CN220275761U - A strap for preparing lower limb deep vein thrombosis model - Google Patents

Abstract

The utility model discloses a strap for preparing a lower limb deep vein thrombosis model, which includes a fixed strap. The fixed strap includes a strap body. The strap body is provided with a fixed structure. One end of the strap body is provided with a button hole, and the other end of the strap body is provided with a strap. The plug can pass through the button hole and be fixed by a fixed structure; the two fixing straps are used to fasten at different joints of the same lower limb of the experimental animal to prevent deep vein thrombosis from forming in the lower limb of the experimental animal. The utility model uses constraint means to prepare deep vein thrombosis, which causes no surgical damage to experimental animals and has a high modeling success rate. It can simulate the actual situation of deep vein thrombosis, is close to reality, and is conducive to further research on deep vein thrombosis.

Description

A strap for preparing lower limb deep vein thrombosis model

Technical field

The utility model relates to the technical field of medical auxiliary tools, and specifically relates to a strap for preparing a lower limb deep vein thrombosis model.

Background technique

Deep vein thrombosis is a blood clot (thrombus) that forms in a deep vein. A blood clot (thrombus) in a deep vein is called deep vein thrombosis (DVT). Deep vein thrombosis mostly occurs in the lower limbs, but can also occur in other important The incidence rate of pulmonary embolism caused by the detachment of deep vein thrombosis in organs and blood vessels is as high as 46%, and the fatality rate is as high as 1.9%-2.9%. Therefore, overcoming deep vein thrombosis is a major national research topic. In this process, regardless of the research on the cause and mechanism, diagnosis and treatment, and drug research and development, it is necessary to have the support of a reliable animal model. Therefore, the establishment of an animal deep vein thrombosis model is a necessary prerequisite, in which the coagulation effect is good. , good molding effect and good stability are necessary conditions for an ideal deep vein thrombosis animal model.

The complex mechanism of human deep vein thrombosis has not been fully understood, so it is very difficult to prepare similar models. The preparation process of deep vein thrombosis models in large animals such as dogs and pigs is cumbersome, expensive and has poor reproducibility. At present, the most commonly used experimental animals are rats and mice, which are widely used due to their low cost and good reproducibility. The preparation methods of deep vein thrombosis models include surgical modeling, drug modeling, mechanical/electrolysis modeling and gene knockout modeling. Surgical modeling has problems such as complicated operations, large animal damage, high complication rate, and high pain; Drug modeling has problems such as large side injuries, easy death of animals, serious damage to the operator, and low molding rate; mechanical/electrolytic modeling has problems such as small emboli, low molding rate, rare causes, and high pain; gene knockout In addition to modeling, there are problems such as uncertain location of thrombus, low modeling rate, and high cost.

Utility model content

The purpose of this utility model is to provide a strap for preparing lower limb deep vein thrombosis models, which solves the above problems existing in the prior art.

In order to achieve the above purpose, the present utility model adopts the following technical solution: a strap for preparing a lower limb deep vein thrombosis model, including a fixed strap, and two fixed straps, namely a first fixed strap and a second fixed strap, and the third fixed strap is A fixed belt and a second fixed belt are respectively used to fasten the same lower limb of the experimental animal at different joints, so that the lower limb of the experimental animal forms deep vein thrombosis; the first fixed belt and the second fixed belt both include a belt body, The belt body is provided with a fixed structure. One end of the belt body is provided with a button hole, and the other end of the belt body is provided with a plug. The plug can pass through the button hole and be fixed by the fixed structure.

In this technical solution, the first fixed belt and the second fixed belt are fastened at different joints of the same lower limb of the experimental animal. By restricting the joint movement of the lower limb of the experimental animal, deep vein thrombosis is formed in the lower limb of the experimental animal. The utility model uses constraint means to prepare deep vein thrombosis, which causes no surgical damage to experimental animals and has a high modeling success rate. It can simulate the actual situation of deep vein thrombosis, is close to reality, and is conducive to further research on deep vein thrombosis.

As an alternative to the above technical solution, the fixing structure includes a first adhesive surface and a second adhesive surface that are adhered to each other. The first adhesive surface and the second adhesive surface are respectively provided on the front and back of the belt body.

In this technical solution, after the plug is passed through the button hole, the belt is wrapped around the lower limbs of the experimental animal and curled up to the maximum tightness. The first adhesive surface on the front of the belt is pasted on the second adhesive surface on the back of the belt, making the belt The body remains fixed; when it is necessary to untie the lower limbs of the experimental animal, the first adhesive surface and the second adhesive surface are separated, so that the belt body loosens the lower limbs of the experimental animal. The utility model has a simple structure, is easy to operate, can be reused, and has high practicability.

