CN220271346U - Sample buffering and liquid homogenizing mechanism - Google Patents
Sample buffering and liquid homogenizing mechanism Download PDFInfo
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- CN220271346U CN220271346U CN202321622028.XU CN202321622028U CN220271346U CN 220271346 U CN220271346 U CN 220271346U CN 202321622028 U CN202321622028 U CN 202321622028U CN 220271346 U CN220271346 U CN 220271346U
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- pipetting
- suction head
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- 230000007246 mechanism Effects 0.000 title claims abstract description 68
- 239000007788 liquid Substances 0.000 title claims abstract description 40
- 230000003139 buffering effect Effects 0.000 title claims description 5
- 239000000523 sample Substances 0.000 claims abstract description 78
- 238000002156 mixing Methods 0.000 claims abstract description 35
- 238000012360 testing method Methods 0.000 claims abstract description 23
- 239000000872 buffer Substances 0.000 claims abstract description 19
- 239000012723 sample buffer Substances 0.000 claims abstract description 15
- 238000007599 discharging Methods 0.000 claims abstract description 5
- 238000011084 recovery Methods 0.000 claims description 18
- 238000000265 homogenisation Methods 0.000 claims description 11
- 230000005540 biological transmission Effects 0.000 claims description 4
- 238000001514 detection method Methods 0.000 abstract description 14
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 238000004445 quantitative analysis Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012123 point-of-care testing Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000003317 immunochromatography Methods 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
The utility model relates to the technical field of sample detection equipment, in particular to a sample buffer and liquid homogenizing mechanism, which comprises a rack, and a sample module, a suction head supply module, a buffer liquid supply module, a mixing module and a liquid transferring mechanism which are arranged on the rack; the sample module comprises a plurality of rows of sample frames, each row of sample frames is provided with a plurality of tube holes for placing test tubes, and the tube holes are inserted with elastic positioning sleeves which elastically prop against the outer walls of the test tubes; the suction head supply module comprises a suction head disc; the buffer liquid supply module comprises a liquid supply box with an upward opening; the mixing module comprises a liquid mixing disc; the frame is also provided with a sample feeding station; the pipetting mechanism comprises a pipetting device and a pipetting drive module, and the pipetting drive module can drive the pipetting device to move among the sample module, the suction head supply module, the buffer liquid supply module, the mixing module and the sample discharging station. The elastic positioning sleeve can avoid shaking of the test tube, the pipette drives the suction head to accurately sample, contact with the wall of the test tube is reduced, and detection accuracy is improved.
Description
Technical Field
The utility model relates to the technical field of sample detection equipment, in particular to a sample buffering and liquid homogenizing mechanism.
Background
POCT (point-of-care testing) is a sub-division industry of in vitro diagnostic devices (IVD), i.e. on-site sampling and immediate analysis, which omits a complex procedure for testing specimens in a laboratory and rapidly obtains test results.
When carrying out fluorescent immunity quantitative detection, most of traditional diagnostic instruments are semi-automatic detection instruments, the existing machine structure only comprises an optical path system and an electronic display system for quantitative detection, and the sample adding and chromatography processes are completed outside the machine manually; in use, firstly, the semi-automatic instrument performs sample loading outdoors, which is very unfavorable for some products with high temperature requirements; secondly, because the steps of manual sampling and sample adding are needed, quantitative analysis is carried out through an instrument, the generated test error of manual intervention is increased, the immunochromatography display time, the sample adding precision and the like are inaccurate, the test speed is low, and the manual sample adding is easy to cause biological pollution.
Thus, the Chinese patent document with publication number of CN204347046U discloses a full-automatic fluorescence immunoassay quantitative analysis device, and belongs to the field of quantitative fluorescence immunoassay detection. The immunity quantitative analysis device comprises a supporting bottom plate, a reagent strip storage and automatic loading module, a reaction plate module, a detection module, a sample adding module, a washing module and a control system, wherein the reagent strip storage and automatic loading module, the reaction plate module, the detection module, the sample adding module and the washing module are sequentially arranged on the supporting bottom plate, the reagent strip storage and automatic loading module provides reagent strips for the reaction plate module, the sample adding module adds samples in the sample module into the reaction plate module for reaction, and the samples enter the detection module for detection after the reaction is completed. The method solves the problem that in-vitro diagnosis products are difficult to realize automation, reduces human errors, improves the accuracy of testing and improves the detection efficiency.
