CN205268831U - Photoelectricity utmost point of implanted nerve stimulation and record - Google Patents

Abstract

The utility model discloses an implantable photoelectrode for nerve stimulation and recording, which comprises: a supporting part, which includes an insertion end, and the insertion end is provided with a recording contact for generating electrical stimulation and recording nerve signals generated by the electrical stimulation; And, the light-emitting component, which is located at the insertion end, is used to generate light stimulation; wherein, the recording contact is also used to record the nerve signal generated by the light stimulation. In the utility model, a recording contact for generating electrical stimulation and recording the nerve signal generated by the electrical stimulation, a light-emitting component for generating light stimulation, and a recording contact for recording the nerve signal generated by the light stimulation are arranged at the insertion end of the photoelectrode. In this way, a photoelectrode with optical/electrical stimulation and multiple recording contacts is formed, and the recording of optical/electrical stimulation and optical/electrical stimulation nerve signals is completed through one photoelectrode, which simplifies equipment, saves materials, and is applicable to multiple parts. Potentiometric measurement, widely used.

Description

Implantable photoelectrodes for neurostimulation and recording

technical field

The utility model relates to the technical field of biomedical engineering, more specifically, the utility model relates to an implanted photoelectrode for nerve stimulation and recording.

Background technique

Optogenetics, also known as light-stimulated genetic engineering, is a method of controlling cell behavior by using optical technology and genetic technology. Optogenetics technology overcomes many shortcomings of the traditional method of only using electrical stimulation to control the activities of cells or organisms, and provides a transformative research method for neuroscience. This technical method controls the emission or inhibition of cells expressing light-sensitive protein through light stimulation of a specific wavelength. At present, the most popular research method of optogenetics is that a laser or LED (Light Emitting Diode, Light Emitting Diode) light source emits light of a certain wavelength, which is transmitted to the brain of an experimental animal, usually a mouse or a rat, through an optical fiber. Optogenetic technology is used as a tool to excite neurons in animals. At the same time, it needs to cooperate with other instruments and electrodes to observe and record neuron discharge, behavioral changes and physiological changes in animals.

At present, most of the similar neuromodulation strategies are electrical stimulation through metal wires, optical stimulation through optical fibers with lasers as light sources, or direct output through LED light-emitting coupling optical fibers. Among them, the electrical stimulation technology is relatively mature and has been successfully applied in the treatment of central nervous system diseases such as Parkinson's. The electrical stimulation electrodes are generally implemented with metal foil wires as electrodes; optical stimulation can stimulate specific neurons more accurately. In the future, it may become a more effective treatment method than electrical stimulation. However, optical fiber-based stimulation has the disadvantages of limited luminous area, light source is limited by the type of external laser generator, and expensive. It cannot achieve multi-point stimulation of neural circuits and Nucleus stimulation and other application requirements; at the same time, although there are a few light-emitting diode-based optodes, their manufacturing process is relatively complicated and the price is high; in addition, light stimulation does not have the functions of electrical stimulation and nerve signal recording. If you need to record stimulation The generated nerve signals must be configured with other recording electrodes and hardware systems, and the electrode products are very expensive.

Utility model content

Aiming at the deficiencies in the above-mentioned technologies, the utility model provides an implantable photoelectrode for nerve stimulation and recording, by setting a recording trigger for generating electrical stimulation and recording the nerve signals generated by the electrical stimulation at the insertion end of the photoelectrode. Points, light-emitting components and recording contacts that generate light stimulation are also used to record nerve signals generated by light stimulation, thereby forming a photoelectrode that integrates light/electric stimulation and has multiple recording contacts. The recording of neural signals of /electrical stimulation and light/electrical stimulation simplifies equipment, saves materials, is suitable for multi-site potential measurement, and has a wide range of applications.

In order to achieve these purposes and other advantages according to the utility model, the utility model is realized through the following technical solutions:

The photoelectrode for implantable nerve stimulation and recording described in the utility model includes:

a support member comprising an insertion end provided with recording contacts for generating electrical stimulation and recording neural signals generated by said electrical stimulation; and,

a light-emitting component located at the insertion end for generating light stimulation;

a cover film covering a surface on the insertion end other than the recording contacts;

Wherein, the recording contacts are also used to record the nerve signals generated by the light stimulation; the covering film layer is a parylene film.

