CN107569215A - A kind of noninvasive liver function multiparameter measuring device and detection method - Google Patents
A kind of noninvasive liver function multiparameter measuring device and detection method Download PDFInfo
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- 230000003908 liver function Effects 0.000 title claims abstract description 17
- 238000001514 detection method Methods 0.000 title claims abstract description 14
- 210000004369 blood Anatomy 0.000 claims abstract description 38
- 239000008280 blood Substances 0.000 claims abstract description 38
- 238000005259 measurement Methods 0.000 claims abstract description 29
- 239000000049 pigment Substances 0.000 claims abstract description 28
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 27
- 239000001301 oxygen Substances 0.000 claims abstract description 27
- 230000003287 optical effect Effects 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 16
- 238000012417 linear regression Methods 0.000 claims abstract description 13
- 230000005611 electricity Effects 0.000 claims abstract description 8
- 230000014759 maintenance of location Effects 0.000 claims abstract description 8
- 230000005055 memory storage Effects 0.000 claims abstract description 3
- 210000003811 finger Anatomy 0.000 claims description 29
- 230000003595 spectral effect Effects 0.000 claims description 22
- 238000004458 analytical method Methods 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 238000001228 spectrum Methods 0.000 claims description 8
- 238000012360 testing method Methods 0.000 claims description 8
- 210000005224 forefinger Anatomy 0.000 claims description 6
- 230000003044 adaptive effect Effects 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 5
- 229910003798 SPO2 Inorganic materials 0.000 claims description 3
- 238000000862 absorption spectrum Methods 0.000 claims description 3
- 238000004364 calculation method Methods 0.000 claims description 3
- 230000005622 photoelectricity Effects 0.000 claims description 3
- 238000004891 communication Methods 0.000 claims description 2
- 230000005540 biological transmission Effects 0.000 claims 1
- 230000002440 hepatic effect Effects 0.000 abstract description 9
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 238000002496 oximetry Methods 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 2
- 238000012546 transfer Methods 0.000 abstract description 2
- 210000004185 liver Anatomy 0.000 description 6
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- 238000004422 calculation algorithm Methods 0.000 description 2
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- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 2
- 229960004657 indocyanine green Drugs 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
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- 241000700605 Viruses Species 0.000 description 1
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- 238000005516 engineering process Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
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Abstract
The invention provides a kind of noninvasive liver function multiparameter measuring device and detection method.The measurement apparatus has two-way identical measuring unit, the light of three kinds of wavelength of finger-clipped sensor emission and it is connected with analog front-end unit, analog front-end unit is connected with single-chip microcomputer, display is connected with the I/O port of single-chip microcomputer, power supply provides electricity for system, single-chip microcomputer is connected with host computer, described host computer memory storage and operation operation software；Detection method is using biological tissue to the mathematical relationship between the optical absorption characteristics of different wave length, establish equation group, composition transfer in biological tissue is converted to the coefficient of equation of linear regression to be asked, try to achieve 15 minutes retention rates of ICG pigments, and the parameter Non-invasive detection such as blood oxygen saturation, pulse heart rate.The pulse frequency of measurement is 30bpm~300bpm, and precision can reach ± 2bpm；Oximetry value is 70% 100%, and precision is ± 2digit；ICG pigments precision is ± 5%, has high accuracy and high stability, assesses for hepatic functional reserve and operation risk and provides reliable apparatus and method.
Description
Technical field
Apparatus of the present invention belong to technical field of medical instruments, and in particular to a kind of noninvasive liver function multiparameter measuring device with
Detection method.By indocyanine green（ICG）Pigment is injected into blood samples of patients, by measuring the blood of ICG pigments at the appointed time
Metabolic condition in liquid, to evaluate the ability of patient's hepatic functional reserve.It is to establish to survey based on spectral measurement principle in technical principle
Model is measured, and uses digital signal filter Processing Algorithm, calculates the parameters such as heart rate, blood oxygen saturation, ICG pigment concentrations.
