CN1981882B - Equipment for treating tumor by inputting air - Google Patents
Equipment for treating tumor by inputting air Download PDFInfo
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- CN1981882B CN1981882B CN2006100786490A CN200610078649A CN1981882B CN 1981882 B CN1981882 B CN 1981882B CN 2006100786490 A CN2006100786490 A CN 2006100786490A CN 200610078649 A CN200610078649 A CN 200610078649A CN 1981882 B CN1981882 B CN 1981882B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M2005/006—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for gases, e.g. CO2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1407—Infusion of two or more substances
- A61M5/1408—Infusion of two or more substances in parallel, e.g. manifolds, sequencing valves
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Abstract
A gas input method for treating tumor includes such steps as inputting high-pressure oxygen to the tumor position, cyclically inputting the anoxic air at short intervals for the acclimatization of normal cells to anoxia, holding the anoxia state for a long time for killing tumor cells while inputting saccharide to normal cells, and inputting high-pressure oxygen for repairing normal cells. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of tumor treatment method, relate in particular to a kind of method for the treatment of at tumor site input gas.The invention still further relates to a kind of equipment for the treatment of tumor by inputting air simultaneously.
Background technology
Human beings'health and life in the tumor serious threat.Tumor also is the cell of body, finds no qualitative difference between tumor cell and the normal cell aspect ultrastructure so far, and the difference of the amount of having only, both are only variant on differentiation degree and special-shaped degree.Tumor cell is different from Normocellular main part and shows as two aspects:
1, naivety: the tumor cell differentiation degree is low, has heteromorphism, loses polarity; Active growth.Tumor cell also shows heterogeneity.
2, wellability: tumor cell does not have peplos, has dilatancy.
Therefore, tumor cell is different from normal cell, can reduce intrinsic naivety, heterogeneity and external wellability.With inmature, heterogeneous relevant having: differentiation degree is low.Characteristics with stem cell, unlimited outgrowth potential is arranged, and (cancer stem-cell hypothesis is thought: tumor derives from stem cell, has tumor stem cell in the tumor.The oncocyte that has minute quantity in the tumor tissues serves as the role of stem cell in tumor, the long-term existence by self renewal, even follow the whole process of life.)。Vicious transformation will take place through inducing 4-7 sudden change of generation in single cell.The naivety of tumor cell also shows as: development degree is poor, and a little less than the repair ability, blood vessel is imperfect, and neurocyte and myocardial cell all are less than normal cell.Often for want of innervation and smooth muscle cause the tumor tissues blood vessel wall to lack and shrink; Tumor tissues is to vasoactive agent and outside stimulus poor response.Tumor tissues draining vein hypoplasia.The tumor neogenetic capillary endothelial is imperfect, or does not have endothelium formation blood sinus, and hemodynamics disorder in the blood vessel endothelium rough surface, tumor area easily forms irregular eddy current.Tumor area often lacks normal lymphoid tissue, has or not the streak lymphatic vessel of function.Tumor area often lacks monokaryon-phagocyte system.The variation of tumor cell mitochondrion, cyclophorase biochemical activity be defectiveness also.There is hypoxic cell in the tumor tissues that has.The tumor center that has is in the hypoxia attitude and the edge is in normal oxygen attitude.Other heterogeneity also show as tumor by be in cell cycle not simultaneously mutually each tumor cell form.
Relevant with wellability has: tumor cell does not have peplos usually, organization internal pressure height, and profile is irregular, and is polygonal, and irregular microvillus can appear in cell surface, and tumor cell can produce more laminin receptor.Tumor tissue growth is rapid, metabolism disorder, based on the metabolism of waste type, consumes the body nutrient substance in a large number.
Above-mentioned technology is quoted below with reference to data:
" Clinical Oncology outline " chief editor Zhu Xiong increases publishing house of Fudan University
" interventional radiology---basis and method " chief editor Li Lin sweet-smelling grass People's Health Publisher
" treatment of clinical tumor biological immune " chief editor Shang Wei Tianjin science tech publishing house
Publishing house of the female Shanghai Univ. of Traditional Chinese Medicine of " modern Chinese medicine oncology " chief editor Yang Jin
Oxygen is the central pivot point that life process is rely and kept, and is all cells Source of life.Bigger than oxygen for the human life to the influence of life without any a kind of other materials (comprising food, medicine).
The stem cell proliferation of single sudden change forms tumor needs 1 year, and after tumor cell started " apoptosis " program, a hour cell could be dead.In case and anoxia is serious, a few minutes just can cause cell death, without any a kind of radiotherapy, chemotherapy effect like this can be arranged.
Human in anoxia, hypoxia, hyperbaric oxygen to aspect the influence of body, tissue and cell, very deep understanding has been arranged.
One. anoxia, hypoxia (hypoxia is the state that partial pressure of oxygen is lower than partial pressure of oxygen under the atmospheric pressure)
The adaptations of human body, tissue mainly is after the anoxia: increase vascularization, increase myoglobin content; Change the activity of oxidoreductase system in the tissue, effectively utilize utilizable oxygen, provide more energy to cell; Reduce the aerobic metabolism process, conserve energy.Even open up another energy channel: sugared anerobic glycolysis, obtain energy.
Studies have shown that: of short duration in advance, slight, repetition hypoxia is handled (being called for short hypoxia stimulates) and can be triggered human body, organize intrinsic protective capacities, thereby severe hypoxia is subsequently damaged generation powerful defence and protective effect.
Above-mentioned technology is quoted " anoxia pre-adaptation: a kind of new concept and New Policy of anoxia control " medical science publishing house of the luxuriant Peking University of chief editor Lu Kingdom
Two. hyperbaric oxygen (hyperbaric oxygen is the state that partial pressure of oxygen is higher than partial pressure of oxygen under the atmospheric pressure)
Studies confirm that: hyperbaric oxygen does not quicken growth of tumor; Hyperbaric oxygen has the effect of accelerating wound healing, damaged tissue repair, promotion nervous cell regenerating.Hyperbaric oxygen can suppress the multiple metabolic response of antibacterial, thereby has slowed down the growth of antibacterial, and the effect of bactericidal is arranged.Report, adopt hyperbaric oxygen can suppress abnormal development unexpectedly, and the tumor that abnormal development is caused is prolonged an appearance in month.
Above-mentioned technology is quoted " practical hyperbaric oxygen medical science " [U.S.] ERIC P.KINDWALLHARRY T.WHELAN chief editor Gao Chunjin, Guo Guoming master translates publishing house of The Fourth Military Medical University
As previously mentioned, tumor is difficult to cure reason and is: tumor by be in cell cycle not simultaneously each tumor cell of phase form.The cell hypoxia that wherein has, insensitive to radiotherapy; The cell that has approaches dormant state, breed low, insensitive to chemotherapy.The difference of oxygen, nutrient environment is relevant in the heterogeneity of tumor cell and the tumor tissues, and hypoxia and nutrition supply deficiency can promote evolution to become the higher tumor cell of malignant phenotype again.Tradition intracavitary administration chemotherapy, only porous is to 1-3 mm depths of tumor for medicine, and therapeutic effect is very undesirable, simultaneously the injuring normal cell that radiation and chemotherapy also can be in various degree.
Summary of the invention
In order to solve the problem of above-mentioned existence, the weakness that the objective of the invention is according to tumor is naivety, and its development degree is poor, a little less than the repair ability, can not in time respond environment change, makes the adjustment of cell function.Tumor vessel growth simultaneously is imperfect, and there has been hypoxic cell in poor activity in the tumor, and tumor cell will never be to there being adaptive ability as normal cell after the anoxia, to the input of hyperbaric oxygen, tumor cell can not in time respond, but hysteresis delay a period of time just begins increment.Thereby the present invention utilizes the characteristic and the defective of tumor cell, provides a kind of gas input that tumor cell is killed, and reaches the method for treatment tumor.
Technical scheme of the present invention is achieved in that a kind of method for the treatment of tumor by inputting air, and the hypoxia that the input low-oxygen gas carries out gas input in tumor tissues stimulates, low oxygen therapy course of treatment.
Described low-oxygen gas refers to gases such as noble gases such as nitrogen, helium and carbon dioxide, is referred to as low-oxygen gas.
For reach better therapeutic effect before the input low-oxygen gas at first at tumor site input hyperbaric oxygen, such once being to cause tumor proliferation growth (retardation on the contrary); The 2nd, make all be in the anoxia attitude thereby, especially make the differentiation of minority tumor stem cell, maturation near the tumor cell of dormancy, make it normalization.Not each cell normalization of phase simultaneously of tumour cell cycle, all make it enter the period of development; The hyperbaric oxygen input makes all cells break away from the anoxia attitude; After hyperbaric oxygen is handled, tumor cell proliferation is before the phase, carry out of short duration, slight, repetition hypoxia input stimulus process at once, in the meantime, make tumor normal structure on every side protect the adaptive capacity that forms in the stimulation later longer-term low-oxygen environment, and make the adjustment in advance of cell tissue at hypoxia; And in this hypoxia stimulated, because the imperfection of tumor cell, tumor cell can not form the protective capacities to hypoxia; Because the hypoxia degree of tumor site more very, thereby in this process, many death of neoplastic cells have been arranged; Carry out the long period hypoxia process of suitable intensity and time subsequently, the kill tumor cell; The intensity of hypoxia and time, not injuring normal cell around the tumor tissues substantially, and tumor is can not be too fast dead to cause neoplasm necrosis, to fester, take place complication such as hemorrhage, infection and be advisable, and is less for tumor tissues, the state of an illness is than the lighter, and the hypoxia time is several hrs or one day or several days.Bigger for tumor tissues, be in a bad way, the hypoxia time can reach some months or 1 year.In longer hypoxia process,, provide normal cell desired material in ready prepd-sugared anerobic glycolysis process in hypoxia stimulates to the input of the normal cell around tumor tissues sugar.Import hyperbaric oxygen at last again, repair normal cell, accelerating wound healing.
The gas of being imported in the hypoxia input stimulus process is noble gas, carbon dioxide such as nitrogen, helium.
The gas of preferred input is carbon dioxide, because carbon dioxide dissolubility of carbon dioxide in blood is big, is easy to by blood transport.Carbon dioxide uses for many years as contrast agent, and the danger of little formation aeroembolism.
Described hypoxia is by noble gas such as nitrogen or carbon dioxide input tumor site, causes the reduction with partial pressure of oxygen of increasing of oxygenless gas noble gas or carbon dioxides such as () nitrogen dividing potential drop after the input, thereby produces hypoxia.
How gas discharges from blood, parts of body diffusion, and human had deep research from theory and practice already in a large amount of deep sea diving experience.
The experiment of big flow gas input dog human body can be used as the safe quantitative reference frame of gas input.People such as Ilyin report is imported up to two liters of gases to dog with the speed of 30 milliliters of per minutes by vein, and dog any symptom can not occur.
The mathematical expression of gas diffusion is:
The gas of the input of being spread finally enters the breathing release of the blood vessel of human body by lung.Because the amount of input gas is very little, approximately per minute is less than one milliliter, to blood vessel, all almost not influences of lung of human body.As long as control input bubble is not too big, the absorption of human body--diffusion is no problem.Because what need most protection in the tumor site normal surrounding tissue is the blood vessel of human body, and this blood vessel place is easy to take away by blood by diffusion gas, thus the hypoxia degree at this blood vessel place much smaller than other zones, blood vessel can not be subjected to big damage naturally.And the intrinsic pressure height of tumor tissues means that the meltage of importing gas is big; Tumor does not have film again, and many mucus are polygonal, and microvillus is arranged, and at this moment the wellability of tumor can only make it enter the higher state of input gas concentration.These physical characteristics all make tumor site can be in darker hypoxia attitude, and the damage of tumor cell hypoxia is bigger.And normal cell is less relatively.The gas input point is again in tumor center, and on CONCENTRATION DISTRIBUTION, the concentration at tumor center place is also inevitable the highest.Therefore make tumor site import the concentration maximum of gas, and normal structure is less, the important vessel place is just littler, reaches better therapeutic effect, and to almost not influence of normal structure.
Another object of the present invention provides a kind of equipment for the treatment of tumor by inputting air, this equipment comprises gas delivery part and gas input pin, wherein the gas delivery part is made up of gas tank, air relief valve, piezometer, flow control valve, flow detecting element, stop valve, air relief valve one end connects gas tank, other end connection traffic control valve, between air relief valve and flow control valve piezometer is set, the flow control valve lower end is connected with gas input pin by flexible pipe and pipe joint.
When many gases are imported, flow control valve lower end connection traffic detecting element, the flow detecting element lower end connects stop valve, and stop valve is connected with gas input pin by flexible pipe and pipe joint.
Described gas tank is noble gas jar, carbon dioxide tank or other required gas tank such as hyperbaric oxygen jar, nitrogen, comprises the chemotherapy gas tank.
Described flow control valve is adjustable throttling, automatically controlled flow control valve or high-speed switch valve.
Described flow detecting element adopts effusion meter or flow transducer.
A gas importation can connect one or more gas input pins, and a gas input pin can be connected with one or more gases importation simultaneously.
Described gas input pin, comprise base, needle body seat, stop valve, vent valve, syringe needle, wherein needle body seat top has injection well, one side of needle body seat has blind hole, the front portion of blind hole intersects with injection well and passes injection well, the upper end of injection well is and flexible pipe and the corresponding screw thread of pipe joint, the lower end of injection well is connected with syringe needle, stop valve tiltedly embeds in the blind hole of needle body seat, vent valve places the centre bore of stop valve, the O RunddichtringO is housed on the circumference of stop valve, and the O RunddichtringO is positioned at the annular groove of needle body seat; The needle body seat snaps on the base of hollow.
The gas input function that pin had: 1, venting promptly bleeds off initial air in flexible pipe and the tubular joint 7 and other can not import the gas of human body; 2, because there is the stop valve can be when when venting or insertion pipe by the gas of importing syringe needle.3, gas input pin can not destroy tissue with normal, the slight activity of human body, and has the long period in human body.Insert the displacement that the syringe needle of tumor can not the normal input of influential gas, also do not break away from tumor.The syringe needle part can suitably be moved and crooked with human body muscle, and the rotation bus of class tapered needle meets the mechanical characteristic that inserts the when injected organism tissue place, guarantees that syringe needle is normal crooked with muscular movement.If it is not dark to puncture, syringe needle also can be the thinner common tubulose syringe needle of diameter.
Compared with prior art, the invention has the beneficial effects as follows:
1, Shu Ru gas mostly is the avirulence gas that health is not had coup injury, and oxygen, nitrogen, carbon dioxide all are already at the gas of cell internal recycle.Gas itself is not poisonous, can the organ of the breathing of health, digestion, liver, kidney not caused damage;
2, gas molecule volume little (molecular weight is little) is easy to excrete by blood, lung at the human body internal diffusion.If wish to discharge more hurry up, can select littler noble gas of molecular weight such as helium (also in deep sea diving, having used already).And the molecular weight of chemotherapy liquid is big, and the row of stagnating also need pass through liver, kidney metabolism, and it is very big that health is caused the toxicity injury.
Description of drawings
Fig. 1 is for open loop of the present invention is controlled, many gas input structure sketch map;
Fig. 2 is closed loop control gas input partial structurtes sketch map;
Fig. 3 controls a kind of gas multiple spot input structure sketch map for open loop;
Fig. 4 is gas input needle construction sketch map;
Fig. 5 is the high-speed switch valve structural representation.
The specific embodiment
Below in conjunction with the drawings and specific embodiments the present invention is described in further detail, but not as a limitation of the invention.