As an alternative to the above technical solution, the first adhesive surface is a matte surface of Velcro, and the second adhesive surface is a hook surface of Velcro.

As an alternative to the above technical solution, one end of the belt body is provided with a circular buckle, and the circular buckle is provided with the button hole.

As an alternative to the above technical solution, the plug is provided with an arc-shaped insertion end.

As an alternative to the above technical solution, a protective ring is provided around the belt body.

As an alternative to the above technical solution, the protective ring is made of metal material.

The beneficial effects of this utility model are:

1. The strap for preparing the lower limb deep vein thrombosis model of the present invention complies with the consistent 3R principles of international and domestic experimental animals, that is, reduction, replacement and optimization, and at the same time satisfies the principles of repeatability and economy.

2. It can protect the health of experimental operators and does not require high operating requirements for experimental operators. The straps have no external trauma to experimental animals and can be reused. They are in line with common pathogenesis and the actual situation of deep vein thrombosis, are close to reality, and are beneficial to deep veins. Further research on thrombosis.

3. There are no surgical injuries and related complications in experimental animals, no related toxic injuries caused by chemical drugs such as ferric chloride, and the disadvantages of reducing the size of emboli, and reducing mechanical injuries such as beating or electrolysis, complex operations, and unstable success rates. Disadvantages: Avoid bias in research results caused by genetic engineering such as V mutation or viral transfection and other unusual causes.

4. It provides an economical, simple, safe and effective bandage for in-depth basic research on deep vein thrombosis. Its simulated real-life mechanism research results are more useful, the modeling success rate is high and stable, non-invasive operation, and experimental animals It is non-invasive, easy to operate, does not require anesthesia, eliminates the interference of anesthetic drugs, and requires no learning curve.

Description of drawings

Figure 1 is a schematic structural diagram of an embodiment of the present utility model;

Figure 2 is a schematic structural diagram of the second fixing belt in an embodiment of the present invention.

In the picture: 1-first fixing strap; 2-second fixing strap; 3-strap body; 4-button hole; 5-plug; 6-velcro rough side; 7-round buckle head; 8-protective ring.

Detailed ways

Example

As shown in Figures 1 and 2, this embodiment provides a strap for preparing a lower limb deep vein thrombosis model, which includes a fixing strap and two fixing straps, namely a first fixing strap 1 and a second fixing strap 2. The first fixation strap 1 and the second fixation strap 2 are respectively used to be fastened to different joints of the same lower limb of the experimental animal, so as to form deep vein thrombosis in the lower limb of the experimental animal. The first fixed belt 1 and the second fixed belt 2 adopt the same structure and can be set to different lengths according to the needs of different joints. Experimental animals usually use rats or mice. Rats and mice are widely used in various experiments. Among them, its cost is low and its reproducibility is good, which is beneficial to the research of human deep vein thrombosis. In specific applications, the first fixed belt 1 and the second fixed belt 2 are fastened at different joints of the same lower limb of the experimental animal. By restricting the joint movement of the lower limb of the experimental animal, deep vein thrombosis is formed in the lower limb of the experimental animal. The utility model uses constraint means to prepare deep vein thrombosis, which causes no surgical damage to experimental animals and has a high modeling success rate. It can simulate the actual situation of deep vein thrombosis, is close to reality, and is conducive to further research on deep vein thrombosis.

As shown in Figure 2, specifically, the first fixed belt 1 and the second fixed belt 2 both include a belt body 3, the belt body 3 is provided with a fixing structure, and one end of the belt body 3 is provided with a button hole 4. The other end of the body 3 is provided with a plug 5, which can pass through the button hole 4 and be fixed through a fixing structure. After the plug 5 passes through the button hole 4, the belt body 3 is ring-shaped and is put on the lower limb joints of the experimental animal. The belt body 3 is fixed through the fixed structure, so that the belt body 3 tightens the lower limb joints of the experimental animal and blocks the blood flow, resulting in the formation of deep vein thrombosis in the lower limbs of experimental animals. The utility model has a simple structure, is easy to operate, can be reused, and has high practicability.

In an exemplary embodiment, the fixing structure includes a first adhesive surface and a second adhesive surface that are adhered to each other. The first adhesive surface and the second adhesive surface are respectively provided on the front and back of the belt body 3 . After the plug 5 passes through the button hole 4, the belt body 3 covers the lower limbs of the experimental animal and curls up to the maximum tightness. The first adhesive surface on the front of the belt body 3 is pasted on the second adhesive surface on the back of the belt body 3, so that the belt body 3 Keep fixed; when it is necessary to untie the lower limbs of the experimental animal, the first adhesive surface and the second adhesive surface are separated, so that the belt body 3 loosens the lower limbs of the experimental animal. It should be noted that the fixing structure can also use the buckle structure of the watch strap to achieve the fixing effect of the strap body 3, which has the same fixing effect as the first adhesive surface and the second adhesive surface, both of which are used to tighten the lower limbs of experimental animals. joints to form deep vein thrombosis.

