CN210923721U - Chemiluminescence instrument - Google Patents
Chemiluminescence instrument Download PDFInfo
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- CN210923721U CN210923721U CN201921397151.XU CN201921397151U CN210923721U CN 210923721 U CN210923721 U CN 210923721U CN 201921397151 U CN201921397151 U CN 201921397151U CN 210923721 U CN210923721 U CN 210923721U
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- reaction cup
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- sample
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- 230000007246 mechanism Effects 0.000 claims abstract description 83
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 51
- 238000004140 cleaning Methods 0.000 claims abstract description 29
- 238000011068 loading method Methods 0.000 claims abstract description 22
- 230000007723 transport mechanism Effects 0.000 claims abstract description 12
- 238000005070 sampling Methods 0.000 claims abstract 2
- 239000000758 substrate Substances 0.000 claims description 27
- 238000005406 washing Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 abstract description 15
- 238000012864 cross contamination Methods 0.000 abstract description 9
- 238000007599 discharging Methods 0.000 abstract description 8
- 238000002425 crystallisation Methods 0.000 abstract description 2
- 230000008025 crystallization Effects 0.000 abstract description 2
- 238000011534 incubation Methods 0.000 description 11
- 238000001514 detection method Methods 0.000 description 8
- 238000005213 imbibition Methods 0.000 description 6
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 238000004020 luminiscence type Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
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- 238000003018 immunoassay Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- RXNXLAHQOVLMIE-UHFFFAOYSA-N phenyl 10-methylacridin-10-ium-9-carboxylate Chemical compound C12=CC=CC=C2[N+](C)=C2C=CC=CC2=C1C(=O)OC1=CC=CC=C1 RXNXLAHQOVLMIE-UHFFFAOYSA-N 0.000 description 2
- 241000252254 Catostomidae Species 0.000 description 1
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- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000036046 immunoreaction Effects 0.000 description 1
- 238000000504 luminescence detection Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
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Abstract
The utility model discloses a chemiluminescence instrument, including the instrument main part, sampling mechanism is installed to one side of instrument main part, application of sample mechanism, reaction cup and suction head loading mechanism, reaction cup transport mechanism and be located the mechanical tongs one of these mechanism tops, reagent dish is installed to one side of reaction cup transport mechanism, reagent needle mechanism is installed with reaction cup transport mechanism's top to reagent dish, reaction cup transport mechanism's opposite side is installed and is hatched the dish, wash dish and detector mechanism, hatch dish and the top of wasing the dish and install mechanical tongs two, the wiper mechanism is still installed to the top of wasing the dish. The reaction cup of the utility model is loaded in a tray form, which avoids the phenomenon of cup clamping which is easy to happen in the traditional automatic loading and causes frequent faults; the sample suction adopts a disposable suction head, so that the cross contamination is completely avoided; the cleaning mechanism is provided with the liquid discharging needle and the liquid sucking needle cleaning device, so that the liquid discharging needle and the liquid sucking needle are prevented from being unclearned for a long time to generate crystallization, and cross contamination during cleaning is avoided.
Description
Technical Field
The utility model relates to the technical field of medical equipment, especially, relate to a chemiluminescence instrument.
Background
The chemiluminescence apparatus combines a chemiluminescence measuring technology with high sensitivity with high specificity immunoreaction, and is used for detecting and analyzing various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins, medicines and the like. Is a latest immunoassay technology developed after radioimmunoassay, enzyme immunoassay, fluoroimmunoassay and time-resolved fluoroimmunoassay.
With the development of the medical level, various chemiluminescent instruments breed in order to effectively and accurately complete the detection of diseases. At present, the market is mainly occupied by the chemiluminescent instruments imported from foreign countries, and the domestic chemiluminescent instruments are still in the primary development stage. The instruments of various manufacturers have various types and different characteristics. In order to cater for diversified luminescent reagent, accurate effectual completion chemiluminescence detects, the utility model provides a chemiluminescent instrument of this money.