At first, learn diagnosis, ultrasonic diagnosis, radionuclide diagnosis, endoscopic diagnosis and tumor markers and relevant clinical check, determine the distance of position, volume, character and the vitals tissue of tumor by tumor imaging according to the modern diagnosis technology.Determine the length of puncture position, direction and piercing needle 10, determine the puncture operation plan.Under the guiding of above-mentioned instrument (fluoroscopic guidance, ultrasonic guidance, conventional CT guiding, real-time ct fluoroscopy system guiding, MR guiding), with modern times intervention and puncture technique, the piercing needle insertion tumor center place of gas input pin of the present invention.Also can insert several gas input pins to a tumor as required.Gas is imported pin be fixed on the human body, at first import hyperbaric oxygen,, all make it enter the period of development not each cell normalization of phase simultaneously of tumour cell cycle.The hyperbaric oxygen input makes all cells break away from the anoxia attitude.After hyperbaric oxygen is handled, before the tumor cell proliferation phase arrives, carry out at once of short duration, slight, repeat to import the hypoxia stimulating course; Carry out the longer hypoxia process of suitable intensity and time, kill tumor cell subsequently according to the state of an illness and doctor's clinical experience.The intensity of hypoxia and time, not injuring normal cell around the tumor tissues substantially, and tumor is can not be too fast dead to cause neoplasm necrosis, to fester, take place complication such as hemorrhage, infection and be advisable. Import hyperbaric oxygen at last again, repair normal cell, accelerating wound healing.
Shown in Fig. 1-5, gas input can be with open-loop control system, also can use closed-loop control system.Open loop control: at first set gas flow and the integrated flow that needs, detect flow with effusion meter 5; Regulate adjustable valve member 4, meet the requirements of gas flow; Control integrated flow input time well by control simultaneously.Closed loop control is more accurate, at any time round-off error; And can work out loading routine, the mode of follow procedure control is controlled the whole input process of gas automatically.The hardware of closed-loop control system mainly is made up of automatically controlled Flow-rate adjustment valve member 42 and flow sensing device 52 except gas tank, air relief valve, piezometer.Carry out algebraic operation 53 pairs of input signals of adder and feedback signal comparison the time among Fig. 2,54 is amplifier.Automatically controlled Flow-rate adjustment valve member 42 also can be replaced by speed-sensitive switch valve member 43.But the control mode of high-speed switch valve is pulsewidth modulation, rather than the mode of Linear Control.The speed-sensitive switch valve arrangement can be the automobile oil nozzle structure, and used material meets the medical sanitary standard.
Gas in the gas tank 1 is through 2 decompressions of traditional decompression valve member, as the input source of the gas; Post-decompression gas pressure is detected by piezometer 3.Gas through flexible pipe and pipe joint 7 input gas input pins 8, and injects human body through the flow control of open loop or closed loop.
As shown in Figure 1, be open loop control, many gas input system structural representation, generally will carry out the gas loading routine of hyperbaric oxygen, hypoxia stimulation, also can carry out the input treatment of other multiple gases, in this process, sometimes need the input of certain gas of temporary close, so be provided with stop valve 6 in the equipment as switch.
Fig. 3 is the schematic diagram of open loop control, long period, the input of a kind of gas two point.It is the mode of long period input gas.According to the needs of treatment tumor, can select the gas input point of 1,2 even a plurality of treatment tumors, one or more gases input pins 8 are inserted human bodies, input simultaneously.Also can select the input (schematic diagram slightly) of multiple gases long period.Before open loop control, long period input gas, need reckon by the piece 5 or the flow of flow sensing device 52 verifications input gas with flow, demarcate input flow rates by adjusting adjustable valve member 4.
As shown in Figure 4, gas input pin comprises base 15, needle body seat 11, stop valve 12, vent valve 13, syringe needle 10, wherein needle body seat 11 tops have injection well 16, one side of needle body seat 11 has blind hole 17, the front portion of blind hole 17 intersects with injection well 16 and passes injection well 16, the upper end of injection well 16 is and flexible pipe and pipe joint 7 corresponding screw threads, the lower end of injection well 16 is connected with syringe needle 10, stop valve 12 tiltedly embeds in the blind hole 17 of needle body seat 11, vent valve 13 places the centre bore of stop valve 12, O RunddichtringO 14 is housed on the circumference of stop valve 12, and O RunddichtringO 14 is positioned at the cannelure 17 of needle body seat 11; Needle body seat 11 snaps on the base 15 of hollow.
