CO5580736A2 - Nueva formulacion pulverulenta que contiene tiotropio desti nada a la inhalacion - Google Patents
Nueva formulacion pulverulenta que contiene tiotropio desti nada a la inhalacionInfo
- Publication number
- CO5580736A2 CO5580736A2 CO05062904A CO05062904A CO5580736A2 CO 5580736 A2 CO5580736 A2 CO 5580736A2 CO 05062904 A CO05062904 A CO 05062904A CO 05062904 A CO05062904 A CO 05062904A CO 5580736 A2 CO5580736 A2 CO 5580736A2
- Authority
- CO
- Colombia
- Prior art keywords
- inhalation
- powder
- capsules
- adjuvant substance
- set consisting
- Prior art date
Links
- MVVPIAAVGAWJNQ-DOFZRALJSA-N Arachidonoyl dopamine Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCC1=CC=C(O)C(O)=C1 MVVPIAAVGAWJNQ-DOFZRALJSA-N 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 9
- 239000002775 capsule Substances 0.000 abstract 8
- 239000002671 adjuvant Substances 0.000 abstract 4
- 239000000126 substance Substances 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 3
- -1 polyethylene Polymers 0.000 abstract 2
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 abstract 2
- 229940110309 tiotropium Drugs 0.000 abstract 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- 239000004698 Polyethylene Substances 0.000 abstract 1
- 239000004743 Polypropylene Substances 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 abstract 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 abstract 1
- 150000002016 disaccharides Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 150000004676 glycans Polymers 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 150000002772 monosaccharides Chemical class 0.000 abstract 1
- 150000002482 oligosaccharides Polymers 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000004033 plastic Substances 0.000 abstract 1
- 229920003023 plastic Polymers 0.000 abstract 1
- 229920000515 polycarbonate Polymers 0.000 abstract 1
- 239000004417 polycarbonate Substances 0.000 abstract 1
- 229920000728 polyester Polymers 0.000 abstract 1
- 229920000573 polyethylene Polymers 0.000 abstract 1
- 229920000139 polyethylene terephthalate Polymers 0.000 abstract 1
- 239000005020 polyethylene terephthalate Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229920001155 polypropylene Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 150000004804 polysaccharides Polymers 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- 150000005846 sugar alcohols Polymers 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
- A61M15/0026—Hinged caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1.- Polvo para inhalación que contiene de 0,001 a 3 % de tiotropio en mezcla con una sustancia coadyuvante fisiológicamente inocua, caracterizado porque la sustancia coadyuvante presenta un tamaño medio de partículas de 10-50 µm, una porción fina del 10 % de 0,5 a 6 µm, así como una superficie específica de 0,1 a 2 m2/g.2.- Polvo para inhalación de acuerdo con la reivindicación 1, caracterizado porque el tiotropio está contenido en forma de su cloruro, bromuro, yoduro, metanosulfonato o para-tolueno-sulfonato.3.- Polvo para inhalación de acuerdo con la reivindicación 1 ó 2, caracterizado porque la sustancia coadyuvante fisiológicamente inocua se selecciona entre el conjunto que consta de los monosacáridos, los disacáridos, los oligo- y poli-sacáridos, los polialcoholes, o también las sales.4.