CN206621657U - A kind of elastic micropin containing solvable syringe needle - Google Patents
A kind of elastic micropin containing solvable syringe needle Download PDFInfo
- Publication number
- CN206621657U CN206621657U CN201621084406.3U CN201621084406U CN206621657U CN 206621657 U CN206621657 U CN 206621657U CN 201621084406 U CN201621084406 U CN 201621084406U CN 206621657 U CN206621657 U CN 206621657U
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- China
- Prior art keywords
- micropin
- syringe needle
- elastic
- needle
- needle body
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
It the utility model is related to a kind of micropin, more particularly to a kind of elastic micropin containing solvable syringe needle.A kind of elastic micropin empty micropin structure containing solvable syringe needle described in the utility model, micropin include hollow channel.Micropin syringe needle is made up of soluble material, and micropin syringe needle dissolves after penetrating skin, and under the driving of flow stream pressure, medicine enters hypodermis by hollow channel.It is effective avoid empty micropin prepare, transport, storage, using link in the phenomenon of drug leakage occurs.A part for micropin is made of polymeric material, has the characteristics of flexible.In administration process, empty micropin will not produce relative displacement because of doser and skin surface and broken needle phenomenon occurs, and improve the security of empty micropin when in use.
Description
Technical field
It the utility model is related to a kind of micropin, more particularly to a kind of elastic micropin containing solvable syringe needle.
Background technology
Drug therapy is a kind of common medical procedure, and the main mode of movement that medicine enters human body includes injection and mouth
Clothes, both modes all have some limitations.Medicine may be inactivated so as to lose during oral due to self metabolism
Curative effect；Hypodermic injection needs trained personnel to implement, and brings unavoidable pain and infection to sufferer
Risk, made troubles to patient.In recent years, micropin administering mode increasingly attracts the concern of people.
Compared with traditional transdermal drug delivery system, micropin has the advantages of notable：About 10~50 μm of micropin diameter, it is sufficient to pierce
Broken keratoderma, but it does not stimulate the nerve in relatively deep tissue, therefore user is painless during use；Micropin belongs to physics
Rush oozes technology, by carrying out painless pore processing to skin, greatly improves insulin, interferon, ucleosides, polypeptide and albumen
The percutaneous absorbtion amount of vaccine etc.；Micropin can release drug targeting to skin certain depth；Micropin can improve the transdermal penetration of medicine
Speed, the skin hold-up of medicine is reduced, extend medicine effective acting time.
According to the design feature of micropin, solid microneedles and empty micropin can be divided into.
Solid microneedles can be divided into load medicine solid microneedles and not carry the class of medicine solid microneedles two.Carry the drugloading rate of medicine solid microneedles very
It is low, the acutance of needle body can be influenceed after packaging medicine, needle body can be caused smoothly to be pierced into skin.Medicine solid microneedles are not carried to act on
It after skin, can temporarily break the barrier action of keratoderma, establish substantial amounts of skin micro-channel.But after micropin removes,
Along with the recovery of stratum corneum barrier function while skin recovery normal condition, this can prevent medicine from continuing to pass through skin, institute
It is extremely limited not carry the active drug conveying capacity that medicine solid microneedles can realize.
Compared to solid microneedles, empty micropin is considered as a kind of more promising micropin drug delivery structure.Empty micropin is
Medicine is conveyed in the form of microinjection, the hollow channel of a micron level is included inside the needle body of empty micropin, medicine can
To be conveyed by hollow channel.Empty micropin can not only realize the drug delivery of long-time larger dose, and hollow
The acutance of micropin needle body can also be maintained in the level for effectively puncturing keratoderma.
Due to the presence of hollow channel, the physical arrangement of empty micropin and built on the sand.In administration process, load hollow micro-
The phenomenon that relative displacement caused by the doser and skin surface of pin can cause micropin to be broken occurs, and easily causes medical thing
Therefore.
Decoction in hollow channel by the way of side or top end opening, is input to subcutaneous group by empty micropin mostly
Knit.The empty micropin of opening easily prepare, transport, storage, using link in drug leakage occurs, cause drug dose failure and
Environmental pollution, serious meeting cause malpractice.
The content of the invention
The shortcomings that the utility model is in order to overcome above-mentioned technical problem, propose a kind of elastic micropin containing solvable syringe needle.
Micropin uses empty micropin structure, and micropin includes hollow channel.Micropin syringe needle is made up of soluble material, penetrates micropin after skin
Syringe needle dissolves, and medicine enters hypodermis by hollow channel.Effectively empty micropin is avoided preparing, transport, store, making
With the phenomenon that drug leakage occurs in link.A part for micropin is made of polymeric material, has the characteristics of flexible.To
During medicine, empty micropin will not produce relative displacement because of doser and skin surface and broken needle phenomenon occurs, and improve empty
The security of heart micropin when in use.
