CN1923232B - Medicine composition for dispersing pathogenic wind and extinguishing phlegm, absorbing clots and softening hard masses, preparation method and use thereof - Google Patents
Medicine composition for dispersing pathogenic wind and extinguishing phlegm, absorbing clots and softening hard masses, preparation method and use thereof Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for dispersing pathogenic wind, removing phlegm, its preparing process and use thereof, wherein the composition is prepared from centipede, pangolin scales, white-stiff silkworm, buthus martensi karsch, turtle shell, tortoise shell, orpiment, rhubarb horsetails and cinnabar. The The medicinal composition can be prepared into capsules, powders, tablets, granules, pills, mixtures and oral liquids.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of be used to dispel the wind expectorant, removing blood stasis with potent drugs softening the hard mass, specifically, it is to be the pharmaceutical composition that feedstock production forms by Chinese crude drug, belongs to drug world.
Background technology
The human tumor of finding is existing historical more than 3000, tumor is a kind of commonly encountered diseases, frequently-occurring disease, and wherein malignant tumor is the most serious class disease of present harm humans health, according to statistics, malignant tumor person is suffered from the whole world 1,400 ten thousand people, has every year 7000000 people to die from malignant tumor approximately.In a lot of countries, the mortality rate of tumor is only second to cardiovascular disease and occupies second.In China, there are every year 1200000 people to die from malignant tumor approximately.Because infectious disease and parasitic disease are controlled gradually, and tumor becomes increasingly conspicuous to the mankind's threat, has become research topic great in the current medical domain.
Tumor be body under the effect of various tumorigenesis factor, the cellular abnormality hypertrophy of local organization and the proliferation that forms often shows as local lump.Tumor cell is compared with normal cell, and form, function and metabolic unusual are arranged, and their growths are vigorous, often are the persistence growth, and are not in tune with whole machine body, and losing the fully-developed ability in varying degrees, even approach inmature embryonic cell.According to the biological behaviour of various tumors, can be divided into optimum and pernicious two big classes to tumor.Unless benign tumor is grown in significant points, general causing death not; Malignant tumor often causes death as developing as one pleases.Common malignancy has cancer and sarcoma to derive from epithelial tissue and mesenchymal tissue respectively.Wherein cancer accounts for more than 90% of all malignant tumor.Canceration is a complexity, multistage process.Most cancerous protuberances may develop from individual cells.The characteristic of cancerous cell comprise cell ceaselessly with unordered division, and aggressive (tissue infiltration towards periphery) and transitivity are arranged.Cancer is one group of disease, it is characterized by paracytic growth out of control, and is located to send out to it by former position, and this sending out as uncontrollable will be invaded critical organ and depletion be caused death at last with causing.
The M ﹠ M of cancer is all increasing every year, and the kind of cancer has also had very big variation.Reason wherein should comprise life and work situation, health care condition etc., and the aging of population also has certain relation.As the immediate cause of cancer, be most important reason as food, smoking, salty peppery food, food rich in fat, alcoholic drink etc. have all become problem.For hepatocarcinoma, the virus of hepatitis B, hepatitis C is important reasons.The genetic problem of cancer susceptible body constitution has also received concern.The genetic predisposition of colorectal cancer is stronger than other cancers.Other carcinogen is because of also having, as air pollution, food additive, lonizing radiation, pesticide, ultraviolet, oncogenic virus etc.The malignant tumor of the common human life's health of China has: ten big tumors such as pulmonary carcinoma, gastric cancer, the esophageal carcinoma, intestinal cancer, hepatocarcinoma, cervical cancer, breast carcinoma, leukemia, malignant lymphoma, nasopharyngeal carcinoma.Wherein see morely, account for the 70%-80% of whole malignant tumor so that pulmonary carcinoma, gastric cancer, the esophageal carcinoma, hepatocarcinoma, breast carcinoma, cervical cancer are the most.
