CN207400722U - Realize big depth of field eye anterior segment analysis system - Google Patents

Abstract

Big depth of field eye anterior segment analysis system is realized the utility model is related to a kind of, the system includes wideband light source, spectral module, galvanometer module, sample arm module, high resolution spectrometer and reference arm, the incident light that wherein wideband light source is sent is divided into two beams after spectral module, it is wherein a branch of through galvanometer module, sample arm module returns after reaching detected eyeball, form the sample arm of acquisition eye information, scanning galvanometer in the galvanometer module per dimension uses off-axis scanning galvanometer, per dimension, off-axis scanning galvanometer rotation axis c deviates the distance that incident light center is t, form off-axis structure, modulation source is introduced all the way in sample arm.The modulation source of the utility model is arranged on sample arm, avoids the problem of modulation source is synchronous with scanning in other schemes, reduces system complexity；Image mosaic is not present in the utility model, avoids the measurement error of depth direction.

Description

Realize big depth of field eye anterior segment analysis system

Technical field

The utility model belongs to ophthalmic medical equipment technical field, refers to a kind of big depth of field anterior ocular segment analysis system of realization System.

Background technology

Eyes are the most important sense organs of human body, and the above are obtained by eyes for the external information that people are received about 80% .In medicine eye dissection concept field, anterior ocular segment includes cornea to lenticular ocular tissue part.In recent years, optical coherence Chromatography (OCT) technology is quickly grown, and with it is quick, non-intruding the advantages that is widely used among medical research.In corneal, consolidate Film, iris, the diagnosis aspect at room angle are with the obvious advantage, while in the diagnosis to glaucoma, cataract and refractive vision problem, Crystal lesion situation is also particularly important.There is conjugation pseudomorphism in traditional OCT image, therefore its imaging depth is only that system is concerned with The half of length.And anterior surface of cornea to crystal distance in 10mm or so, the distance to crystal rear surface also wants bigger, much More than the imaging depth range of frequency domain OCT, therefore tradition OCT can not be suitable for the panoramic imagery of anterior ocular segment.

In order to expand the areas imaging of frequency domain OCT, some research groups have used the frequency swept laser of super-narrow line width to replace Wideband light source, but the axial resolution of its system is generally less than common wide light-source system, and phase stability is bad, very according to Rely in laser performance, involve great expense simultaneously, be unfavorable for being widely popularized under current development level.On the other hand, use Two classes can be substantially divided by comparing the technology of more extended parallel port scopes：More plane of reference splicings and phase modulation technique.

Patent CN102670172 describes a kind of frequency domain OCT image system based on more plane of references.It is provided in the system Two plane of references are respectively placed in before anterior surface of cornea and after crystal rear surface, can obtain two width respectively under such configuration Then the OCT image of artifact-free interference handles splicing through computer and obtains a secondary complete anterior segment image.This kind of device lacks Point is to need the distance between two plane of reference of Accurate Calibration difference, and stated accuracy should be higher than that the axial resolution of system, otherwise can Larger depth survey error is introduced, causes diagnosis risk, accuracy and repeatability can not ensure, be not suitable for commercial scale life Production.

Patent WO2010011656 describes a kind of imaging method based on additional modulation source, which draws in reference arm Enter modulation source, the signal of acquisition, which is analyzed and processed, can remove OCT pseudomorphisms, although and the method can be extended scope It is interior to be imaged simultaneously, but need to synchronize between sample arm and modulation source and match, it is affected by hardware case, added simultaneously System complexity is not easy to adjustment.

The utility model is intended to develop anterior ocular segment a kind of simple in structure, can be imaged cornea to crystal gamut simultaneously Analysis system.

The content of the invention

The purpose of this utility model is to overcome the deficiencies in the prior art, provide a kind of realization big depth of field anterior ocular segment analysis System.

The utility model solves its technical problem and following technical scheme is taken to realize：

A kind of to realize big depth of field eye anterior segment analysis system, which includes wideband light source, spectral module, galvanometer module, sample Product arm module, high resolution spectrometer and reference arm, the incident light that wherein wideband light source is sent are divided into after spectral module The proportional light of two beam energies wherein a branch of return after galvanometer module, sample arm module reach and be detected eyeball, is formed The sample arm of eye information is gathered, the scanning galvanometer in the galvanometer module per dimension is each using off-axis scanning galvanometer The off-axis scanning galvanometer rotation axis c of dimension deviates the distance that incident light center is t, forms off-axis structure, i.e., in one pass of sample arm Enter modulation source, wherein t meets t=N λ/8a, and N is the sampling number in scanning range, and λ is wideband light source centre wavelength, and a is light Beam rotation angle.

Moreover, the spectral resolution of the high resolution spectrometer is more than or equal to 25 micromicrons, corresponding coherence length is big In 14 millimeters.

