CN201578881U - Subcritical Fluid Extraction Device for Active Components of Natural Products - Google Patents

Abstract

The utility model subcritical fluid extraction device for active ingredients of natural products is composed of a control system part and a leaching system part, wherein the leaching system part is composed of an extraction tank, an evaporation tank, a buffer tank, a condenser, a solvent tank, an ultrasonic generator, a vacuum pump, Flame arrester, compressor, hot water pump and hot water tank; one end of the extraction tank is connected to the solvent tank through a regulating valve and a pipeline; one end of the vacuum pump is connected to the extraction tank, evaporation tank and buffer tank through a pipeline and a regulating valve, and the other end is connected to the The pipeline is connected to the flame arrester; one end of the compressor is connected to the buffer tank through a pipeline and a regulating valve, and the buffer tank is connected to the extraction tank and the evaporation tank through a pipeline and a regulating valve. An ultrasonic generator is installed on the top of the extraction tank. on the outside of the extraction tank. According to different extraction objects, the utility model combines the subcritical fluid extraction technology with the ultrasonic extraction technology, which can improve the extraction rate and shorten the extraction time.

Description

Subcritical Fluid Extraction Device for Active Components of Natural Products

technical field

The utility model relates to an extraction device for functional components of natural products, in particular to a device for extracting fat-soluble functional components of natural products by using fluids such as subcritical lower alkanes, tetrafluoroethane or sulfur hexafluoride under the assistance of ultrasound.

Background technique

Our country has a vast territory, complex geographical environment and changeable climatic conditions have created the diversity of species in our country, especially the natural resources such as special oils, flavors and fragrances, pigments, etc. , onion, wolfberry seed, seabuckthorn, red pepper, pepper, osmanthus, rose and jasmine, etc.

Due to their thermal sensitivity, the high value-added physiologically active substances in natural products not only have low yields but also destroy functional components by conventional heat reflux extraction methods and organic solvent extraction methods. Although supercritical CO2 extraction is an ideal method, which has the advantages of strong extraction capacity, high extraction rate, and good product quality, it must be carried out under ultra-high pressure conditions above 25MPa. The extremely high pressure limits the expansion of the effective volume of the equipment. At the same time, the high equipment manufacturing and operating costs restrict the application of this technology in the production of natural product active ingredients. Therefore, finding a new technology and equipment that can efficiently extract heat-sensitive and easily oxidized active ingredients in natural products, and is easy to industrialize, has become a research hotspot in the field of natural product extraction in recent years.

Subcritical fluid refers to a substance that exists in the form of a fluid above the boiling point and below the critical temperature and critical pressure. Subcritical fluid extraction uses subcritical state fluid or a mixed solution of subcritical fluid as a solvent, and successively undergoes leaching, evaporation precipitation, compression, condensation recovery and other processes with solutes in the system to extract target components from natural products a new technology. For example, when liquefied petroleum gas (LPG), propane, butane, high-purity isobutane (R600a), dimethyl ether (DME), 1,1,1,2-tetrafluoroethane (R134a) and hexafluoride When sulfur exists in a subcritical fluid state, the diffusion performance of molecules is enhanced, the mass transfer speed is accelerated, and the permeability and solubility of weakly polar and non-polar substances in natural products are significantly improved. Therefore, the above-mentioned subcritical fluid is particularly suitable for the extraction of volatile oil, fat or fat-soluble components in natural products. Extraction in a subcritical environment does not destroy heat-sensitive components and the target object is complete. It is regarded as a transformative technology with green environmental protection and broad prospects.

