CN210429734U - Ion molecule reaction tube with quadrupole funnel structure - Google Patents
Ion molecule reaction tube with quadrupole funnel structure Download PDFInfo
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- CN210429734U CN210429734U CN201921718431.6U CN201921718431U CN210429734U CN 210429734 U CN210429734 U CN 210429734U CN 201921718431 U CN201921718431 U CN 201921718431U CN 210429734 U CN210429734 U CN 210429734U
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- 238000000605 extraction Methods 0.000 abstract 1
- 238000001824 photoionisation detection Methods 0.000 abstract 1
- 238000001819 mass spectrum Methods 0.000 description 17
- 230000005684 electric field Effects 0.000 description 15
- 238000001514 detection method Methods 0.000 description 14
- 238000005516 engineering process Methods 0.000 description 7
- 238000006276 transfer reaction Methods 0.000 description 5
- 239000012855 volatile organic compound Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 238000000170 chemical ionisation mass spectrum Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000001184 proton transfer reaction mass spectrometry Methods 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000000262 chemical ionisation mass spectrometry Methods 0.000 description 1
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- 238000005040 ion trap Methods 0.000 description 1
- 230000005596 ionic collisions Effects 0.000 description 1
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- 230000007774 longterm Effects 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
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Abstract
本实用新型涉及一种四极漏斗结构的离子分子反应管，包括电离源、管前电极、多片反应管电极、离子出口电极；所述的电离源与管前电极相连；所述的管前电极、多片反应管电极和离子出口电极之间都通过电阻依次相连；所述的多片反应管电极从离子入口端向离子出口端内径逐渐缩小，形成漏斗状；所述管前电极和离子出口电极中心分别设有离子进入和离子引出的小孔；所述的多片反应管电极在径向上被垂直切分为四个小电极，形成四极结构，相对的两个小电极通过导线接通，相邻的两个小电极通过电感相连。本实用新型对于提高化学电离和光电离类检测仪器的灵敏度具有重要价值。
The utility model relates to an ion molecule reaction tube with a quadrupole funnel structure, comprising an ionization source, an electrode in front of the tube, a multi-piece reaction tube electrode and an ion outlet electrode; The electrodes, the multi-piece reaction tube electrodes and the ion outlet electrodes are connected in sequence through resistances; the inner diameter of the multi-piece reaction tube electrodes is gradually reduced from the ion inlet end to the ion outlet end, forming a funnel shape; the front electrode of the tube and the ion The center of the outlet electrode is respectively provided with small holes for ion entry and ion extraction; the multi-piece reaction tube electrode is vertically cut into four small electrodes in the radial direction to form a quadrupole structure, and the opposite two small electrodes are connected by wires. The two adjacent small electrodes are connected by an inductance. The utility model has important value for improving the sensitivity of chemical ionization and photoionization detection instruments.
Description
Technical Field
The utility model belongs to the analysis and detection field, concretely relates to ion molecule reaction tube of quadrupole funnel structure.
Background
The proton transfer reaction mass spectrum technology is a new developed chemical ionization mass spectrum technology using ion-molecule reaction as a principle, and comprises an ion source, a reaction tube, a transition cavity, a mass spectrum detector and other core components. It is usually prepared by a water vapor discharge ion source to produce a parent ion H for an ion-molecule reaction3O+Then the parent ion H is put through a small hole between the ion source and the reaction tube3O+Introducing into a reaction tube in which volatile organic compounds M and H to be detected3O+Ion-molecule reaction occurs and is ionized into MH+。MH+And finally, the molecular weight can be detected by mass spectrometry, and molecular weight information and concentration information are obtained. The technology has the advantages of high sensitivity, quick response, soft ionization, no need of calibration and the like, and has more and more attention in the field of volatile organic compound monitoring and analysis in recent years.