Benign tumor is generally answered excision, and regularly checks and have or not recurrence.Some tumor is if the inconvenience operation can be carried out radiotherapy, as hemangioma.The basic principle for the treatment of malignant tumor is to implement radical operation in early days, thorough tumor resection and estimate the surrounding tissue that tumor cell has soaked into, and remove regional nodes.Need carry out after the operation radiotherapy (applying X-ray or radionuclide, as
226R,
60Co,
32P etc.) or chemotherapy (as 5-fluorouracil, chlormethine, mitomycin, vincristine etc.).But, patient to put, the poor compliance of chemotherapy, feed difficulty, alopecia, easily side effect such as hemorrhage are arranged after the treatment, quality of life is also relatively poor, brings great psychological burden to patient, even also very easily recur after curing.
At present, the treatment by Chinese herbs tumor is used methods such as strengthening the body resistance, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, has obtained certain curative effect; Especially the untoward reaction that alleviates after radiotherapy or the chemotherapy there is obvious effects.Feel people's " surgery ten three partss " representative prescription is opened by gold centipede ball system, and its medicine consists of Scolopendra, Squama Manis, Bombyx Batryticatus, Scorpio, Realgar, Radix Et Rhizoma Rhei, Cinnabaris.The various poisonous insect class of Fang Zhongju medicine, function dispel the wind removing blood stasis with potent drugs, reducing swelling and alleviating pain, hard masses softening and resolving, this prescription cures mainly boil, does not see the relevant report of treatment tumor." golden centipede pill for curing lump clinical application is inquired into " that Zheng Tingbin delivered in " the Sichuan traditional Chinese medical science " 2004 the 22nd the 12nd phases of volume discloses the new purposes of golden centipede ball, consumption (Gekko Swinhonis 30-60g comprising raw material and raw material, Scorpio 150g, Bombyx Batryticatus 150g, Squama Manis 100g, Realgar 10g, Radix Et Rhizoma Rhei 30g, Cinnabaris a little), the side separates, indication, pointing out in the paper that golden centipede ball cures mainly " the high person of rising of the red and swollen heat pain of YANG syndrome and the above lump of costa sternales all have suitable curative effect; the lump that has the bottom only fails to use one by one ", therefore, gold centipede ball is narrow at the tumor indication, can not meet clinical needs.And the particularity of Chinese medical theory, raw material flavour of a drug difference, the consumption difference, at pathogenesis difference, method of treatment rule of treatment difference, at indication also inequality.So a kind of more effective treatment of present clinical needs various, tumor everywhere, good, the medicine of improving the quality of living of patient compliance in therapeutic process simultaneously.
Summary of the invention
Technical scheme of the present invention has provided a kind of pharmaceutical composition of be used to dispel the wind expectorant, removing blood stasis with potent drugs softening the hard mass, and another technical scheme of the present invention has provided this preparation of drug combination method and purposes.
The invention provides a kind of pharmaceutical composition of be used to dispel the wind expectorant, removing blood stasis with potent drugs softening the hard mass, it is to add the medicament that acceptable accessories or complementary composition are prepared from by containing the following weight proportion raw material:
20～50 parts of Scolopendras, 30～90 parts of Squama Maniss, 45～135 parts of Bombyx Batryticatus, 10～45 parts on Scorpio tail, 25～90 parts of Carapax Trionycis, 25～90 parts of Carapax et Plastrum Testudiniss, 3～9 parts of Realgars, 20～30 parts of Radix Et Rhizoma Rhei, 2～9 parts in Cinnabaris.