Among the existing subcritical related extraction devices in China, the Chinese patent application number ZL200620135969.0 was published on October 11, 2006. The name of the invention is "suitable for polar and non-polar intermediates in various solvents Extraction device", the application discloses that by changing the composition of the extraction solvent and the action procedures of the valves, pipelines, and equipment in the system, the requirements of different solvents for extraction temperature, pressure, time, and flow direction are met, and the extraction of active ingredients in animal and plant materials is completed. extraction. The device takes into account the extraction process requirements of non-polar and polar active ingredients. Its disadvantage is that the process route is complicated, so the equipment manufacturing cost is high; manual control is adopted, and the operation is cumbersome. The Chinese patent with the application number 200610070495.0 was published on December 5, 2006. The name of the invention is "a low-pressure supercritical extraction process and its device". The application discloses the use of tetrafluoroethane as a supercritical fluid. Non-polar, weakly polar and highly polar substances can be extracted by nature. The invention uses tetrafluoroethane in a supercritical state, and the system pressure can reach up to 8MPa, so the manufacturing of the equipment is difficult and costly. Chinese patent application number 200710032663.1, published on December 18, 2007, the name of the invention is "Ultrasonic Enhanced Subcritical Water Extraction Method and Device for Active Components of Natural Products", the application discloses the use of subcritical water as the extraction medium , to selectively extract the extract by changing the extraction parameters. The disadvantage of this invention is that subcritical water is used as the extraction medium, and the extraction pressure is as high as 20MPa, so the equipment manufacturing is relatively difficult and expensive. The above-mentioned devices related to subcritical fluid extraction disclosed in China have different structures due to the large difference in the properties of the extraction solvents used and the different processes. However, there are generally complex structures, high manufacturing costs, high working pressure, and difficulty in enlarging equipment; and they are all manually controlled, and the operation is cumbersome; at the same time, the extraction kettle for pressurized solvent extraction generally uses multiple bolts to fasten, seal, fill and discharge. The material is very inconvenient, and the above-mentioned inventions all do not relate to the specific structure of the charging port.

Among the existing related subcritical fluid extraction methods in China, the Chinese patent No. ZL 01108701.3 was published on August 2, 2001. The name of the invention is "Method for Extracting Pyrethrins from Subcritical Liquefied Petroleum Gas". The application discloses using subcritical liquefied petroleum gas as a solvent, extracting for 20-300 minutes at a temperature of 20-90°C and a pressure of 0.3-3.5MPa, and then extracting at a temperature of 20-90°C and a pressure of 0.1-2MPa Next, the liquefied petroleum gas is vaporized to separate the pyrethrins. The patent number is 200610104744.3 Chinese patent, the publication date is April 16, 2008, the name of the invention is "subcritical fluid extraction solvent and extraction method", the application discloses a subcritical fluid extraction solvent, which contains compounds or The composition is used as an extraction solvent for extracting a compound or composition from the raw materials of the constituent parts, and its main feature is to use liquid sulfur hexafluoride as the extraction solvent. The application also discloses the extraction method of the subcritical fluid extraction solvent. The above-mentioned methods related to the subcritical extraction disclosed in China adopt different methods due to the different extraction agents selected. But the disclosed methods are all limited to a specific sub-method such as liquefied petroleum gas, propane, butane, high-purity isobutane, dimethyl ether, 1,1,1,2-tetrafluoroethane and sulfur hexafluoride. Critical fluid; at the same time, when the above-mentioned subcritical fluid is used as the extraction medium, the extraction efficiency of medium polarity and polar compounds is low. None of the above methods involves a mixture of two or more subcritical fluids as an extraction medium, or a method for selectively extracting a target component by adding an entrainer.

In order to overcome the low degree of automation of the existing subcritical fluid extraction device, the cumbersome loading and unloading of the extraction kettle, and the high working pressure of the equipment; at the same time, the subcritical fluid extraction method is limited to a specific subcritical fluid, and the extraction of medium polar and polar compounds Low efficiency and other defects, the present invention makes full use of the characteristics of subcritical fluids such as liquefied petroleum gas, high-purity isobutane, dimethyl ether and sulfur hexafluoride at the same temperature close to the subcritical pressure, and designs a set of simple structure, extraction It is a device that is easy to open, has a high degree of automation, and is suitable for the above-mentioned various subcritical fluid extractions, and describes in detail the method of using the device to extract fat-soluble or medium-polar functional components of natural products.

Contents of the invention

The purpose of this utility model is to overcome the above-mentioned defects existing in the prior art, and to provide a device for ultrasonically assisted subcritical fluid extraction of fat-soluble functional components of natural products. , sulfur hexafluoride and other solvents.

