CN106038743A - Blood pressure reducing electuary, and preparation method and application thereof - Google Patents
Blood pressure reducing electuary, and preparation method and application thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention relates to the field of traditional Chinese medicinal preparations, and concretely provides a blood pressure reducing electuary, and a preparation method and an application thereof. The blood pressure reducing electuary comprises, by weight, 30-45 parts of celery, 20-25 parts of lavender, 10-15 parts of hawthorn fruits, 5-10 parts of Medicago sativa Linn and 10-15 parts of chrysanthemum flowers. The blood pressure reducing electuary prepared through reasonable compatibility of above raw medicines has the advantages of good medicine effects, short treatment period, difficulty in rebounding, and no side effects, can be used for treating hypertension and secondary hypertension, also has a very good treatment effect on coronary heart disease, diabetes, arteriosclerosis, hepatopathy and other hypertension complications, and also has the efficacy of clearing heat and discharging internal heat, relaxing muscles and tendons and stimulating blood circulation, invigorating brains and tranquillizing mind, improving immunity, and clearing heart heat and improving eyesight. The raw materials perform respective efficacy, further enhance the curative effects, and have a better hypertension treatment effect than present medicines.
Description
Technical field
The present invention relates to field of traditional Chinese, in particular to a kind of blood pressure lowering electuary, preparation method and applications.
Background technology
Hypertension (hypertension) refers to increase as mainly with systemic arterial blood pressure (shrinking pressure and/or diastolic pressure)
Feature (shrinks pressure >=140 millimetress of mercury, diastolic pressure >=90 millimetres of mercury), can be with the function of the organs such as the heart, brain, kidney or device matter
Property infringement clinical syndrome.Hypertension is modal chronic disease, is also the topmost risk factor of cardiovascular and cerebrovascular disease.High blood
The common sympton of pressure be dizzy, have a headache, neck plate is tight, weak, cardiopalmus, severe patient it may also occur that severe headache, obnubilation, takes out
The symptom such as jerk, and hypertension also can cause infringement and the pathological changes of the organs such as the heart, brain, kidney.
The medicine effect of the treatment hypertension occurred in the market is notable, treatment cycle length and cure rate low, especially
The side effect being Western medicine is relatively strong, and the injury to Liver and kidney is relatively big, easily rebounds after drug withdrawal.
In view of this, the special proposition present invention.
Summary of the invention
The first object of the present invention is to provide a kind of blood pressure lowering electuary, and this blood pressure lowering electuary is by the conjunction of each taste crude drug
Reason compatibility, has good drug efficacy, treatment cycle is short, be difficult to bounce-back and the advantage that has no side effect.
The second object of the present invention is to provide the preparation method of a kind of described blood pressure lowering electuary, the method to have operation letter
Just, the advantage that can be mass, the blood pressure lowering electuary utilizing the method to prepare remains each taste medicine in crude drug to greatest extent
The drug effect of material and granule are fine and smooth, have beneficiating ingredient content height, good absorbing and eutherapeutic advantage.
The third object of the present invention is to provide a kind of described blood pressure lowering electuary in preparation for the medicine treating hypertension
In application, this blood pressure lowering electuary, based on the principle for the treatment of both the principal and secondary aspects of a disease, can reduce patients' blood at short notice, adheres to taking absolutely
Most patients all can reach the purpose of healing, does not has side effects simultaneously, and then fundamentally improve patient's body constitution, improve life
Bioplasm amount.
In order to realize the above-mentioned purpose of the present invention, spy by the following technical solutions:
A kind of blood pressure lowering electuary that the present invention provides, including the crude drug of following weight portion: Herba Apii graveolentis 30-45 part, lavandula angustifolia
20-25 part, Fructus Crataegi 10-15 part, Herba Medicaginis 5-10 part and Flos Chrysanthemi 10-15 part.
Apium L samphire, rich in proteins, carbohydrate, carotene, vitamin B group, calcium, phosphorus, ferrum, sodium
Deng, meanwhile, have and have calming liver and clearing heat, expelling wind and removing dampness, relieving restlessness subsides a swelling, cooling blood for hemostasis, and detoxify lung qi dispersing, stomach invigorating profit blood, bowel relieving be convenient,
Effect that nourishing the lung to arrest cough, blood pressure lowering, blood sugar lowering, brain-strengthening are calm.Often eat Herba Apii graveolentis, especially eat leaf of Herba Apii graveolentis, to prophylaxis of hypertension, move
Arteries and veins hardening etc. are the most highly beneficial, and have auxiliary therapeutic action.
In the present invention, counting by weight, the typical but non-limiting content of Herba Apii graveolentis is: 30 parts, 31 parts, 32 parts, 33 parts,
34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts or 45 parts.
Lavandula angustifolia acrid in the mouth, cool in nature, be referred to as " king of BAICAO ", have calmness, releive, sleeping effect, the most also press down
The effects such as hypertension processed, hepatoprotective, blood circulation promoting, regulation physiological function and raising immunity.