Wherein, the Scorpio tail is the postabdomen of Scorpio, and the Scorpio tail has identical effect with Scorpio, but the effectiveness of Scorpio tail is better than Scorpio, and the Scorpio tail can replace with Scorpio; Bombyx Batryticatus is the manufactured goods of Pupa bombycis through fermentation of white muscardine fungi, Bombyx Batryticatus is that the larva in 4～5 ages of Bombycidae insecticide silkworm Bombyx mori Linnaeus infects muscardine and lethal dry body, Bombyx Batryticatus and Bombyx Batryticatus are the dry body of fermentation of white muscardine fungi, has identical effect, but the effectiveness of Bombyx Batryticatus is better than Bombyx Batryticatus, so Bombyx Batryticatus also can be equal to replacement with Bombyx Batryticatus.These replacements all are based on the above-mentioned replacement medicine that is equal to and have equal effect, but render a service the replacements that strong and weak difference is done, and the function that this replacement does not influence pharmaceutical composition of the present invention cures mainly.
Further, it is the medicament that is prepared from by the following weight proportion raw material:
20～50 parts of Scolopendras, 30～90 parts of Squama Maniss, 45～135 parts of Bombyx Batryticatus, 10～45 parts on Scorpio tail, 25～90 parts of Carapax Trionycis, 25～90 parts of Carapax et Plastrum Testudiniss, 3～9 parts of Realgars, 20～30 parts of Radix Et Rhizoma Rhei, 2～9 parts in Cinnabaris.
Further, it is the medicament that is prepared from by the following weight proportion raw material:
20 parts of Scolopendras, 30 parts of Squama Maniss, 45 parts of Bombyx Batryticatus, 10 parts on Scorpio tail, 25 parts of Carapax Trionycis, 25 parts of Carapax et Plastrum Testudiniss, 3 parts of Realgars, 20 parts of Radix Et Rhizoma Rhei, 2.5 parts in Cinnabaris.
Pharmaceutical composition of the present invention is to be active component by the powder of Scolopendra, Squama Manis, Bombyx Batryticatus, Scorpio tail, Carapax Trionycis, Carapax et Plastrum Testudinis, Realgar, Radix Et Rhizoma Rhei, Cinnabaris or water extract, adds the medicament that acceptable accessories or complementary composition are prepared from.
Medicament described in the pharmaceutical composition of the present invention is solid preparation or liquid preparation.
Wherein, described solid preparation is capsule, powder, tablet, granule or pill; Described liquid preparation is mixture, oral liquid.
The present invention also provides this preparation of drug combination method, and it comprises the steps:
A, get Scolopendra, Squama Manis, Bombyx Batryticatus, Scorpio tail, Carapax Trionycis, Carapax et Plastrum Testudinis, Realgar, Radix Et Rhizoma Rhei, Cinnabaris, pulverize or extracting in water;
B, get described powder of a step or extract, add acceptable accessories or complementary composition and be prepared into medicament pharmaceutically commonly used.
The present invention also provides the purposes of this pharmaceutical composition in the medicine of preparation treatment tumor.
Further, described tumor is mastadenoma, thyroid tumor, melanoma, sarcoma, rhinitis cancer, hysteromyoma, gastric cancer, colon cancer, hepatocarcinoma, esophageal carcinoma or skin carcinoma.
The present invention also provides the purposes of this pharmaceutical composition in preparation treatment polyp, outgrowth medicine.
The present invention also provides the purposes of this pharmaceutical composition in the medicine of preparation treatment throat worry bubble.Wherein throat worry bubble is a said globus hystericus in the traditional Chinese medical science, is the worry bubble on the throat wall, and pushing the worry bubble during inflammation aside is tiny blister, is worry bubble, hypertrophy during not inflammation.