Although proton transfer reaction mass spectrometry is the most sensitive chemical ionization mass spectrometry technology for detecting volatile organic compounds at present, the technology itself still has the improvement that the improvement can be further improved, for example, parent ions and product ions in a reaction tube can be diffused off-axis, so that the ions cannot be completely guided into a transition cavity and a mass spectrum cavity, thereby influencing the detection sensitivity, so the ion funnel concept is introduced into the reaction tube, and the detection sensitivity is improved by the royal jade and the like (the proton transfer reaction mass spectrometry technology and the application thereof in medical material detection research, doctor paper of research institute of Chinese academy of sciences, 2011). The ion funnel is characterized in that radio frequency voltage is applied to a wafer electrode with the gradually reduced inner diameter, so that funnel-shaped potential can be formed inside the electrode, the diffusion of ions is reduced, and the ion permeation efficiency is improved. The inventor also proposes to add a first-stage ion funnel between the ion source and the reaction tube to form a double-focusing ion funnel structure of the ion source and the reaction tube, which can further improve the efficiency of introducing the parent ions into the reaction tube and improve the detection sensitivity of organic matters. The technologies can improve the detection sensitivity of the proton transfer reaction mass spectrum to a certain extent, but for the monitoring research of the organic matter with ultra-low concentration characteristics, the proton transfer reaction mass spectrum with higher sensitivity is still a long-term demand at present or even in the future.
SUMMERY OF THE UTILITY MODEL
The technical problem of the utility model is solved: aiming at the monitoring and research requirements of ultralow-concentration characteristic organic matters, the ion molecule reaction tube with the quadrupole funnel structure is provided. The ion molecule reaction tube comprises a plurality of quadrupole sheet electrodes with gradually reduced inner diameters, the inner part of the quadrupole sheet electrode is funnel-shaped, and parent ions and product ions generated by reaction can be converged and led out to a central small hole of an ion outlet electrode under the combined action of a radio frequency electric field and a direct current electric field in the reaction tube. On one hand, the ion loss is further reduced, on the other hand, the reaction time is prolonged, and more product ions are generated, so that the high-sensitivity detection of the mass spectrum detector on organic matters is realized.
The utility model discloses technical solution: an ion molecule reaction tube with a quadrupole funnel structure comprises an ion source (1), a tube front electrode (2), a plurality of reaction tube electrodes (3) and an ion outlet electrode (4); the ion source (1) is connected with the tube front electrode (2); the tube front electrode (2), the multiple reaction tube electrodes (3) and the ion outlet electrode (4) are connected in sequence through resistance elements; the inner diameter of the central hole of each of the reaction tube electrodes (3) is gradually reduced from the ion inlet end to the ion outlet end to form a funnel shape; the center of the tube front electrode (2) is respectively provided with a small hole for the ion to enter, and the center of the ion outlet electrode (4) is provided with a small hole for the ion to be led out; the reaction tube electrodes (3) are vertically divided into four fan-shaped small electrodes in the radial direction to form a quadrupole structure, two opposite first small electrodes (5) are connected through a lead, two opposite second small electrodes (6) are also connected through a lead, and the adjacent first small electrodes (5) and the second small electrodes (6) are connected through inductors.
The reaction tube electrodes (3) are separated by adopting an insulating sealing gasket to form a reaction tube cavity, or the reaction tube electrodes are integrally placed in the sealed cavity to form the reaction tube cavity; the air pressure in the cavity of the reaction tube is 10 Pa-1000 Pa.
The diameter of the ion leading-out small hole at the center of the ion outlet electrode (4) is 0.1 mm-5 mm.
Compared with the prior art, the utility model difference and advantage lie in:
(1) in the proton transfer reaction mass spectrum, ion molecular reaction can efficiently occur only by certain reaction air pressure in the reaction tube, and the mass spectrum device can safely work only by low air pressure in the mass spectrum cavity, so that the tail end of the reaction tube can only guide ions through the flow-limiting small hole, and the mother ions and the product ions in the reaction tube are difficult to leave the reaction tube through the small hole. This reduces the signal intensity of the ions detected by the mass spectrometer, impairing the detection sensitivity. The utility model adopts a quadrupole funnel structure as an ion molecule reaction tube, realizes the high-efficiency focusing of ions, and realizes the focusing and guiding of parent ions and product ions in the reaction tube; meanwhile, ions oscillate under the action of a radio-frequency electric field, so that the time of ion molecule reaction is prolonged, the generation efficiency of product ions is improved, the detection sensitivity is improved, and the high-sensitivity detection of the chemical ionization mass spectrum similar to the proton transfer reaction mass spectrum is realized. The utility model mainly comprises an ion source, a tube front electrode, a multi-disc reaction tube electrode, an ion outlet electrode and the like. The multi-sheet reaction tube electrode not only forms a funnel-shaped reaction tube structure with gradually reduced inner diameter, but also vertically divides each reaction tube electrode into four small electrodes in the radial direction to form a quadrupole structure, two opposite small electrodes are connected through a lead, two adjacent small electrodes are connected through an inductor, and the connection mode of the ion molecule reaction tube of the quadrupole funnel structure is different from that of the prior art.