The ultrasonic-assisted subcritical fluid extraction device provided by the utility model is realized through the following scheme:

The device is mainly composed of the following two parts:

Leaching system part: this part is mainly composed of extraction tank 1, evaporation tank 2, buffer tank 3, condenser 4, solvent tank 5, ultrasonic generator 11, vacuum pump 9, flame arrester 10, compressor 8, hot water pump 7, hot water Box 6 etc. constitute. One end of the extraction tank 1 is connected to the solvent tank 5 through the regulating valve 17, 25 and the pipeline, and the liquid lysozyme in the solvent tank 5 is input into the extraction tank 1 by using the pressure difference; the other end is connected to the evaporation tank 2 through the regulating valve 19 and the pipeline , the mixture of the extraction product and lysozyme is discharged into the evaporation tank 2. One end of the vacuum pump 9 is connected to the extraction tank 1, the evaporation tank 2, and the buffer tank 3 through pipelines and regulating valves 13, 14, 20, and 21, respectively, to remove incompressible gases in the tanks—air, etc.; the other end is connected to the flame arrester through pipelines. 10 connections, discharge the air and a very small amount of vaporized extraction medium out of the system, and play a role in fire prevention. One end of the compressor 8 is connected with the buffer tank 3 through the pipeline and the regulating valve 22, and the buffer tank 3 is connected with the extraction tank 1 and the evaporation tank 2 through the pipeline and the regulating valve 14, 21, and the liquid lysozyme is decompressed and gasified; The other end is connected to the condenser 4 through a pipeline and a regulating valve 15 to cool and liquefy the compressed gaseous lysozyme. The other end of the condenser 4 is connected to the solvent tank 5 through a pipeline and a regulating valve 18, and the liquefied lysozyme is injected into the solvent tank 5; the ball valves 33 and 34 are the inlets and outlets of the circulating cooling water respectively. One end of the hot water pump 7 is respectively connected to the hot water tank 6 through a pipeline and a regulating valve 28; 2. The gasification of liquid lysozyme provides heat and is used to keep the extraction tank at a constant temperature.

The top of the extraction tank 1 of the subcritical fluid extraction device for active ingredients of natural products is provided with an ultrasonic generator 11, the ultrasonic generator 11 is connected to the top of the extraction tank 1, the ultrasonic generator 11 is placed outside the extraction tank 1, and the ultrasonic generator 11 is placed outside the extraction tank 1. The transducer head of the generator 11 is placed on the upper part of the extraction tank 1 . This part introduces ultrasound into the subcritical fluid extraction process, and utilizes the unique cavitation effect of ultrasound in liquid media, coupled with multipolar effects such as mechanical vibration and micro jets generated by ultrasound transmission, to make functional substances easier to extract come out.

The extraction tank 1 is a cylindrical device made of high-temperature and high-pressure stainless steel. The extraction tank cover adopts an extraction tank quick-opening device 12 to facilitate loading and unloading of leached materials, and a polytetrafluoroethylene material is used as a sealing ring to ensure the airtightness of the system. sex. There is a stainless steel filter at the bottom of the extraction tank to prevent the powder raw material from blocking the outlet of the pipeline, and an outlet at the lower end is connected to the evaporation tank through a pipeline; the evaporation tank 2, buffer tank 3, and solvent tank 5 are cylindrical or rectangular containers made of stainless steel; The hot water tank 6 is a cylindrical or rectangular device made of stainless steel or plastic; the condenser 4 is a tubular cooler, which is cooled by continuously feeding cooling water, and the lower side of the cooler is provided with a cooling water inlet. There is a cooling water outlet on the upper side.

The compressor 8 is a diaphragm compressor, which can adjust and display the pressure, and the pressure range is 0-20MPa. The extraction tank 1 can be designed into various volumes according to actual needs, and other parts are configured into corresponding sizes according to the requirements of the extraction process.

Control system part: including leaching temperature adjustment control, leaching time control, leaching frequency control, material-dissolution ratio control, precipitation temperature adjustment control, precipitation pressure feedback control, electrical control of the entire device, and over-temperature, over-pressure and leakage alarms, etc. . This part adopts PLC design, through the parameter setting on the control panel 35, completes the whole extraction process automatically.

