/002,546 patent/US7977336B2/en active Active
- 2007-12-20 BR BRPI0718966A patent/BRPI0718966B8/pt active IP Right Grant
- 2007-12-20 JP JP2008552168A patent/JPWO2008081914A1/ja not_active Ceased
- 2007-12-20 EP EP07851126A patent/EP2116543A4/en not_active Withdrawn
- 2007-12-20 CL CL200703758A patent/CL2007003758A1/es unknown
- 2007-12-20 AU AU2007340530A patent/AU2007340530B2/en active Active
- 2007-12-20 TW TW096149071A patent/TW200835485A/zh unknown
- 2007-12-20 CA CA002668738A patent/CA2668738A1/en not_active Abandoned
- 2007-12-20 CN CN2007800488795A patent/CN101573361B/zh active Active
- 2007-12-20 WO PCT/JP2007/075224 patent/WO2008081910A1/en active Application Filing
- 2007-12-20 EP EP07851112A patent/EP2114942B1/en active Active
- 2007-12-20 AR ARP070105784A patent/AR064619A1/es not_active Application Discontinuation
- 2007-12-20 WO PCT/JP2007/075240 patent/WO2008081914A1/ja active Application Filing
- 2007-12-20 MX MX2009004920A patent/MX2009004920A/es active IP Right Grant
- 2007-12-20 KR KR1020097013324A patent/KR101481388B1/ko active Active
- 2007-12-20 RU RU2009128966/04A patent/RU2458062C2/ru active
- 2007-12-20 NZ NZ577273A patent/NZ577273A/en not_active IP Right Cessation
-
2008
- 2008-01-02 PE PE2008000054A patent/PE20081845A1/es not_active Application Discontinuation
-
2009
- 2009-05-08 CR CR10784A patent/CR10784A/es not_active Application Discontinuation
- 2009-05-10 IL IL198675A patent/IL198675A0/en unknown
- 2009-05-12 SV SV2009003258A patent/SV2009003258A/es active IP Right Grant
- 2009-05-12 CO CO09048000A patent/CO6190523A2/es not_active Application Discontinuation
- 2009-05-12 EC EC2009009324A patent/ECSP099324A/es unknown
- 2009-05-12 GT GT200900124A patent/GT200900124A/es unknown
- 2009-07-23 MA MA32115A patent/MA31109B1/fr unknown
- 2009-07-27 NO NO20092770A patent/NO20092770L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |