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CO5570656A2 - Liberacin controlada de una sustancia activa a un entorno rico en grasa - Google Patents

Liberacin controlada de una sustancia activa a un entorno rico en grasa

Info

Publication number
CO5570656A2
CO5570656A2 CO05056576A CO05056576A CO5570656A2 CO 5570656 A2 CO5570656 A2 CO 5570656A2 CO 05056576 A CO05056576 A CO 05056576A CO 05056576 A CO05056576 A CO 05056576A CO 5570656 A2 CO5570656 A2 CO 5570656A2
Authority
CO
Colombia
Prior art keywords
composition
active substance
environment
controlled release
weight
Prior art date
Application number
CO05056576A
Other languages
English (en)
Inventor
Mark Brian Chidlaw
Thomas Friesen Dwayne
Scott Max Herbig
Nightingale James Alan Schriver
West James Blair
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CO5570656A2 publication Critical patent/CO5570656A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1.- Un procedimiento para la liberación controlada de una sustancia activa a un entorno de uso, que comprende:preparar una composición de liberación controlada que comprende un núcleo que contiene sustancia activa y un recubrimiento polimérico asimétrico sobre él, en la que el polímero utilizado para formar dicho recubrimiento polimérico asimétrico es aquel que, cuando se ensaya mediante imbibición durante al menos 16 horas en una solución acuosa que comprende 0,5% en peso de grasa de la dieta, gana menos de aproximadamente un 15% en peso, y administrar dicha composición a dicho entorno de uso, comprendiendo dicho entorno de uso al menos aproximadamente un 0,5% en peso de grasa de la dieta.2.- Un procedimiento para la liberación controlada de una sustancia activa a un entorno de uso, que comprende:preparar una composición de liberación controlada que comprende un núcleo que contiene sustancia activa y un recubrimiento polimérico asimétrico sobre el mismo, en la que el tiempo para liberar un 50% de dicha sustancia activa desde dicha composición a dicho entorno de uso es al menos 0,5 veces, pero menos de 2,0 veces, el tiempo necesario para que dicha composición libere un 50% de dicha sustancia activa a un entorno de uso control que comprende menos de aproximadamente un 0,1 % de grasa de la dieta, y administrar dicha composición a dicho entorno de uso, comprendiendo dicho entorno de uso al menos aproximadamente un 0,5% en peso de grasa de la dieta.3.- Un procedimiento para la liberación controlada de una sustancia activa a un entorno de uso, que comprende:preparar una composición de liberación controlada que comprende un núcleo que contiene sustancia activa y un recubrimiento polimérico asimétrico sobre el mismo, en la que la cantidad de fármaco liberado de dicha composición en cualquier momento entre la 2ª y la 10a hora después de la introducción de dicha composición a dicho entorno de uso es al menos 0,5 veces, pero menos de 2,0 veces, la cantidad de dicho fármaco liberado en el mismo tiempo entre la 2a y la 10ª hora por dicha composición a un entorno de uso control que comprende menos de aproximadamente un 0,1% de grasa de la dieta, y administrar dicha composición a dicho entorno de uso, comprendiendo dicho entorno de uso al menos aproximadamente un 0,5% en peso de grasa de la dieta.
CO05056576A 2002-12-11 2005-06-10 Liberacin controlada de una sustancia activa a un entorno rico en grasa CO5570656A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43286002P 2002-12-11 2002-12-11

Publications (1)

Publication Number Publication Date
CO5570656A2 true CO5570656A2 (es) 2005-10-31

Family

ID=32508002

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05056576A CO5570656A2 (es) 2002-12-11 2005-06-10 Liberacin controlada de una sustancia activa a un entorno rico en grasa

Country Status (18)

Country Link
US (1) US20040121015A1 (es)
EP (1) EP1572163A1 (es)
JP (1) JP2006510655A (es)
KR (1) KR20050088311A (es)
CN (1) CN1726012A (es)
AR (1) AR042340A1 (es)
AU (1) AU2003283688A1 (es)
BR (1) BR0317275A (es)
CA (1) CA2508722A1 (es)
CO (1) CO5570656A2 (es)
MX (1) MXPA05005812A (es)
NO (1) NO20053068L (es)
NZ (1) NZ539915A (es)
PL (1) PL377479A1 (es)
RU (1) RU2308263C2 (es)
TW (1) TWI257302B (es)
WO (1) WO2004052343A1 (es)
ZA (1) ZA200503812B (es)

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Also Published As

Publication number Publication date
JP2006510655A (ja) 2006-03-30
MXPA05005812A (es) 2005-08-16
WO2004052343A1 (en) 2004-06-24
AU2003283688A1 (en) 2004-06-30
NO20053068L (no) 2005-09-07
ZA200503812B (en) 2006-07-26
CA2508722A1 (en) 2004-06-24
KR20050088311A (ko) 2005-09-05
EP1572163A1 (en) 2005-09-14
BR0317275A (pt) 2005-11-08
RU2308263C2 (ru) 2007-10-20
AR042340A1 (es) 2005-06-15
NZ539915A (en) 2007-09-28
US20040121015A1 (en) 2004-06-24
PL377479A1 (pl) 2006-02-06
RU2005118101A (ru) 2006-01-20
CN1726012A (zh) 2006-01-25
NO20053068D0 (no) 2005-06-22
TW200425888A (en) 2004-12-01
TWI257302B (en) 2006-07-01

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