CO5011075A1 - Proceso de reduccion de alta presion - Google Patents
Proceso de reduccion de alta presionInfo
- Publication number
- CO5011075A1 CO5011075A1 CO98064433A CO98064433A CO5011075A1 CO 5011075 A1 CO5011075 A1 CO 5011075A1 CO 98064433 A CO98064433 A CO 98064433A CO 98064433 A CO98064433 A CO 98064433A CO 5011075 A1 CO5011075 A1 CO 5011075A1
- Authority
- CO
- Colombia
- Prior art keywords
- formula
- pharmaceutically acceptable
- substituted
- compound
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un procedimiento para preparar un compuesto de fórmula (I): o una de sus formas tautómeras o una de sus sales farmacéuticamente aceptables, o uno de sus solvatos farmacéuticamente aceptables, en la que: A1 representa un grupo heterocíclilo aromático, sustituido o no sustituido; R1 representa un átomo de hidrógeno, un grupo alquilo, un grupo acilo, un grupo aralquilo, en el que el resto arilo puede estar sustituido o no sustituido, o un grupo arilo sustituido o no sustituido; A2 representa un anillo de benceno que tiene en total hasta cinco sustituyentes; y n representa un número entero en el intervalo de 2 a 6,comprendiendo dicho procedimiento reducir catalíticamente un compuesto de fórmula (II): en la que A1 , R1 , A2 y n son como se han definido con relación a la fórmula (I), caracterizado porque la reacción de reducción se realiza usando una presión de hidrógeno superior a 1,4 kg/cm2 (20 psi); y a continuación, si se requiere, formar una sal farmacéuticamente aceptable y/o un solvato farmacéuticamente aceptable del compuesto de fórmula (I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9723295.3A GB9723295D0 (en) | 1997-11-04 | 1997-11-04 | Novel process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5011075A1 true CO5011075A1 (es) | 2001-02-28 |
Family
ID=10821570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98064433A CO5011075A1 (es) | 1997-11-04 | 1998-11-03 | Proceso de reduccion de alta presion |
Country Status (44)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7091359B2 (en) | 1997-11-04 | 2006-08-15 | Smithkline Beecham Plc | Process for the preparation of thiazolidinedione derivatives |
| GB9723295D0 (en) | 1997-11-04 | 1998-01-07 | Smithkline Beecham Plc | Novel process |
| HU225919B1 (en) * | 1999-12-18 | 2007-12-28 | Richter Gedeon Nyrt | Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates |
| GB0023971D0 (en) * | 2000-09-29 | 2000-11-15 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB0023970D0 (en) * | 2000-09-29 | 2000-11-15 | Smithkline Beecham Plc | Novel pharmaceutical |
| CA2470075A1 (en) * | 2001-12-20 | 2003-07-03 | Teva Pharmaceutical Industries Ltd. | Hydrogenation of precursors to thiazolidinedione antihyperglycemics |
| GB0307259D0 (en) * | 2003-03-28 | 2003-05-07 | Glaxo Group Ltd | Process |
| GB2405403A (en) * | 2003-08-29 | 2005-03-02 | Cipla Ltd | Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base |
| AR047541A1 (es) * | 2004-02-13 | 2006-01-25 | Sandoz Ag | Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas |
| EP1745043A1 (en) * | 2004-05-12 | 2007-01-24 | Medichem S.A. | Process for the preparation of rosiglitazone |
| CZ297266B6 (cs) * | 2004-09-10 | 2006-10-11 | Zentiva, A. S. | Zpusob prípravy rosiglitazonu |
| CZ297347B6 (cs) * | 2004-09-21 | 2006-11-15 | Zentiva, A. S. | Zpusob prípravy rosiglitazonu |
| CZ298424B6 (cs) * | 2005-05-24 | 2007-09-26 | Zentiva, A. S. | Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel |
| CN102727489A (zh) * | 2012-07-18 | 2012-10-17 | 西南大学 | 5-芳(杂环)亚甲基噻唑烷-2，4-二酮在制备ppar激动剂中的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5522636A (en) | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| US4812570A (en) | 1986-07-24 | 1989-03-14 | Takeda Chemical Industries, Ltd. | Method for producing thiazolidinedione derivatives |
| US5194443A (en) * | 1987-09-04 | 1993-03-16 | Beecham Group P.L.C. | Compounds |
| US5232925A (en) * | 1987-09-04 | 1993-08-03 | Beecham Group P.L.C. | Compounds |
| US5646169A (en) * | 1987-09-04 | 1997-07-08 | Beecham Group P.L.C. | Compounds for treating eating disorders in which blood glucose levels are raised |
| US6288095B1 (en) * | 1987-09-04 | 2001-09-11 | Beecham Group P.L.C. | Compounds |
| US5260445A (en) * | 1987-09-04 | 1993-11-09 | Beecham Group P.L.C. | 2,4-thiazolidinediones |
| DE3856378T2 (de) * | 1987-09-04 | 2000-05-11 | Beecham Group P.L.C., Brentford | Substituierte Thiazolidindionderivate |
| US20020049240A1 (en) * | 1994-12-19 | 2002-04-25 | Beecham Group P.1.C. | Novel compounds |