Background technology
Liver diseases are a kind of evil sexually transmitted diseases.Number of the China with hepatopathy reaches 30,000,000 in recent years, Chronic Liver
Virus carrier reaches 1.2 hundred million.Hepatic functional reserve refers to the summation of human hepatocyte cells' maximum function.Hepatic functional reserve detection can
Intuitively to reflect the level of effective liver cell.Before being performed the operation to liver, hepatic functional reserve analysis measurement, Ke Yiyou are
Operation risk is assessed on effect ground, reduces operative mortality rate.Traditional liver deposit measuring method, it is based on blood sampling chemical analysis detection mostly
Method.This method shortcoming is obvious, there is wound, chemical examination time length, patient pain, extremely easy infection medical personnel.
At present, noninvasive liver function multiparameter measuring device is not met by hepatic functional reserve analysis measurement needs with method,
It can not overcome that pulse wave signal intensity present in practical application is weak, noise mixing is serious, conventional low-pass filtering is difficult to completely filter
The problem of except causing to extract signal message loss after noise or excessive denoising.
The content of the invention
In order to solve the problems, such as that prior art is present, the invention provides a kind of noninvasive liver function multiparameter measuring device with
Detection method.By indocyanine green（ICG）Pigment is injected into blood samples of patients, by measuring the blood of ICG pigments at the appointed time
Metabolic condition in liquid, to evaluate the ability of patient's hepatic functional reserve.It is to establish to survey based on spectral measurement principle in technical principle
Model is measured, and uses digital signal filter Processing Algorithm, calculates 15 minutes heart rate, blood oxygen saturation, ICG pigments retention rates
The parameters such as (abbreviation R15), ICG pigment concentrations, are shown with image and digital form, realize hepatic functional reserve it is quick,
Quantitative determination.
A kind of noninvasive liver function multiparameter measuring device provided by the invention has two-way measuring unit, two-way measuring unit knot
Structure is identical and a shared display；Finger-clipped sensor per road measuring unit is connected with analog front-end unit；AFE(analog front end)
Unit is connected by I2C buses with single-chip microcomputer；Display is connected with the I/O port of single-chip microcomputer；Power supply provides the straight of stabilization for system
Stream electricity, single-chip microcomputer are connected with host computer, and described host computer is an industrial computer, and host computer memory storage and operation operation are soft
Part；
Described finger-clipped sensor has light source cell and photelectric receiver unit, and described light source cell has three light sources, often
Individual light source launches the optical signal of 1 wavelength respectively, and wavelength is 660nm, 805nm, 940nm respectively, from forefinger, middle finger, the third finger
In select two fingers to press from both sides 1 road finger-clipped sensor respectively；Described photelectric receiver crosses human body hand for receiving lit transmissive
Optical signal after finger, and convert optical signals to current signal；
Described analog front-end unit has two structure difference identical Current Voltage converting units and two AFE units（AFE
For the abbreviation of active front end）；Described Current Voltage converting unit receives the electricity of the photelectric receiver output of finger-clipped sensor
Signal is flowed, and is converted into voltage signal；AFE units are by I2C buses and single chip communication, before single-chip microcomputer receives simulation
The voltage signal that the Current Voltage converting unit of analog front-end unit is changed is carried out data by the data that end unit is sent, single-chip microcomputer
Processing, calculate the semaphore that light source receives through photelectric receiver after finger；Control analog front-end unit receives single-chip microcomputer and referred to
Order, the gain of the AFE units control driving current of light source, lighting time and incorporated amplifier；Meanwhile AFE units complete signal
Analog-to-digital conversion and by I2C buses, data are actively sent to display and show absorption spectrum signal data；After injecting ICG,
The content that host computer passes through ICG in software detection blood；Host computer removes background to the spectral signal received by software and made an uproar
Sound, sectional carry out least square fitting model coefficient, and blood oxygen saturation SPO is calculated by formula 1,22, by formula 3,
4th, 5 ICG 15 minutes retention rates (abbreviation R15) of pigment are calculated, calculates the measured value per road measuring unit and each drive test value
Weights, to obtaining final measurement after two-way measured value ranking operation；By whole measurement result, calculate blood oxygen saturation,
R15, ICG concentration returns curve are shown over the display；Two described Current Voltage converting units turn for the first Current Voltage
Unit and the second Current Voltage converting unit are changed, two AFE units are the first AFE units and the 2nd AFE units；
Calculate blood oxygen saturation SPO2Formula 1,2 it is as follows：
1
2
Wherein, the AC in formula 2 and DC is respectively the DC component and AC compounent of corresponding wavelength light source, and Φ is defined as exchanging
With direct current than linear superposition and；A and b in formula 1 are demarcation constant, this equipment can be measured by blood oxygen saturation instrument
Demarcation, obtains its value.