However, the applicant found that the test tube at the sample module is prone to jolt, so that errors are prone to occur when the sample module sucks the blood sample, or the pipette collides with the test tube or rubs with the test tube greatly.
Disclosure of Invention
Aiming at the technical problems in the prior art, the utility model provides a sample buffering and liquid homogenizing mechanism.
In order to achieve the above purpose, the present utility model provides the following technical solutions:
providing a sample buffer and liquid homogenizing mechanism, which comprises a frame, a sample module, a suction head supply module, a buffer liquid supply module, a mixing module and a liquid transferring mechanism, wherein the sample module, the suction head supply module, the buffer liquid supply module, the mixing module and the liquid transferring mechanism are arranged on the frame;
the sample module comprises a plurality of rows of sample frames, each row of sample frames is provided with a plurality of tube holes for placing test tubes, and the tube holes are inserted with elastic positioning sleeves which elastically prop against the outer walls of the test tubes; the suction head supply module comprises a suction head disc, and a plurality of placing holes for the suction heads to be inserted are formed in the suction head disc; the buffer liquid supply module comprises a liquid supply box with an upward opening; the mixing module comprises a liquid mixing disc, wherein the liquid mixing disc is provided with a plurality of mixing grooves with upward openings; the frame is also provided with a sample feeding station;
the pipetting mechanism comprises a pipetting device and a pipetting drive module, and the pipetting drive module can drive the pipetting device to move among the sample module, the suction head supply module, the buffer liquid supply module, the mixing module and the sample discharging station.
Specifically, the sample module still includes the location base, and the top of location base is provided with many location slide rails, and the bottom of sample frame is provided with the constant head tank, constant head tank and the mutual sliding fit of location slide rail.
Specifically, the front end of the sample rack is provided with an I-shaped push-pull handle.
Specifically, the inner wall of the pipe hole of the sample frame is provided with a longitudinally arranged dovetail groove, the elastic positioning sleeve is provided with a dovetail, and the dovetail groove are in sliding fit with each other.
Specifically, the elastic locating sleeve comprises a ring sleeve and an elastic locating arm extending towards the inside of the pipe hole, the elastic locating arm is fixed on the ring sleeve, and the ring sleeve is matched with the inner wall of the pipe hole.
Specifically, the pipetting drive module comprises an X-axis slide rail, an X-axis drive mechanism, an arch door frame, a Y-axis slide rail, a Y-axis drive mechanism, a Z-axis slide rail and a Z-axis drive mechanism, wherein the X-axis slide rail is fixed on the frame, the arch door frame is slidably arranged on the X-axis slide rail, and the X-axis drive mechanism drives the arch door frame to move along the X axis; the Y-axis sliding rail is fixed on the arch portal, the Z-axis sliding rail is slidably arranged on the Y-axis sliding rail, and the Y-axis driving mechanism drives the Z-axis sliding rail to move along the Y axis; the pipettor is slidably mounted on the Z-axis sliding rail, and the Z-axis driving mechanism drives the pipettor to move along the Z axis.
Specifically, the X-axis driving mechanism, the Y-axis driving mechanism and the Z-axis driving mechanism all comprise a pipetting motor, a driving wheel and a belt, and the pipetting motor drives the belt to move through the driving wheel.
Specifically, still be provided with the bearing plate in the frame, sample module, suction head supply module, buffer liquid supply module and mixing module all set up on the bearing plate.
Specifically, a push-pull plate is slidably arranged on the supporting plate, and the suction head supply die and the mixing die set are arranged on the push-pull plate; the push-pull plate is provided with a handle.
Specifically, the bottom of frame still is equipped with the suction head and retrieves the chamber, and the suction head retrieves the chamber and has placed the recovery box, and the frame has opened the recovery hole that pipetting mechanism can align, and recovery hole aligns the recovery box.