Drug ratio of the present invention is under Chinese medical theory tumor to be carried out dialectical executing to control, the hot temperature of Scolopendra is poisonous in the raw material prescription, and its property is arrogated to oneself the power steepest walked, interior and internal organs, outer and meridians, all QI and blood part of condensing all can disappear it, and its property is poisonous, the detoxifcation of usurping authority, all all poison all can be attacked it, so can chase after wind spasmolytic, the counteracting toxic substances knot that disappears is monarch drug.The Scorpio tail is salty, hot, flat, poisonous, and its property is arrogated to oneself and passed four other, easy relaxing the bowels with lubricant drugs, so can relieve dizziness, high fever, infantile convulsions, epilepsy, etc. by expectorant, detoxify, stimulate the menstrual flow, sending down the abnormal ascending QI, decide convulsion; Squama Manis is cold and cool poisonous, and the gas suffering is arrogated to oneself and scurried and very careful, interior logical internal organs, and the meridians hole key of passing through inside, the disease of all blood clotting blood agglomeration all can be changed it, so can call prisoners in after letting them out for exercise, subside a swelling, logical muscle, dissipating blood stasis poison; Bombyx Batryticatus suffering, salty, flat, its property arrogates to oneself, and through meat, skin, so can call prisoners in after letting them out for exercise, weigh down expectorant, decides convulsion, calmness, change knot and brings down a fever; Carapax Trionycis is salty, cold, flat; Its property dissipation, all rotten pieces, hard knot all can disappear it, so can call prisoners in after letting them out for exercise spasmolytic, hard masses softening and resolving, clearing away deficiency-heat; Carapax et Plastrum Testudinis is salty, sweet, flat, and its property is apt to YIN nourishing, and the disease of all YIN-fluid being insufficient all can be mended it, so can nourishing YIN to lower pathogenic fire, the kidney invigorating fills out marrow, increases unit; Realgar suffering, hardship, temperature, poisonous, its property arrogates to oneself, passages through which vital energy circulates and heat clearing away counteracting toxic substances, all stasis of bloods give birth to transconversion into heat wind person all can be clearly it, so can call prisoners in after letting them out for exercise, detoxify, bring down a fever, dampness; Radix Et Rhizoma Rhei hardship, salty, its property is arrogated to oneself descending, and all " endogenous toxins " all can be cloudy and move it along key, so can promoting the circulation of blood, break knot, blood stasis dispelling and let out all poison.Above Squama Manis, Bombyx Batryticatus, Scorpio, Carapax Trionycis, Carapax et Plastrum Testudinis, Realgar, Radix Et Rhizoma Rhei seven flavors are ministerial drug altogether, help monarch's power more violent.Cinnabaris is sweet, cool, and its property is arrogated to oneself to walk to arrogate to oneself and fallen, and changes unpredictably, go into the heart and can calm the nerves and walk blood vessels, but go into the lung sending down the abnormal ascending QI and walk skin, go into spleen and can and walk muscle by expectorant, go into the feasible stasis of liver and walk fascia, go into kidney can relieve oedema or abdominal distension through diuresis or purgation poison and walk bone marrow, the trouble of all diseases is all available, this guiding drug it, can make cloudy divide no heat and blood vessels from logical, mind is from peace, vital essence is from admittedly, for assistant makes it medicine, thus can relieving palpitation by expectorant, counteracting toxic substances get rid of evils, pathogenic fire reducing.