Preferably, the insertion side of the insertion end is trapezoidal along the insertion direction.

Preferably, the support component includes an upper substrate layer, a lower substrate layer, and a shielding layer connected between the upper substrate layer and the lower substrate layer; the support component also includes a connection end connected to an external connector;

Wherein, the upper substrate layer includes a signal collection line for collecting neural signals, the recording contact, and a first pad and a second pad respectively located at the connection end; the lower substrate layer includes a power line; the recording The contact is connected to the first pad through the signal collection line, and the light emitting component is connected to the second pad through the power line.

Preferably, the connection end is provided with a first through hole, and the insertion end is provided with a second through hole; the second pad is connected to one end of the power line through the first through hole, and the power supply The other end of the wire is connected to the light emitting component through the second through hole.

Preferably, the insertion side of the insertion end is trapezoidal along the insertion direction.

Preferably, at least one of the recording contacts and at least one of the light-emitting components are arranged sequentially on the insertion side of the insertion end along the insertion direction; wherein at least one of the recording contacts is arranged on the insertion side perpendicular to the insertion direction. The insertion side of the insertion end; at least one of the light-emitting components is arranged sequentially on the insertion side of the insertion end along the insertion direction.

Preferably, one of the recording contacts and one of the light-emitting components are sequentially arranged on the insertion side of the insertion end along the insertion direction; wherein, one of the recording contacts generates electrical stimulation, and records the nerve signal generated by the electrical stimulation And record a neural signal generated by light stimulation of the light-emitting component.

Preferably, several of the recording contacts and at least one of the light-emitting components are sequentially arranged on the insertion side of the insertion end along the insertion direction; wherein, several of the recording contacts generate electrical stimulation, and the recording of the electrical stimulation generates neural signals and record the neural signals generated by light stimulation of at least one light-emitting component.

Preferably, several of the recording contacts and at least one of the light-emitting components are sequentially arranged on the insertion side of the insertion end along the insertion direction; wherein, several of the recording contacts include generating electrical stimulation and recording the electrical stimulation A first recording contact for neural signals generated and a second recording contact for recording at least one neural signal generated by said light stimulation.

The utility model at least includes the following beneficial effects:

1) By setting the recording contacts for generating electrical stimulation and recording the neural signals generated by the electrical stimulation at the insertion end of the photoelectrode and the light-emitting components for generating optical stimulation, the recording contacts are also used to record the neural signals generated by optical stimulation, thereby A photoelectrode that forms photo/electric stimulation and has multiple recording contacts in one, completes the recording of photo/electric stimulation and photo/electric stimulation nerve signals respectively through one photoelectrode, simplifies equipment and saves materials;

2) The surface of the insertion end of the photoelectrode except for the recording contact is covered with a covering film layer, which is a parylene film, which eliminates the contact between the recording contact and the insertion end. Unsafe effects brought about by high charge leakage current, improving the safety of photoelectrodes;

3) The insertion side of the insertion end has a trapezoidal shape along the insertion direction, and the trapezoidal shape of the insertion side is equivalent to a triangle without the tip, similar to an arc design, which reduces the damage to the nerve tissue when the insertion end is inserted;

4) The recording contacts and light-emitting components are arranged at the insertion end in sequence along the insertion direction; at least one recording contact is arranged at the insertion end perpendicular to the insertion direction, which can provide at least one electrical stimulation or at least one neural signal generated by recording light stimulation ; At least one light-emitting component is arranged sequentially at the insertion end along the insertion direction, and can provide light stimulation of at least one or at least one wavelength.

Other advantages, objectives and features of the utility model will partly be embodied through the following description, and partly will be understood by those skilled in the art through the research and practice of the utility model.

Description of drawings

Fig. 1 is the structural representation of the photoelectrode of implantable nerve stimulation and recording described in the utility model;

Fig. 2 is the top view of the photoelectrode of implantable nerve stimulation and recording described in the utility model;

Fig. 3 is a right view of the photoelectrode for implantable nerve stimulation and recording according to the utility model.