The utility model has the beneficial effects that:
compared with the prior art, the sample buffer and liquid homogenizing mechanism can automatically add buffer liquid and sample, and the elastic positioning sleeve is inserted into the sample rack for placing the test tube, so that the test tube can be prevented from shaking, the pipette can accurately sample when driving the suction head to sample, the contact with the wall of the test tube is reduced, and the detection accuracy is improved.
Drawings
FIG. 1 is a schematic diagram of a sample buffer mechanism applied to an immunofluorescence analyzer in an embodiment.
Fig. 2 is a schematic structural diagram of a sample buffer homogenization mechanism in an embodiment.
Fig. 3 is a schematic structural view of a pipetting mechanism in the embodiment.
Fig. 4 is a schematic structural view of a row of sample holders of a sample module according to an embodiment, in which an elastic positioning sleeve is separated.
Reference numerals:
the device comprises a frame 1, a sample loading station 11 and a suction head recycling cavity 12;
sample module 21, sample holder 211, tube hole 2111, dovetail slot 2112, positioning slot 2113, push-pull handle 2114, elastic positioning sleeve 212, ring sleeve 2121, elastic positioning arm 2122, dovetail 2123, positioning base 213, positioning slide 2131;
a suction head supply module 22, a suction head tray 221, and a mounting hole 222;
a buffer liquid supply module 23 and a liquid supply box 231;
mixing module 24, mixing tray 241, mixing tank 242;
pipetting mechanism 25, pipettor 251, X-axis slide rail 252, X-axis drive mechanism 253, arch 254, Y-axis slide rail 255, Y-axis drive mechanism 256, Z-axis slide rail 257, Z-axis drive mechanism 258;
a support plate 26 and a push-pull plate 27.
Detailed Description
The present utility model will be described in detail with reference to specific embodiments and drawings.
The sample buffer and homogenization mechanism of this embodiment, as shown in fig. 1 to 4, comprises a frame 1, and a sample module 21, a suction head supply module 22, a buffer liquid supply module 23, a mixing module 24 and a pipetting mechanism 25 which are arranged on the frame 1.
The sample module 21 includes a plurality of rows of sample frames 211, the number of this example is five, and every row of sample frames 211 is provided with a plurality of tube holes 2111 that are used for placing test tubes, and tube holes 2111 are inserted with elastic positioning sleeves 212 that elastically support the outer wall of test tubes, and elastic positioning sleeves 212 include ring sleeve 2121 and more than two elastic positioning arms 2122 that extend towards tube holes 2111, and elastic positioning arms 2122 are fixed in ring sleeve 2121, and ring sleeve 2121 cooperates with the inner wall of tube holes 2111, and the test tubes placed on sample frames 211 are supported by elastic positioning arms 2122, can avoid test tube rocking, and the accurate sample of pipetting mechanism 25 of being convenient for. Specifically, the inner wall of the tube hole 2111 of the sample holder 211 is provided with a longitudinally arranged dovetail groove 2112, the elastic positioning sleeve 212 is provided with a dovetail 2123, the dovetail 2123 and the dovetail groove 2112 are in sliding fit with each other, and the insertion of the elastic positioning sleeve 212 is more accurate and convenient. Specifically, the sample module 21 further includes a positioning base 213, a plurality of positioning slide rails 2131 are disposed on top of the positioning base 213, and a positioning groove 2113 is disposed at the bottom of the sample rack 211, where the positioning groove 2113 and the positioning slide rails 2131 are slidably matched with each other. The front end of the sample rack 211 is provided with an I-shaped push-pull handle 2114, which is convenient for medical staff or peripheral mechanical arms to take and put the sample rack 211.
