CN204500713U - Can the fluorescent optical fiber sensor of dissolved oxygen in Real-Time Monitoring blood - Google Patents
Can the fluorescent optical fiber sensor of dissolved oxygen in Real-Time Monitoring blood Download PDFInfo
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- CN204500713U CN204500713U CN201520128260.7U CN201520128260U CN204500713U CN 204500713 U CN204500713 U CN 204500713U CN 201520128260 U CN201520128260 U CN 201520128260U CN 204500713 U CN204500713 U CN 204500713U
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 42
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 42
- 239000001301 oxygen Substances 0.000 title claims abstract description 42
- 239000013307 optical fiber Substances 0.000 title claims abstract description 41
- 238000012544 monitoring process Methods 0.000 title claims abstract description 28
- 239000008280 blood Substances 0.000 title claims abstract description 21
- 210000004369 blood Anatomy 0.000 title claims abstract description 21
- 238000006243 chemical reaction Methods 0.000 claims abstract description 31
- 238000012545 processing Methods 0.000 claims abstract description 23
- 230000010363 phase shift Effects 0.000 claims abstract description 18
- 239000000523 sample Substances 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 11
- 230000005284 excitation Effects 0.000 claims abstract description 10
- 230000003287 optical effect Effects 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 230000005693 optoelectronics Effects 0.000 claims abstract description 7
- 239000012528 membrane Substances 0.000 claims description 8
- 239000000017 hydrogel Substances 0.000 claims description 7
- 229920002635 polyurethane Polymers 0.000 claims description 7
- 239000004814 polyurethane Substances 0.000 claims description 7
- 150000004767 nitrides Chemical class 0.000 claims description 5
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 238000000862 absorption spectrum Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000000695 excitation spectrum Methods 0.000 description 2
- PARWUHTVGZSQPD-UHFFFAOYSA-N phenylsilane Chemical compound [SiH3]C1=CC=CC=C1 PARWUHTVGZSQPD-UHFFFAOYSA-N 0.000 description 2
- 208000028399 Critical Illness Diseases 0.000 description 1
- 108010064719 Oxyhemoglobins Proteins 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000013100 final test Methods 0.000 description 1
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- -1 polyethylene terephthalate Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
Landscapes
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
Can the fluorescent optical fiber sensor of dissolved oxygen in Real-Time Monitoring blood, comprise fibre-optical probe, Y-shaped optical fiber, optic electric interface module, digital signal processing module, computer, D/A converter module, the first low pass filter, the second low pass filter, analog-to-digital conversion module.The sine wave signal that digital signal processing module produces is by inputting optic electric interface CMOS macro cell exciting light after D/A converter module, the first low pass filter process, exciting light access Y-shaped optical fiber makes fibre-optical probe produce fluorescence, exciting light and fluorescence input optic electric interface module are by optical excitation signal filtering, fluorescence through after opto-electronic conversion by the second low pass filter, analog-to-digital conversion module after convert digital signal to, obtain the lagging phase shift of fluorescence signal through digital signal processing module process, computer realizes calculating and the display of dissolved oxygen dividing potential drop according to lagging phase shift.This utility model has selectivity and good reliability, highly sensitive feature, can dissolved oxygen dividing potential drop in monitoring of blood real-time and accurately.
Description
Technical field
This utility model relate to a kind of can the fluorescent optical fiber sensor of dissolved oxygen in Real-Time Monitoring blood.
Background technology
Being determined in all kinds of scientific research and practical application of dissolved oxygen dividing potential drop is very important.In medical diagnosis; in blood, partial pressure of oxygen is the important monitoring index of evaluating patient; particularly in the diagnosis of some patients that are critically ill, great operation in the monitoring of patient and the monitoring of premature newborn baby, the concentration can monitoring its blood oxygen timely and effectively is continuously vital.
Having the continuous non-invasive oxygen saturation monitor technology that two kinds relatively ripe at present in the world, is transcutaneous oxygen pressure (TcPO2) monitoring and detecting sphygmus and blood oxygen saturation monitoring respectively.TcPO2 monitoring is by skin heating, increases the permeability of skin, then monitors disperse oxygen out in skin with Clark oxygen electrode; Pulse blood oxygen monitoring then carrys out the blood oxygen saturation of the interior tremulous pulse composition of monitoring peripheral tissue based on the diversity of the near-infrared absorption spectrum of HbO2 Oxyhemoglobin and reduced hemoglobin.Although these two kinds monitoring methods are simple, cost is lower, can realize the Real-Time Monitoring of oxygen concentration, and the accuracy of its monitoring is not high, and is merely able to indirectly oxygen content be detected.Outside this, this two classes sensor is also subject to the impact of factors, as patient's cacosphyxia, shock, content of hemoglobin exception etc., makes final testing result accurate not.