In the picture:

10-support component; 11-insert end; 111-record contact; 11A-insert side; 12-connection end; 13-signal acquisition line; 14-first pad; 15-second pad; 16-power line ; 17-the first through hole; 18-the second through hole;

20 - Lighting component.

detailed description

The utility model will be described in further detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it by referring to the description.

It should be understood that terms such as "having", "comprising" and "including" used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

The neuromodulation function can be manifested in two ways. One can generate electrical pulse stimulation with adjustable parameters through electrode contacts, and the other can perform light stimulation on specific neural tissues expressing light-sensitive proteins through micro-optic electrodes of specific wavelengths. As shown in Fig. 1, Fig. 2 and Fig. 3, the utility model provides a photoelectrode for implantable nerve stimulation and recording, including: a supporting part 10, which includes an insertion end 11, and the insertion end 11 is provided with a device for generating electrical stimulation and recording The recording contact 111 of the nerve signal generated by electrical stimulation; the light emitting part 20, which is located at the insertion end 11, for generating light stimulation; and the covering film layer, which covers the surface of the insertion end 11 except the recording contact 111; Wherein, the recording contacts 111 are also used for recording nerve signals generated by light stimulation; the covering film layer is a parylene film.

The photoelectrode for implantable nerve stimulation and recording provided by the utility model is provided with a recording contact 111 for generating electrical stimulation and recording nerve signals generated by electrical stimulation and a light-emitting component 20 for generating optical stimulation at the insertion end 11 of the photoelectrode. The recording contact 111 also records the nerve signal generated by light stimulation, thereby forming a light/electric stimulation and a photoelectrode with a recording contact integrated, that is, the light/electric stimulation and the light/electric stimulation nerve signal are respectively completed through one photoelectrode It not only has the precise stimulation of specific neurons stimulated by light, but also records the nerve signals of light stimulation in time through the recording contacts 111 that generate electrical stimulation, simplifies equipment, saves materials, and improves the measurement accuracy and convenience of photoelectrodes.

Wherein, the recording contact 111 not only generates electrical stimulation and records the nerve signal generated by the electrical stimulation, but also records the nerve signal generated by the light stimulation, so as to improve the utilization rate of the recording contact 111 . The light source of the light-emitting component 20 can be a laser generator that emits light waves to optically stimulate nerve tissue. In this embodiment, considering the size and application of the photoelectrode for implantable nerve stimulation and recording, it is preferable to generate light of a specific wavelength, Furthermore, the miniature light-emitting diodes that control the expression of light-sensitive proteins have a small active area and a large scattered light-emitting area, which can be applied to the potential measurement of multiple parts of the animal body, and expand the application range of photoelectrodes for implantable nerve stimulation and recording. The photoelectrode for implantable nerve stimulation and recording is a flexible photoelectrode, which is suitable for both epidermis and deep tissue. The photoelectrode can be placed freely in the nerve tissue, which improves the flexibility of the photoelectrode and expands its potential. The application range of the photoelectrode is widened. The cover film layer eliminates the unsafe influence caused by the high charge leakage current passing through the recording contact 111 around the contact between the recording contact 111 and the insertion end 11, and improves the safety of the photoelectrode. Parylene film has good insulation and anti-leakage, and at the same time, it will not produce mutual exclusion reaction with the inside of the organism, and has biocompatibility.

As another embodiment of the present utility model, the support member 10 includes an upper substrate layer, a lower substrate layer, and a shielding layer connected between the upper substrate layer and the lower substrate layer; the support member 10 also includes a connection end connected to an external connector 12; wherein, the upper substrate layer includes a signal acquisition line 13 for collecting nerve signals, a recording contact 111, and the first pad 14 and the second pad 15 respectively located at the connection end 12; the lower substrate layer includes a power line 16; the recording contact The point 111 is connected to the first pad 14 through the signal collection line 13 , and the light emitting component 20 is connected to the second pad 15 through the power line 16 . The first pad 14, the second pad 15, the signal collection line 13, and the power line 16 are all gold-plated copper materials, the shielding layer adopts copper foil, and the hole walls of the first through hole 17 and the second through hole 18 are plated with a Layer copper, so as to realize the electrical connection between the recording contact 111 and the first pad 14 between the upper substrate layer, the lower substrate layer and the shielding layer of the support component 10, and the electrical connection between the light emitting component 20 and the second pad 15. The shielding layer provided between the upper substrate layer and the lower substrate layer of the support component 10 reduces the interference of the power line 16 driving the light-emitting component 20 on the signal collection line 13 .