SUMMERY OF THE UTILITY MODEL
In order to overcome the defects of the prior art, the utility model provides a chemiluminescence instrument which can solve the problems in the background technology.
In order to solve the technical problem, the utility model provides a following technical scheme:
the utility model provides a chemiluminescent instrument, includes the instrument main part, the mechanical tongs that advance a kind mechanism, application of sample mechanism, reaction cup and suction head loading mechanism, reaction cup transport mechanism and be located these mechanism tops is installed to one side of instrument main part, the reagent dish is installed to one side of reaction cup transport mechanism, reagent needle mechanism is installed with reaction cup transport mechanism's top to the reagent dish, reaction cup transport mechanism's opposite side is installed and is hatched the dish, wash dish and detector mechanism, hatch dish and wash the top of dish and install mechanical tongs two, the wiper mechanism is still installed to the top of wasing the dish.
As an optimized technical scheme of the utility model, reaction cup and suction head loading mechanism are for loading the tray, be provided with a plurality of evenly distributed's hole groove on loading the tray.
As a preferred technical scheme of the utility model, detector mechanism independently installs in the instrument main part.
As an optimal technical scheme of the utility model, wiper mechanism is including spitting liquid needle, imbibition needle and spitting liquid needle and imbibition needle belt cleaning device.
As an optimized technical proposal of the utility model, one end of the sample feeding mechanism is provided with two substrate channels.
Compared with the prior art, the utility model discloses the beneficial effect that can reach is:
the reaction cup of the utility model is loaded in a tray form, which avoids the phenomenon of cup clamping which is easy to happen in the traditional automatic loading and causes frequent faults; the sample suction adopts a disposable suction head, so that the cross contamination is completely avoided; the detection device is loaded at an independent single position, so that the influence on the result caused by interference is avoided; the cleaning mechanism is provided with a liquid discharging needle and a liquid sucking needle cleaning device, so that the liquid discharging needle and the liquid sucking needle are prevented from being unclearned for a long time to generate crystals, and cross contamination during cleaning is avoided; the substrate is provided with two substrate channels, and can be used for two reagent modes of enzyme-promoted light emission and direct light emission.
Drawings
Fig. 1 is a schematic structural diagram of the present invention;
fig. 2 is a front view of the present invention;
fig. 3 is a side view of the present invention;
wherein: 1. a sample introduction mechanism; 2. a sample adding mechanism; 3. a reaction cup and suction head loading mechanism; 4. A first mechanical gripper; 5. a reaction cup transfer device; 6. a reagent needle mechanism; 7. a reagent tray; 8. an incubation tray; 9. a mechanical gripper II; 10. cleaning the disc; 11. a cleaning mechanism; 12. a detector mechanism; 13. a substrate channel.
Detailed Description
The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are presented herein only to illustrate and explain the present invention, and not to limit the present invention.
Referring to fig. 1-3, a chemiluminescent instrument comprises an instrument main body, wherein a sample introduction mechanism 1, a sample adding mechanism 2, a reaction cup and suction head loading mechanism 3, a reaction cup conveying mechanism 5 and a mechanical gripper I4 positioned above the mechanisms are arranged on one side of the instrument main body, a reagent disc 7 is arranged on one side of the reaction cup conveying mechanism 5, a reagent needle mechanism 6 is arranged above the reagent disc 7 and the reaction cup conveying mechanism 5, an incubation disc 8, a cleaning disc 10 and a detector mechanism 12 are arranged on the other side of the reaction cup conveying mechanism 5, a mechanical gripper II 9 is arranged above the incubation disc 8 and the cleaning disc 10, and a cleaning mechanism 11 is further arranged above the cleaning disc 10.
Wherein, reaction cup and suction head loading mechanism 3 is for loading the tray, is provided with a plurality of evenly distributed's hole groove on loading the tray, and the reaction cup adopts the tray form to load, avoids the easy card cup phenomenon that takes place of traditional automatic loading, causes the trouble frequently.