The calculation formula 3 of the retention rate of ICG pigments 15 minutes (abbreviation R15) is as follows:
R15%=eBT 3
Wherein, T is the time, B is tried to achieve by equation of linear regression, after sectional, as i sectionsValue；
Wherein, formula 4WithRefer to the different wave length photoelectricity conversion signal of clip-style sensor；The cg of formula 5 be with
Concentration factor related R15, β is constant term；For the ICG pigment values of t,To inject ICG pigment values during t=0；Using
The coefficient entry in mathematical modeling is tried to achieve in least square method, linear regression analysisWithValue.
A kind of measuring method of noninvasive liver function multiparameter measuring device of the present invention is as follows：
（1）On device after electricity, the light source of finger-clipped sensor launches the optical signal of 3 wavelength, two finger-clipped sensors
Clip in forefinger, middle finger and the third finger on two fingers selected, finger contact is good, and upper computer software sets electric current and passage
Gain parameter, after the amplitude for adjusting optical signal, start data acquisition, data validity is judged by software；
（2）The interception of preceding 30 second data is given up after spectral signature data is received, is not involved in data operation by host computer automatically,
Computing is participated in from the spectral signature data after 30 seconds；
（3）Host computer is filtered by software to the data-signal received；
（4）Host computer by software to receive the adaptive amplitude of spectral signal, frequency spectrum calculate；
（5）After seeing that two-way pulse signal that display is shown is steady, the ICG pigments prepared are injected in 1 minute；
（6）After injecting ICG, host computer detects the content of ICG in blood in real time, the data-signal received by software analysis, passes through
Signal intensity, catastrophe point can be detected；
（7）Host computer removes background noise by software to the spectral signal received, and subregion calculates the spectrum of each period
Signal；
（8）By stages progress least square method, linear regression analysis try to achieve the value of the coefficient entry in mathematical modeling, calculate per drive test
The weighted value of unit measured value and each drive test value is measured, after the measuring unit measured value ranking operation of two-way road, is obtained final
Measurement result；Blood oxygen saturation SPO is calculated by formula 1,22, by formula formula 3 calculate R15 value, the formula 4,5 being related to
As described above；
（9）Final measurement, blood oxygen saturation, ICG concentration returns curve are shown on display 4.
Coefficient and multichannel measurement ICG concentration are solved using by stages linear regression, can greatly improve the measurement of equipment
Precision, meet detection needs.
Beneficial effect：A kind of noninvasive liver function multiparameter measuring device and method of the present invention, there is the light of three kinds of wavelength, shine
It is mapped in biological tissue, such as finger, ear, the pigment of blood, muscle, injection in biological tissue is to the light of three kinds of wavelength
Absorption characteristic is different, using biological tissue to the mathematical relationship between the optical absorption characteristics of different wave length, equation group is established, by life
Composition transfer in thing tissue is converted to the coefficient of equation of linear regression to be asked, and then tries to achieve 15 minutes retention rates of ICG pigments,
And the parameter such as blood oxygen saturation, pulse heart rate.
A kind of noninvasive liver function multiparameter measuring device of the present invention is to detect blood oxygen saturation, arteries and veins with three-wavelength source
The multiparameter measuring device of rate, ICG concentration, there is the characteristics of high accuracy, high stability.In liver section of No.1 Hospital of Jilin Univ.
Do clinical trial in room, the results showed that, in the range of 30bpm~300bpm, precision can reach the pulse frequency of measurement device of the invention
To ± 2bpm；For oximetry value in the range of 70% -100%, precision can reach ± 2digit；ICG pigments precision can reach
To ± 5%.