As another embodiment of the present invention, the connection end 12 is provided with a first through hole 17, and the insertion end 11 is provided with a second through hole 18; the second pad 15 is connected to one end of the power line 16 through the first through hole 17 , the other end of the power line 16 is connected to the light emitting component 20 through the second through hole 18 . The first through hole 17 and the second through hole 18 provide convenient wiring for the light-emitting component 20 of the power-driven photoelectrode, and promote the reasonable wiring of the signal collection line 13 and the power line 16 . Wherein, the power line 16 is welded to the second pad 15 of the connecting end 12 through the first through hole 17; the light-emitting component 20 is welded to the inserting end 11 through the second through hole 18; Connected by welding.

As another embodiment of the present invention, the insertion side 11A of the insertion end 11 is trapezoidal along the insertion direction. Usually, the insertion side of the photoelectrode insertion end 11 adopts a triangular shape with a sharp point to improve the convenience of the photoelectrode insertion into the living body. The width of the insertion side 11A is 500um, and the thickness of the insertion side 11A and the light-emitting part 20 is 300um. The insertion side 11A of the insertion end 11 is in the shape of a trapezoid along the insertion direction. 1. In the case of not affecting the work of the light-emitting component 20 and the recording contact, the damage to the nerve tissue caused by the insertion of the photoelectrode is reduced.

As another embodiment of the present utility model, at least one recording contact 111 and at least one light-emitting component 20 are arranged sequentially on the insertion side 11A of the insertion end 11 along the insertion direction, so as to facilitate recording contacts 111, light-emitting components 20, and signal acquisition lines. 13 and the power line 16 are rationally laid out while reducing the size of the insertion end of the photoelectrode to provide convenience for the insertion of the photoelectrode. In order to further improve the rationality of the layout and the convenience of insertion, it is preferred in this embodiment that at least one recording contact 111 is arranged in sequence on the insertion side 11A of the insertion end 11 along the direction perpendicular to the insertion direction: as shown in Figure 2, three recording contacts 111 The contacts 111 are sequentially arranged on the insertion side 11A of the insertion end 11 along the direction perpendicular to the insertion direction; at least one light-emitting component 20 is sequentially arranged on the insertion side 11A of the insertion end 11 along the insertion direction.

As another embodiment of the present utility model, a recording contact 111 and a light-emitting component 20 are sequentially arranged on the insertion side 11A of the insertion end 11 along the insertion direction; neural signals and record the neural signals generated by a light-stimulating component 20 . This embodiment is a one-to-one mode in which one recording contact 111 corresponds to one light-emitting component 20, which satisfies photoelectrode electrical stimulation/photostimulation recording, and at the same time saves materials to the greatest extent, has a high degree of integration, and improves the convenience of photoelectrode use sex.

As another embodiment of the present utility model, several recording contacts 111 and at least one light-emitting component 20 are arranged sequentially on the insertion side 11A of the insertion end 11 along the insertion direction; wherein, several recording contacts 111 generate electrical stimulation, record The neural signals generated by electrical stimulation and the neural signals generated by optical stimulation of at least one light-emitting component 20 are recorded. This embodiment is a many-to-one mode in which several recording contacts 111 correspond to one light-emitting component 20 or a many-to-many mode in which several recording contacts 111 correspond to several light-emitting components 20: in the many-to-one mode of this embodiment, Several recording contacts 111 record the nerve signals generated by the light stimulation of the same light-emitting component 20, specifically, several recording contacts 111 record the nerve signals generated by the light-stimulation of one light-emitting component 20 from different channels, so that the photoelectrode has multiple Differential recording of channel nerve electrical signals and dual-mode neuromodulation function of electrical stimulation and light stimulation, multi-channel recording also improves the accuracy of nerve signal acquisition generated by light stimulation; in the many-to-many mode of this embodiment, the specific It means that when several recording contacts 111 respectively send out electrical stimulation and record the nerve signals generated by electrical stimulation, they also record the nerve signals generated by light stimulation of several light-emitting components 20, in order to record the nerve signals generated by light stimulation of a variety of different wavelengths. Provides a way to further improve the accuracy of photostimulation recordings.

