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CO5690562A2 - Metodos para la preparacion del acido {2-[(8,9)-dioxo-2-6-diazabiciclo[5.2.0] non-1(7)-en-2-il]} fosfonico y sus esteres - Google Patents

Metodos para la preparacion del acido {2-[(8,9)-dioxo-2-6-diazabiciclo[5.2.0] non-1(7)-en-2-il]} fosfonico y sus esteres

Info

Publication number
CO5690562A2
CO5690562A2 CO06037264A CO06037264A CO5690562A2 CO 5690562 A2 CO5690562 A2 CO 5690562A2 CO 06037264 A CO06037264 A CO 06037264A CO 06037264 A CO06037264 A CO 06037264A CO 5690562 A2 CO5690562 A2 CO 5690562A2
Authority
CO
Colombia
Prior art keywords
diazabiciclo
dioxo
phosphonic
esters
preparation
Prior art date
Application number
CO06037264A
Other languages
English (en)
Inventor
Bogdan Kazimierz Wilk
Galina Vid
Weiguo Liu
Xinxu Shi
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CO5690562A2 publication Critical patent/CO5690562A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1.- Un método para preparar un compuesto de Fórmula IV: donde R1 y R2 son independientemente alquilo C1-6 o haloalquilo C1-6, consistente en la etapa de hacer reaccionar, en un solvente, un compuesto de Fórmula II: con un compuesto de fórmula III: donde: Q1 y Q2 son cada uno independientemente OH, halógeno o OX1, donde X1 es alquilo C1-6, haloalquilo C1-6 o arilo.
CO06037264A 2003-10-22 2006-04-20 Metodos para la preparacion del acido {2-[(8,9)-dioxo-2-6-diazabiciclo[5.2.0] non-1(7)-en-2-il]} fosfonico y sus esteres CO5690562A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51361103P 2003-10-22 2003-10-22

Publications (1)

Publication Number Publication Date
CO5690562A2 true CO5690562A2 (es) 2006-10-31

Family

ID=34520119

Family Applications (1)

Application Number Title Priority Date Filing Date
CO06037264A CO5690562A2 (es) 2003-10-22 2006-04-20 Metodos para la preparacion del acido {2-[(8,9)-dioxo-2-6-diazabiciclo[5.2.0] non-1(7)-en-2-il]} fosfonico y sus esteres

Country Status (17)

Country Link
US (2) US7345032B2 (es)
EP (1) EP1675863A2 (es)
JP (1) JP2007509857A (es)
KR (1) KR20060094967A (es)
CN (1) CN1871246A (es)
AR (1) AR046130A1 (es)
AU (1) AU2004284066A1 (es)
BR (1) BRPI0415857A (es)
CA (1) CA2543008A1 (es)
CO (1) CO5690562A2 (es)
GT (1) GT200400213A (es)
MX (1) MXPA06004397A (es)
PA (1) PA8615401A1 (es)
PE (1) PE20050908A1 (es)
TW (1) TW200514775A (es)
WO (1) WO2005040176A2 (es)
ZA (1) ZA200603236B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1622625A1 (en) * 2003-04-09 2006-02-08 Wyeth Pharmaceutical compositions for intranasal administration of [2-(8,9-dioxo-2,6-diazabicyclo [5.2.o] non-1 (7)-en-2-yl )alkyl] phosphonic acid and derivatives and methods of use thereof
BRPI1009900A2 (pt) 2009-03-19 2016-03-15 Wyeth Llc métodos para a preparação de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfônico e seus precursores
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
CN110996948A (zh) 2017-06-12 2020-04-10 格莱泰施有限责任公司 用nmda拮抗剂和d2/5ht2a或选择性5ht2a拮抗剂治疗抑郁症

