CN1973849A - Medicine composition for inducing diuresis to treat stranguria and its prepn process - Google Patents
Medicine composition for inducing diuresis to treat stranguria and its prepn process Download PDFInfo
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- CN1973849A CN1973849A CNA2006101680775A CN200610168077A CN1973849A CN 1973849 A CN1973849 A CN 1973849A CN A2006101680775 A CNA2006101680775 A CN A2006101680775A CN 200610168077 A CN200610168077 A CN 200610168077A CN 1973849 A CN1973849 A CN 1973849A
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- 239000003814 drug Substances 0.000 title claims abstract description 16
- 208000004880 Polyuria Diseases 0.000 title claims abstract description 6
- 230000035619 diuresis Effects 0.000 title claims abstract description 6
- 230000001939 inductive effect Effects 0.000 title claims abstract description 6
- 238000000034 method Methods 0.000 title claims description 11
- 229940079593 drug Drugs 0.000 title claims description 9
- 239000000203 mixture Substances 0.000 title abstract description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- 239000002775 capsule Substances 0.000 claims abstract description 5
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims abstract description 4
- 201000007094 prostatitis Diseases 0.000 claims abstract description 4
- 241001243091 Gryllotalpa Species 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 210000000582 semen Anatomy 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 13
- 239000000843 powder Substances 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000002671 adjuvant Substances 0.000 claims description 6
- 241000533849 Gleditsia Species 0.000 claims description 4
- 229920000609 methyl cellulose Polymers 0.000 claims description 4
- 239000001923 methylcellulose Substances 0.000 claims description 4
- 208000011580 syndromic disease Diseases 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 3
- 239000000890 drug combination Substances 0.000 claims description 3
- 206010013990 dysuria Diseases 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 239000007901 soft capsule Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 3
- 235000013211 Adiantum capillus veneris Nutrition 0.000 abstract 1
- 241001148501 Adiantum pedatum Species 0.000 abstract 1
- 241000931143 Gleditsia sinensis Species 0.000 abstract 1
- 244000060234 Gmelina philippensis Species 0.000 abstract 1
- 241000238814 Orthoptera Species 0.000 abstract 1
- 244000178320 Vaccaria pyramidata Species 0.000 abstract 1
- 235000010587 Vaccaria pyramidata Nutrition 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000027939 micturition Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 229920002472 Starch Polymers 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- -1 carboxy-propyl Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000001253 polyvinylpolypyrrolidone Substances 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses medicine composition, and is especially one kind of Chinese medicine composition for inducing diuresis to treat stranguria. The Chinese medicine composition is prepared with herb of maidenhair, cricket, cowherb seed, Chinese honeylocust spine, hedgehog skin and other Chinese medicinal materials in certain weight proportion. The Chinese medicine composition has obvious curative effect on difficult urination, stranguria, prostatitis and hyperplasia of prostate caused by wet-heat stasis. The present invention also discloses the preparation process of tablet, capsule and bolus of the medicine composition, and the preparation process is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, especially a kind of Chinese medicine composition that is used for inducing diuresis for treating stranguria syndrome belongs to the field of Chinese medicines.
Background technology
Prostatitis, prostatic hyperplasia are a kind of male's commonly encountered diseases frequently-occurring diseases, have dysuria when serious, the symptom of odynuria, and this is referred to as dampness and heat stasis disease on the doctor.Equally, in the middle of the dampness and heat stasis disease that other factors cause, also above-mentioned symptom can appear.These diseases seriously are stranded orthobiosis of scratching the patient and healthy, as treat untimelyly, also cause more serious diseases such as urinary tract infection, calculus of urethra easily.Thereby it is very important fast and effeciently to treat dampness and heat stasis disease.
Summary of the invention
One of purpose of the present invention provides a kind of pharmaceutical composition, can treat dampness and heat stasis disease; Another object of the present invention provides this preparation of pharmaceutical compositions method.
The present invention seeks to realize by following technical solution.
Pharmaceutical composition of the present invention is to be made by the raw material of following weight ratio: 80～120 parts of Herba Adiantis, 4～8 parts of Gryllotalpas, 8～12 parts of Semen Vaccariae, 45～55 parts of Spina Gleditsiaes, 8～12 parts of Corium Erinacei Seu Hemiechianuss.
The optimum ratio of each crude drug is after preferred: 100 parts of Herba Adiantis, 6 parts of Gryllotalpas, 10 parts of Semen Vaccariae, 50 parts of Spina Gleditsiaes, 10 parts of Corium Erinacei Seu Hemiechianuss.
For making things convenient for clinical practice, this pharmaceutical composition is made into several formulations, comprises tablet, capsule, granule, soft capsule etc.
Above preparation of drug combination method is:
Get crude drug in proportion, Gryllotalpa, Semen Vaccariae, Corium Erinacei Seu Hemiechianus are pulverized, sieve, standby; All the other Herba Adiantis, Spina Gleditsiae added the water reflux, extract, 2～3 hours, and relative density was 1.20～1.25 clear paste when extracting solution was concentrated into 80 ℃, added above-mentioned medicated powder mixing, and drying is pulverized, the adjuvant that adding suits/or directly make required dosage form.
Specifically, the method for making tablet when above pharmaceutical composition is:
Get crude drug in proportion, Gryllotalpa, Semen Vaccariae, Corium Erinacei Seu Hemiechianus are pulverized, sieve, standby; All the other Herba Adiantis, Spina Gleditsiae, added the water reflux, extract, 2～3 hours, relative density was 1.20～1.25 clear paste when extracting solution was concentrated into 80 ℃, added above-mentioned medicated powder mixing, drying, be ground into fine powder, carboxylic third methylcellulose of adding 80～150% is with 80～90% alcohol granulations, drying, mixing, compacting are in flakes.
The preparation method of capsule is:
Get crude drug in proportion, Gryllotalpa, Semen Vaccariae, Corium Erinacei Seu Hemiechianus are pulverized, sieve, standby; All the other Herba Adiantis, Spina Gleditsiae added the water reflux, extract, 2～3 hours, and relative density was 1.20～1.25 clear paste when extracting solution was concentrated into 80 ℃, added above-mentioned medicated powder mixing, and drying is pulverized, and incapsulates promptly.
In above-mentioned preparation method, use a large amount of adjuvants, these adjuvants can replace by other similar adjuvants.These adjuvants comprise: diluent can be any in starch, pregelatinized Starch, dextrin, Icing Sugar, the little smart cellulose; Binding agent can be any in carboxylic third methylcellulose, polyvidone, the starch slurry; Disintegrating agent can be any in cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium, the low replacement carboxy-propyl cellulose; Fluidizer can magnesium stearate, in the Pulvis Talci, micropowder silica gel any.
Pharmaceutical composition by technical solution of the present invention makes through animal and clinical trial certificate, has eliminating damp-heat, blood circulation promoting and blood stasis dispelling, the effect of inducing diuresis for treating stranguria syndrome is to the dysuria due to the dampness and heat stasis, odynuria, and prostatitis, prostatic hyperplasia see that above-mentioned patient has the obvious treatment effect.
The specific embodiment
Embodiment 1:
Prescription: Herba Adianti 1000g Gryllotalpa 60g Semen Vaccariae 100g
Spina Gleditsiae 500g Corium Erinacei Seu Hemiechianus 100g
Method for making: above five tastes medical material, Gryllotalpa, Semen Vaccariae, Corium Erinacei Seu Hemiechianus are pulverized, and sieve, and be standby.All the other Herba Adiantis, Spina Gleditsiae added the water reflux, extract, 2 hours, and extracting solution is concentrated into the clear paste that relative density is 1.20～1.25 (80 ℃), adds above-mentioned medicated powder mixing, and vacuum drying is pulverized, and sieves, and incapsulates, promptly.
Embodiment 2:
Prescription: Herba Adianti 1200g Gryllotalpa 80g does not stay capable 80g
Spina Gleditsiae 550g Corium Erinacei Seu Hemiechianus 120g
Method for making: Gryllotalpa, Semen Vaccariae, Corium Erinacei Seu Hemiechianus are pulverized, sieve, standby; All the other Herba Adiantis, Spina Gleditsiae added the water reflux, extract, 3 hours, and relative density was 1.20～1.25 clear paste when extracting solution was concentrated into 80 ℃, added above-mentioned medicated powder mixing, drying is ground into fine powder, adds carboxylic third methylcellulose of 350g, granulates with 80% alcohol, drying, mixing, compacting is in flakes.
Embodiment 3:
Prescription: Herba Adianti 800g Gryllotalpa 40g does not stay capable 120g
Spina Gleditsiae 450g Corium Erinacei Seu Hemiechianus 80g
Method for making: above five tastes medical material, Gryllotalpa, Semen Vaccariae, Corium Erinacei Seu Hemiechianus are pulverized, and sieve, and be standby.All the other Herba Adiantis, Spina Gleditsiae added the water reflux, extract, 2 hours, and extracting solution is concentrated into the clear paste that relative density is 1.20～1.25 (80 ℃), adds above-mentioned medicated powder mixing, vacuum drying is pulverized, and adds starch slurry and the 30g carboxymethyl starch sodium of 160g, mixing, the system soft material is pressed into ball.
Claims (7)
1, a kind of pharmaceutical composition that is used for inducing diuresis for treating stranguria syndrome is characterized in that this pharmaceutical composition is to be made by the raw material of following weight ratio: 80～120 parts of Herba Adiantis, 4～8 parts of Gryllotalpas, 8～12 parts of Semen Vaccariae, 45～55 parts of Spina Gleditsiaes, 8～12 parts of Corium Erinacei Seu Hemiechianuss.
2, pharmaceutical composition as claimed in claim 1 is characterized in that the best proportioning of each crude drug is: 100 parts of Herba Adiantis, 6 parts of Gryllotalpas, 10 parts of Semen Vaccariae, 50 parts of Spina Gleditsiaes, 10 parts of Corium Erinacei Seu Hemiechianuss.
3, pharmaceutical composition as claimed in claim 1 or 2 is characterized in that being made into useful clinically dosage form, comprises tablet, capsule, granule, soft capsule.
4, preparation is characterized in that as the method for pharmaceutical composition as described in the claim 3 this method is:
Get crude drug in proportion, Gryllotalpa, Semen Vaccariae, Corium Erinacei Seu Hemiechianus are pulverized, sieve, standby; All the other Herba Adiantis, Spina Gleditsiae added the water reflux, extract, 2～3 hours, and relative density was 1.20～1.25 clear paste when extracting solution was concentrated into 80 ℃, added above-mentioned medicated powder mixing, and drying is pulverized, the adjuvant that adding suits/or directly make required dosage form.
5, as preparation of drug combination method as described in the claim 4, it is characterized in that the preparation method of tablet is:
Get crude drug in proportion, Gryllotalpa, Semen Vaccariae, Corium Erinacei Seu Hemiechianus are pulverized, sieve, standby; All the other Herba Adiantis, Spina Gleditsiae, added the water reflux, extract, 2～3 hours, relative density was 1.20～1.25 clear paste when extracting solution was concentrated into 80 ℃, added above-mentioned medicated powder mixing, drying, be ground into fine powder, carboxylic third methylcellulose of adding 80～150% is with 80～90% alcohol granulations, drying, mixing, compacting are in flakes.
6, as preparation of drug combination method as described in the claim 4, it is characterized in that the preparation method of capsule is:
Get crude drug in proportion, Gryllotalpa, Semen Vaccariae, Corium Erinacei Seu Hemiechianus are pulverized, sieve, standby; All the other Herba Adiantis, Spina Gleditsiae added the water reflux, extract, 2～3 hours, and relative density was 1.20～1.25 clear paste when extracting solution was concentrated into 80 ℃, added above-mentioned medicated powder mixing, and drying is pulverized, and incapsulates promptly.
7, pharmaceutical composition is used for the treatment of dysuria due to the dampness and heat stasis in preparation as claimed in claim 1 or 2, and odynuria, and prostatitis, prostatic hyperplasia are seen the application in the medicine of above-mentioned patient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101680775A CN1973849A (en) | 2006-12-25 | 2006-12-25 | Medicine composition for inducing diuresis to treat stranguria and its prepn process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101680775A CN1973849A (en) | 2006-12-25 | 2006-12-25 | Medicine composition for inducing diuresis to treat stranguria and its prepn process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1973849A true CN1973849A (en) | 2007-06-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101680775A Pending CN1973849A (en) | 2006-12-25 | 2006-12-25 | Medicine composition for inducing diuresis to treat stranguria and its prepn process |
Country Status (1)
| Country | Link |
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| CN (1) | CN1973849A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804090A (en) * | 2010-04-27 | 2010-08-18 | 贵州太和制药有限公司 | Tablet used for treating prostate diseases as well as preparation method and application thereof |
| CN106361953A (en) * | 2016-11-22 | 2017-02-01 | 张宾 | Foot bath traditional Chinese medicine prescription for treating patient with dysuria |
-
2006
- 2006-12-25 CN CNA2006101680775A patent/CN1973849A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804090A (en) * | 2010-04-27 | 2010-08-18 | 贵州太和制药有限公司 | Tablet used for treating prostate diseases as well as preparation method and application thereof |
| CN101804090B (en) * | 2010-04-27 | 2013-02-13 | 贵州太和制药有限公司 | Tablet used for treating prostate diseases as well as preparation method and application thereof |
| CN106361953A (en) * | 2016-11-22 | 2017-02-01 | 张宾 | Foot bath traditional Chinese medicine prescription for treating patient with dysuria |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| DD01 | Delivery of document by public notice |
Addressee: Li Jian Document name: Notification that Application Deemed to be Withdrawn |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20070606 |