In the present invention, counting by weight, the typical but non-limiting content of lavandula angustifolia is: 20 parts, 20.5 parts, 21 parts,
22.5 parts, 23 parts, 23.5 parts, 24 parts, 24.5 parts or 25 parts.
Fructus Crataegi is Chinese distinctive medicine fruit dual-purpose seeds, has the effects such as blood fat reducing, blood pressure, heart tonifying, arrhythmia, with
Time be also the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting, the disease such as, hernia, blood stasis full to chest and diaphragm spleen, amenorrhea has well
Curative effect.Flavone compound vitexin in Fructus Crataegi, is the medicine that a kind of antitumaous effect is stronger, and its extract is to suppressing internal cancer
Cell growth, propagation and infiltration metastasis all have certain effect.
In the present invention, counting by weight, the typical but non-limiting content of Fructus Crataegi is: 10 parts, 11.5 parts, 12 parts,
12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts or 15 parts.
Herba Medicaginis cold nature, slightly sweet flavor, rich in proteins, fat, crude fibre, saccharide, carotene, vitamin, calcium, phosphorus,
Ferrum, additionally contains the compositions such as 7-hydroxy-11,12-(methylenedioxy)coumestan, tricin, daidzein, Herba Medicaginis have clearing away heat and promoting diuresis, relaxing muscles and tendons and activating QI and blood in the collateral, dredge profit intestinal,
Calculus, effects such as Zhichuan of enriching blood.
In the present invention, counting by weight, the typical but non-limiting content of Herba Medicaginis is: 5 parts, 5.5 parts, 6 parts, 6.5 parts,
7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts or 10 parts.
Flos Chrysanthemi acrid in the mouth, sweet, bitter；Cold nature, returns lung, Liver Channel, can dissipate wind heat clearing away, antibacterial, antiinflammatory, suppressing the hyperactive liver improving eyesight, and Flos Chrysanthemi can
Blood pressure lowering, expansion artery, have preferable curative effect to coronary heart disease, hypertension and arteriosclerosis.
In the present invention, counting by weight, the typical but non-limiting content of Flos Chrysanthemi is: 10 parts, 11.5 parts, 12 parts,
12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts or 15 parts.
The blood pressure lowering electuary that the present invention makes after carrying out reasonable compatibility by above-mentioned raw materials medicine, has good drug efficacy, treatment week
Phase is short, be difficult to bounce-back and the advantage having no side effect, it is possible to be used for treating essential hypertension and secondary hypertension, and to hat
Cardiopathia, diabetes, arteriosclerosis and hepatopathy contour blood pressure complication also has good therapeutic effect；Additionally, the punching of above-mentioned blood pressure lowering
Agent also has heat clearing away solution fire, relaxing muscles and tendons and activating QI and blood in the collateral, invigorating brain and relieving mental uneasiness, raising immunity and the effect of the improving eyesight that clears away heart-fire.Former in above-mentioned compatibility
Material medicine is not only able to each play effect of original medicine, more can strengthen its curative effect further, excellent to the therapeutic effect of hypertension
In existing medicine.
Further, described blood pressure lowering electuary includes the crude drug of following weight portion: Herba Apii graveolentis 32-43 part, lavandula angustifolia 21-24
Part, Fructus Crataegi 11-14 part, Herba Medicaginis 6-9 part and Flos Chrysanthemi 11-14 part.
Further, described blood pressure lowering electuary includes the crude drug of following weight portion: Herba Apii graveolentis 33-42 part, lavandula angustifolia 22-23
Part, Fructus Crataegi 12-13 part, Herba Medicaginis 7-8 part and Flos Chrysanthemi 12-13 part.
Further, described Herba Apii graveolentis is Herba Apii graveolentis, plucks when described Herba Apii graveolentis and lavandula angustifolia are to bloom in the fall.Herba Apii graveolentis nutrition is rich
Richness, the nutrient substance such as rich in proteins, carbohydrate, mineral and multivitamin, possibly together with Celery oil, there is fall blood
The curative effects such as pressure, calmness, stomach invigorating, diuresis；Herba Apii graveolentis and the active constituent content of lavandula angustifolia during fall flowering are high, good effect.
Further, described crude drug also include Semen Cassiae, Spica Prunellae, Radix Rehmanniae Preparata, Bulbus Lilii, Folium Mori, Folium Nelumbinis, Stigma Maydis,
Any one or the mixture of at least two in Fructus Momordicae charantiae, Folium Ginkgo and Radix Puerariae.
Further, described crude drug also includes the mixture of Semen Cassiae, Spica Prunellae and Radix Rehmanniae Preparata, and wherein Semen Cassiae is
30-40 weight portion, Spica Prunellae be 10-15 weight portion, Radix Rehmanniae Preparata be 10-15 weight portion.