In order to facilitate the automatic control of working temperature and pressure, the device is equipped with pressure measuring devices in the extraction tank 1, evaporation tank 2, buffer tank 3, condenser 4 and solvent tank 5, and in the extraction tank 1, evaporation tank 2, buffer tank 3 There is an electric contact temperature measuring device, and one end of the pressure measuring device and the temperature measuring device is set inside the tank. First, manually set the extraction parameters such as leaching temperature, leaching time, leaching times, material-solubilization ratio, and precipitation temperature on the control panel 35, and feed back signals to the PLC through the pressure measuring device and temperature measuring device of the system, and then the PLC issues instructions. , to control the opening of each valve until the entire extraction process is completed.

The working process of this device is as follows:

(1) First put the material into the barrel, then put it into the extraction tank, and use a vacuum pump to exhaust the air in the container;

(2) Use the pressure difference to pump the subcritical fluid in the solvent tank into the extraction tank, use circulating hot water to heat the extraction tank, and turn on the ultrasonic generating device to assist in the extraction;

(3) After the material is extracted for a certain period of time, the liquid mixed oil (subcritical fluid containing fat-soluble components) is discharged from the bottom of the extraction tank, and enters the evaporation tank for decompression evaporation, and the subcritical fluid in the mixed oil is fully Gasification, during the evaporation process, the hot water in the interlayer is heated to supplement the heat required for the transformation of the subcritical fluid from liquid to gaseous state. The gasified gas is compressed by the compressor and becomes liquid in the condenser, and returns to the solvent Recycle after tank;

(4) After the extraction is completed, use a compressor to evaporate the residual subcritical fluid in the material in the extraction tank under reduced pressure. After the pressure in the extraction tank reaches 0Mpa, use a vacuum pump to perform negative pressure evaporation until the pressure drops to -0.09MPa Next, open the mouth of the extraction tank and take out the residue;

(5) After the mixed oil is decompressed and evaporated to 0Mpa by the compressor, it is also converted to negative pressure evaporation with a vacuum pump until the pressure of the evaporation tank is below -0.09MPa, and the extracted fat-soluble substances are released from the lower part of the evaporation tank;

(6) Except for the loading and unloading of materials, the above process is done manually, and the other steps are set by PLC program to automatically complete the whole extraction process.

The extraction method of the ultrasonic-assisted subcritical fluid extraction device provided by the utility model is realized through the following scheme: put the fat-soluble material into the extraction tank, then inject the subcritical fluid, and under certain pressure conditions, the fat-soluble material is in the subcritical fluid After a certain period of ultrasonic-assisted extraction, supplemented by hot water heating in the interlayer of the container, the fat-soluble components in the solid material gradually diffuse into the liquid subcritical fluid, and finally reach an equilibrium. Then the subcritical fluid (mixed oil) containing fat-soluble components is discharged from the bottom of the extraction tank into the gas-liquid separation vessel (evaporation tank), and evaporated under reduced pressure by a compressor to continuously convert the subcritical fluid from the mixed oil liquid into Gaseous state, and under the action of the compressor, it is compressed from gaseous state to liquid state, and returned to the solvent tank for recycling. According to the amount of fat-soluble components in the material, through multiple extractions, the fat-soluble components of the material are finally fully extracted.

The extraction method of the ultrasonic-assisted subcritical fluid extraction device provided by the utility model includes the following steps:

(1) First, the raw materials are pretreated to make 30-120 mesh granules, including impurity removal, crushing, granulation, etc. Then put the pretreated material into the barrel, put it into the extraction tank, and use a vacuum pump to exhaust the air in the container, and the vacuum degree is below -0.1MPa.

(2) Utilizing the pressure difference to inject the subcritical fluid in the solvent tank into the extraction tank, the material-solution ratio is 1: 1～5, wherein the subcritical fluid can be methane, ethane, propane, isopropane, butane, One of high-purity isobutane, liquefied petroleum gas, dimethyl ether, tetrafluoroethane, sulfur hexafluoride, etc., or a mixture of two or more of them.

(3) For the extraction of the medium polarity functional group in the raw material, can add 1～10% extraction entrainer by mass in step (2), wherein said extraction entrainer can be ethanol or acetone, thereby will mix The solvent is adjusted to a weakly polar solvent in order to realize the extraction and separation of medium polar components.

