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CO5280223A1 - Nuevos compuestos - Google Patents

Nuevos compuestos

Info

Publication number
CO5280223A1
CO5280223A1 CO01025487A CO01025487A CO5280223A1 CO 5280223 A1 CO5280223 A1 CO 5280223A1 CO 01025487 A CO01025487 A CO 01025487A CO 01025487 A CO01025487 A CO 01025487A CO 5280223 A1 CO5280223 A1 CO 5280223A1
Authority
CO
Colombia
Prior art keywords
group
formula
compound
mfi
jpeg
Prior art date
Application number
CO01025487A
Other languages
English (en)
Inventor
Gerald Brooks
Eric Hunt
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0008260.2A external-priority patent/GB0008260D0/en
Priority claimed from GB0027182A external-priority patent/GB0027182D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of CO5280223A1 publication Critical patent/CO5280223A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Un compuesto de fórmula (I): <EMI FILE="01025487_1" ID="1" IMF=JPEG >en la que:R1 es un grupo heteroarilo de 5 ó 6 miembros opcionalmente sustituido; yR2 es vinilo o etilo. Un procedimiento para preparar un compuesto de fórmula (I) según la reivindicación 1, cuyo procedimiento cornprende hacer reaccionar un compuesto de fórmula (II): <EMI FILE="01025487_2" ID="2" IMF=JPEG >en la que X y P son hidrógeno o un grupo protector de hidroxilo, tal como un grupo acilo, y R2 es como se ha definido en la reivindicación 1 ;con un isocianato de acilo de fórmula R1ACONCO en la que R1A es R1 como se ha definido aquí anteriormente o un grupo convertible en R1, por ejemplo un grupo que comprende un sustituyente protegido en sí mismo y después de esto, si es necesario:(i) Separar un grupo p y/o X protector para generar grupos hidroxilo en posición 2 y 11, respectivamente,(j) convertir un grupo R1A en R1, por ejemplo separando un grupo protector,(k) convertir un grupo R1 en otro grupo R1, y(I) hidrogenar el grupo vinilo en la posición 12 para formar un grupo etilo.
CO01025487A 2000-04-04 2001-03-30 Nuevos compuestos CO5280223A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0008260.2A GB0008260D0 (en) 2000-04-04 2000-04-04 Novel compounds
GB0027182A GB0027182D0 (en) 2000-11-04 2000-11-04 Novel comounds

Publications (1)

Publication Number Publication Date
CO5280223A1 true CO5280223A1 (es) 2003-05-30

Family

ID=26244040

Family Applications (1)

Application Number Title Priority Date Filing Date
CO01025487A CO5280223A1 (es) 2000-04-04 2001-03-30 Nuevos compuestos

Country Status (21)

Country Link
US (1) US6972297B2 (es)
EP (1) EP1268443B1 (es)
JP (1) JP2003529593A (es)
KR (1) KR100758441B1 (es)
CN (1) CN1210267C (es)
AR (1) AR030203A1 (es)
AT (1) ATE437860T1 (es)
AU (2) AU6382701A (es)
BR (1) BR0109809A (es)
CA (1) CA2405132A1 (es)
CO (1) CO5280223A1 (es)
CZ (1) CZ20023290A3 (es)
DE (1) DE60139382D1 (es)
ES (1) ES2328109T3 (es)
HU (1) HUP0300370A3 (es)
IL (1) IL151887A0 (es)
MX (1) MXPA02009816A (es)
NO (1) NO324229B1 (es)
NZ (1) NZ521536A (es)
PL (1) PL358666A1 (es)
WO (1) WO2001074788A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0024811D0 (en) 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
US7176310B1 (en) 2002-04-09 2007-02-13 Ucb Sa Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
GB0209262D0 (en) * 2002-04-23 2002-06-05 Biochemie Gmbh Organic compounds
ATE377001T1 (de) * 2002-07-24 2007-11-15 Nabriva Therapeutics Forschung Pleuromutilinderivate als antimikrobielle mittel
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
FR2856685B1 (fr) * 2003-06-25 2005-09-23 Merck Sante Sas Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US20090291987A1 (en) * 2004-12-13 2009-11-26 Glaxo Group Limited Novel polymorph of (5-amino-6-methoxy-3-pyridincarbonyl) carbamic acid 2-(s)-hydroxymutilin 14-ester
US20080221330A1 (en) * 2004-12-27 2008-09-11 Masanori Takadoi Mutilin-Derivative Substituted at Position 12
US20080139626A1 (en) * 2005-03-10 2008-06-12 Rittenhouse Stephen F Novel Method
TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
KR100695541B1 (ko) * 2005-10-31 2007-03-16 한국단자공업 주식회사 연결터미널
WO2007079173A2 (en) * 2005-12-30 2007-07-12 Emergent Biosolutions Inc. Novel 2-heteroaryloxy-phenol derivatives as antibacterial agents
WO2008143343A1 (ja) 2007-05-24 2008-11-27 Kyorin Pharmaceutical Co., Ltd. １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
EP2014640A1 (en) * 2007-07-13 2009-01-14 Nabriva Therapeutics AG Pleuromutilin derivatives
JP2010100582A (ja) * 2008-10-24 2010-05-06 Kyorin Pharmaceut Co Ltd １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
EP2184273A1 (de) 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
EP2253617A1 (de) 2009-05-20 2010-11-24 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
JP6818019B2 (ja) 2015-06-17 2021-01-20 ナブリヴァ セラピュティクス ゲーエムベーハー レファムリンの注射可能医薬組成物
AU2020229360B2 (en) 2019-02-27 2025-01-23 Oticara, Inc. Method for treating nasal, sinonasal, and nasopharyngeal tissue infection and/or inflammation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU715229B2 (en) 1996-01-03 2000-01-20 Smithkline Beecham Plc Carbamoyloxy derivatives of mutiline and their use as antibacterials
HUP0001741A3 (en) * 1996-08-02 2000-11-28 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
UY25225A1 (es) * 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
FR2771008B1 (fr) 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
GB9817029D0 (en) 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds

Also Published As

Publication number Publication date
WO2001074788A8 (en) 2001-12-20
CA2405132A1 (en) 2001-10-11
WO2001074788A1 (en) 2001-10-11
ES2328109T3 (es) 2009-11-10
JP2003529593A (ja) 2003-10-07
US6972297B2 (en) 2005-12-06
EP1268443A1 (en) 2003-01-02
CN1210267C (zh) 2005-07-13
EP1268443B1 (en) 2009-07-29
KR100758441B1 (ko) 2007-09-14
PL358666A1 (en) 2004-08-09
CZ20023290A3 (cs) 2003-03-12
BR0109809A (pt) 2003-01-21
MXPA02009816A (es) 2003-03-27
AU2001263827B2 (en) 2004-06-17
CN1427827A (zh) 2003-07-02
NO20024745D0 (no) 2002-10-02
NO20024745L (no) 2002-11-19
ATE437860T1 (de) 2009-08-15
IL151887A0 (en) 2003-04-10
DE60139382D1 (de) 2009-09-10
KR20030011815A (ko) 2003-02-11
HUP0300370A3 (en) 2005-07-28
US20030114674A1 (en) 2003-06-19
NZ521536A (en) 2004-05-28
NO324229B1 (no) 2007-09-10
HUP0300370A2 (hu) 2003-06-28
AU6382701A (en) 2001-10-15
AR030203A1 (es) 2003-08-13

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Legal Events

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