Semen Cassiae bitter in the mouth, sweet, salty, cold nature, enter liver, kidney, large intestine channel；Loosening bowel to relieve constipation, blood fat reducing improving eyesight, treatment constipation and height
Blood fat, hypertension." book on Chinese herbal medicine justice ": " Semen Cassiae improving eyesight, is to grow liver and kidney tonifying, with tranquillizing and subduing nourishing YIN as justice, is the routine treatment of reinforcing, non-
Such as the pungent scattered wind of temperature, cold and cool fall heat is only that secondary disease legislator is comparable, has every advantage and not a single disadvantage the most.”
In the present invention, counting by weight, the typical but non-limiting content of Semen Cassiae is: 30 parts, 31 parts, 32 parts, 33
Part, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts or 40 parts.
Spica Prunellae is dry, bitter, cold, can clearing away heat-fire, improving eyesight, mass dissipating and swelling eliminating, its tool of clinical research has efficacy in lowering high blood pressure,
Spica Prunellae compatibility Flos Chrysanthemi has liver heat removing, cool liver, the merit of suppressing the hyperactive liver.
In the present invention, counting by weight, the typical but non-limiting content of Spica Prunellae is: 10 parts, 10.5 parts, 11 parts,
11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts or 15 parts.
Radix Rehmanniae Preparata is the Preparation process product of Radix Rehmanniae, and its surface is pitch-black glossy, and matter is soft and pliable and tough, sweet in the mouth, and slightly warm in nature is returned
Liver, kidney channel, have nourishing YIN and supplementing blood, benefit essence fill out the effects such as marrow；It cures mainly the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat something lost
The diseases such as essence, interior-heat are quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, vertigo and tinnitus, early whitening of beard and hair.
In the present invention, counting by weight, the typical but non-limiting content of Radix Rehmanniae Preparata is: 10 parts, 10.5 parts, 11 parts,
11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts or 15 parts.
Preferably, described blood pressure lowering electuary includes the crude drug of following weight portion: Herba Apii graveolentis 30-45 part, lavandula angustifolia 20-25
Part, Fructus Crataegi 10-15 part, Herba Medicaginis 5-10 part, Flos Chrysanthemi 10-15 part, Semen Cassiae 30-40 part, Spica Prunellae 10-15 part and Radix Rehmanniae Preparata 10-
15 parts.This blood pressure lowering electuary can not only effectively reduce blood pressure, and more can grow liver and kidney tonifying, the syndrome of alleviating hypertension.
Further, described crude drug also includes the mixture of Bulbus Lilii, Folium Mori and Folium Ginkgo, and wherein Bulbus Lilii is 5-10 weight
Part, Folium Mori be 5-15 weight portion, Folium Ginkgo be 5-10 weight portion.
Bulbus Lilii sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung meridian, there is the merit of nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization, to lung-heat dry cough, expectorant
The diseases such as middle band blood, the weak deficiency of vital energy of lung, hemoptysis of pulmonary tuberculosis have good curative effect.
In the present invention, counting by weight, the typical but non-limiting content of Bulbus Lilii is: 5 parts, 5.5 parts, 6 parts, 6.5 parts,
7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts or 10 parts.
Folium Mori are cold in nature, sweet in the mouth, hardship, and cold nature has effect of dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.The drug effect of Folium Mori
Extremely wide, there are clearing away lung-heat and moistening for dryness, cough-relieving, reduce phlegm and internal heat, reduce phlegm, control night sweat；Tonifying liver, liver heat removing and eyesight improving, treatment dizziness and blurred vision, have a sleepless night, disappear
Except eye strain；Detumescence, purify the blood, treatment dysentery, suffer from abdominal pain, lose weight, except tinea pedis, sharp large and small intestinal；Anti-stress, removing heat from blood, blood pressure lowering,
Blood fat reducing, prevention myocardial infarction, cerebral hemorrhage, dispel headache, long hair；Blood sugar lowering etc..
In the present invention, counting by weight, the typical but non-limiting content of Folium Mori is: 5 parts, 6 parts, 7 parts, 8 parts, 9 parts,
10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts.
Folium Ginkgo sweet in the mouth, hardship, puckery, property is put down, GUIXIN, lung meridian, has blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, astringes the lung and relieving asthma, change turbid fall
Effect of fat, it is possible to treatment obstruction of collaterals by blood stasis, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, cough and asthma due to lung deficiency, contained based on flavone in Folium Ginkgo
Effective ingredient can lowering blood pressure and blood fat.
In the present invention, counting by weight, the typical but non-limiting content of Folium Ginkgo is: 5 parts, 5.5 parts, 6 parts, 6.5
Part, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts or 10 parts.
Preferably, described blood pressure lowering electuary includes the crude drug of following weight portion: Herba Apii graveolentis 30-45 part, lavandula angustifolia 20-25
Part, Fructus Crataegi 10-15 part, Herba Medicaginis 5-10 part, Flos Chrysanthemi 10-15 part, Bulbus Lilii 5-10 part, Folium Mori 5-15 part and Folium Ginkgo 5-10 part.Should
Blood pressure lowering electuary can not only effectively reduce blood pressure, more can nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization and regulation blood fat, alleviating hypertension is also
Send out symptom.