Summary of the invention
The purpose of this utility model is for the deficiencies in the prior art, there is provided a kind of can the fluorescent optical fiber sensor of dissolved oxygen in Real-Time Monitoring blood, oxygen is experienced film and is coated in fiber tip by it, bio-compatible sex modification is done on surface, gained fluorescent optical fiber sensor has that reaction is fast, selectivity and good reliability, highly sensitive feature, can dissolved oxygen dividing potential drop in monitoring of blood real-time and accurately.
A kind of can the fluorescent optical fiber sensor of dissolved oxygen in Real-Time Monitoring blood, comprise fibre-optical probe, Y-shaped optical fiber, optic electric interface module, it is characterized in that: also comprise digital signal processing module, computer, D/A converter module, first low pass filter, second low pass filter, analog-to-digital conversion module, fibre-optical probe plates sensitive membrane after organic covering removed by optical fiber to be formed, fibre-optical probe is connected with the tail end of Y-shaped optical fiber, digital signal processing module is for generation of sine wave signal, described sine wave signal passes through D/A converter module, optic electric interface CMOS macro cell exciting light is inputted after first low pass filter process, a head end of exciting light access Y-shaped optical fiber makes fibre-optical probe produce with frequency but has the fluorescence of certain phase shift, exciting light and fluorescence input optic electric interface module by optical excitation signal filtering along Y-shaped optical fiber, fluorescence passes through the second low pass filter after optic electric interface module opto-electronic conversion, digital signal is converted to after analog-to-digital conversion module, then be input in digital signal processing module and carry out processing the lagging phase shift obtaining fluorescence signal, computer realizes calculating and the display of dissolved oxygen dividing potential drop according to the lagging phase shift of fluorescence signal.
Further, optic electric interface module comprises the first bandpass filter, electro-optical conversion circuit, the second bandpass filter and photoelectric switching circuit, described sine wave signal generates exciting light by inputting electro-optical conversion circuit after D/A converter module and the first low pass filter process, exciting light is by connecing a head end of Y-shaped optical fiber after the first bandpass filter, exciting light and fluorescence input the second bandpass filter with by optical excitation signal filtering along Y-shaped optical fiber, and fluorescence inputs the second low pass filter after photoelectric switching circuit opto-electronic conversion.
Further, described sensitive membrane is followed successively by poly nitride layer, indicator layer and polyurethane hydrogel layer from bottom to up.
Further, digital signal processing module comprises DDS waveform generator and vector orthogonal digital lock-in amplifier, the signal output part of DDS waveform generator is connected with the signal input part of D/A converter module and DDS waveform generator, the signal output part of analog-to-digital conversion module is connected with the signal input part of vector orthogonal digital lock-in amplifier, the signal output part of vector orthogonal digital lock-in amplifier is connected with computer, the signal output part of D/A converter module is connected with the signal input part of the first low pass filter, the signal output part of the second low pass filter is connected with the signal input part of analog-to-digital conversion module.
This utility model can dissolved oxygen dividing potential drop in Real-Time Monitoring blood, have that reaction is fast, selectivity and good reliability, highly sensitive, low cost, the feature such as portable, wherein optic electric interface part can realize miniaturization and cheapization, due to signal generation and process all under single-frequency, DDS and phase-detection can be realized by a slice dsp chip simultaneously, thus greatly simplify the space of circuit board.
Accompanying drawing explanation
Fig. 1 is that this utility model can the structural representation of the fluorescent optical fiber sensor of dissolved oxygen in Real-Time Monitoring blood;
Fig. 2 is the structural representation of sensitive membrane in this utility model;
Fig. 3 is the structural representation of this utility model fibre-optical probe;
Fig. 4 is the excitation spectrum of indicator in toluene and absorption spectrum schematic diagram.
In figure: 1-fibre-optical probe, 2-Y-shaped optical fiber, 3-optic electric interface module, 4-digital signal processing module, 5-computer, 6-sensitive membrane, 7-D/A converter module, the 8-the first low pass filter, 9-the second low pass filter, 10-analog-to-digital conversion module, the 31-the first bandpass filter, 32-electro-optical conversion circuit, 33-the second bandpass filter, 34-photoelectric switching circuit, 41-DDS waveform generator, 42-vector orthogonal digital lock-in amplifier, 61-poly nitride layer, 62-indicator layer, 63-polyurethane hydrogel layer, 64-indicator.