As another embodiment of the present utility model, several recording contacts 111 and at least one light-emitting component 20 are sequentially arranged on the insertion side 11A of the insertion end 11 along the insertion direction; A first recording contact for recording neural signals generated by electrical stimulation and a second recording contact for recording at least one neural signal generated by optical stimulation. Dividing the first recording contact only for generating electrical stimulation and recording the neural signal generated by electrical stimulation from the second recording contact only for recording at least one neural signal generated by optical stimulation improves the optical stimulation/electrical Accuracy of stimulus recording.

Although the embodiments of the present invention have been disclosed above, they are not limited to the applications listed in the specification and implementation. It can be applied to various fields suitable for the utility model. Additional modifications can be readily effected by those skilled in the art. Therefore, the invention should not be limited to the specific details and examples shown and described herein, without departing from the general concept defined by the claims and their equivalents.

Claims (8)

1. an implantable nerve stimulates and the optoelectronic pole of record, it is characterised in that, comprising:

Support component, it comprises insertion end, and described insertion end is provided with the record contact producing electricity irritation and recording the nerve signal that described electricity irritation produces;

Luminous component, it is positioned at described insertion end, for generation of light stimulus; And,

Cover rete, its surface covered in described insertion end except described record contact;

Wherein, described record contact is also for recording the nerve signal that described light stimulus produces; Described covering rete is parylene film.

2. implantable nerve as claimed in claim 1 stimulates and the optoelectronic pole of record, it is characterised in that, the screen layer that described support component comprises upper substrate layer, lower substrate layer and is connected between described upper substrate layer and described lower substrate layer; Described support component also comprises the coupling end connecting external device;

Wherein, described upper substrate layer comprises the signals collecting line gathering nerve signal, described record contact and lays respectively at the first pad and the 2nd pad of described coupling end; Described lower substrate layer comprises supply lead; Described record contact is connected to described first pad by described signals collecting line, and described luminous component is connected to described 2nd pad by described supply lead.

3. implantable nerve as claimed in claim 2 stimulates and the optoelectronic pole of record, it is characterised in that,

Described coupling end is provided with the first through hole, and described insertion end is provided with the 2nd through hole; Described 2nd pad is connected to described supply lead one end by described first through hole, and the described supply lead the other end is connected to described luminous component by described 2nd through hole.

4. implantable nerve as claimed in claim 1 stimulates and the optoelectronic pole of record, it is characterised in that, the inserting side of described insertion end is trapezoidal shape along direction of insertion.

5. implantable nerve as claimed in claim 4 stimulates and the optoelectronic pole of record, it is characterised in that, record contact described at least one and luminous component described at least one is sequentially arranged in the inserting side of described insertion end along direction of insertion;

Wherein, contact is recorded described at least one along being perpendicular to the inserting side that direction of insertion is sequentially arranged in described insertion end; Luminous component described at least one is sequentially arranged in the inserting side of described insertion end along direction of insertion.

6. implantable nerve as claimed in claim 5 stimulates and the optoelectronic pole of record, it is characterised in that, a described record contact and described luminous component are sequentially arranged in the inserting side of described insertion end along direction of insertion;

Wherein, the nerve signal that described record contact produces electricity irritation, the nerve signal that records described electricity irritation and produce and record described luminous component light stimulus produce.

7. implantable nerve as claimed in claim 5 stimulates and the optoelectronic pole of record, it is characterised in that,

Some described record contacts and luminous component described at least one are sequentially arranged in the inserting side of described insertion end along direction of insertion;

Wherein, some described record contacts produce electricity irritation, the nerve signal that records described electricity irritation and produce and record the nerve signal that luminous component light stimulus described at least one produces.

8. implantable nerve as claimed in claim 5 stimulates and the optoelectronic pole of record, it is characterised in that,

Some described record contacts and luminous component described at least one are sequentially arranged in the inserting side of described insertion end along direction of insertion;

Wherein, some described record contacts comprise only for generation of electricity irritation with record the first record contact of the nerve signal that described electricity irritation produces and only record contact for recording the 2nd of the nerve signal that light stimulus described at least one produces the.