Further, described crude drug also include Semen Cassiae, Spica Prunellae, Radix Rehmanniae Preparata, Bulbus Lilii, Folium Mori, Folium Nelumbinis, Stigma Maydis,
The mixture of Fructus Momordicae charantiae, Folium Ginkgo and Radix Puerariae, counts by weight, wherein Semen Cassiae 30-40 part, Spica Prunellae 10-15 part, Radix Rehmanniae Preparata
10-15 part, Bulbus Lilii 5-10 part, Folium Mori 5-15 part, Folium Ginkgo 5-10 part, Folium Nelumbinis 5-15 part, Stigma Maydis 5-10 part, Radix Puerariae 5-15
Part.
Folium Nelumbinis bitter in the mouth, pungent, micro-puckery, cool in nature, there is spleen invigorating yang invigorating, the expelling summer-heat that clears away heart-fire, dissipating blood stasis hemostasis, effect of pathogenic wind expelling damp eliminating,
Capable of lowering blood pressure and decreasing blood fat, fat-reducing, prevents and treats coronary heart disease, gallbladder inflammation, cholelithiasis, fatty liver, obesity etc..
In the present invention, counting by weight, the typical but non-limiting content of Folium Nelumbinis is: 5 parts, 6 parts, 7 parts, 8 parts, 9 parts,
10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts.
Stigma Maydis sweet in the mouth, light, property is put down, and returns bladder, liver, gallbladder meridian, has inducing diuresis to remove edema, effect of liver heat removing function of gallbladder promoting, cure mainly edema,
Dribbling urination, jaundice, cholecystitis, cholelithiasis, hypertension, diabetes etc..
In the present invention, counting by weight, the typical but non-limiting content of Stigma Maydis is: 5 parts, 5.5 parts, 6 parts, 6.5
Part, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts or 10 parts.
Radix Puerariae sweet in the mouth, pungent, cool in nature, attach to the lung and stomach meridians, have expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, the merit of yang invigorating antidiarrheal, Radix Puerariae
Include the flavone compound of 12%, the also mineral such as the ferrum of protein, aminoacid, sugar and needed by human, calcium, copper, selenium, be
Famous and precious tonic, has the good reputation of " Radix Ginseng in thousand "；Radix Puerariae energy lowering blood pressure and blood fat, prevent and treat coronary heart disease and strengthening liver and gall cell,
Promote immunity.
In the present invention, counting by weight, the typical but non-limiting content of Radix Puerariae is: 5 parts, 6 parts, 7 parts, 8 parts, 9 parts,
10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts.
Preferably, described blood pressure lowering electuary includes the crude drug of following weight portion: Herba Apii graveolentis 30-45 part, lavandula angustifolia 20-25
Part, Fructus Crataegi 10-15 part, Herba Medicaginis 5-10 part, Flos Chrysanthemi 10-15 part, Semen Cassiae 30-40 part, Spica Prunellae 10-15 part, Radix Rehmanniae Preparata 10-15
Part, Bulbus Lilii 5-10 part, Folium Mori 5-15 part, Folium Ginkgo 5-10 part, Folium Nelumbinis 5-15 part, Stigma Maydis 5-10 part and Radix Puerariae 5-15 part.Should
Blood pressure lowering electuary can not only effectively reduce blood pressure, have good drug efficacy, treatment cycle is short, be difficult to bounce-back and have no side effect excellent
Point, also has taste liver and kidney tonifying, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization, liver heat removing function of gallbladder promoting, prevents and treats coronary heart disease, diabetes, reduction blood fat and raising
Effect of body immunity, the syndrome of alleviating hypertension.
Present invention also offers the preparation method of a kind of described blood pressure lowering electuary, comprise the following steps: weigh formula ratio
Crude drug, completing described crude drug respectively until being dried, then breaking cellular wall, finally sieving and obtaining described blood pressure lowering electuary.
Further, described in complete as microwave deactivation of enzyme, the temperature that completes is 90-140 DEG C, and described breaking cellular wall uses wall-breaking machine to enter
OK, the sieve number sieved described in is 120-400 mesh.
Use wall breaking technology, first can increase the absorbance of medicine, improve its bioavailability, through breaking cellular wall and sieving
After process, grain diameter reduces, and medicine can preferably disperse, be dissolved in gastro-intestinal Fluid, and increases with the contact area of gastrointestinal mucosa
Greatly, it is more easy to by gastrointestinal absorption, thus substantially increases bioavailability；Secondly, be conducive to retaining bioactive ingredients, improve
Drug effect, is conducive to retaining the bioactive ingredients of non-refractory and various nutritional labeling, thus improves drug effect；Finally, save former
Material, it is simple to application, Chinese medicine is after micronizing, and available smaller dose obtains curative effect.