| GB9023583D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| GB9023585D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| GB9124513D0 (en) * | 1991-11-19 | 1992-01-08 | Smithkline Beecham Plc | Novel process |
| US6462337B1 (en) * | 2000-04-20 | 2002-10-08 | Agilent Technologies, Inc. | Mass spectrometer electrospray ionization |
| AU3231093A (en) | 1991-12-20 | 1993-07-28 | Upjohn Company, The | A reduction method for substituted 5-methylene-thiazolidinediones |
| US5741803A (en) * | 1992-09-05 | 1998-04-21 | Smithkline Beecham Plc | Substituted thiazolidinedionle derivatives |
| GB9218830D0 (en) | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| US6632947B2 (en) * | 1997-02-18 | 2003-10-14 | Smithkline Beecham Plc | Process for the preparation of substituted thiazolidinedione |
| UY24886A1 (es) | 1997-02-18 | 2001-08-27 | Smithkline Beecham Plc | Tiazolidindiona |
| GB9723295D0 (en) | 1997-11-04 | 1998-01-07 | Smithkline Beecham Plc | Novel process |
| US7091359B2 (en) * | 1997-11-04 | 2006-08-15 | Smithkline Beecham Plc | Process for the preparation of thiazolidinedione derivatives |
-
1997
- 1997-11-04 GB GBGB9723295.3A patent/GB9723295D0/en not_active Ceased
-
1998
- 1998-10-27 CA CA002309461A patent/CA2309461A1/en not_active Abandoned
- 1998-10-27 EP EP98959834A patent/EP1028960B1/en not_active Expired - Lifetime
- 1998-10-27 ID IDW20000822A patent/ID24644A/id unknown
- 1998-10-27 ES ES98959834T patent/ES2197519T3/es not_active Expired - Lifetime
- 1998-10-27 SK SK650-2000A patent/SK285233B6/sk not_active IP Right Cessation
- 1998-10-27 JP JP2000518965A patent/JP3723448B2/ja not_active Expired - Fee Related
- 1998-10-27 SI SI9830468T patent/SI1028960T1/xx unknown
- 1998-10-27 PT PT98959834T patent/PT1028960E/pt unknown
- 1998-10-27 AP APAP/P/2000/001808A patent/AP1519A/en active
- 1998-10-27 EP EP02075969A patent/EP1219620A1/en not_active Withdrawn
- 1998-10-27 CZ CZ20001633A patent/CZ297209B6/cs not_active IP Right Cessation
- 1998-10-27 DK DK98959834T patent/DK1028960T3/da active
- 1998-10-27 EA EA200000484A patent/EA002722B1/ru not_active IP Right Cessation
- 1998-10-27 WO PCT/EP1998/006997 patent/WO1999023095A1/en active IP Right Grant
- 1998-10-27 HU HU0100144A patent/HU224547B1/hu not_active IP Right Cessation
- 1998-10-27 TR TR2000/01239T patent/TR200001239T2/xx unknown
- 1998-10-27 CN CNB98810959XA patent/CN1160351C/zh not_active Expired - Fee Related
- 1998-10-27 AU AU15595/99A patent/AU1559599A/en not_active Abandoned
- 1998-10-27 RS YUP-338/00A patent/RS49793B/sr unknown
- 1998-10-27 BR BR9814622-0A patent/BR9814622A/pt not_active Application Discontinuation
- 1998-10-27 KR KR1020007004783A patent/KR100602551B1/ko not_active IP Right Cessation
- 1998-10-27 UA UA2000042451A patent/UA56269C2/uk unknown
- 1998-10-27 OA OA1200000131A patent/OA11521A/en unknown
- 1998-10-27 PL PL340366A patent/PL192503B1/pl not_active IP Right Cessation
- 1998-10-27 AT AT98959834T patent/ATE238302T1/de active
- 1998-10-27 IL IL13589898A patent/IL135898A/xx unknown
- 1998-10-27 DE DE69813869T patent/DE69813869T2/de not_active Expired - Lifetime
- 1998-10-28 UY UY25227A patent/UY25227A1/es not_active IP Right Cessation
- 1998-11-02 AR ARP980105505A patent/AR016660A1/es active IP Right Grant
- 1998-11-02 MY MYPI98004975A patent/MY118605A/en unknown
- 1998-11-02 MA MA25328A patent/MA26560A1/fr unknown
- 1998-11-03 ZA ZA9810033A patent/ZA9810033B/xx unknown
- 1998-11-03 IN IN3258DE1998 patent/IN192870B/en unknown
- 1998-11-03 CO CO98064433A patent/CO5011075A1/es unknown
- 1998-11-03 PE PE1998001038A patent/PE129399A1/es not_active Application Discontinuation
- 1998-11-03 DZ DZ980247A patent/DZ2637A1/xx active
- 1998-11-03 TW TW087118222A patent/TW538037B/zh not_active IP Right Cessation
- 1998-11-25 SA SA98190820A patent/SA98190820B1/ar unknown
-
2000
- 2000-04-27 NO NO20002174A patent/NO315557B1/no not_active IP Right Cessation
- 2000-05-04 HR HR20000263A patent/HRP20000263B1/xx not_active IP Right Cessation
- 2000-06-05 BG BG104505A patent/BG64559B1/bg unknown
-
2001
- 2001-02-02 HK HK01100772A patent/HK1032046A1/xx not_active IP Right Cessation
- 2001-02-02 HK HK02108713.7A patent/HK1048804A1/zh unknown
-
2002
- 2002-07-09 AU AU2002300593A patent/AU2002300593B8/en not_active Ceased
-
2004
- 2004-08-04 JP JP2004228226A patent/JP2004339235A/ja active Pending
-
2006
- 2006-01-05 US US11/326,003 patent/US20060106221A1/en not_active Abandoned
- 2006-10-18 US US11/550,506 patent/US7351832B2/en not_active Expired - Fee Related
-
2008
- 2008-07-08 EC EC2008002712A patent/ECSP082712A/es unknown
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