A kind of elastic micropin containing solvable syringe needle described in the utility model includes：One internally contains fluid passage
Pipeline；And solid, soluble, positioned at pipeline top a syringe needle.The above-mentioned pipeline comprising inner passage with
It is referred to as " needle body " down, above-mentioned solid, soluble, positioned at pipeline top syringe needle is referred to as " syringe needle ".
Further, above-mentioned needle body includes：Using made of hard material, being connected with syringe needle and in the micropin of lateral opening
Rigid element, and it hereinafter is referred to as " needle body rigid element "；Using the micropin elasticity made of flexible polymer, being connected with substrate
Part, and it hereinafter is referred to as " needle body elastic part ".The hollow channel of empty micropin runs through micropin needle body rigid element and micropin
Needle body flexible portion.Needle body elastic part can prevent micropin when relative displacement occurs with skin for the administration device for loading micropin
Phenomenon of rupture.
Preferably, micropin syringe needle described in the utility model is made up of maltose.
Preferably, micropin needle body rigid element described in the utility model is born photoresist by the SU-8 of hard and is made.
Preferably, the affiliated micropin needle body elastic part of the utility model is by dimethyl silicone polymer（PDMS）It is made.
To achieve these goals, the utility model uses following technical scheme：
1. micropin syringe needle is the solid syringe needle made of maltose, hardness is high, it is sufficient to punctures skin.After puncturing skin, profit
With the hydrolysis of maltose-glucolase in skin, maltose is set to dissolve in vivo so as to remove；
2. contain the hollow channel for being available for medicine to circulate inside micropin needle body.Micropin syringe needle dissolves after puncturing skin, medicine
Hypodermis is flowed into via the hollow channel inside empty micropin, hollow channel has run through micropin needle body rigid element and micropin pin
Body elasticity part；
3. micropin needle body rigid element is made up of negative photoresist, hardness is high, it is not easy to fractures.Micropin needle body rigid element top
End is connected with micropin needle point, and the bottom of micropin needle body rigid element is connected with the top of needle body elastic part；
4. micropin needle body elastic part is made up of the polymer poly dimethyl siloxane of flexibility, possessing can reversible and repetition change
Characteristic of the shape without permanent damage occurs.The top of micropin needle body elastic part and the bottom phase of micropin needle body rigid element
Even, the bottom of micropin needle body elastic part is connected with micropin substrate.
A kind of elastic micropin based on polymer described in the utility model has following benefit：
1. micropin syringe needle described in the utility model is solid, solvable syringe needle, hardness is high, it is sufficient to punctures skin, pin
Area of bed can greatly reduce when puncturing skin much smaller than the stainless steel syringe needle used in common syringe and even completely avoid pain
Sense.After punctures skin, it is dissolved in skin so that decoction can flow into internal from hollow channel；
It is available for 2. containing inside a kind of elastic micropin containing solvable syringe needle described in the utility model in medicine circulation
Empty passage, oxidation of drug or pollution caused by contact of the medicine with outside air in delivery process can be effectively prevent；
3. micropin rigid element hardness described in the utility model is high, it is not easy to fractures, avoids needle body rigid element and exist
Fracture caused risk during being pierced into skin；
4. micropin flexible portion described in the utility model is made of flexible polymer, possessing can reversible and repeated deformation
Characteristic without permanent damage occurs, micropin needle body elastic part can integrally bear the bending scope at positive and negative 10 degree of angles, effectively
Avoid and load administration device and the skin of micropin caused micropin phenomenon of rupture during relative displacement occurs.
Brief description of the drawings
Fig. 1 is a kind of side view of the elastic micropin containing solvable syringe needle.
Fig. 2 is a kind of sectional view of the elastic micropin containing solvable syringe needle.
Embodiment
The utility model is achieved through the following technical solutions：
A kind of elastic micropin containing solvable syringe needle described in the utility model, as illustrated in fig. 1 and 2, including micropin syringe needle
1, micropin needle body rigid element 2, micropin needle body flexible portion 3, micropin substrate 4, micropin hollow channel 5.
The micropin syringe needle 1 is solid syringe needle, is made up of maltose, and the angle of needle point is 30~40 degree, and needle height is
70~180 microns.
The micropin needle body includes micropin needle body rigid element and micropin needle body elastic part, and micropin needle level is 140
~360 microns, basal diameter is 50-200 microns.