Therefore the blood pressure lowering electuary using above-mentioned preparation method to prepare remains ingredients in crude drug to greatest extent
Drug effect and granule fine and smooth, have that beneficiating ingredient content is high, good absorbing and an eutherapeutic advantage.
Present invention also offers a kind of described blood pressure lowering electuary and prepare the application in the medicine treating hypertension, should
Blood pressure lowering electuary, based on the principle for the treatment of both the principal and secondary aspects of a disease, can reduce patients' blood at short notice, adheres to taking most patient
All can reach the purpose of healing, do not have side effects simultaneously, and then fundamentally improve patient's body constitution, improve the quality of living.
Compared with prior art, the invention have the benefit that
The blood pressure lowering electuary that the present invention provides by the reasonable compatibility of above-mentioned raw materials medicine, have good drug efficacy, treatment cycle short,
Be difficult to bounce-back and the advantage that has no side effect, it is possible to be used for treating essential hypertension and secondary hypertension, and to coronary heart disease,
Diabetes, arteriosclerosis and hepatopathy contour blood pressure complication also has good therapeutic effect；Additionally, above-mentioned blood pressure lowering electuary also has
There are heat clearing away solution fire, relaxing muscles and tendons and activating QI and blood in the collateral, invigorating brain and relieving mental uneasiness, raising immunity and the effect of the improving eyesight that clears away heart-fire.Crude drug in above-mentioned compatibility is not
But can each play effect of original medicine, more can strengthen its curative effect further, the therapeutic effect of hypertension is better than existing
Medicine.
Additionally, the blood pressure lowering electuary adding Semen Cassiae, Spica Prunellae and Radix Rehmanniae Preparata compatibility in formula can also play taste
The effect of liver and kidney tonifying, the syndrome of alleviating hypertension；Bulbus Lilii, Folium Mori and the fall blood of Folium Ginkgo compatibility is added in formula
Pressure electuary can also play nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization and the effect of regulation blood fat, the syndrome of alleviating hypertension；In formula
Add the blood pressure lowering punching of Semen Cassiae, Spica Prunellae, Radix Rehmanniae Preparata, Bulbus Lilii, Folium Mori, Folium Ginkgo, Folium Nelumbinis, Stigma Maydis and Radix Puerariae compatibility
The combined therapy effect of agent more preferably, can not only effectively reduce blood pressure, have good drug efficacy, treatment cycle is short, be difficult to bounce-back and nothing
The advantage of side effect, also has taste liver and kidney tonifying, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization, liver heat removing function of gallbladder promoting, prevents and treats coronary heart disease, diabetes, reduction
Blood fat and effect of raising body immunity, the syndrome of alleviating hypertension.
The preparation method of the above-mentioned blood pressure lowering electuary that the present invention provides has advantage easy and simple to handle, that can be mass, profit
The blood pressure lowering electuary prepared by the method remains drug effect and the granule exquisiteness of ingredients in crude drug to greatest extent, has
Beneficiating ingredient content height, good absorbing and eutherapeutic advantage.
The above-mentioned blood pressure lowering electuary that the present invention provides is used for the application treating in the medicine of hypertension, this blood pressure lowering in preparation
Electuary, based on the principle for the treatment of both the principal and secondary aspects of a disease, can reduce patients' blood at short notice, adhere to taking most patient all up to
To the purpose cured, do not have side effects simultaneously, and then fundamentally improve patient's body constitution, improve the quality of living.
The curative effect of medication of the present invention be exemplified below:
1, patient Lee, man 57 years old, Yinchuan City hyperpietic.Lee's readme suffers from hypertension 3 years, head of often having a headache
Dizzy, syncope of fainting suddenly before in JIUYUE, 2014, ate medicine and took a favorable turn after one month, i.e. rebounded after drug withdrawal, in January, 2015
To find that its blood pressure is 160/110mmHg when here checks.The blood pressure lowering electuary giving the present invention is taken, three times a day, and each 5
Gram, warm water is taken after mixing it with water, and takes continuously one month, further consultation after month, and blood pressure is down to 130/80mmHg, Lee's readme headache and vertigo disease
Shape alleviates, and vision is significantly improved relatively before, uncomfortable without other；Continuing to take this electuary 2 months, blood pressure detecting reaches normal
Value range, and the symptom such as no headache is dizzy again, follow up a case by regular visits to after drug withdrawal 1 year, and the state of an illness does not recur, and body constitution has strengthened.