Compared with prior art, the present invention realizes the Non-invasive detection of ICG concentration using pulse spectrophotometric method, uses
Adaptive to filter out physiology and measurement interference effect, detection method hurtless measure, accurate and precision are high, can effectively solve the problem that pulse wave is believed
Number intensity is weak, noise mixing is serious, conventional low-pass filtering is difficult to cause to extract signal letter after completely filtering out noise or excessive denoising
The problem of breath is lost.The present invention can completely retain useful information needed for testing result, can be widely applied to liver function, blood oxygen is satisfied
With degree, pulse frequency, ICG measurement of concetrations, these parameters can be very good to react liver reserve capabillity, the energy of blood carrying conveying oxygen
Power, is assessed for hepatic functional reserve and operation risk is assessed and provides reliable parameter.
Brief description of the drawings
Fig. 1 is the measuring unit structured flowchart of measurement apparatus of the present invention.
Fig. 2 is the flow chart of the present invention.
Fig. 3 is whole signal data figures of a clinical examination process collection.
The error map of the contrast experiment of Fig. 4 raw experimental datas.
Embodiment
Embodiment 1 is as shown in figure 1, a kind of noninvasive liver function multiparameter measuring device has two-way measuring unit, two-way measurement
Cellular construction is identical and a shared display 4；Finger-clipped sensor 1 per road measuring unit is connected with analog front-end unit 2；
Analog front-end unit 2 is connected by I2C buses with single-chip microcomputer 3；Display 4 is connected with the I/O port of single-chip microcomputer 3；Power supply 5 is is
System provides galvanic current, and single-chip microcomputer 3 is connected with host computer 6, and described host computer 6 is an industrial computer, in host computer 6
Storage and operation operation software；
Described finger-clipped sensor 1 has light source cell and photelectric receiver unit, and described light source cell has three light sources, often
Individual light source launches the optical signal of 1 wavelength respectively, and wavelength is 660nm, 805nm, 940nm respectively, from forefinger, middle finger, the third finger
In, select two fingers to press from both sides 1 road finger-clipped sensor 1 respectively；Described photelectric receiver crosses human body for receiving lit transmissive
Optical signal after finger, and convert optical signals to current signal；
Described analog front-end unit 2 has two structure difference identical Current Voltage converting units and two AFE units（AFE
For the abbreviation of active front end）；Described Current Voltage converting unit receives the electricity of the photelectric receiver output of finger-clipped sensor 1
Signal is flowed, and is converted into voltage signal；AFE units are communicated by I2C buses with single-chip microcomputer 3, and single-chip microcomputer 3 receives simulation
The data that front end unit 2 is sent, single-chip microcomputer 3 enter the voltage signal that the Current Voltage converting unit of analog front-end unit 2 is changed
Row data processing, calculate the semaphore that light source receives through photelectric receiver after finger；Control analog front-end unit 2 receives list
Piece machine 3 instructs, the gain of the AFE units control driving current of light source, lighting time and incorporated amplifier；Meanwhile AFE units are complete
Into signal analog-to-digital conversion and by I2C buses, data are actively sent to display 4 and show absorption spectrum signal data；Note
After entering ICG, content that host computer passes through ICG in software detection blood；Host computer is gone by software to the spectral signal received
Except background noise, sectional carries out least square fitting model coefficient, and blood oxygen saturation SPO is calculated by formula 1,22, it is logical
Cross formula 3,4,5 and calculate ICG 15 minutes retention rates (abbreviation R15) of pigment, calculate the measured value of every road measuring unit and per all the way
The weights of measured value, to obtaining final measurement after two-way measured value ranking operation；Whole measurement result, the blood oxygen calculated are satisfied
Shown with degree, R15, ICG concentration returns curve on display 4；Two described Current Voltage converting units are the first electric current
Voltage conversion unit and the second Current Voltage converting unit, two AFE units are the first AFE units and the 2nd AFE units；
Calculate blood oxygen saturation SPO2Formula 1,2 it is as follows：
1
2
Wherein, the AC in formula 2 and DC is respectively the DC component and AC compounent of corresponding wavelength light source, and Φ is defined as exchanging
With direct current than linear superposition and；A and b in formula 1 are demarcation constant, this equipment can be measured by blood oxygen saturation instrument
Demarcation, obtains its value.