The micropin needle body rigid element 2 is born photoresist by SU-8 and is made, and top is connected with micropin syringe needle 1, bottom with
Micropin needle body elastic part 3 is connected.The outer wall of needle body rigid element 2 is highly 70~180 microns, and inside wall height is 100~210
Micron, the inwall of needle body rigid element 2 are higher than outer wall 30 microns.
The micropin needle body elastic part 3 is made up of dimethyl silicone polymer, and top is connected with micropin needle body rigid element 2
Connect, bottom is connected with micropin substrate 4.The outer wall of needle body elastic part 3 is highly 70~180 microns, and inside wall height is 30~170
Micron, the outer wall of needle body elastic part 3 and inwall are high 30 microns.
The micropin substrate 4 is made up of dimethyl silicone polymer, includes the microfluidic channel of conveying medicine.
The micropin hollow channel 5 is included in micropin needle body, through micropin needle body rigid element and micropin needle body
Flexible portion.
Embodiment of the present utility model is elaborated above.But the utility model is not limited to above-mentioned implementation
Mode, in art those of ordinary skill's possessed knowledge, the utility model ancestor can also not departed from
Made a variety of changes on the premise of purport.
Claims (9)
1. a kind of elastic micropin containing solvable syringe needle, including needle body, syringe needle, hollow channel, it is characterised in that：The syringe needle by
Maltose is made.
A kind of 2. elastic micropin containing solvable syringe needle according to claim 1, it is characterised in that：The needle point of the syringe needle
Angle is 30~40 degree, and needle height is 70~180 microns.
A kind of 3. elastic micropin containing solvable syringe needle according to claim 1, it is characterised in that：The needle level is
140~360 microns, basal diameter is 50-200 microns.
A kind of 4. elastic micropin containing solvable syringe needle according to claim 1, it is characterised in that：The needle body includes pin
Body rigid element and needle body elastic part.
A kind of 5. elastic micropin containing solvable syringe needle according to claim 4, it is characterised in that：The needle body rigid portion
Point bearing photoresist by SU-8 is made.
A kind of 6. elastic micropin containing solvable syringe needle according to claim 4, it is characterised in that：The needle body elastic portion
Divide and be made up of dimethyl silicone polymer, can bear to bend.
A kind of 7. elastic micropin containing solvable syringe needle according to claim 4, it is characterised in that：The needle body rigid portion
It is connected at the top of point with syringe needle, bottom is connected with the needle body elastic part.
A kind of 8. elastic micropin containing solvable syringe needle according to claim 4, it is characterised in that：The needle body elastic portion
It is connected at the top of point with needle body rigid element.
A kind of 9. elastic micropin containing solvable syringe needle according to claim 1, it is characterised in that：In the hollow channel
It is contained in inside needle body, has run through above-mentioned micropin needle body rigid element and above-mentioned micropin needle body elastic part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621084406.3U CN206621657U (en) | 2016-09-28 | 2016-09-28 | A kind of elastic micropin containing solvable syringe needle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621084406.3U CN206621657U (en) | 2016-09-28 | 2016-09-28 | A kind of elastic micropin containing solvable syringe needle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206621657U true CN206621657U (en) | 2017-11-10 |
Family
ID=60212874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621084406.3U Expired - Fee Related CN206621657U (en) | 2016-09-28 | 2016-09-28 | A kind of elastic micropin containing solvable syringe needle |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206621657U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114849054A (en) * | 2022-06-16 | 2022-08-05 | 山东大学 | A kind of soluble needle point hollow injection microneedle patch and method |
| CN115887902A (en) * | 2022-12-15 | 2023-04-04 | 武汉大学 | A drug delivery device imitating scorpion stinger and its application method |
| WO2025036331A1 (en) * | 2023-08-14 | 2025-02-20 | 重庆金赛星医疗科技有限公司 | Soluble hollow microneedle, microneedle array chip and transdermal drug delivery patch |
-
2016
- 2016-09-28 CN CN201621084406.3U patent/CN206621657U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114849054A (en) * | 2022-06-16 | 2022-08-05 | 山东大学 | A kind of soluble needle point hollow injection microneedle patch and method |
| CN115887902A (en) * | 2022-12-15 | 2023-04-04 | 武汉大学 | A drug delivery device imitating scorpion stinger and its application method |
| WO2025036331A1 (en) * | 2023-08-14 | 2025-02-20 | 重庆金赛星医疗科技有限公司 | Soluble hollow microneedle, microneedle array chip and transdermal drug delivery patch |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171110 Termination date: 20210928 |