Moreover, being further fitted with Diopter accommodation sighting target module in above system, the Diopter accommodation sighting target module is led to It crosses dichroscope to be sent into sighting target image in tested eyeball through sample arm module, focuses on different position, induce measured and bend Light adjusting force.

Moreover, being further fitted with pupil monitoring module in above system, pupil monitoring module sends light beam through two It is radiated to Look mirror, sample arm module on tested eyeball, Returning beam carries pupil position information.

The advantages of the utility model and good effect are：

1st, the modulation source of the utility model is arranged on sample arm, avoids in other schemes modulation source and scanning is synchronous asks Topic, reduces system complexity；

2nd, the high resolution spectrometer design spectral resolution of the utility model is more than 25 micromicrons, and correspondence system is concerned with length Degree is more than 14 millimeters, and cooperation modulation and demodulation algorithm can realize that the panorama of cornea to crystal rear surface is imaged simultaneously；

3rd, image mosaic is not present in the utility model, avoids the measurement error of depth direction.

4th, the three-dimensional optical coherent tomographic scan image that the utility model is sent out models for 3D algorithm for reconstructing, with obtaining cornea Shape figure, crystal front and rear surfaces topographic map, anterior ocular segment three-dimensional configuration provide data basis.

5th, the utility model carries out vertical direction scanning imagery to measured's anterior ocular segment, obtains lacrimal river height measurement information, Available for evaluation scheroma degree.

Description of the drawings

Fig. 1 is Tthe utility model system structure diagram；

Fig. 2 is the off-axis scanning galvanometer module diagram of a dimension in Tthe utility model system；

Fig. 3 is that Tthe utility model system modem procedue illustrates schematic diagram.

Specific embodiment

The utility model implementation is further described below in conjunction with attached drawing, following embodiment is descriptive, is not Limited, it is impossible to the scope of protection of the utility model is limited with this.

It is a kind of to realize big depth of field eye anterior segment analysis system, as shown in Figure 1, the system include wideband light source 3, spectral module 5, Galvanometer module 7, sample arm module 6, high resolution spectrometer 4 and reference arm 8, the optical signal that wherein wideband light source is sent pass through It is divided into the proportional light of two beam energies after spectral module, wherein a branch of reached through galvanometer module, sample arm module is detected It is returned after eyeball 9, forms the sample arm of acquisition eye information, the innovative point of the utility model is, as shown in Fig. 2, the galvanometer Scanning galvanometer in module per dimension using off-axis scanning galvanometer, deviate per the off-axis scanning galvanometer rotation axis c of dimension into The distance that light center is t is penetrated, forms off-axis structure, wherein t meets t=N λ/8a, and N is the sampling number in scanning range, and λ is Wideband light source centre wavelength, a are Beam rotation angle, i.e., introduce modulation source all the way in sample arm.

By taking the scanning theory of a dimension as an example, scanning galvanometer is rotated along rotation axis penetrates incident light with different reflection angles Go out, Beam rotation angle is a, and rotation axis is t with offset of the incident light axis on x scanning directions, due to the rotation of scanning galvanometer Gyration is smaller, and according to low-angle arc length formula, the optical path difference b formed due to scanning galvanometer is in different angle can be approximately considered B=at, i.e., in arbitrary scan position, the light path that incident light is passed by sample arm is all different from being passed by adjacent scan position Light path, and incident light light path with scanning galvanometer rotation angle change, in monotonicity.

It can be obtained by the π z/ λ of optical path difference phase formula Φ=4, δ Φ=4 π at/N λ, wherein N are the sampled point in scanning range Number, λ are wideband light source centre wavelength, and therefore, when scanning ray in the x-direction samples sample, off-axis scanning galvanometer exists Adjacent scanning element introduces approximate fixed optical path difference, generates time domain Doppler effect, i.e., adds a modulation frequency in the x-direction Rate.When the phase difference between neighbouring sample point meets δ Φ=pi/2, i.e. t=N λ/8a, the OCT image obtained by demodulating algorithm In pseudomorphism can be inhibited, realize the analysis of big depth of field anterior ocular segment.Scanning for two dimensions, principle is identical, each Realize that respective dimensions scanning adds modulating frequency using off-axis scanning galvanometer structure in a dimension.

As shown in figure 3, optical coherence tomography image be using wave number (* 2 π reciprocal of wavelength) and x scanning directions position as The two-dimensional array of coordinate system.Due to scanning while adding modulation in the x-direction, the frequency distribution of sample tissue translates near 0 Fourier filtering is done to modulating frequency, therefore to x bearing datas, complex field sample information can be obtained, so as to eliminate The pseudomorphism overlap problem caused by real number field does Fourier transformation, filtered data carry out OCT demodulation in complex field, you can To the image of the artifact-free influence in whole coherence lengths, so as to fulfill to anterior ocular segment part from anterior surface of cornea to crystal after table The panorama real time imagery in face.

