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CO2019001367A2 - Proteínas de unión de tipo anticuerpo biespecíficas que se unen específicamente a cd3 y cd123 - Google Patents

Proteínas de unión de tipo anticuerpo biespecíficas que se unen específicamente a cd3 y cd123

Info

Publication number
CO2019001367A2
CO2019001367A2 CONC2019/0001367A CO2019001367A CO2019001367A2 CO 2019001367 A2 CO2019001367 A2 CO 2019001367A2 CO 2019001367 A CO2019001367 A CO 2019001367A CO 2019001367 A2 CO2019001367 A2 CO 2019001367A2
Authority
CO
Colombia
Prior art keywords
specifically bind
binding proteins
bispecific antibody
antibody
type binding
Prior art date
Application number
CONC2019/0001367A
Other languages
English (en)
Inventor
Christian Lange
Jochen Beninga
Ercole Rao
Wulf Dirk Leuschner
Christian Beil
Jana Albrecht
Katja Kroll
Marion Schneider
Peter Wonerow
Stéphane Guerif
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of CO2019001367A2 publication Critical patent/CO2019001367A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a proteínas de unión de tipo anticuerpo que se unen específicamente a CD3 y CD123. La invención también se refiere a composiciones farmacéuticas que comprenden dicha proteína de unión de tipo anticuerpo y al uso de dichas composiciones farmacéuticas y proteína de unión de tipo anticuerpo para tratar el cáncer. La invención se refiere además a ácidos nucleicos aislados, vectores y células huésped que comprenden una secuencia que codifica dicha proteína de unión de tipo anticuerpo.
CONC2019/0001367A 2016-07-18 2019-02-15 Proteínas de unión de tipo anticuerpo biespecíficas que se unen específicamente a cd3 y cd123 CO2019001367A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16305923 2016-07-18
PCT/EP2017/068020 WO2018015340A1 (en) 2016-07-18 2017-07-17 Bispecific antibody-like binding proteins specifically binding to cd3 and cd123

Publications (1)

Publication Number Publication Date
CO2019001367A2 true CO2019001367A2 (es) 2019-02-19

Family

ID=56507555

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0001367A CO2019001367A2 (es) 2016-07-18 2019-02-15 Proteínas de unión de tipo anticuerpo biespecíficas que se unen específicamente a cd3 y cd123

Country Status (24)

Country Link
US (1) US20190241657A1 (es)
EP (1) EP3484924A1 (es)
JP (2) JP7071329B2 (es)
KR (1) KR20190028771A (es)
CN (1) CN109715665A (es)
AR (1) AR109264A1 (es)
AU (1) AU2017299125A1 (es)
BR (1) BR112019000770A2 (es)
CA (1) CA3030943A1 (es)
CL (1) CL2019000119A1 (es)
CO (1) CO2019001367A2 (es)
CR (1) CR20190072A (es)
DO (1) DOP2019000011A (es)
EA (1) EA201990321A1 (es)
EC (1) ECSP19011185A (es)
IL (1) IL264248A (es)
MA (1) MA45680A (es)
MX (1) MX2019000844A (es)
PE (1) PE20190514A1 (es)
PH (1) PH12019500122A1 (es)
SG (1) SG11201900400QA (es)
TN (1) TN2019000015A1 (es)
TW (1) TWI790206B (es)
WO (1) WO2018015340A1 (es)

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TWI744242B (zh) 2015-07-31 2021-11-01 德商安美基研究（慕尼黑）公司 Egfrviii及cd3抗體構築體
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Also Published As

Publication number Publication date
CR20190072A (es) 2019-06-25
WO2018015340A1 (en) 2018-01-25
TN2019000015A1 (en) 2020-07-15
CL2019000119A1 (es) 2019-06-14
PE20190514A1 (es) 2019-04-10
MX2019000844A (es) 2019-07-04
IL264248A (en) 2019-02-28
JP7071329B2 (ja) 2022-05-18
SG11201900400QA (en) 2019-02-27
CN109715665A (zh) 2019-05-03
EA201990321A1 (ru) 2019-06-28
KR20190028771A (ko) 2019-03-19
US20190241657A1 (en) 2019-08-08
CA3030943A1 (en) 2018-01-25
JP2019531701A (ja) 2019-11-07
TW201811830A (zh) 2018-04-01
JP2022105138A (ja) 2022-07-12
DOP2019000011A (es) 2019-05-15
EP3484924A1 (en) 2019-05-22
MA45680A (fr) 2019-05-22
TWI790206B (zh) 2023-01-21
ECSP19011185A (es) 2019-02-28
BR112019000770A2 (pt) 2019-07-02
AU2017299125A1 (en) 2019-03-07
AR109264A1 (es) 2018-11-14
PH12019500122A1 (en) 2019-04-15

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