When stop valve 12 is in rest position, air vent 18 also just in time aligns injection well 16, this moment is along with the screw thread rotation of vent valve 13, bleed passage is opened, groove and the thread pitch of d/d gas by opening on the annular gap between stop valve 12 and the vent valve 13 and venting screw thread and the relative stop valve screw thread bleeds off d/d gas.Vent valve 13 close then be with respect to the venting direction of rotation opposite spin; Taper seat on the vent valve 13 will seal bleed passage.Stop valve 12 also is by the taper seat on it injection well 16 air flues to be sealed.Along with the screw thread on the stop valve 12 with respect to the opposite spin of closing, will open injection well 16 air flues.O RunddichtringO 14 on stop valve 12 circumference is in the annular groove of needle body seat 11, annular gap between its sealing needle body seat 11 and the stop valve 12, guarantee no matter to be in by or be in opening, the gases in the gas input pin 8 can not leak in the atmosphere.
Can bendings except syringe needle 10, also need, reliably, be fixed on the human body easily gas input pin safety.So base 15 lightweights, area are bigger, can be fixed on base 15 on the human body, can firmly fix needle body seat 11 again.Base element 15 areas are bigger, and are customized by relative human body shape with the human body contact surface.Fixing reliable in order to guarantee, available medical double faced adhesive tape, medical adhesive tape or other method are fixed on base 15 on the human body.Base 15 has tapering with needle body seat 11 contact positions, utilizes this tapering, and needle body seat 11 can make things convenient for, be fixed on reliably on the base 15.As long as base 15 does not break away from human body, needle body seat 11 all will fixedly secure on base 15.Pad 9 is set below the needle body seat among Fig. 4, and pad 9 can be made with the flexible material that the anti-inflammatory analgetic effect is arranged, and can play the anti-inflammatory analgetic effect to the syringe needle wound, can be used as the cushion pad of needle body seat 11 again, the pressure of 11 pairs of human bodies of buffering needle body seat.The length of syringe needle 10 is consistent to the distance of tumor center with skin surface.The screw thread that is connected with flexible pipe and tubular joint 7 is arranged at needle body seat 11 tops.The conduit that the screw thread place needs in the time of also fixing a puncture.There is a through hole to can be used as gas or liquid input hole in the syringe needle 10, also can be used as interposing catheter and penetrate seal wire, convenient puncture operation.The axis of stop valve 12 centre bores and the axis of injection well 16 are non-perpendicular to intersect, about 75 degree of its angle of intersection.Such benefit is: be convenient to open and close stop valve 12 and vent valve 13 during use.Syringe needle 10 can be with the money base soldering, high-strength adhesive is bonding or the technology of laser weld and needle body seat 11 firmly connect as one.
Claims (9)
1. the equipment of a treating tumor by inputting air, it is characterized in that this equipment comprises gas delivery part and gas input pin, wherein the gas delivery part is made up of gas tank, air relief valve, piezometer, flow control valve, flow detecting element, stop valve, air relief valve one end connects gas tank, other end connection traffic control valve, between air relief valve and flow control valve piezometer is set, the flow control valve lower end is connected with gas input pin by flexible pipe and pipe joint.
2. the equipment of a kind for the treatment of tumor by inputting air according to claim 1, it is characterized in that described flow control valve lower end connection traffic detecting element, the flow detecting element lower end connects stop valve, and stop valve is connected with gas input pin by flexible pipe and pipe joint.
3. the equipment of a kind for the treatment of tumor by inputting air according to claim 1 is characterized in that described gas tank is hyperbaric oxygen jar, nitrogen pot, helium jar or carbon dioxide tank.
4. according to the equipment of claim 1,2 or 3 described a kind for the treatment of tumor by inputting air, it is characterized in that described flow control valve is adjustable throttling, automatically controlled flow control valve or high-speed switch valve, described flow detecting element adopts effusion meter or flow transducer.
5. according to the equipment of claim 1,2 or 3 described a kind for the treatment of tumor by inputting air, it is characterized in that an one or more and gas importation of described gas input pin is connected.
6. according to the equipment of claim 1,2 or 3 described a kind for the treatment of tumor by inputting air, it is characterized in that a while of described gas input pin is connected with one or more gases importation.