Medicine material prescription compatibility of the present invention is tight, plays strengthening the body resistance, nourishing YIN and clearing away heat altogether, relieves dizziness, high fever, infantile convulsions, epilepsy, etc. and weigh down the merit of expectorant, the heavily fortified pointization that disappears disease, Repercusion analgesia.All all tangible things all can disappear it.Medicine material prescription of the present invention is many based on poisonous insect class medicine, its shape is the human body, its property is arrogated to oneself to become to arrogate to oneself and is scurried, and clinical all enclosed mass are born among the soft muscular tissue more, so attack it with it, its enclosed mass origin cause of formation is a stagnation of QI due to depression of the liver, and the stasis of blood undermines kidney yin for a long time, and the kidney failing to nourish the liver, cause stagnation of liver-QI to give birth to air slaking expectorant, wind folder expectorant is capable, rocks and cause heart-wind syndrome, cause the five internal organs all to shake, wind-phlegm can be with meridians the fluidization tower whole body, where be parked in, cause its blood stasis congelation and form enclosed mass, all intractable enclosed mass are all the disease of vital QI being weakened and pathogen being violent, and disease must be decreased cloudy consumption gas for a long time.Compare with golden centipede ball, in the selection of raw material, medicine material prescription of the present invention has increased Carapax Trionycis, Carapax et Plastrum Testudinis, and wherein, Carapax Trionycis is arrogated to oneself and assaulted fortified position and do not decrease gas; Carapax et Plastrum Testudinis is the key medicine of nourishing kidney-yin, and the negative and positive of kidney are the motive power of each organ, and the moon is the material base of sun existence, positive cloudy helping, its QI and blood, body fluid biochemistry are infinite, can strengthen the whole body resistance against diseases, the cloudy liquid of the whole body must be filled, and it is multiple that unit is so incensed that, thereby reach the purpose of strengthening vital QI to eliminate pathogenic factors.The present invention's plus-minus is so be the principle of certificate " cure the disease and must ask it ".Tangible thing and cloudy liquid loss are all this, and the kidney being the origin of congenital constitution, Source of life, and Carapax et Plastrum Testudinis can make the water of life continually, and Carapax Trionycis does not decrease the human body functional activities of the body fluid in the counteracting toxic substances process.
Pharmaceutical composition of the present invention can make disease fundamentally obtain control, thus about all negative and positive tangible thing such as all addiction pieces, polyp, tumor, cancer, hypertrophy and red, swollen, hot, bitterly, Gao Qizhe all can control it, its curative effect is better than golden centipede ball.Gold centipede ball is attacked the above lump of costa sternales on mainly, but curative effect is incomplete, it is extensive that the purposes of no pharmaceutical composition of the present invention relates to indication, and curative effect is quick not as good as the purposes of pharmaceutical composition of the present invention, though it is remarkable at nasopharyngeal carcinoma, breast carcinoma, thyroid tumor effect, but have only certain curative effect or not obvious at other tumor, lump, its property of walking to scurry fails to be not fully exerted, and not obvious even invalid to bottom enclosed mass curative effect.Medicine of the present invention and golden centipede ball have relatively increased Carapax Trionycis, Carapax et Plastrum Testudinis two flavor medicines on flavour of a drug, make pharmaceutical composition of the present invention, walking to scurry the power of assaulting fortified position is not fully exerted, compare curative effect with golden centipede ball and obviously strengthen, indication obviously increases, and makes golden centipede ball weak point obtain replenishing and improving.
Medicine of the present invention has obvious curative effects to various tumors, and the sufferer compliance is good, quality of life is good, for clinical treatment tumour provides new selection.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
The preparation of embodiment 1 capsule of the present invention
Get Scolopendra 20g, Squama Manis 30g, Bombyx Batryticatus 45g, Scorpio tail 10g, Carapax Trionycis 25g, Carapax et Plastrum Testudinis 25g, Realgar 3g, Radix Et Rhizoma Rhei 20g, Cinnabaris 2g.Be ground into superfine powder altogether, incapsulate, get final product.
The preparation of embodiment 2 capsules of the present invention
Get Scolopendra 50g, Squama Manis 90g, Bombyx Batryticatus 135g, Scorpio tail 45g, Carapax Trionycis 90g, Carapax et Plastrum Testudinis 90g, Realgar 9g, Radix Et Rhizoma Rhei 30g, Cinnabaris 9g.Be ground into superfine powder altogether, incapsulate, get final product.
The preparation of embodiment 3 capsules of the present invention
Get Scolopendra 20g, Squama Manis 30g, Bombyx Batryticatus 45g, Scorpio tail 10g, Carapax Trionycis 25g, Carapax et Plastrum Testudinis 25g, Realgar 3g, Radix Et Rhizoma Rhei 20g, Cinnabaris 2.5g.Be ground into superfine powder altogether, incapsulate, make 360 capsules, every contains crude drug amount 0.5 gram approximately.