(2) The utility model discloses an innovation part lies in: each electrode of the conventional funnel-shaped reaction tube is equally divided into four small electrodes to form a quadrupole structure, two opposite small electrodes are connected through a lead, and two adjacent small electrodes are connected through an inductor. Positive and negative radio frequency voltages are respectively applied to the two small electrodes connected with each group of inductors, the positive and negative radio frequency voltages are also respectively applied to the electrodes sequentially connected through the resistors, and the application mode of the direct current voltage is the same as that in the conventional funnel-shaped reaction tube. Thus, the radio-frequency voltage forms a focusing electric field in the funnel-shaped reaction tube, and the ion collision loss is avoided; the direct current voltage forms an ion guide electric field to lead ions out of the ion outlet electrode. Compare current conventional direct current reaction tube and leak hopper-shaped reaction tube, the utility model discloses the biggest advantage is in can improving more female ion and product ion departure reaction tube, is detected by rear end mass spectrum, can prolong ion molecule reaction time in the reaction tube simultaneously, consequently, it is more sensitive to detect volatile organic compounds.
Drawings
Fig. 1 is a schematic view of an ion-molecule reaction tube with a quadrupole funnel structure according to the present invention;
fig. 2 is a schematic diagram of a quadrupole structure of each of the plurality of reaction tube electrodes 3 according to the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. The components of embodiments of the present invention, as generally described and illustrated in the figures herein, may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present invention, presented in the accompanying drawings, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. Based on the embodiment of the present invention, all other embodiments obtained by the person skilled in the art without creative work belong to the protection scope of the present invention.
As shown in fig. 1, the ion molecule reaction tube with quadrupole funnel structure according to an embodiment of the present invention includes: the device comprises an ion source 1, a tube front electrode 2, a plurality of reaction tube electrodes 3 and an ion outlet electrode 4; the ion source 1 is connected with the tube front electrode 2; the tube front electrode 2, the multiple reaction tube electrodes 3 and the ion outlet electrode 4 are connected in sequence through resistance elements; the inner diameter of the center of the electrodes 3 of the reaction tubes is gradually reduced from the ion inlet end to the ion outlet end to form a funnel shape; the distance between the adjacent electrodes of the plurality of reaction tube electrodes 3 can be between 0.5mm and 10mm, the number of the electrodes is determined according to the length requirement of the reaction tube, and generally the number of the electrodes can be between 5 and 50; the tube front electrode 2 is provided with a small hole for ion to enter, and the outlet electrode 4 is provided with a small hole for ion to exit; as shown in fig. 2, each of the plurality of reaction tube electrodes 3 has a polygonal shape such as a pie or a quadrangle, and is divided into four fan-shaped small electrodes vertically and equally in the radial direction, inner walls of the four small electrodes are circular and fixed uniformly with the same axis, so as to form a quadrupole structure, two opposite first small electrodes 5 are connected through a lead, two opposite second small electrodes 6 are connected through a lead, and the adjacent first small electrodes 5 and the adjacent second small electrodes 6 are connected through an inductor; the plurality of reaction tube electrodes 3 can be separated by insulating sealing gaskets to form reaction tube cavities, and can also be integrally placed in the sealing cavities to form reaction tube cavities.
A direct current voltage is applied between the tube front electrode 2 and the ion outlet electrode 4, and a uniform electric field is formed in the reaction tube through voltage division of a resistance element between each electrode in the reaction tube electrode 3; applying radio frequency voltages with opposite polarities to a first small electrode 5 and a second small electrode 6 which are adjacent in each electrode of the reaction tube, so as to form an ion focusing electric field in the reaction tube; the mother ions generated by the discharge ion source and the product ions generated by the reaction of the mother ions and the ions to be detected, or the product ions directly generated by photoionization can migrate towards the ion outlet electrode 4 under the guidance of a uniform electric field, and are focused towards the axis under the action of the ion focusing electric field, and finally can be led out through the central small hole of the ion outlet electrode 4, so that the high-efficiency focusing guidance of the ions is realized. The high-efficiency transmission of the parent ions and the product ions is realized through the focusing guidance of the ion molecular reaction tube with the quadrupole funnel structure, so that the high-sensitivity detection of the mass spectrometer instrument is realized.