(4) Using circulating hot water to heat the extraction tank, the temperature is controlled between 20-80° C., and the pressure is controlled at 0.2-2.0 MPa. Ultrasound-assisted extraction is used, the ultrasonic power is 50-2500W, and the ultrasonic frequency is 20-50KHz.

(5) After 5-180 minutes of ultrasonic-assisted extraction, the liquid mixed oil (subcritical fluid containing fat-soluble components) is released from the lower part of the extraction tank, and enters the evaporation tank for vacuum evaporation, and the lysozyme in the mixed oil is Fully gasified, heating through the hot water in the interlayer during the evaporation process, supplementing the heat required for the conversion of lysozyme from liquid to gaseous state, the gasified gas is compressed by the compressor and becomes liquid in the condenser, and returns to the solvent Recycle after canning.

(6) According to the content of fat-soluble components in the raw materials, the number of extractions is selected from 1 to 5 times, and the above-mentioned processes of 2, 3 and 4 can be repeated each time. It is also possible to achieve 2 to 4 countercurrent extractions by adding 1 to 3 buffer tanks.

(7) After the extraction is finished, use a compressor to evaporate the residual lysozyme in the material in the extraction tank under reduced pressure. During the evaporation process, the hot water in the interlayer is heated to supplement the heat required for the lysozyme to convert from liquid to gaseous state. After the pressure of the extraction tank drops to 0Mpa, use a vacuum pump to evaporate under negative pressure until the pressure drops below -0.09MPa, open the mouth of the extraction tank, and take out the residue.

(8) After the mixed oil is decompressed and evaporated to 0Mpa by the compressor, it is also converted to vacuum pump for negative pressure evaporation until the pressure of the evaporation tank is below -0.09Mpa, and the extracted fat-soluble substances can be discharged from the lower part of the evaporation tank. .

(9) After the above parameters are set on the control panel, the device can automatically complete the extraction process according to the process requirements; the above steps can also be completed by manual operation.

Advantage of the utility model:

(1) The device of the utility model can meet the requirements of various subcritical fluid extraction processes, and can make experimental devices or pilot devices of different scales according to the needs; PLC control is adopted, and the degree of automation is high; the tank body adopts a quick-opening door structure design, easy to operate , Maintenance is very simple.

(2) The device of the present utility model belongs to the scope of medium and low pressure pressure vessels, which greatly reduces the technical difficulty and engineering cost of the device manufacturing process; and the operating cost is low, the relative output is large, and it is suitable for extraction experiments and research of various materials. It is easy to promote and apply in universities, research institutes and enterprises.

(3) The method based on the utility model utilizes the lower characteristic of the subcritical fluid boiling point, and by improving the vacuum degree of the process, the extraction solvent is evaporated rapidly at a temperature of 10 to 50° C., which improves the solvent recovery rate and reduces the solvent loss, reducing energy consumption; and the extraction is carried out under airtight conditions, so the "heat-sensitive" ingredients will not be denatured and oxidized, which is an ideal process for the quality-guaranteed extraction of natural product functional ingredients.

(4) The method based on the utility model can flexibly select different subcritical extraction media according to different extraction objects; meanwhile, multiple extraction methods can be flexibly selected according to the content of the target substance in the raw material.

(5) The processing flow based on the method of the present utility model is completed under a relatively safe medium and low pressure state, the effective volume of the equipment is less restricted by the processing technology, and the safety performance index of the system is relatively improved. At the same time, there are no "three wastes" in production Pollution" is an environmental protection project.

(6) The device and method of the present invention combine subcritical fluid extraction technology with ultrasonic extraction technology, which can significantly increase the extraction rate, shorten the extraction time, and not destroy the functional components. Prospects for new techniques for the extraction of active ingredients from natural products.

Description of drawings:

Fig. 1 is the structural representation of the subcritical fluid extraction device of the active ingredient of the natural product of the present invention, wherein 1 is an extraction tank, 2 is an evaporation tank, 3 is a buffer tank, 4 is a condenser, 5 is a solvent tank, and 6 is hot water Box, 7 is a hot water pump, 8 is a compressor, 9 is a vacuum pump, 10 is a flame arrester, 11 is an ultrasonic generating device, 12 is a quick opening device for an extraction tank, and 13～34 are regulating valves.