In this embodiment, the tip supply module 22 includes a tip tray 221, where the tip tray 221 is provided with a plurality of placement holes 222 into which the tips are inserted, and a row of tips, actually a plurality of rows, are shown in the figure, and the upper ends of the tips are located above the tip tray 221 for the pipetting mechanism 25 to take away. The buffer liquid supply module 23 includes a liquid supply box 231 with an upward opening, so that the pipetting mechanism 25 sucks the buffer liquid into the mixing module 24. The mixing module 24 comprises a liquid mixing disc 241, wherein the liquid mixing disc 241 is provided with a plurality of mixing grooves 242 with upward openings, and each mixing groove 242 is elliptical; the rack 1 is also provided with a sample discharging station 11, the sample discharging station 11 is provided with a reagent card, and the pipetting mechanism 25 sucks the blood sample and the buffer solution to the mixing tank 242 for a preset time, and then sucks the mixed solution to the reagent card for detection.
The pipetting mechanism 25 includes a pipetting device 251 and a pipetting drive module, which can drive the pipetting device 251 to move between the sample module 21, the pipette tip supply module 22, the buffer supply module 23, the mixing module 24 and the sample loading station 11. The pipetting drive module comprises an X-axis slide rail 252, an X-axis drive mechanism 253, an arch frame 254, a Y-axis slide rail 255, a Y-axis drive mechanism 256, a Z-axis slide rail 257 and a Z-axis drive mechanism 258, wherein the X-axis slide rail 252 is fixed on the frame 1, the arch frame 254 is slidably arranged on the X-axis slide rail 252, and the X-axis drive mechanism 253 drives the arch frame 254 to move along the X-axis; the Y-axis sliding rail 255 is fixed on the arch frame 254, the Z-axis sliding rail 257 is slidably mounted on the Y-axis sliding rail 255, and the Y-axis driving mechanism 256 drives the Z-axis sliding rail 257 to move along the Y-axis; the pipette 251 is slidably mounted on a Z-axis slide 257, and a Z-axis drive mechanism 258 drives the pipette 251 to move along the Z-axis.
Specifically, the X-axis driving mechanism 253, the Y-axis driving mechanism 256 and the Z-axis driving mechanism 258 each include a pipetting motor, a transmission wheel and a belt, the pipetting motor drives the belt to move through the transmission wheel, for example, the gantry 254, the Z-axis sliding rail 257 and the pipettor 251 are respectively fixed on the corresponding belts, and the belts can drive the belts to move linearly when moving.
In this embodiment, the support plate 26 is further disposed on the frame, and the sample module 21, the suction head supply module 22, the buffer liquid supply module 23 and the mixing module 24 are all disposed on the support plate 26, and during manufacturing, these modules are positioned on the support plate 26, and then the support plate 26 is fixed on the frame, so that the whole module is convenient to install.
Specifically, a push-pull plate 27 is slidably arranged on the support plate 26, and the suction head supply die and mixing die set 24 is placed on the push-pull plate 27; the push-pull plate 27 is provided with a handle to facilitate the separate insertion or withdrawal of the two modules.
Specifically, the bottom of frame still is equipped with suction head recovery chamber 12, and suction head recovery chamber 12 has placed the recovery box that does not show in the figure, and the frame is opened there is the recovery hole that pipetting mechanism 25 can align, and recovery hole aligns the recovery box, and the suction head is disposable, and after the sample next time, the suction head can be abandoned, falls to in the recovery box from recovery hole.
In the description of the present utility model, unless explicitly stated and limited otherwise, the terms "mounted," "connected," and "secured" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
Standard parts used in the utility model can be purchased from the market, special-shaped parts can be customized according to the description of the specification and the drawings, the specific connection modes of all parts adopt conventional means such as mature bolts, rivets and welding in the prior art, the machinery, the parts and the equipment adopt conventional models in the prior art, and the circuit connection adopts conventional connection modes in the prior art, so that the details are not described.
Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present utility model, and not for limiting the scope of the present utility model, and although the present utility model has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made to the technical solution of the present utility model without departing from the spirit and scope of the technical solution of the present utility model.