The uniform electric field direction is related to the polarity requirement of the guided ions, and if the guided positive ions migrate towards the outlet electrode 4, the uniform electric field direction should point from the tube front electrode 2 to the ion outlet electrode 4; if the negative ions are directed to migrate towards the exit electrode 4, the uniform electric field direction should be directed from the ion exit electrode 4 towards the tube front electrode 2. Namely, the utility model can be used for focusing and guiding positive ions and negative ions.
In order to obtain the chemical ionization high-sensitivity detection effect, the air pressure in the cavity of the reaction tube can be set within the range of 10 Pa-1000 Pa; according to different vacuum system configurations, the diameter of the ion leading-out small hole at the center of the ion outlet electrode 4 is 0.1 mm-5 mm; the effective electric field range formed by the radio frequency electric field and the direct current electric field in the source drift tube and the reaction tube is 10V/cm-700V/cm; the front electrode 2 or the ion outlet electrode 4 is provided with a sample inlet for introducing the substance to be detected into the reaction tube.
In specific implementation, the ion source 1 may be a discharge ion source that generates parent ions, an ultraviolet lamp light ionization source, or a collective ionization source that can be individually switched on and off to select any one of the ions to be used; when the ion source 1 is an ultraviolet lamp ionization source, an object to be detected in the reaction tube is directly ionized into product ions, the product ions are focused to move forward in the ion molecule reaction tube with the quadrupole funnel structure, and finally the product ions are led out of the ion outlet electrode 4; if the ionization source is an integrated ionization source, selective ionization can be carried out on molecules with different properties, and more species can be detected; according to the ion detection requirement, the ion molecule reaction tube can be connected with detectors such as a quadrupole mass spectrum, a flight time mass spectrum, an ion trap mass spectrum, a Fourier transform ion cyclotron resonance mass spectrum or a magnetic mass spectrum, and a high-sensitivity mass spectrum detection system is formed.
The detailed description of the present invention is not provided in the detailed description of the present invention, which belongs to the technical field.
The above description is only a part of the embodiments of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention should be covered by the scope of the present invention.
Claims (6)
1. The utility model provides an ion molecule reaction tube of quadrupole funnel structure which characterized in that: comprises an ion source (1), a tube front electrode (2), a plurality of reaction tube electrodes (3) and an ion outlet electrode (4); the ion source (1) is connected with the tube front electrode (2); the tube front electrode (2), the multiple reaction tube electrodes (3) and the ion outlet electrode (4) are connected in sequence through resistance elements; the inner diameter of the central hole of each of the reaction tube electrodes (3) is gradually reduced from the ion inlet end to the ion outlet end to form a funnel shape; the center of the tube front electrode (2) is respectively provided with a small hole for the ion to enter, and the center of the ion outlet electrode (4) is provided with a small hole for the ion to be led out; the reaction tube electrodes (3) are vertically divided into four fan-shaped small electrodes in the radial direction to form a quadrupole structure, two opposite first small electrodes (5) are connected through a lead, two opposite second small electrodes (6) are also connected through a lead, and the adjacent first small electrodes (5) and the second small electrodes (6) are connected through inductors.
2. The ion-molecule reaction tube of a quadrupole funnel structure according to claim 1, wherein: the reaction tube electrodes (3) are separated by adopting an insulating sealing gasket to form a reaction tube cavity, or are integrally placed in the sealed cavity to form the reaction tube cavity.
3. The ion-molecule reaction tube of a quadrupole funnel structure according to claim 1, wherein: the diameter of the ion leading-out small hole at the center of the ion outlet electrode (4) is 0.1 mm-5 mm.
4. The ion-molecule reaction tube of a quadrupole funnel structure according to claim 1, wherein: the ion source (1) is a discharge ion source that generates parent ions.
5. The ion-molecule reaction tube of a quadrupole funnel structure according to claim 1, wherein: the ion source (1) is an ultraviolet lamp photoionization source.
6. The ion-molecule reaction tube of a quadrupole funnel structure according to claim 1, wherein: the ion source (1) is a collective ionization source with individual switch control to select any one of the ion sources for use.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110648897A (en) * | 2019-10-15 | 2020-01-03 | 中国科学院合肥物质科学研究院 | An ion molecule reaction tube with a quadrupole funnel structure and its ion focusing method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110648897A (en) * | 2019-10-15 | 2020-01-03 | 中国科学院合肥物质科学研究院 | An ion molecule reaction tube with a quadrupole funnel structure and its ion focusing method |
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