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CO5150165A1 - Inhibidores de proteasa: tipo catepsina k - Google Patents

Inhibidores de proteasa: tipo catepsina k

Info

Publication number
CO5150165A1
CO5150165A1 CO99070943A CO99070943A CO5150165A1 CO 5150165 A1 CO5150165 A1 CO 5150165A1 CO 99070943 A CO99070943 A CO 99070943A CO 99070943 A CO99070943 A CO 99070943A CO 5150165 A1 CO5150165 A1 CO 5150165A1
Authority
CO
Colombia
Prior art keywords
katepsin
type
protease inhibitors
compound according
mfi
Prior art date
Application number
CO99070943A
Other languages
English (en)
Inventor
Andrew D Gribble
Jason Witherington
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of CO5150165A1 publication Critical patent/CO5150165A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

U n compuesto de acuerdo con la fórmula (I) :<EMI FILE="99070943_1" ID="1" IMF=JPEG >en la que:n es 1 ó 2;o una de sus sales farmacéuticamente aceptables.Un método para inhibir una cisteína-proteasa que comprende administrar a un paciente que necesita de ello una cantidad eficaz de un compuesto de acuerdo con la reivindicación 1.
CO99070943A 1998-11-13 1999-11-10 Inhibidores de proteasa: tipo catepsina k CO5150165A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10841098P 1998-11-13 1998-11-13

Publications (1)

Publication Number Publication Date
CO5150165A1 true CO5150165A1 (es) 2002-04-29

Family

ID=22322023

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99070943A CO5150165A1 (es) 1998-11-13 1999-11-10 Inhibidores de proteasa: tipo catepsina k

Country Status (5)

Country Link
AR (1) AR021241A1 (es)
AU (1) AU1393900A (es)
CO (1) CO5150165A1 (es)
PE (1) PE20001237A1 (es)
WO (1) WO2000029408A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
US6583137B1 (en) 1999-11-10 2003-06-24 Smithkline Beecham Corporation Protease inhibitors
JP2003513924A (ja) 1999-11-10 2003-04-15 スミスクライン・ビーチャム・コーポレイション プロテア−ゼ阻害剤
JP2003513971A (ja) 1999-11-10 2003-04-15 スミスクライン・ビーチャム・コーポレイション プロテア−ゼ阻害剤
IL150964A0 (en) 2000-03-21 2003-02-12 Smithkline Beecham Corp Protease inhibitors
JP2004520439A (ja) * 2000-11-17 2004-07-08 メディヴィル・アクチボラグ システインプロテアーゼインヒビター
WO2002057249A1 (en) * 2001-01-17 2002-07-25 Amura Therapeutics Limited Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases
WO2002057246A2 (en) * 2001-01-17 2002-07-25 Amura Therapeutics Limited Inhibitors of cruzipain and other cysteine proteases
JP4608183B2 (ja) 2001-01-17 2011-01-05 アミュラ テラピューティクス リミテッド クルジパインおよび他のシステインプロテアーゼの阻害剤
US7132449B2 (en) 2001-01-17 2006-11-07 Amura Therapeutics Limited Inhibitors of cruzipain and other cysteine proteases
EP1465862A1 (en) 2002-01-17 2004-10-13 SmithKline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors
JP5587790B2 (ja) 2008-01-09 2014-09-10 アミュラ セラピューティクス リミティド 化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374623A (en) * 1992-08-20 1994-12-20 Prototek, Inc. Cysteine protease inhibitors effective for in vivo use
CA2111930A1 (en) * 1992-12-25 1994-06-26 Ryoichi Ando Aminoketone derivatives
MA26487A1 (fr) * 1997-04-29 2004-12-20 Smithkline Beecham Corp Heterocyclecetohydrazides inhibiteurs de proteases, procede pour leur preparation et compositions pharmaceutiques les contenant .
AR013079A1 (es) * 1997-05-06 2000-12-13 Smithkline Beecham Corp Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios
BR9815469A (pt) * 1997-05-08 2001-03-06 Smithkline Beecham Corp Inibidores de protease
JP2001525809A (ja) * 1997-05-08 2001-12-11 スミスクライン・ビーチャム・コーポレイション プロテアーゼ阻害剤
MA26618A1 (fr) * 1998-04-09 2004-12-20 Smithkline Beecham Corp Composes et compositions pharmaceutiques pour le traitement du paludisme
MA26631A1 (fr) * 1998-05-21 2004-12-20 Smithkline Beecham Corp Composes a fonction bis-aminomethyl-carbonyle nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
AR021241A1 (es) 2002-07-03
PE20001237A1 (es) 2000-12-23
AU1393900A (en) 2000-06-05
WO2000029408A1 (en) 2000-05-25

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