The calculation formula 3 of the retention rate of ICG pigments 15 minutes (abbreviation R15) is as follows:
R15%=eBT 3
Wherein, T is the time, B is tried to achieve by equation of linear regression, after sectional, as i sectionsValue；
Wherein, formula 4WithRefer to the different wave length photoelectricity conversion signal of clip-style sensor；The cg of formula 5 be with
Concentration factor related R15, β is constant term；For the ICG pigment values of t,To inject ICG pigment values during t=0；Using
The coefficient entry in mathematical modeling is tried to achieve in least square method, linear regression analysisWithValue.
A kind of measuring method of noninvasive liver function multiparameter measuring device of the present invention is as follows：
（1）On device after electricity, the light source of finger-clipped sensor 1 launches the optical signal of 3 wavelength, two finger-clipped sensors
1 clips in forefinger, middle finger and the third finger on two fingers selected, and finger contact is good, the software design patterns electric current of host computer 6 with
Channel gain parameter, after the amplitude for adjusting optical signal, start data acquisition, data validity is judged by software；
（2）The interception of preceding 30 second data is given up after spectral signature data is received, is not involved in data operation by host computer 6 automatically,
Computing is participated in from the spectral signature data after 30 seconds；
（3）Host computer 6 is filtered by software to the data-signal received；
（4）Host computer 6 by software to receive the adaptive amplitude of spectral signal, frequency spectrum calculate；
（5）After seeing that two-way pulse signal that display is shown is steady, the ICG pigments prepared are injected in 1 minute；
（6）After injecting ICG, host computer 6 detects the content of ICG in blood in real time, the data-signal received by software analysis, passes through
Signal intensity, catastrophe point can be detected；
（7）Host computer 6 removes background noise by software to the spectral signal received, and subregion calculates the spectrum of each period
Signal；
（8）By stages progress least square method, linear regression analysis try to achieve the value of the coefficient entry in mathematical modeling, calculate per drive test
The weighted value of unit measured value and each drive test value is measured, after the measuring unit measured value ranking operation of two-way road, is obtained final
Measurement result；Blood oxygen saturation SPO is calculated by formula 1,22, by formula formula 3 calculate R15 value, the formula 4,5 being related to
As described above；
（9）Final measurement, blood oxygen saturation, ICG concentration returns curve are shown on display 4.
Coefficient and multichannel measurement ICG concentration are solved using by stages linear regression, can greatly improve the measurement of equipment
Precision, meet detection needs.
The software flow of the present invention is as shown in Figure 2:
Step 100 is carried out, is started, control instruction, initialization are sent to single-chip microcomputer；
Step 105 is carried out, the light source of finger-clipped sensor launches 3 wavelength channels；
Step 110 is carried out, two-way finger-clipped sensor is clipped on two fingers respectively, contact is good, what host computer received
Pulse signal waveform can determine whether to refer to whether folder clips；It is no, continue step 110；It is to carry out step 115；
Step 115 is carried out, host computer is by software design patterns electric current and channel gain parameter, after the amplitude for adjusting optical signal, starts
Data acquisition, the signal of 30 seconds, gives up to fall, the spectrum after 30 seconds before intercepting after the spectral signal that host computer collects
Signal data participates in computing；
Step 120 is carried out, host computer is filtered by software to the data-signal received；
Carry out step 125, host computer by software to receive the adaptive amplitude of spectral signal, frequency spectrum calculate；
Step 130 is carried out, the data-signal that host computer is received by software analysis, by signal intensity, mutation can be detected
Point, that is, detect the time of injection ICG pigments；
Step 135 is carried out, host computer removes background noise by software to the spectral signal received, and subregion calculates each time
The spectral signal of section；
Step 140 is carried out, host computer carries out least square fitting model coefficient by software to the spectral signal received；
Step 145 is carried out, host computer calculates blood oxygen saturation, R15 by software；
Step 150 is carried out, blood oxygen saturation, R15 values, is shown over the display；
Step 155 is carried out, is terminated.