2, patient Zhang, female 63 years old, Jilin hyperpietic.Zhang's readme suffers from more than 10 years of hypertension, often feels
Dizzy, tired out weak, and suffer from diabetes simultaneously, take various medicine and do not feel any better for many years, when in May, 2014, here checked
Finding that its blood pressure is 150/100mmHg, blood sugar concentration is 16mol/L.The blood pressure lowering electuary giving the present invention is taken, three times a day,
Each 5 grams, warm water is taken after mixing it with water, and takes continuously one month, further consultation after month, and blood pressure is down to 130/90mmHg, and blood sugar concentration is down to
12mol/L, Zhang's readme appetite strengthens, and weak sense dizzy, tired out alleviates, and legs and feet are more flexible, sleep quality improves；Continue
Taking this electuary 2 months, blood pressure and blood sugar test reach normal range value, and again without dizzy, weak symptom, after drug withdrawal with
Visiting 1 year, the state of an illness does not recur, and immunity improves.
3, patient chaste tree, man 60 years old, Xi'an hyperpietic.Chaste tree readme headache, dizzy, weak, with nervous breast
Vexed, hospital diagnosis is secondary hypertension, finds that its blood pressure is 165/116mmHg, electrocardiogram during in February, 2015 here inspection
Display TV4-V6 is inverted and shoals, coronary insufficiency.The blood pressure lowering electuary giving the present invention is taken, three times a day, and each 5
Gram, warm water is taken after mixing it with water, and takes continuously one month, further consultation after month, and blood pressure is down to 125/80mmHg, and electrocardiogram the most just shows
Often, Zhang's headache, weak sense dizzy, tired out alleviate, and it is uncomfortable in chest no longer to have palpitation；Continue to take this electuary 3 months, blood pressure and electrocardio
Figure detection is all normal, and again without dizzy, weak symptom, follows up a case by regular visits to 1 year after drug withdrawal, and the state of an illness does not recur, and chaste tree self-inductor
Power strengthens, is difficult to get angry.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but those skilled in the art will
Understanding, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.In embodiment unreceipted specifically
Condition person, the condition advised according to normal condition or manufacturer is carried out.
A kind of blood pressure lowering electuary that the present invention provides, including the crude drug of following weight portion: Herba Apii graveolentis 30-45 part, lavandula angustifolia
20-25 part, Fructus Crataegi 10-15 part, Herba Medicaginis 5-10 part and Flos Chrysanthemi 10-15 part.
The preparation method of a kind of above-mentioned blood pressure lowering electuary that the present invention provides, comprises the following steps: weigh the former of formula ratio
Material medicine, completing described crude drug respectively until being dried, then breaking cellular wall, finally sieving and obtaining described blood pressure lowering electuary.
Below in conjunction with embodiment and comparative example, blood pressure lowering electuary provided by the present invention and preparation method thereof is made further
Detailed description.
Embodiment 1
A kind of blood pressure lowering electuary, including the crude drug of following weight portion: Herba Apii graveolentis 45 parts, lavandula angustifolia 22 parts, Fructus Crataegi 13 parts, lucerne
Mu 7 parts and Flos Chrysanthemi 13 parts.
Embodiment 2
A kind of blood pressure lowering electuary, including the crude drug of following weight portion: Herba Apii graveolentis 45 parts, lavandula angustifolia 25 parts, Fructus Crataegi 15 parts, lucerne
Mu 10 parts, Flos Chrysanthemi 15 parts, Semen Cassiae 30 parts, Spica Prunellae 15 parts and Radix Rehmanniae Preparata 15 parts.
Embodiment 3
A kind of blood pressure lowering electuary, including the crude drug of following weight portion: Herba Apii graveolentis 32 parts, lavandula angustifolia 21 parts, Fructus Crataegi 11 parts, lucerne
Mu 6 parts, Flos Chrysanthemi 11 parts, Bulbus Lilii 10 parts, 15 parts of Folium Mori and Folium Ginkgo 5 parts.
Embodiment 4
A kind of blood pressure lowering electuary, including the crude drug of following weight portion: Herba Apii graveolentis 36 parts, lavandula angustifolia 23 parts, Fructus Crataegi 13 parts, lucerne
Mu 8 parts, Flos Chrysanthemi 13 parts, Semen Cassiae 30 parts, Spica Prunellae 12 parts, Radix Rehmanniae Preparata 13 parts, Bulbus Lilii 7 parts, 10 parts of Folium Mori, Folium Ginkgo 5 parts, lotus
5 parts of leaf, Stigma Maydis 7 parts and Radix Puerariae 15 parts.
Embodiment 5
The preparation method of a kind of blood pressure lowering electuary, comprises the following steps: weigh Herba Apii graveolentis 30 parts, lavandula angustifolia 20 parts, Fructus Crataegi 10
Part, Herba Medicaginis 5 parts and Flos Chrysanthemi 10 parts；Extremely being dried by Herba Apii graveolentis, lavandula angustifolia, Fructus Crataegi, Herba Medicaginis and Flos Chrysanthemi microwave deactivation of enzyme respectively, complete temperature
Degree is 105 DEG C, then carries out breaking cellular wall with wall-breaking machine, finally crosses 200 mesh sieves, obtain blood pressure lowering electuary.