The preparation of embodiment 4 powders of the present invention
Get Scolopendra 50g, Squama Manis 90g, Bombyx Batryticatus 135g, Scorpio tail 45g, Carapax Trionycis 90g, Carapax et Plastrum Testudinis 90g, Realgar 9g, Radix Et Rhizoma Rhei 30g, Cinnabaris 9g.Be ground into superfine powder altogether, get final product.
The preparation of embodiment 5 tablets of the present invention
Get Scolopendra 30g, Squama Manis 35g, Bombyx Batryticatus 45g, Scorpio tail 15g, Carapax Trionycis 35g, Carapax et Plastrum Testudinis 28g, Realgar 3g, Radix Et Rhizoma Rhei 20g, Cinnabaris 2.5g.Be ground into superfine powder altogether, adding dried starch 30g, mixing adds starch slurry and makes soft material, granulates, dry back granulate, behind adding starch and the magnesium stearate mixing, tabletting, promptly.
The preparation of embodiment 6 pills of the present invention
Get Scolopendra 20g, Squama Manis 30g, Bombyx Batryticatus 45g, Scorpio tail 10g, Carapax Trionycis 25g, Carapax et Plastrum Testudinis 25g, Realgar 3g, Radix Et Rhizoma Rhei 20g, Cinnabaris 2.5g.Be ground into superfine powder altogether, sieve, molding, molding, capping, drying, select ball, promptly get medicine water pill of the present invention.
The preparation of embodiment 7 mixture of the present invention
Get the powder of embodiment 4 gained, decocted 1 hour with the octuple water gaging for the first time, decocted 0.5 hour with six times of water gagings for the second time, filter, merging filtrate, promptly.
Below prove beneficial effect of the present invention by clinical trial.
Medicine of the present invention at indication be based on the guidance of theory of Chinese medical science, by the clinical manifestation of traditional Chinese medical doctor,, select following case to carry out clinical trial in conjunction with tcm clinical practice diagnoses and treatment standard according to patient:
Sarcoma class: mastadenoma 6 examples, thyroid tumor 3 examples, melanoma 1 example, oophoroma 5 examples, hysteromyoma 3 examples;
Cancer class: nasopharyngeal carcinoma 3 examples, gastric cancer 3 examples, colon cancer 5 examples, hepatocarcinoma 1 example, esophageal carcinoma 1 example, skin carcinoma 5 examples;
Other: polyp 11 examples; Throat is considered bubble 6 examples; Cyclomastopathy 49 examples; Apoplexy 12 examples; Gout 7 examples.
Test example 1 medicine composite for curing case statistics of the present invention
Medicine of the present invention: the capsule that is prepared into by embodiment 3 carries out clinical trial.
The clinical efficacy evaluation criteria:
Criterion of cure: enclosed mass disappears, no pain, and General Symptoms is eliminated, and quality of life is good;
The produce effects standard: enclosed mass obviously dwindles, and pain disappears substantially or idol has sense of discomfort, and General Symptoms is eliminated substantially, and the state of an illness is controlled, and life is normal;
Effective standard: enclosed mass diminishes, and pain takes a turn for the better, and can stand, and General Symptoms takes a turn for the better, and life is taken care of oneself substantially;
Invalid standard: enclosed mass no change, pain do not have and alleviate, and General Symptoms does not have change, can't take care of oneself
Treatment case statistics sees Table 1
Table 1 treatment case statistics
| Title | Amount to (example) | Cure (example) | Cure rate (%) | Produce effects (example) | Obvious effective rate (%) | Effectively (example) | Effective percentage (%) | Invalid (example) | Inefficiency (%) |
| Gout | 7 | 5 | 71.4％ | 2 | 28.6％ | ||||
| The sarcoma class | 23 | 16 | 69.6％ | 5 | 22％ | 2 | 8.7％ | ||
| The cancer class | 18 | 9 | 50％ | 5 | 28％ | 1 | 5％ | 3 | 17％ |
| Polyp | 11 | 9 | 81％ | 2 | 19％ | ||||
| Throat is considered bubble | 6 | 5 | 83％ | 1 | 17％ | ||||
| Cyclomastopathy | 49 | 49 | 100％ | ||||||
| Apoplexy | 12 | 9 | 75％ | 3 | 25％ |
The result shows: the cure rate and the obvious effective rate of the various tumors of Drug therapy of the present invention, hypertrophy, polyp are higher, and therapeutic effect is remarkable.