Fig. 3 is whole signal data figures that a clinical examination process of the present embodiment gathers.Wherein abscissa is data
Point sequence 1-35000, collection signal frequency are 100HZ, and ordinate is the code value for being converted into electric signal.Can from figure
Go out, before and after injecting ICG, at abscissa 0.6, the amplitude of signal has a greater change.
Made of a kind of noninvasive liver function multiparameter measuring device of the present invention in liver section office of No.1 Hospital of Jilin Univ.
Clinical trial.Gather patient data 300, wherein man 190, Ms 110.As a result show, measurement device of the invention
Pulse frequency in the range of 30bpm~300bpm, precision can reach ± 2bpm；Oximetry value is in 70% -100% scope
Interior, precision can reach ± 2digit；ICG pigments precision can reach ± 5%.
Fig. 4 is the error map of the contrast experiment of the experimental data of the present embodiment.The measurement error of every patient is survey
Value subtracts true value.Abscissa is patient's sequence number, and ordinate is error amount, error map, it may be said that the precision of bright equipment is steady
It is qualitative.A kind of precision stability of noninvasive liver function multiparameter measuring device of the invention is high as seen from Figure 4.
Claims (2)
1. a kind of noninvasive liver function multiparameter measuring device, it is characterised in that have two-way measuring unit, two-way measuring unit structure
An identical and shared display（4）；Per the finger-clipped sensor of road measuring unit（1）With analog front-end unit（2）It is connected；Mould
Intend front end unit（2）Pass through I2C buses and single-chip microcomputer（3）It is connected；Display（4）With single-chip microcomputer（3）I/O port be connected；Power supply
（5）Galvanic current, single-chip microcomputer are provided for system（3）And host computer（6）Connection, described host computer（6）It is a work
Control machine, host computer（6）Memory storage and operation operation software；
Described finger-clipped sensor（1）There are light source cell and photelectric receiver unit, described light source cell has three light sources,
Each light source launches the optical signal of 1 wavelength respectively, and wavelength is 660nm, 805nm, 940nm respectively, from forefinger, middle finger, unknown
In finger, two fingers are selected to press from both sides 1 road finger-clipped sensor respectively（1）；Described photelectric receiver is used to receive lit transmissive mistake
Optical signal after human finger, and convert optical signals to current signal；
Described analog front-end unit（2）There are two structure difference identical Current Voltage converting units and two AFE units；
Described Current Voltage converting unit receives finger-clipped sensor（1）Photelectric receiver output current signal, and by its turn
It is changed to voltage signal；AFE units pass through I2C buses and single-chip microcomputer（3）Communication, single-chip microcomputer（3）Receive analog front-end unit（2）
The data of transmission, single-chip microcomputer（3）Analog front-end unit（2）Current Voltage converting unit conversion voltage signal carry out data
Processing, calculate the semaphore that light source receives through photelectric receiver after finger；Control analog front-end unit（2）Receive single-chip microcomputer
（3）Instruction, the gain of the AFE units control driving current of light source, lighting time and incorporated amplifier；Meanwhile AFE units are completed
Data are actively sent to display by the analog-to-digital conversion of signal and by I2C buses（4）Show absorption spectrum signal data；Note
After entering ICG, content that host computer passes through ICG in software detection blood；Host computer is gone by software to the spectral signal received
Except background noise, sectional carries out least square fitting model coefficient, and blood oxygen saturation SPO is calculated by formula 1,22, it is logical
Cross formula 3,4,5 and calculate ICG 15 minutes retention rates (abbreviation R15) of pigment, calculate the measured value of every road measuring unit and per all the way
The weights of measured value, to obtaining final measurement after two-way measured value ranking operation；Whole measurement result, the blood oxygen calculated are satisfied
With degree, R15, ICG concentration returns curve in display（4）Upper display；Two described Current Voltage converting units are the first electricity
It is the first AFE units and the 2nd AFE units to flow voltage conversion unit and the second Current Voltage converting unit, two AFE units；
Calculate blood oxygen saturation SPO2Formula 1,2 it is as follows：
1
2
Wherein, the AC in formula 2 and DC is respectively the DC component and AC compounent of corresponding wavelength light source, and Φ is defined as exchanging
With direct current than linear superposition and；A and b in formula 1 are demarcation constant, this equipment can be measured by blood oxygen saturation instrument
Demarcation, obtains its value；
R15 calculation formula 3 is as follows:
R15%=eBT 3
Wherein, T is the time, B is tried to achieve by equation of linear regression, after sectional, as i sectionsValue；
Wherein, formula 4WithRefer to the different wave length photoelectricity conversion signal of clip-style sensor；The cg of formula 5 be with
Concentration factor related R15, β is constant term；For the ICG pigment values of t,To inject ICG pigment values during t=0；Using
The coefficient entry in mathematical modeling is tried to achieve in least square method, linear regression analysisWithValue.