Embodiment 6
The preparation method of a kind of blood pressure lowering electuary, comprises the following steps: weigh Herba Apii graveolentis 36 parts, lavandula angustifolia 23 parts, Fructus Crataegi 13
Part, Herba Medicaginis 8 parts, Flos Chrysanthemi 13 parts, Semen Cassiae 30 parts, Spica Prunellae 12 parts, Radix Rehmanniae Preparata 13 parts, Bulbus Lilii 7 parts, 10 parts of Folium Mori, Folium Ginkgo 5
Part, 5 parts of Folium Nelumbinis, Stigma Maydis 7 parts and Radix Puerariae 15 parts；Respectively by withered in Herba Apii graveolentis, lavandula angustifolia, Fructus Crataegi, Herba Medicaginis, Flos Chrysanthemi, Semen Cassiae, summer
Grass, Radix Rehmanniae Preparata, Bulbus Lilii, Folium Mori, Folium Ginkgo, Folium Nelumbinis, Stigma Maydis and Radix Puerariae are with microwave deactivation of enzyme to being dried, and the temperature that completes is 110 DEG C,
Then carry out breaking cellular wall with wall-breaking machine, finally cross 300 mesh sieves, obtain blood pressure lowering electuary.
Comparative example 1
A kind of blood pressure lowering electuary, including the crude drug of following weight portion: Herba Apii graveolentis 20 parts, lavandula angustifolia 30 parts, Fructus Crataegi 5 parts, lucerne
Mu 12 parts and Flos Chrysanthemi 25 parts.
Comparative example 2
A kind of blood pressure lowering electuary, including the crude drug of following weight portion: Herba Apii graveolentis 50 parts, lavandula angustifolia 17 parts, Fructus Crataegi 8 parts, lucerne
Mu 12 parts, Flos Chrysanthemi 18 parts, Semen Cassiae 25 parts, Spica Prunellae 8 parts and Radix Rehmanniae Preparata 18 parts.
Comparative example 3
A kind of blood pressure lowering electuary, including the crude drug of following weight portion: Herba Apii graveolentis 23 parts, lavandula angustifolia 30 parts, Fructus Crataegi 18 parts, lucerne
Mu 12 parts, Flos Chrysanthemi 12 parts, Bulbus Lilii 15 parts, 3 parts of Folium Mori and Folium Ginkgo 15 parts.
Comparative example 4
A kind of blood pressure lowering electuary, including the crude drug of following weight portion: Herba Apii graveolentis 28 parts, lavandula angustifolia 28 parts, Fructus Crataegi 20 parts, lucerne
Mu 3 parts, Flos Chrysanthemi 5 parts, Semen Cassiae 28 parts, Spica Prunellae 16 parts, Radix Rehmanniae Preparata 7 parts, Bulbus Lilii 3 parts, 17 parts of Folium Mori, Folium Ginkgo 12 parts, lotus
3 parts of leaf, Stigma Maydis 3 parts and Radix Puerariae 20 parts.
Toxicology test:
Test example 1: acute toxicity test of the present invention
One, test material:
Animal: Kunming mouse, body weight 20-25g, male and female half and half, laboratory breeding.
Medicine: the blood pressure lowering electuary of the embodiment of the present invention 1.
Two, method:
1, LD50 calculates: use improvement karber's method, mice is randomly divided into 5 groups, often group 10, and male and female half and half will be implemented
Blood pressure lowering electuary in example 1 warm water dissolves, and is configured to Cmax, is administered by the maximum allowable capacity of mice, and institute presses to dosage
Medicated powder amount is followed successively by 92,90,94,86,85g/Kg d, after animal fasting (can't help water) 18 hours, be administered in three times in one day
(interval half an hour), each 10mL (is roughly equal to 1/3rd above-mentioned medicated powder amounts), observes animal dead situation.
2, maximum tolerated dose measures (MTD value): take mice 20, each 10 of male and female.Blood pressure lowering in embodiment 1 is rushed
Agent warm water dissolves, and is configured to Cmax, by the maximum tolerated dose of animal, can twitch with injection filling hello device and be as the criterion.Animal
After fasting (can't help water) 18 hours, it is administered (interval half an hour), each 10mL (containing 30g medicated powder amount), total medicine in one day in three times
Amount 90g medicated powder amount/Kg d, is equivalent to 300 times of clinical adult's 50Kg body weight consumption.Continuous Observation 7 days after administration.
Three, experimental result:
In LD50 calculates when giving mice with maximum acceptable concentration and maximum allowable capacity (90g medicated powder amount/Kg
D), have no dead mouse, i.e. do not measure LD50, seek maximum tolerated dose only, in 7 day observation period, mice appetite, activity,
Hair color, the mental status etc. are all normal, grow normal, there are no death.I.e. select and be equivalent to 300 times of doses of clinical dosage, there is no
Untoward reaction, shows that acute poison is minimum, MTD > 90g/Kg d.
Test example 2: long term toxicity test
Animal: regular grade SD rat 30, body weight 200g ± 10g, male and female half and half, is randomly divided into 3 groups.