- Polvo para inhalación de acuerdo con la reivindicación 3, caracterizado porque la sustancia coadyuvante fisiológicamente inocua se selecciona entre el conjunto que consta de glucosa, arabinosa, lactosa, sacarosa, maltosa y trehalosa, eventualmente en forma de sus hidratos.5.- Utilización de un polvo para inhalación de acuerdo con una de las reivindicaciones 1 a 4 para la preparación de un medicamento destinado al tratamiento de enfermedades de las vías respiratorias, en particular al tratamiento de la COPD y/o del asma.6.- Cápsulas que contienen un polvo para inhalación de acuerdo con una de las reivindicaciones 1 a 4.7.- Cápsulas de acuerdo con la reivindicación 6, caracterizadas porque el material de las cápsulas consta de un material plástico sintético.8.- Cápsulas de acuerdo con la reivindicación 7, caracterizadas porque el material de las cápsulas se selecciona entre el conjunto que consta de un polímero de polietileno, policarbonato, poliéster, polipropileno y poli(tereftalato de etileno).9.- Cápsulas de acuerdo con una de las reivindicaciones 6 a 8, caracterizadas porque contienen aproximadamente de 1 a 20 mg del polvo para inhalación de acuerdo con una de las reivindicaciones 1 a 4.10.- Estuche para inhalación que consta de una cápsula de acuerdo con una de las reivindicaciones 6 a 9 y de un inhalador, que se puede utilizar para la aplicación de polvos para inhalación a partir de cápsulas que contienen polvos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10255387A DE10255387A1 (de) | 2002-11-28 | 2002-11-28 | Neue Tiotropium-haltige Pulverformulierung für die Inhalation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5580736A2 true CO5580736A2 (es) | 2005-11-30 |
Family
ID=32308760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05062904A CO5580736A2 (es) | 2002-11-28 | 2005-06-27 | Nueva formulacion pulverulenta que contiene tiotropio desti nada a la inhalacion |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP1567135B1 (es) |
| JP (1) | JP4977321B2 (es) |
| KR (1) | KR101066805B1 (es) |
| CN (1) | CN100574751C (es) |
| AR (1) | AR042242A1 (es) |
| AT (1) | ATE401861T1 (es) |
| AU (1) | AU2003294714B2 (es) |
| BR (1) | BR0316343A (es) |
| CA (1) | CA2507579C (es) |
| CO (1) | CO5580736A2 (es) |
| CY (1) | CY1108420T1 (es) |
| DE (2) | DE10255387A1 (es) |
| DK (1) | DK1567135T3 (es) |
| EA (1) | EA011549B1 (es) |
| EC (1) | ECSP055821A (es) |
| ES (1) | ES2310681T3 (es) |
| HK (1) | HK1085918A1 (es) |
| HR (1) | HRP20050468A2 (es) |
| IL (1) | IL168810A (es) |
| ME (1) | MEP51608A (es) |
| MX (1) | MXPA05005485A (es) |
| MY (1) | MY140890A (es) |
| NO (1) | NO20053090D0 (es) |
| PE (1) | PE20040848A1 (es) |
| PL (1) | PL376229A1 (es) |
| PT (1) | PT1567135E (es) |
| RS (1) | RS20050400A (es) |
| SA (1) | SA04240467B1 (es) |
| SI (1) | SI1567135T1 (es) |
| TW (1) | TWI332837B (es) |
| UA (1) | UA81930C2 (es) |
| UY (1) | UY28096A1 (es) |
| WO (1) | WO2004047796A2 (es) |
| ZA (1) | ZA200502859B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006016904A1 (de) | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator |
| DE102008014025A1 (de) * | 2008-03-13 | 2009-09-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator und Sieb für einen Inhalator |
| TR200909788A2 (tr) | 2009-12-25 | 2011-07-21 | Bi̇lgi̇ç Mahmut | Tiotropyum içeren inhalasyona uygun kuru toz formülasyonu |