2. a kind of noninvasive liver function multiparameter measuring device, it is characterised in that the step of its detection method and condition is as follows：
（1）On device after electricity, finger-clipped sensor（1）Light source launch the optical signals of 3 wavelength, two finger-clippeds are sensed
Device（1）Clip in forefinger, middle finger and the third finger on two fingers selected, finger contact is good, and upper computer software sets electric current
With channel gain parameter, after the amplitude for adjusting optical signal, start data acquisition, data validity is judged by software；
（2）The interception of preceding 30 second data is given up after spectral signature data is received, is not involved in data operation by host computer automatically,
Computing is participated in from the spectral signature data after 30 seconds；
（3）Host computer is filtered by software to the data-signal received；
（4）Host computer by software to receive the adaptive amplitude of spectral signal, frequency spectrum calculate；
（5）After seeing that two-way pulse signal that display is shown is steady, the ICG pigments prepared are injected in 1 minute；
（6）After injecting ICG, host computer detects the content of ICG in blood in real time, the data-signal received by software analysis, passes through
Signal intensity, catastrophe point can be detected；
（7）Host computer removes background noise by software to the spectral signal received, and subregion calculates the spectrum of each period
Signal；
（8）By stages progress least square method, linear regression analysis try to achieve the value of the coefficient entry in mathematical modeling, calculate per drive test
The weighted value of unit measured value and each drive test value is measured, after the measuring unit measured value ranking operation of two-way road, is obtained final
Measurement result；Blood oxygen saturation SPO is calculated by formula 1,22, by formula formula 3 calculate R15 value, the formula 4,5 being related to
As claimed in claim 1；
（9）By final measurement, blood oxygen saturation, ICG concentration returns curves in display（4）Upper display.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109567751A (en) * | 2018-11-15 | 2019-04-05 | 陈圣开 | A kind of puncture needle and its application method for measurement cirrhosis hardness in art |
| CN110516903A (en) * | 2019-07-11 | 2019-11-29 | 广州中智达信科技有限公司 | A kind of method and apparatus of artificial intelligence risk assessment |
| CN114259228A (en) * | 2021-12-16 | 2022-04-01 | 吉林亚泰中科医疗器械工程技术研究院股份有限公司 | Portable liver storage function detection device and detection method thereof |
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2017
- 2017-11-06 CN CN201711076018.XA patent/CN107569215A/en active Pending
Non-Patent Citations (1)
| Title |
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| 刘光达等: "基于光电脉搏色素浓度谱分析的肝储备功能检测方法", 《光电子激光》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109567751A (en) * | 2018-11-15 | 2019-04-05 | 陈圣开 | A kind of puncture needle and its application method for measurement cirrhosis hardness in art |
| CN109567751B (en) * | 2018-11-15 | 2021-09-24 | 陈圣开 | A puncture needle for intraoperative determination of liver cirrhosis hardness |
| CN110516903A (en) * | 2019-07-11 | 2019-11-29 | 广州中智达信科技有限公司 | A kind of method and apparatus of artificial intelligence risk assessment |
| CN114259228A (en) * | 2021-12-16 | 2022-04-01 | 吉林亚泰中科医疗器械工程技术研究院股份有限公司 | Portable liver storage function detection device and detection method thereof |
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