Detailed description of the invention
Below in conjunction with the accompanying drawing in this utility model, the technical scheme in this utility model is clearly and completely described.
Figure 1 shows that this utility model can the structural representation of the fluorescent optical fiber sensor of dissolved oxygen in Real-Time Monitoring blood, describedly can comprise fibre-optical probe 1, Y-shaped optical fiber 2, optic electric interface module 3, digital signal processing module 4, computer 5, D/A converter module 7, first low pass filter 8, second low pass filter 9, analog-to-digital conversion module 10 by the fluorescent optical fiber sensor of dissolved oxygen in Real-Time Monitoring blood.
Fibre-optical probe 1 is connected with the tail end of Y-shaped optical fiber 2 by optical fiber interface (such as SMA905 joint), optic electric interface module 3 comprises the first bandpass filter 31, electro-optical conversion circuit 32, second bandpass filter 33 and photoelectric switching circuit 34, digital signal processing module 4 is for generation of sine wave signal, described sine wave signal processes rear input electro-optical conversion circuit 32 by D/A converter module 7 and the first low pass filter 8 and generates exciting light, exciting light makes fibre-optical probe 1 produce with frequency by the head end connecing Y-shaped optical fiber 2 after the first bandpass filter 31 but has the fluorescence of certain phase shift, another head end of Y-shaped optical fiber 2 is by connecing photoelectric switching circuit 34 after the second bandpass filter 33, exciting light and fluorescence input the second bandpass filter 33 by optical excitation signal filtering along Y-shaped optical fiber 2, fluorescence passes through the second low pass filter 9 after photoelectric switching circuit 34 opto-electronic conversion, digital signal is converted to after analog-to-digital conversion module 10, then be input in digital signal processing module 4 and carry out the lagging phase shift that Digital Signal Processing obtains fluorescence signal, the lagging phase shift input computer 5 of fluorescence signal realizes calculating and the display of dissolved oxygen dividing potential drop.The utility model has the advantages that: low cost, microminiature; Stable performance, highly sensitive, linear relationship is good, repeatable and reversibility is good.
As shown in Figures 2 and 3, fibre-optical probe 1 plates sensitive membrane 6 after organic covering removed by optical fiber to be formed, described sensitive membrane 6 is followed successively by poly nitride layer 61, indicator layer 62 and polyurethane hydrogel layer 63 from bottom to up, wherein the tail end of Y-shaped optical fiber 2 plates the thick polymer of one deck 125nm (polyethylene terephthalate) to form poly nitride layer 61 as support, the hydrochloric acid of the ethanol of 25mL, the 0.1mol/L of 6mL, the trimethyl oxygen base phenyl silane of 25mL continue 2.5 hours in the water-bath of 65 DEG C, then add the Ru (dpp) of 5mg
3(TMS)
21 hour is continued with the trimethyl oxygen base phenyl silane of 1.5mL, it is plated in uniformly poly nitride layer 61 and obtains indicator layer 62, the last polyurethane hydrogel plating one deck in indicator layer 62 forms polyurethane hydrogel layer 63, and polyurethane hydrogel layer 63 has good bio-compatibility.Indicator 64 in indicator layer 62 is Ru (dpp)
3(TMS)
2, its excitation peak is at 468nm, and emission peak is at 608nm.
Fig. 4 is excitation spectrum and the absorption spectrum of indicator, and the peak absorbtivity wavelength of indicator is 468nm, peak emission wavelength 608nm.Based on the waveform modulated technology of existing DDS, produce the sinusoidal wave exciting light of 30KHz, electro-optical conversion circuit 32 produces after light source by the first bandpass filter 31 input optical fibre again, the exciting light of indicator is just in time excited at peak value, and indicator can produce with frequency but have the fluorescence of certain phase shift under the exciting of sinusoidal light.
Exciting light and fluorescence can turn back to input second bandpass filter 33 with by optical excitation signal filtering along Y-shaped optical fiber 2, thus single fluorescence signal detected, and fluorescence inputs the second low pass filter 9 after photoelectric switching circuit 34 opto-electronic conversion.First bandpass filter 31 and the second bandpass filter 33 are selected according to the peak excitation wavelength 468nm of indicator and peak emission ripple 608nm respectively.Because the generation of optical signal only needs single wavelength, the acceptance of fluorescence signal also only needs single wavelength, therefore is easy to realize microminiaturization to optic electric interface.