Detailed ways

Below in conjunction with embodiment the utility model is described in detail.

Example 1 Subcritical Liquefied Petroleum Gas Extraction of Natural Greenthorn Fruit Oil

Take 2.5kg of natural green sorrel fruit, the raw material contains 0.3% impurities after pretreatment, the thickness of the embryo sheet is 0.35mm, the water content is 8.5%, and the temperature is 45°C. Then subcritical liquefied petroleum gas was used as the lysozyme to extract the thorn fruit oil, the extraction temperature was 45°C, the extraction time was 45 minutes, and the extraction times were 5 times. The mixed oil is decompressed and gasified, and when it reaches 0Mpa (gauge pressure), it is vacuumed and precipitated. When the gauge pressure is -0.09MPa, it is kept at a temperature of 45°C for 30min. The wet material embryo is decompressed and gasified, and the lysozyme is recovered by compression. Determination results of the main quality indicators of the green thorn fruit oil: 0.85ppm residual solubility in the oil; 0.1% impurity; 2.0% oil content in the meal; 222ppm residual solubility in the meal.

Example 2 Ultrasonic-assisted subcritical propane extraction of natural green thorn fruit oil

Take 2.5kg of natural green sorrel fruit, the raw material contains 0.3% impurities after pretreatment, the thickness of the embryo sheet is 0.35mm, the water content is 8.5%, and the temperature is 45°C. Then subcritical propane was used as the lysozyme, and the thorn fruit oil was extracted with ultrasonic assistance. The extraction temperature was 45°C, the extraction time was 30 minutes, the extraction times were 3 times, the ultrasonic power was 1500W, and the ultrasonic frequency was 20KHz. The mixed oil is decompressed and gasified, and when it reaches 0Mpa (gauge pressure), it is vacuumed and precipitated. When the gauge pressure is -0.09MPa, it is kept at a temperature of 45°C for 30min. The wet material embryo is decompressed and gasified, and the lysozyme is recovered by compression. Determination results of the main indicators of green thorn fruit oil: residual solubility in oil is 0.85ppm; impurity content is 0.1%; oil content in meal is 1.2%; residual solubility in meal is 195ppm.

Example 3 Subcritical Propane and Butane Extraction of Wheat Germ Oil

Take 2.5kg of wheat germ, after cleaning, microwave drying and other pretreatments, the impurity content is 0.15%, and the water content is 7.5%. Using subcritical propane and butane, the extraction is carried out according to the countercurrent three-immersion process. The first and second times are respectively extracted with the second and third times of mixed oil leached from the previous tank, and each time is soaked for 35 minutes. The mixed oil leached in the first pass is pumped into the evaporation tank, and the other two passes are pumped into the buffer tank. The leaching temperature is room temperature, the pressure is 0.4MPa, the ratio of material to solution is 1:2.5, and the ratio of propane to butane is 3:1. When the mixed oil evaporates, the temperature of the circulating hot water is controlled below 50°C, and when it reaches 0Mpa (gauge pressure), it is vacuumed and precipitated. When the gauge pressure is -0.09MPa, it is kept at a temperature of 45°C for 30min. Control the heating temperature below 50°C for wet meal desolventization, and the obtained wheat germ protein is a high-grade food additive. Measuring results of main indicators of wheat germ oil: residual soluble in oil 0.75ppm; impurity 0.2%; oil in meal 0.9%; soluble in meal 402ppm.