Test example 2 pharmaceutical compositions of the present invention and golden centipede ball are in the comparison of cure rate
Medicine of the present invention: the capsule that is prepared from by embodiment 3.
Drugs compared: golden centipede ball: depletion head Scolopendra 45g, Scorpio 150g, Bombyx Batryticatus 150g, Squama Manis 100g, Realgar 10g, Radix Et Rhizoma Rhei 30g, Cinnabaris a little, be prepared into capsule by the method for embodiment 3.Cure the case statistics and see Table 2.
Table 2 pharmaceutical composition of the present invention and golden centipede ball are in the comparison of cure rate
| Name of disease | Pharmaceutical composition cure rate of the present invention | Gold centipede ball cure rate |
| The sarcoma class | 69.6％ | 26.6％ |
| The cancer class | 50％ | 20％ |
| Gout | 71.4％ | Do not have |
| Polyp | 81％ | Do not have |
| Cyclomastopathy | 100％ | Do not have |
| Apoplexy | 75％ | Do not have |
The result shows: medicine of the present invention and golden centipede ball are from indication relatively, gold centipede ball can be treated about 20% tumor class disease, but it is invalid to gout, polyp, hypertrophy, apoplexy, but pharmaceutical composition of the present invention but can be cured the tumor more than 50%, and remarkable to curative effect of disease such as gout, polyp, hypertrophy, apoplexy, illustrate that medicine indication of the present invention is extensive.
Test example 3 medicines of the present invention and the comparison of golden centipede ball on drug effect
Table 3 invention medicine and the comparison of golden centipede ball on drug effect
The result shows: medicine of the present invention and golden centipede ball are from drug effect relatively, the type of gold centipede pill for curing disease obviously is less than medicine of the present invention, and the golden centipede ball clinical treatment time obviously be longer than medicine of the present invention, diseases such as gold centipede pill for curing gout, polyp, hypertrophy, apoplexy are invalid fully, so extensive, rapid-action, the short treating period, evident in efficacy of clinical drug application adaptation disease of the present invention.
Case result according to test example 1～3 shows, medicine of the present invention is compared with golden centipede ball, the clinical practice indication is extensive, rapid-action, short treating period, evident in efficacy, and this effect is not pharmaceutical composition of the present invention simple plus-minus and coming on the flavour of a drug basis of golden centipede ball.Medicine material of the present invention and golden centipede ball raw material ratio have increased Carapax Trionycis, Carapax et Plastrum Testudinis two flavor medicines; Medicine material of the present invention and golden centipede ball raw material are from consumption relatively, consumption proportion also is diverse, medicine material combination of the present invention just and consumption, brought that indication is extensive, rapid-action, short treating period, effect evident in efficacy, this effect is not that the effect that can reach is cut out in the simplification of traditional Chinese medical science prescription, be non-obvious, medicine of the present invention provides a kind of new selection for clinical.