Wherein, detector mechanism 12 independently installs on the instrument main part, and detection device adopts independent single position to load, avoids taking place to disturb and influences the result.
Wherein, wiper mechanism 11 includes liquid-discharging needle, imbibition needle and liquid-discharging needle and imbibition needle belt cleaning device, and wiper mechanism loads liquid-discharging needle and imbibition needle belt cleaning device, avoids liquid-discharging needle, imbibition needle long-time not clear hair and produces the crystallization to and avoid the cross contamination who takes place when wasing.
Wherein, two substrate channels are arranged on the right side of the sample injection mechanism 1, and two reagent modes of enzymatic luminescence and direct luminescence can be compatible at the same time. When enzyme-promoted light emission is adopted, two substrate channels are set as the same substrate, and can be automatically switched to be used when the substrate 1 is used up, and can be automatically switched to be used as the substrate 2 when the substrate 1 is used up. When a direct luminescence mode is employed or compatible with simultaneous use of enzymatic luminescence, substrate 1 and substrate 2 are provided as two different substrates.
Specifically, the sample feeding mechanism 1 of the device adopts a crawler belt for sample feeding, so that the device is stable in structure, not prone to failure and accurate in position;
the sample injection mechanism 1 adopts 10 hole sample racks for sample injection, and the sample racks are arranged on the left side and the right side of the sample injection mechanism 1. The sample injection mechanism 1 can hold up to 9 sample holders, i.e. 90 samples. The sample introduction frame is conveyed forwards and backwards by adopting a crawler, the Y1 crawler pushes the sample frame to the X1 shaft position, and when the sensor at the upper left corner of the sample introduction frame senses the sample frame, the X1 shaft motor drives the sample frame to be conveyed to the sample introduction position. Before entering the sample adding position, two sensors are used for sensing whether a test tube and a small cup are placed. And is provided with a sample bar code scanner for identifying the sample bar code. When the sample rack enters the sample adding position, the sample adding mechanism 2 works. After the sample suction is finished, the X1 shaft motor continues to push the sample frame to the right side, after the sensor at the upper right corner senses the frame, the X1 shaft motor stops pushing and returns to the original point position, the Y2 crawler pushes the finished sample frame forward as far as possible, and the frame outlet position in the X1 shaft direction is vacated. And waiting for the next sample rack to reach the X1 position, and circulating.
A sample adding mechanism 2 is arranged above the sample feeding mechanism 1, and the sample adding mechanism 2 adopts a disposable suction head, so that the occurrence of cross contamination is completely avoided; the sample adding mechanism 2 is used for placing the suction head required by sample adding on the reaction cup and the suction head loading mechanism 3 below.
The sample adding mechanism 2 adopts an air gun nozzle, automatically installs a suction head, and then sucks samples through an air injector. The automatic liquid level sensing and blockage sensing functions are realized during sample suction. And after the sample suction is finished, automatically removing the suction head and carrying out next sample suction work.
The reaction cup and suction head loading mechanism 3 is used for placing 2 boxes of reaction cups and 2 boxes of suction heads. The mechanism can move in the X-axis direction and can load the reaction cup and the sucker by one key. The number of the reaction cups and the suckers is recorded by a control system, and position numbers of all positions are set. When the mechanical gripper is to grip the reaction cup, the reaction cup and suction head loading mechanism 3 moves the designated position to the position corresponding to the mechanical gripper, and the gripping of the reaction cup is completed. When the sample adding mechanism 2 needs to pick up the suction head, the reaction cup and suction head loading mechanism 3 moves the position of the designated suction head to the lower part of the gun head of the sample adding mechanism 2, and the grabbing work of the suction head is completed. After the mechanical hand grab takes the reaction cups to the incubation plate or the reaction cup conveying device, the number of the reaction cups is automatically updated.