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518660A1 (de) 1965-07-09 1969-08-14 Huels Chemische Werke Ag Verfahren zur Herstellung aminosubstituierter Dioxocyclobutene
DE2428691A1 (de) * 1974-06-14 1976-01-08 Merck Patent Gmbh Hexahydro-diazepino-indolderivate und verfahren zu ihrer herstellung
US4390701A (en) * 1981-05-18 1983-06-28 Bristol-Myers Company 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids
US5212291A (en) * 1986-10-23 1993-05-18 American Cyanamid Company Anthracycline derivatives as solubilized pro-drugs
JPH02184673A (ja) * 1989-01-11 1990-07-19 Yoshitomi Pharmaceut Ind Ltd スルホンアミド化合物
US5236695A (en) * 1989-11-27 1993-08-17 Concat, Ltd. MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
ATE120753T1 (de) * 1990-08-21 1995-04-15 Upjohn Co Bisphosphonsäurederivate als antiarthritische mittel.
US5168103A (en) * 1991-01-22 1992-12-01 American Home Products Corporation [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives
US5124319A (en) * 1991-10-11 1992-06-23 American Home Products Corporation Benzimidazole phosphono-amino acids
US5708152A (en) * 1992-03-27 1998-01-13 Ciba Specialty Chemicals Corporation N-substituted chitosan derivatives in a process for their preparation
DK124393D0 (da) 1993-11-03 1993-11-03 Lundbeck & Co As H Compounds
US5583123A (en) * 1994-12-22 1996-12-10 Ciba-Geigy Corporation Certain tetrazole derivatives
TW427904B (en) 1995-12-07 2001-04-01 American Home Prod Neuroprotective agents
UA52698C2 (uk) 1996-10-04 2003-01-15 Х. Луннбек А/С Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі
AU746119B2 (en) 1997-08-01 2002-04-18 Wyeth Process for the preparation of (2-((8,9)- dioxo-2,6-diazabicyclo (5.2.0)-non-1(7)-en-2-yl)-ethyl) phosphonic acid
US5990307A (en) * 1997-08-01 1999-11-23 American Home Products Corporation Process for the preparation of [2-((8.9)-Dioxo-2,6-Diazabicyclo [5.2.0]-Non-1(7)-en-2yl) Ethyl]Phosphonic acid
US6541669B1 (en) 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
UA78529C2 (en) * 2001-10-10 2007-04-10 Wyeth Corp Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain
US20040082543A1 (en) * 2002-10-29 2004-04-29 Pharmacia Corporation Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
DK1611144T3 (da) * 2003-04-09 2010-11-22 Wyeth Llc Derivater af 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl-phosphonsyre og deres avendelse som n-methyl-D-aspartat (NMDA)-receptor-antagonister
EP1622625A1 (en) 2003-04-09 2006-02-08 Wyeth Pharmaceutical compositions for intranasal administration of [2-(8,9-dioxo-2,6-diazabicyclo [5.2.o] non-1 (7)-en-2-yl )alkyl] phosphonic acid and derivatives and methods of use thereof
US20050142192A1 (en) 2003-10-15 2005-06-30 Wyeth Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
KR20070100233A (ko) 2004-10-08 2007-10-10 와이어쓰 [2-(8,9-디옥소-2,6-디아자바이사이클로[5.2.0]논-1(7)-엔-2-일)알킬]포스폰산의 유도체 및 이의 제조 방법

Also Published As

Publication number Publication date
JP2007509857A (ja) 2007-04-19
GT200400213A (es) 2007-09-05
PE20050908A1 (es) 2005-12-02
MXPA06004397A (es) 2006-06-14
AR046130A1 (es) 2005-11-23
KR20060094967A (ko) 2006-08-30
BRPI0415857A (pt) 2007-01-09
CA2543008A1 (en) 2005-05-06
WO2005040176A2 (en) 2005-05-06
ZA200603236B (en) 2009-09-30
TW200514775A (en) 2005-05-01
PA8615401A1 (es) 2005-11-25
WO2005040176A3 (en) 2005-12-01
US20050090470A1 (en) 2005-04-28
US7345032B2 (en) 2008-03-18
US20080114165A1 (en) 2008-05-15
CN1871246A (zh) 2006-11-29
EP1675863A2 (en) 2006-07-05
AU2004284066A1 (en) 2005-05-06

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