Claims (9)
1. the pharmaceutical composition of be used to dispel the wind expectorant, removing blood stasis with potent drugs softening the hard mass, it is characterized in that: it is to add the medicament that acceptable accessories is prepared from by the following weight proportion raw material: 20～50 parts of Scolopendras, 30～90 parts of Squama Maniss, 45～135 parts of Bombyx Batryticatus, 10～45 parts on Scorpio tail, 25～90 parts of Carapax Trionycis, 25～90 parts of Carapax et Plastrum Testudiniss, 3～9 parts of Realgars, 20～30 parts of Radix Et Rhizoma Rhei, 2～9 parts in Cinnabaris.
2. the pharmaceutical composition of be used to dispel the wind expectorant, removing blood stasis with potent drugs softening the hard mass according to claim 1 is characterized in that: it is to add the medicament that acceptable accessories is prepared from by the following weight proportion raw material: 20 parts of Scolopendras, 30 parts of Squama Maniss, 45 parts of Bombyx Batryticatus, 10 parts on Scorpio tail, 25 parts of Carapax Trionycis, 25 parts of Carapax et Plastrum Testudiniss, 3 parts of Realgars, 20 parts of Radix Et Rhizoma Rhei, 2.5 parts in Cinnabaris.
3. the pharmaceutical composition of be used to dispel the wind expectorant, removing blood stasis with potent drugs softening the hard mass according to claim 1 and 2, it is characterized in that: it is to be active component by the powder of Scolopendra, Squama Manis, Bombyx Batryticatus, Scorpio tail, Carapax Trionycis, Carapax et Plastrum Testudinis, Realgar, Radix Et Rhizoma Rhei, Cinnabaris or water extract, adds the medicament that acceptable accessories is prepared from.
4. the pharmaceutical composition of be used to dispel the wind expectorant, removing blood stasis with potent drugs softening the hard mass according to claim 3, it is characterized in that: described medicament is capsule, powder, tablet, granule, pill, mixture.
5. the pharmaceutical composition of be used to dispel the wind expectorant, removing blood stasis with potent drugs softening the hard mass according to claim 4, it is characterized in that: described mixture is an oral liquid.
6. method for preparing the pharmaceutical composition of claim 1-5 each described be used to dispel the wind expectorant, removing blood stasis with potent drugs softening the hard mass, it comprises the steps:
A, get Scolopendra, Squama Manis, Bombyx Batryticatus, Scorpio tail, Carapax Trionycis, Carapax et Plastrum Testudinis, Realgar, Radix Et Rhizoma Rhei, Cinnabaris, pulverize or extracting in water;
B, get described powder of a step or extract, add acceptable accessories and be prepared into medicament pharmaceutically commonly used.
7. the purposes of each described pharmaceutical composition of claim 1-5 in the medicine of preparation treatment tumor, it is characterized in that: described tumor is melanoma, hysteromyoma, gastric cancer, colon cancer, hepatocarcinoma, esophageal carcinoma or skin carcinoma.
8. the purposes of each described pharmaceutical composition of claim 1-5 in the medicine of preparation treatment cyclomastopathy.
9. each described pharmaceutical composition of claim 1-5 is preparing the purposes for the treatment of in the follicular medicine of throat.
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| CN1155428A (en) * | 1996-10-26 | 1997-07-30 | 迟经惠 | Medicine for relieving nasal passage and throat |
| CN1404867A (en) * | 2002-11-12 | 2003-03-26 | 吉林华康药业股份有限公司 | Chinese medicine for treating hyperplasia of mammary glands |
| CN1429601A (en) * | 2002-12-30 | 2003-07-16 | 李宝泰 | Powder for clearing fire, expelling toxin and eliminating swelling |
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| CN1155428A (en) * | 1996-10-26 | 1997-07-30 | 迟经惠 | Medicine for relieving nasal passage and throat |
| CN1404867A (en) * | 2002-11-12 | 2003-03-26 | 吉林华康药业股份有限公司 | Chinese medicine for treating hyperplasia of mammary glands |
| CN1429601A (en) * | 2002-12-30 | 2003-07-16 | 李宝泰 | Powder for clearing fire, expelling toxin and eliminating swelling |
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