And the mechanical gripper I4 grabs and places the reaction cup from the reaction cup and suction head loading mechanism 3 to the reaction cup conveying device 5, and then samples and reagents are added.
The reaction cup conveying device is provided with 2-5 reaction cup placing hole sites, and when the empty reaction cup needs to be added with a reagent, the reaction cup conveying device moves the empty reaction cup to the reagent needle sample adding position, and then the reagent needle completes sample adding. When the reaction cup needs to add a sample, the reaction cup conveying device moves the reaction cup to the sample adding position, and other operations are performed after the sample adding mechanism 2 finishes adding the sample. In addition, the reaction cup conveying device is also provided with an automatic blending function. The mixing function drives the guide rail to move back and forth at high speed through the eccentric motor, thereby completing the homogeneous mixing of the sample and the reagent in the reaction cup. When the reaction cup needs to enter the incubation disc or the detection mechanism, the reaction cup can also complete the transmission work of the reaction cup, and the reaction cup is accurately conveyed to the designated position.
The reagent is placed in the reagent tray 7. The reagent bottle has a bar code function, and a bar code reading scanner is arranged in the reagent tray to finish automatic identification of the bar code on the reagent bottle.
The reagent needle mechanism 6 performs a reagent adding operation of adding a reagent into the cuvette above the cuvette conveyer 5. The reagent needle has a liquid level sensing function, can finish sample adding under a certain depth below the liquid level, and avoids bringing out excessive reagents on the reagent arm. After the reagent needle mechanism 6 finishes sample adding, the reagent needle mechanism moves to the reagent needle cleaning tank to finish the washing of the outer wall and the inner wall of the reagent needle. The inner wall of the reagent is filled with cleaning liquid to complete cleaning work, and the outer wall of the reagent is washed through a water inlet of the cleaning tank. The reagent needle mechanism 6 is designed to move obliquely in XY directions, the movement direction is controlled by adopting a linear guide rail, one end of the reagent needle mechanism controls the reagent needle to reach the reagent tray, and the other end of the reagent needle mechanism controls the reagent needle to reach the reaction cup conveying mechanism 5.
After sample and reagent are added, the first mechanical gripper 4 grabs the reaction cup into the incubation disc 8 for incubation. The incubation disc adopts an electronic heat conduction direct heating mode, and the heating speed is high. The temperature of the whole incubation plate was strictly controlled at 37. + -. 0.5 ℃ by a temperature sensor.
After incubation is finished, the second mechanical gripper 9 grips the reaction cup into the cleaning disc 10, and then the cleaning mechanism 11 finishes cleaning the reaction cup by rotating to the position below the cleaning mechanism 11. During cleaning, the hole position rotates and each rotating time is controlled by the system. The process of spitting and absorbing liquid is completed, and the binder and the non-binder are effectively separated. The substrate is subsequently added.
The substrate channel 13 may accommodate two different substrates or the same substrate. When the system is in an enzymatic mode, a substrate is provided, and a substrate filling pump and two valves are provided for control. When the left substrate bottle 1 is used up, the system automatically switches to the right substrate bottle 2 for use. When using an acridinium ester or other luminophore system, a filling channel is provided in the cover above the detector for the addition of the substrate 2. The substrate 1 and the substrate 2 are scanned by a manual scanning gun and put into a system, and the system finishes an alarm function.
After the filling of the substrate is finished, the second mechanical gripper 9 grips the reaction cup from the cleaning disc 10 to the incubation disc 8, and then the first mechanical gripper 4 grips the reaction cup to the detection mechanism 12 for detection. And after the detection is finished, the mechanical gripper I4 throws the reaction cup into the garbage box, and the whole luminescence detection process is finished.
The utility model discloses it has following technical characterstic to compare other similar luminous products:
1. and an independent detection mechanism is adopted, so that cross interference among hole sites is avoided.