Claims (10)
1. Sample buffering mechanism, characterized by: comprises a frame, a sample module, a suction head supply module, a buffer liquid supply module, a mixing module and a pipetting mechanism which are arranged on the frame;
the sample module comprises a plurality of rows of sample frames, each row of sample frames is provided with a plurality of tube holes for placing test tubes, and the tube holes are inserted with elastic positioning sleeves which elastically prop against the outer walls of the test tubes; the suction head supply module comprises a suction head disc, and a plurality of placing holes for the suction heads to be inserted are formed in the suction head disc; the buffer liquid supply module comprises a liquid supply box with an upward opening; the mixing module comprises a liquid mixing disc, wherein the liquid mixing disc is provided with a plurality of mixing grooves with upward openings; the frame is also provided with a sample feeding station;
the pipetting mechanism comprises a pipetting device and a pipetting drive module, and the pipetting drive module can drive the pipetting device to move among the sample module, the suction head supply module, the buffer liquid supply module, the mixing module and the sample discharging station.
2. The sample buffer homogenization mechanism of claim 1, wherein: the sample module still includes the location base, and the top of location base is provided with many location slide rails, and the bottom of sample frame is provided with the constant head tank, constant head tank and the mutual sliding fit of location slide rail.
3. The sample buffer homogenization mechanism of claim 2, wherein: the front end of the sample rack is provided with an I-shaped push-pull handle.
4. The sample buffer homogenization mechanism of claim 1, wherein: the inner wall of the tube hole of the sample frame is provided with a longitudinally arranged dovetail groove, the elastic positioning sleeve is provided with a dovetail, and the dovetail groove are mutually matched in a sliding way.
5. The sample buffer homogenization mechanism of claim 1, wherein: the elastic positioning sleeve comprises a ring sleeve and an elastic positioning arm extending towards the inside of the pipe hole, the elastic positioning arm is fixed on the ring sleeve, and the ring sleeve is matched with the inner wall of the pipe hole.
6. The sample buffer homogenization mechanism of claim 1, wherein: the pipetting drive module comprises an X-axis slide rail, an X-axis drive mechanism, an arch portal frame, a Y-axis slide rail, a Y-axis drive mechanism, a Z-axis slide rail and a Z-axis drive mechanism, wherein the X-axis slide rail is fixed on the frame, the arch portal frame is slidably arranged on the X-axis slide rail, and the X-axis drive mechanism drives the arch portal frame to move along the X axis; the Y-axis sliding rail is fixed on the arch portal, the Z-axis sliding rail is slidably arranged on the Y-axis sliding rail, and the Y-axis driving mechanism drives the Z-axis sliding rail to move along the Y axis; the pipettor is slidably mounted on the Z-axis sliding rail, and the Z-axis driving mechanism drives the pipettor to move along the Z axis.
7. The sample buffer homogenization mechanism of claim 6, wherein: the X-axis driving mechanism, the Y-axis driving mechanism and the Z-axis driving mechanism all comprise a pipetting motor, a transmission wheel and a belt, and the pipetting motor drives the belt to move through the transmission wheel.
8. The sample buffer homogenization mechanism of claim 1, wherein: the rack is also provided with a support plate, and the sample module, the suction head supply module, the buffer liquid supply module and the mixing module are all arranged on the support plate.
9. The sample buffer homogenization mechanism of claim 8, wherein: the support plate is slidably provided with a push-pull plate, and the suction head supply die and the mixing die set are arranged on the push-pull plate; the push-pull plate is provided with a handle.
10. The sample buffer homogenization mechanism of claim 1, wherein: the bottom of the frame is also provided with a suction head recovery cavity, the suction head recovery cavity is provided with a recovery box, the frame is provided with a recovery hole which can be aligned by the pipetting mechanism, and the recovery hole is aligned with the recovery box.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321622028.XU CN220271346U (en) | 2023-06-26 | 2023-06-26 | Sample buffering and liquid homogenizing mechanism |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321622028.XU CN220271346U (en) | 2023-06-26 | 2023-06-26 | Sample buffering and liquid homogenizing mechanism |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220271346U true CN220271346U (en) | 2023-12-29 |
Family
ID=89311178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321622028.XU Active CN220271346U (en) | 2023-06-26 | 2023-06-26 | Sample buffering and liquid homogenizing mechanism |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220271346U (en) |
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2023
- 2023-06-26 CN CN202321622028.XU patent/CN220271346U/en active Active
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