Specifically, the first adhesive surface is the matte surface 6 of Velcro, and the second adhesive surface is the hook surface of Velcro. The first sticking surface can also be set as the hook surface of Velcro, and the second sticking surface can be set as the matte side of Velcro 6. The matte side of Velcro 6 and the hook surface of Velcro can be pasted together to ensure that the belt body 3 can bind the experimental animals. The lower limb joints are tightened, and the Velcro fur surface 6 and the Velcro hook surface have a certain length to facilitate adaptation to the size of the lower limb joints of experimental animals.

Among them, one end of the belt body 3 is provided with a circular buckle 7, and the circular buckle 7 is provided with the button hole 4. The size of the button hole 4 matches the size of the plug 5, making it easier for the plug 5 to be inserted into the button hole. 4 in. Preferably, the plug 5 is provided with an arc-shaped insertion end so that the plug 5 can be inserted into the button hole 4 smoothly.

There is a protective ring 8 around the belt body 3. The protective ring 8 is made of metal material. The protective ring 8 is arranged along the edge of the belt body 3, which can increase the strength of the belt body 3 and extend the life of the belt body 3. service life.

Compared with the existing technology, this utility model has the following advantages:

1. The strap for preparing the lower limb deep vein thrombosis model of the present invention complies with the consistent 3R principles of international and domestic experimental animals, that is, reduction, replacement and optimization, and at the same time satisfies the principles of repeatability and economy.

2. It can protect the health of experimental operators and does not require high operating requirements for experimental operators. The straps have no external trauma to experimental animals and can be reused. They are in line with common pathogenesis and the actual situation of deep vein thrombosis, are close to reality, and are beneficial to deep veins. Further research on thrombosis.

3. There are no surgical injuries and related complications in experimental animals, no related toxic injuries caused by chemical drugs such as ferric chloride, and the disadvantages of reducing the size of emboli, and reducing mechanical injuries such as beating or electrolysis, complex operations, and unstable success rates. Disadvantages: Avoid bias in research results caused by genetic engineering such as V mutation or viral transfection and other unusual causes.

4. It provides an economical, simple, safe and effective strap for in-depth basic research on deep vein thrombosis. Its simulated real-life mechanism research results are more useful, the modeling success rate is high and stable, non-invasive operation, and experimental animals It is non-invasive, easy to operate, does not require anesthesia, eliminates the interference of anesthetic drugs, and requires no learning curve.

In the description of the present utility model, the terms "installation", "connection", "connection", "fixing", etc. should be understood in a broad sense. It can be a fixed connection, a detachable connection, or an integration; it can be a mechanical connection or an electrical connection; It can be a direct connection or an indirect connection through an intermediary. It can be an internal connection between two elements or an interaction between two elements. Those skilled in the art can understand the specific meanings of the above terms in the present invention. In addition, the specific features, structures, etc. described in the embodiments are included in at least one implementation, and those skilled in the art can combine the features of different implementations unless they are inconsistent with each other. The protection scope of the present utility model is not limited to the above-mentioned specific examples. According to the basic technical concept of the present utility model, those of ordinary skill in the art can think of implementations without creative work, all of which belong to the protection scope of the present utility model. .

Claims (1)

1. A strap for preparing a lower limb deep vein thrombosis model, characterized in that it includes a fixed belt, and the fixed belt includes a belt body (3), and the belt body (3) is provided with a fixed structure, and the belt body (3) One end of the belt body (3) is provided with a button hole (4), and the other end of the belt body (3) is provided with a plug (5). The plug (5) can pass through the button hole (4) and be fixed by a fixed structure; two The fixation straps are used to fasten at different joints of the same lower limb of the experimental animal to prevent deep vein thrombosis from forming in the lower limb of the experimental animal; The fixing structure includes a first adhesive surface and a second adhesive surface that are adhered to each other. The first adhesive surface and the second adhesive surface are respectively arranged on the front and back of the belt body (3); the first adhesive surface is magic. The matte surface (6), the second pasting surface is the Velcro hook surface; One end of the belt body (3) is provided with a circular buckle (7), and the circular buckle (7) is provided with the button hole (4); the plug (5) is provided with an arc-shaped insertion end. ; A protective ring (8) is provided around the belt body (3); the protective ring (8) is made of metal material.