| LT2600830T (lt) * | 2010-08-03 | 2018-04-10 | Chiesi Farmaceutici S.P.A. | Sausų miltelių kompozicija, apimanti fosfodiesterazės inhibitorių |
| WO2014074797A1 (en) * | 2012-11-09 | 2014-05-15 | Civitas Therapeutics, Inc. | Ultra low density pulmonary powders |
| KR101748796B1 (ko) * | 2015-09-30 | 2017-06-19 | 한미약품 주식회사 | 활성성분의 전달량이 향상된 흡입용 캡슐제 |
| KR101728116B1 (ko) * | 2015-11-03 | 2017-04-18 | 한미약품 주식회사 | 티오트로피움 또는 이의 약학적으로 허용가능한 염을 함유하는 흡입용 건조분말 조성물 |
| CN111514418B (zh) * | 2019-06-12 | 2022-01-14 | 中南大学湘雅二医院 | 一种自吸式经鼻粉末材料给送装置 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1242211A (en) * | 1967-08-08 | 1971-08-11 | Fisons Pharmaceuticals Ltd | Pharmaceutical composition |
| DE4140689B4 (de) * | 1991-12-10 | 2007-11-22 | Boehringer Ingelheim Kg | Inhalationspulver und Verfahren zu ihrer Herstellung |
| DE4318455A1 (de) * | 1993-06-03 | 1994-12-08 | Boehringer Ingelheim Kg | Kapselhalterung |
| GB9322014D0 (en) * | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| DE4425255A1 (de) * | 1994-07-16 | 1996-01-18 | Asta Medica Ag | Formulierung zur inhalativen Applikation |
| ES2192866T3 (es) * | 1998-11-13 | 2003-10-16 | Jago Res Ag | Polvo seco para inhalacion. |
| GB9902689D0 (en) * | 1999-02-08 | 1999-03-31 | Novartis Ag | Organic compounds |
| UA75375C2 (en) * | 2000-10-12 | 2006-04-17 | Boehringer Ingelheim Pharma | Method for producing powdery preparations for inhaling |
| PT1292281E (pt) * | 2000-10-12 | 2004-11-30 | Boehringer Ingelheim Pharma | Novos pos para inalacao contendo tiotropio |
| DE10126924A1 (de) * | 2001-06-01 | 2002-12-05 | Boehringer Ingelheim Pharma | Inhalationskapseln |
| DE10141377A1 (de) * | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Aufstreuverfahren zur Herstellung von Pulverformulierungen |
| DE60308497T2 (de) * | 2002-04-04 | 2007-02-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverzubereitungen zur inhalation |
| UA80123C2 (en) * | 2002-04-09 | 2007-08-27 | Boehringer Ingelheim Pharma | Inhalation kit comprising inhalable powder of tiotropium |
-
2002
- 2002-11-28 DE DE10255387A patent/DE10255387A1/de not_active Withdrawn
-
2003
- 2003-11-19 EP EP03785648A patent/EP1567135B1/de not_active Revoked
- 2003-11-19 AT AT03785648T patent/ATE401861T1/de active
- 2003-11-19 CA CA2507579A patent/CA2507579C/en not_active Expired - Fee Related
- 2003-11-19 JP JP2004554384A patent/JP4977321B2/ja not_active Expired - Lifetime
- 2003-11-19 UA UAA200506224A patent/UA81930C2/uk unknown
- 2003-11-19 ES ES03785648T patent/ES2310681T3/es not_active Expired - Lifetime
- 2003-11-19 CN CN200380104599A patent/CN100574751C/zh not_active Expired - Lifetime
- 2003-11-19 RS YUP-2005/0400A patent/RS20050400A/sr unknown
- 2003-11-19 WO PCT/EP2003/012911 patent/WO2004047796A2/de active IP Right Grant
- 2003-11-19 ME MEP-516/08A patent/MEP51608A/xx unknown
- 2003-11-19 DE DE50310208T patent/DE50310208D1/de not_active Expired - Lifetime
- 2003-11-19 PL PL03376229A patent/PL376229A1/xx unknown
- 2003-11-19 DK DK03785648T patent/DK1567135T3/da active
- 2003-11-19 EA EA200500864A patent/EA011549B1/ru not_active IP Right Cessation
- 2003-11-19 MX MXPA05005485A patent/MXPA05005485A/es active IP Right Grant
- 2003-11-19 KR KR1020057009548A patent/KR101066805B1/ko active IP Right Grant
- 2003-11-19 AU AU2003294714A patent/AU2003294714B2/en not_active Expired
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2004
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