The phase shift phi tangent value of fluorescence and the fluorescence life τ of indicator and exciting light frequency f
modbe directly proportional, just can be detected the fluorescence lifetime of indicator by the size detecting phase shift.
tanΦ＝2πf
modτ (1)
Different dissolved oxygen dividing potential drops is different to the quenching effect of indicator, according to Stern-Volmer equation, just can calculate dissolved oxygen dividing potential drop by detecting fluorescence lifetime.
Wherein: I and I
0be respectively fluorescence intensity when aerobic and anaerobic;
τ and τ
0be respectively fluorescence lifetime when aerobic and anaerobic;
Ksv is Stern-Volmer constant;
[O
2] be the concentration of dissolved oxygen.
DDS waveform generator 41 in digital signal processing module 4 sets up sine wave table, according to DDS Sine Modulated technology, adds corresponding D/A converter module 7 and the first low pass filter 8, just can realize the generation of sinusoidal signal in chip periphery.Fluorescence signal is by after photoelectric switching circuit 34, fluorescence signal is just convertible into the signal of telecommunication that can be processed, by converting digital signal to after the second low pass filter 9 and analog-to-digital conversion module 10, be input to the vector orthogonal digital lock-in amplifier 42 in digital signal processing module 4, according to the relative theory of vector orthogonal phase lock amplifying technology, the sine wave signal produced by DDS waveform generator 41, as with reference to signal, carries out correlation computations to the fluorescence signal gathered, just can obtain phase-shift value.Owing to being the excitation signal under single-frequency, orthogonal Phase Lock Technique detected phase is also realize under this frequency, therefore only need to produce with a dsp chip to carry out Digital Signal Processing, be equipped with the process that corresponding ADC and DAC just can realize the signal of telecommunication again, therefore realize the microminiaturization of signal processing.
After signal processing is complete, phase shift signalling is transferred to computer 5, computer 5 goes out the curve of fluorescence lifetime and dissolved oxygen dividing potential drop according to Stern-Volmer equation model, the different phase shift calculated according to DSP when measuring, obtain the value of corresponding dissolved oxygen dividing potential drop, then shown the value of dissolved oxygen dividing potential drop by display module in real time.Concrete, vector orthogonal digital lock-in amplifier 42 calculates the lagging phase shift of fluorescence signal, and computer 5 calculates fluorescence lifetime by formula (1), calculates dissolved oxygen dividing potential drop by formula (2).
Claims (4)
1. one kind can the fluorescent optical fiber sensor of dissolved oxygen in Real-Time Monitoring blood, comprise fibre-optical probe (1), Y-shaped optical fiber (2), optic electric interface module (3), it is characterized in that: also comprise digital signal processing module (4), computer (5), D/A converter module (7), first low pass filter (8), second low pass filter (9), analog-to-digital conversion module (10), fibre-optical probe (1) plates sensitive membrane (6) after organic covering removed by optical fiber to be formed, fibre-optical probe (1) is connected with the tail end of Y-shaped optical fiber (2), digital signal processing module (4) is for generation of sine wave signal, described sine wave signal is by D/A converter module (7), after first low pass filter (8) process, input optic electric interface module (3) generates exciting light, a head end of exciting light access Y-shaped optical fiber (2) makes fibre-optical probe (1) produce with frequency but has the fluorescence of certain phase shift, exciting light and fluorescence input optic electric interface module (3) by optical excitation signal filtering along Y-shaped optical fiber (2), fluorescence passes through the second low pass filter (9) after optic electric interface module (3) opto-electronic conversion, analog-to-digital conversion module converts digital signal to after (10), then be input in digital signal processing module (4) and carry out processing the lagging phase shift obtaining fluorescence signal, computer (5) realizes calculating and the display of dissolved oxygen dividing potential drop according to the lagging phase shift of fluorescence signal.
2. as claimed in claim 1 can the fluorescent optical fiber sensor of dissolved oxygen in Real-Time Monitoring blood, it is characterized in that: optic electric interface module (3) comprises the first bandpass filter (31), electro-optical conversion circuit (32), second bandpass filter (33) and photoelectric switching circuit (34), described sine wave signal generates exciting light by inputting electro-optical conversion circuit (32) after D/A converter module (7) and the first low pass filter (8) process, exciting light is by connecing a head end of Y-shaped optical fiber (2) after the first bandpass filter (31), exciting light and fluorescence input the second bandpass filter (33) with by optical excitation signal filtering along Y-shaped optical fiber (2), fluorescence inputs the second low pass filter (9) after photoelectric switching circuit (34) opto-electronic conversion.