7. according to claim 1, the equipment of 2 or 3 described a kind for the treatment of tumor by inputting air, it is characterized in that described gas input pin, comprise base, the needle body seat, stop valve, vent valve, syringe needle, wherein needle body seat top has injection well, one side of needle body seat has blind hole, the front portion of blind hole intersects with injection well and passes injection well, the upper end of injection well is and flexible pipe and the corresponding screw thread of pipe joint, the lower end of injection well is connected with syringe needle, stop valve tiltedly embeds in the blind hole of needle body seat, the venting valve member places the centre bore of stop valve, and the O RunddichtringO is housed on the circumference of stop valve, and the O RunddichtringO is positioned at the annular groove of needle body seat; The needle body seat snaps on the base of hollow.
8. the equipment of a kind for the treatment of tumor by inputting air according to claim 6, the injection well axis that it is characterized in that described gas input pin are 75 with the axis of stop valve, vent valve and spend the angles of cut.
9. the equipment of a kind for the treatment of tumor by inputting air according to claim 4 is characterized in that described high-speed switch valve adopts the automobile oil nozzle structure, is to be processed by the material that meets medical standard.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100786490A CN1981882B (en) | 2006-04-29 | 2006-04-29 | Equipment for treating tumor by inputting air |
| PCT/CN2007/000814 WO2007124653A1 (en) | 2006-04-29 | 2007-03-14 | Method and device for treating tumor by gas feeding |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100786490A CN1981882B (en) | 2006-04-29 | 2006-04-29 | Equipment for treating tumor by inputting air |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1981882A CN1981882A (en) | 2007-06-20 |
| CN1981882B true CN1981882B (en) | 2011-02-16 |
Family
ID=38164907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006100786490A Expired - Fee Related CN1981882B (en) | 2006-04-29 | 2006-04-29 | Equipment for treating tumor by inputting air |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN1981882B (en) |
| WO (1) | WO2007124653A1 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1218697A (en) * | 1997-12-05 | 1999-06-09 | 李灵山 | Tumor curing instrument importing Chinese drug ion at high temperature |
| CN1537646A (en) * | 2003-10-22 | 2004-10-20 | 高春平 | Tumour local comprehensive therepy method and device |
| CN1541628A (en) * | 2003-04-29 | 2004-11-03 | 陈绍勇 | Constantly high temperature high pressure oxygen bed microwave treating device for cancer prevention and treatment |
| WO2004093945A1 (en) * | 2003-04-22 | 2004-11-04 | Antisense Pharma Gmbh | Portable equipment for administration of fluids into tissues and tumors by convection enhanced delivery technique |
-
2006
- 2006-04-29 CN CN2006100786490A patent/CN1981882B/en not_active Expired - Fee Related
-
2007
- 2007-03-14 WO PCT/CN2007/000814 patent/WO2007124653A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1218697A (en) * | 1997-12-05 | 1999-06-09 | 李灵山 | Tumor curing instrument importing Chinese drug ion at high temperature |
| WO2004093945A1 (en) * | 2003-04-22 | 2004-11-04 | Antisense Pharma Gmbh | Portable equipment for administration of fluids into tissues and tumors by convection enhanced delivery technique |
| CN1541628A (en) * | 2003-04-29 | 2004-11-03 | 陈绍勇 | Constantly high temperature high pressure oxygen bed microwave treating device for cancer prevention and treatment |
| CN1537646A (en) * | 2003-10-22 | 2004-10-20 | 高春平 | Tumour local comprehensive therepy method and device |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007124653A1 (en) | 2007-11-08 |
| CN1981882A (en) | 2007-06-20 |
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Owner name: TIANJIN DADE ENVIRONMENTAL ENGINEERING CO., LTD. Free format text: FORMER OWNER: DADA FOUNTAIN SCIENCE + TECHNOLOGY CO., LTD., TIANJIN Effective date: 20101124 |
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Effective date of registration: 20101124 Address after: 300402, Tianjin Beichen science and Technology Park, Vanke Huayuan Road No. 6 Applicant after: Tianjin Deeduck Environmental Engineering Co., Ltd. Address before: 300402, Tianjin Beichen science and Technology Park, Vanke Huayuan Road No. 6 Applicant before: Dada Fountain Science & Technology Co., Ltd., Tianjin |
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