In the specific implementation of the utility model, in order to match with the big depth of field optical signal that sample arm gathers, the height Resolution spectrometer selects achromatic lens, reduces aberration present in light path of optical spectrometer design, spectrum distortion is reduced, using height Fast linear array CCD camera improves sample frequency, the distortion of modulated signal is reduced, according to optical coherence tomography principle, coherence length L =λ²/ 2 δ λ, high resolution spectrometer design spectral resolution are greater than or equal to 25 micromicrons, and corresponding coherence length is more than 14 millimeters, Structure in the range of corneal front surface to crystal rear surface is imaged simultaneously.

In the specific implementation of the utility model, to observe the anterior ocular segments tissue change situation such as crystal and pupil, above-mentioned It is further fitted with Diopter accommodation sighting target module 2 in system, the Diopter accommodation sighting target module is by dichroscope by sighting target figure As being sent into through sample arm module in tested eyeball, different position is focused on, measured's diopter accommodation is induced, in optical coherence The anterior ocular segments tissue change such as crystal and pupil can be observed in tomographic map.

In the specific implementation of the utility model, wideband light source as system source, incident light through spectral module respectively into Entering sample arm and reference arm, sample arm incident light focuses on measured's eyes prosthomere part by off-axis scanning galvanometer module, after Organizational information is carried to scattering light and phase modulation returns, and returns to optical superposition with reference arm and is formed and interfere, and interference light enters height Resolution spectrometer is sent out through Dispersive Devices with spectral form, to handle spectral form data, is further pacified in above system Equipped with data processing computer 10, the spectral signal that high resolution spectrometer is sent out is converted to three-dimensional light by data processing computer Coherent tomographic scan image is learned, three-dimensional optical coherent tomographic scan image models for 3D algorithm for reconstructing, obtains corneal topography, brilliant Body front and rear surfaces topographic map, anterior ocular segment three-dimensional configuration provide data basis.

In the specific implementation of the utility model, pupil monitoring module 1, pupil prison are further fitted in above system It is connected depending on module with data processing computer, pupil monitoring module sends light beam through dichroscope, sample arm module tested It tries on eyeball, Returning beam carries pupil position information, the pupil position that data processing computer gathers pupil monitoring module Generation system compensation signal is compared with the pupil position information that high resolution spectrometer is sent out for information, and system compensation signal is used In system fine jitter or the correction of offset.

In the specific implementation of the utility model, spectral module can be fiber optic splitter or space Amici prism or thin Film beam splitter etc., any species optical device including that can realize light splitting function, splitting ratio can be any ratio；

Above-described embodiment is only to illustrate the technical concepts and features of the utility model, and its object is to brief this realities of elaboration Implement with new content and according to this, the scope of protection of the utility model can not be limited.All spirit according to the present utility model The equivalent change or modification that essence is done should be covered within the scope of the utility model.

Claims (4)

1. a kind of realize big depth of field eye anterior segment analysis system, which includes wideband light source, spectral module, galvanometer module, sample The incident light that arm module, high resolution spectrometer and reference arm, wherein wideband light source are sent is divided into two after spectral module The proportional light of beam energy, wherein a branch of return after galvanometer module, sample arm module reach and be detected eyeball, composition is adopted Collect the sample arm of eye information, it is characterised in that：Scanning galvanometer in the galvanometer module per dimension is using off-axis scanning Galvanometer, per dimension, off-axis scanning galvanometer rotation axis c deviates the distance that incident light center is t, forms off-axis structure, i.e., in sample Arm introduces modulation source all the way, and wherein t meets t=N λ/8a, and N is the sampling number in scanning range, and λ is cardiac wave in wideband light source Long, a is Beam rotation angle.

2. according to claim 1 realize big depth of field eye anterior segment analysis system, it is characterised in that：The high-resolution spectroscopy The spectral resolution of instrument is more than or equal to 25 micromicrons, and corresponding coherence length is more than 14 millimeters.

3. according to claim 1 realize big depth of field eye anterior segment analysis system, it is characterised in that：Into one in above system Step is equipped with Diopter accommodation sighting target module, and the Diopter accommodation sighting target module is by dichroscope by sighting target image through sample arm mould Block is sent into tested eyeball, focuses on different position, induces measured's diopter accommodation.

4. according to claim 1 realize big depth of field eye anterior segment analysis system, it is characterised in that：Into one in above system Step is equipped with pupil monitoring module, pupil monitoring module send light beam be radiated at through dichroscope, sample arm module it is tested On eyeball, Returning beam carries pupil position information.