2. And the outer wall of the cleaning needle is cleaned by adopting a flexible cleaning tank, so that adverse effects such as cross contamination are avoided.
3. The reaction cup is loaded in a tray mode, and adverse effects such as cup clamping and the like caused by automatic cup feeding are avoided.
4. And the disposable sample adding suction head is adopted, so that the cross contamination during sample adding is avoided, and the cross contamination is completely avoided.
5. The reagent disk is provided with reagent bottles with 3 hole sites, 5 hole sites and other different hole sites for simultaneous loading, and is suitable for different types of reagents.
6. The two substrate channels are arranged, so that the reagent system is suitable for the reagent system which emits light by direct luminescent substances such as enzyme-promoted light and acridinium ester. The compatibility is good.
The embodiments of the present invention are not limited to the above embodiments, and according to the contents of the above embodiments of the present invention, the above preferred embodiments can also make modifications, replacements or combinations of other forms by using conventional technical knowledge and conventional means in the field without departing from the basic technical idea of the present invention, and the obtained other embodiments all fall within the scope of the present invention.
Claims (5)
1. The utility model provides a chemiluminescence instrument, includes the instrument main part, its characterized in that, sampling mechanism (1), application of sample mechanism (2), reaction cup and suction head loading mechanism (3), reaction cup transport mechanism (5) and be located mechanical tongs (4) of these mechanism tops are installed to one side of instrument main part, reagent dish (7) are installed to one side of reaction cup transport mechanism (5), reagent needle mechanism (6) are installed to reagent dish (7) and the top of reaction cup transport mechanism (5), the opposite side of reaction cup transport mechanism (5) is installed and is hatched dish (8), washing dish (10) and detector mechanism (12) are hatched the top of dish (8) and washing dish (10) and is installed mechanical tongs two (9), washing mechanism (11) are still installed to the top of washing dish (10).
2. A chemiluminescent instrument according to claim 1 wherein the reaction cup and tip loading mechanism (3) is a loading tray with a plurality of evenly distributed wells.
3. A chemiluminescent instrument according to claim 1 wherein the detector means (12) is mounted independently on the instrument body.
4. A chemiluminescent instrument according to claim 1 wherein the cleaning mechanism (11) comprises a spitting needle, a pipetting needle and a spitting and pipetting needle cleaning device.
5. A chemiluminescent instrument according to claim 1 is characterized in that two substrate channels (13) are provided at one end of the sample introduction mechanism (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921397151.XU CN210923721U (en) | 2019-08-27 | 2019-08-27 | Chemiluminescence instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921397151.XU CN210923721U (en) | 2019-08-27 | 2019-08-27 | Chemiluminescence instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210923721U true CN210923721U (en) | 2020-07-03 |
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ID=71365783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921397151.XU Active CN210923721U (en) | 2019-08-27 | 2019-08-27 | Chemiluminescence instrument |
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| Country | Link |
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| CN (1) | CN210923721U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110514822A (en) * | 2019-08-27 | 2019-11-29 | 晶旭生物科技(上海)有限公司 | A kind of chemiluminescence instrument |
| CN114236129A (en) * | 2021-12-20 | 2022-03-25 | 江苏集萃纳米应用技术研究所有限公司 | In-vitro immunodiagnosis reagent background luminescence processing system |
-
2019
- 2019-08-27 CN CN201921397151.XU patent/CN210923721U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110514822A (en) * | 2019-08-27 | 2019-11-29 | 晶旭生物科技(上海)有限公司 | A kind of chemiluminescence instrument |
| CN114236129A (en) * | 2021-12-20 | 2022-03-25 | 江苏集萃纳米应用技术研究所有限公司 | In-vitro immunodiagnosis reagent background luminescence processing system |
| CN114236129B (en) * | 2021-12-20 | 2022-09-23 | 江苏集萃中科纳米科技有限公司 | In-vitro immunodiagnosis reagent background luminescence processing system |
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