Example 4 Subcritical tetrafluoroethane countercurrent extraction of tomato seed oil

Take 2.5 kg of tomato seeds, after pretreatments such as cleaning, softening, and embryo rolling, they contain 0.15% impurities, 0.30mm thickness of embryo slices, and 9.5% water content. Subcritical tetrafluoroethane is used to extract according to the countercurrent four immersion process. The first, second and third times are respectively extracted with the second, third and fourth times of mixed oil leached from the previous tank. Soak all over for 35 minutes. The mixed oil leached in the first pass is pumped into the evaporation tank, and the remaining three passes are pumped into the buffer tank. The leaching temperature is room temperature, the pressure is 1.25MPa, the ratio of material to solution is 1:1.5, and 1.5% absolute ethanol is added. When the mixed oil is evaporating, the temperature of the circulating hot water is controlled below 60°C, and when it reaches 0Mpa (gauge pressure), it is vacuumed and precipitated. When the gauge pressure is -0.09MPa, it is kept at a temperature of 45°C for 30min. Control the heating temperature below 50°C for the desolvation of the wet meal, and the obtained tomato seed meal is a high-grade food additive. Determination results of main indicators of tomato seed oil: residual soluble in oil 0.85ppm; impurity 0.1%; oil in meal 1.2%; soluble in meal 314ppm.

Claims (3)

1. the subcritical fluid extraction device of active ingredient of natural product, constitute by control system part and leaching components of system as directed, it is characterized in that described leaching components of system as directed is made of extractor (1), evaporator (2), surge tank (3), condenser (4), solvent tank (5), ultrasonic generating means (11), vavuum pump (9), spark arrester (10), compressor (8), heat-exchanger pump (7), boiler (6); Wherein extractor (1) one end is connected with solvent tank (5) by control valve (17), (25) and pipeline, utilizes pressure reduction with the liquid lyase input extractor (1) in the solvent tank (5); The other end is connected with evaporator (2) with pipeline by control valve (19), and the mixture that extracts product and lyase is entered in the evaporator (2); Vavuum pump (9) one ends are connected with extractor (1), evaporator (2), surge tank (3) respectively with control valve (13), (14), (20), (21) by pipeline, and the other end is connected with spark arrester (10) by pipeline; One end of compressor (8) is connected with surge tank (3) with control valve (22) by pipeline, and surge tank (3) is connected with extractor (1), evaporator (2) with control valve (14), (21) by pipeline again, with the gasification of reducing pressure of liquid lyase; The other end is connected with condenser (4) with control valve (15) by pipeline, with compressed gaseous state lyase cooling liquid; The other end of condenser (4) is connected with solvent tank (5) with control valve (18) by pipeline, with the lyase injection solvent tank (5) of liquefaction; Ball valve (33), (34) are respectively the import and export of recirculated cooling water; Heat-exchanger pump (7) one ends are connected with boiler (6) respectively with control valve (28) by pipeline; The other end is connected with the heating jacket of extractor (1), evaporator (2) bottom with control valve (26), (29) by pipeline, for lyase gasification liquid in extractor (1), the evaporator (2) provides heat and is used for guaranteeing that extractor is in temperature constant state; Wherein extractor (1) top is provided with ultrasonic generating means (11), and ultrasonic generator (11) places the outside of described extractor (1), and the transducing head of ultrasonic generator (11) places the top of extractor (1); Wherein said extractor (1) is the cylindric device of the stainless steel of high temperature resistant, high pressure, the extraction cover adopts extractor quick-opening device (12), with polytetrafluoroethylmaterial material as sealing ring, extractor (1) bottom has a stainless steel filtering net, lower end to have an outlet to link to each other with evaporator (2) by pipeline; Described evaporator (2), surge tank (3), solvent tank (5) are the cylindric or rectangular-shaped container of stainless steel; Described boiler (6) is the cylindrical or rectangular devices of stainless steel or plastic material; Described condenser (4) is a chimney cooler, cools off by continuous feeding cooling water, and the cooler downside is provided with a cooling water inlet, and upside has a coolant outlet.

2. the subcritical fluid extraction device of active ingredient of natural product according to claim 1 is characterized in that described compressor (8) is a diaphragm type compressor, can regulate and show the pressure size, and pressure limit is 0～20MPa.

3. the subcritical fluid extraction device of active ingredient of natural product according to claim 1, it is characterized in that extractor (1), evaporator (2), surge tank (3), condenser (4) and solvent tank (5) are provided with pressure tester, extractor (1), evaporator (2), surge tank (3) also are provided with the temperature measuring device of electric contact type, and pressure tester and temperature measuring device all have an end to be located at a jar inside.

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