3. as claimed in claim 1 can the fluorescent optical fiber sensor of dissolved oxygen in Real-Time Monitoring blood, it is characterized in that: described sensitive membrane (6) is followed successively by poly nitride layer (61), indicator layer (62) and polyurethane hydrogel layer (63) from bottom to up.
4. as claimed in claim 1 can the fluorescent optical fiber sensor of dissolved oxygen in Real-Time Monitoring blood, it is characterized in that: digital signal processing module (4) comprises DDS waveform generator (41) and vector orthogonal digital lock-in amplifier (42), the signal output part of DDS waveform generator (41) is connected with the signal input part of D/A converter module (7) and DDS waveform generator (41), the signal output part of analog-to-digital conversion module (10) is connected with the signal input part of vector orthogonal digital lock-in amplifier (42), the signal output part of vector orthogonal digital lock-in amplifier (42) is connected with computer (5), the signal output part of D/A converter module (7) is connected with the signal input part of the first low pass filter (8), the signal output part of the second low pass filter (9) is connected with the signal input part of analog-to-digital conversion module (10).
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106618494A (en) * | 2016-11-30 | 2017-05-10 | 深圳职业技术学院 | PPG pulse wave signal extraction processing system based on phase-locked amplifier |
| CN108776571A (en) * | 2018-05-28 | 2018-11-09 | 中南民族大学 | A kind of optical fiber oxygen determination experiment virtual simulated training system and method |
| CN109452944A (en) * | 2017-09-06 | 2019-03-12 | 东北大学 | Blood fluorescence substance non-invasive detection system based on fluorescence pulse wave |
| CN110261356A (en) * | 2019-06-11 | 2019-09-20 | 浙江工业大学 | A kind of online dissolved oxygen sensing system based on Fluorimetric Quenching Method |
| CN112147121A (en) * | 2020-10-26 | 2020-12-29 | 上海电力大学 | A Dissolved Oxygen Monitoring System Based on Hydrogel Optical Fiber |
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| WO2024109702A1 (en) * | 2022-11-21 | 2024-05-30 | 深圳湃诺瓦医疗科技有限公司 | Brain oxygen monitoring system, intracranial monitoring system, and method |
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- 2015-03-05 CN CN201520128260.7U patent/CN204500713U/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106618494A (en) * | 2016-11-30 | 2017-05-10 | 深圳职业技术学院 | PPG pulse wave signal extraction processing system based on phase-locked amplifier |
| CN109452944A (en) * | 2017-09-06 | 2019-03-12 | 东北大学 | Blood fluorescence substance non-invasive detection system based on fluorescence pulse wave |
| CN109452944B (en) * | 2017-09-06 | 2023-08-15 | 东北大学 | Blood fluorescent substance noninvasive detection system based on fluorescent pulse wave |
| CN108776571A (en) * | 2018-05-28 | 2018-11-09 | 中南民族大学 | A kind of optical fiber oxygen determination experiment virtual simulated training system and method |
| CN110261356A (en) * | 2019-06-11 | 2019-09-20 | 浙江工业大学 | A kind of online dissolved oxygen sensing system based on Fluorimetric Quenching Method |
| CN112304912A (en) * | 2020-10-15 | 2021-02-02 | 上海电力大学 | Hydrogel optical fiber sensing system for monitoring blood sugar |
| CN112147121A (en) * | 2020-10-26 | 2020-12-29 | 上海电力大学 | A Dissolved Oxygen Monitoring System Based on Hydrogel Optical Fiber |
| WO2024109702A1 (en) * | 2022-11-21 | 2024-05-30 | 深圳湃诺瓦医疗科技有限公司 | Brain oxygen monitoring system, intracranial monitoring system, and method |
| CN117451681A (en) * | 2023-11-09 | 2024-01-26 | 山东省科学院海洋仪器仪表研究所 | Fluorescence sensors for alkylbenzene monitoring |
| CN117451681B (en) * | 2023-11-09 | 2024-03-29 | 山东省科学院海洋仪器仪表研究所 | Fluorescence sensors for alkylbenzene monitoring |
| CN117571679A (en) * | 2024-01-12 | 2024-02-20 | 中国科学技术大学 | Oxygen partial pressure measurement method and system based on laser and single photon detector |
| CN117571679B (en) * | 2024-01-12 | 2024-05-07 | 中国科学技术大学 | A method and system for measuring oxygen partial pressure based on laser and single photon detector |
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