Medicine: the blood pressure lowering electuary of the embodiment of the present invention 1.
Method and result:
1, medicine preparation: point high, medium and low three dosage groups, the 300 of respectively clinical application amount, 150,75 times, with containing
The normal saline 1:1 mixing of 2% arabic gum；
2, test uses gastric infusion mode, successive administration 60 days, i.e. 3 clinical cycles, observes animal general toxicity anti-
Should and the order of severity, place after death checks each position by rule of operation, and carry out hematology, ALT, BUN and the heart, liver, lung, spleen,
The pathological examination of the main organs such as kidney, stomach；
3, long term administration, there is not toxic reaction, physically well develop in high, medium and low three dosage treated animals, macroscopic appearance and master
Want internal organs no abnormality seen, peripheral hemogram and Serum ALT, BUN compare with matched group without pathologic change, the case report heart, liver,
The most significant changes such as lung, spleen, kidney, stomach, it can thus be assumed that proved by pathology to animal without poisoning manifestations.
Method that above test example 1 is identical with test example 2 and the blood pressure lowering electuary that embodiment 2-4 is provided by standard is used to divide
Not testing, result of the test is consistent with the toxicology test result of embodiment 1.
Effect example 1
For showing this blood pressure lowering electuary therapeutical effect to hypertension, 100 example hyperpietics are selected to carry out Ureteral Calculus,
Select 100 suitable example hyperpietics of medical history, the state of an illness, age and former Therapeutic Method selects tradition Western medicine (as according to Promised Land simultaneously
Flat) treatment as a control group 1, additionally select the 100 example hyperpietics clothes that medical history, the state of an illness, age and former Therapeutic Method are suitable
With Chinese medicine treatment as a control group 2.The blood pressure lowering electuary that test group 1 uses the embodiment of the present invention 1 to make is treated, right
Treating by above-mentioned traditional method according to group 1 and matched group 2, clinical test results is as shown in table 1.
Therapeutic Method: taking the blood pressure lowering electuary in embodiment 1, three times a day, each 5 grams, warm water is taken after mixing it with water.
Table 1 clinical test results 1
After taking this blood pressure lowering electuary 10 days, hyperpietic's blood pressure of 85% reduces, and headache, cardio palmus shape have delayed
Solve；After taking this blood pressure lowering electuary 20 days, hyperpietic's blood pressure of 85% steadily declines, and headache, dizziness, cardio palmus shape have
It is obviously improved；After taking this blood pressure lowering electuary 60 days, hyperpietic's blood pressure of 85% continues to decline, headache, dizziness, cardiopalmus,
The symptoms such as agitation have clear improvement；After taking this blood pressure lowering electuary 90 days, hyperpietic's blood pressure of 83% is reduced to normal value,
The symptom such as headache, dizzy, weak, cardiopalmus, agitation, hypomnesis is the most substantially cured, and patient's self-induction is full of physical strength, without secondary
Effect produces.Following up a case by regular visits to after drug withdrawal 1 year, hyperpietic's state of an illness of 95% is without recurrence.
In matched group 1 selection, selection tradition Western medicine (such as taking efonidipine) is though the patients' blood treated can quickly reduce,
But the side effect such as nausea and vomiting easily occur, and more after can not drug withdrawal, need to periodically take medicine, in addition patient occur headache, cardiopalmus
The most it is not clearly better etc. complication.
The patient taking Chinese medicine in matched group 2 takes effect slowly, and headache, cardiopalmus, the symptom such as weak, irritated improve effect not
Substantially.
Meanwhile select 3 groups of similar hyperpietics of background ill to experimental group 1 respectively as experimental group 2-4, point
Not taking the blood pressure lowering electuary that embodiment 2-4 is made, found by Ureteral Calculus, the patient of 85% is almost recovered, remaining patient
Blood pressure has a significantly reduction, and headache, the complication such as dizzy, weak, irritated have also been obtained effective alleviation, and have no side effect product
Raw.Following up a case by regular visits to after drug withdrawal 1 year, hyperpietic's state of an illness of 93% is without recurrence.
Effect example 2
For showing this blood pressure lowering electuary therapeutical effect to hypertension, alternative selects 100 example medical histories, the state of an illness and age and experiment
Organizing 1 suitable hyperpietic and carry out Ureteral Calculus, this 100 example patient 1-1 as a control group takes comparative example 1 of the present invention and provides
Blood pressure lowering electuary, result of the test is as shown in table 2.
Therapeutic Method: taking the blood pressure lowering electuary in comparative example 1, three times a day, each 5 grams, warm water is taken after mixing it with water.
Table 2 clinical test results 2
As shown in Table 2, compared to experimental group 1, the patient in matched group 1-1 takes effect slowly, and blood pressure is difficult to reduce, headache, the heart
The symptom such as throb with fear, weak, irritated has been alleviated but has been got better the most completely, and therefore the therapeutic effect of the blood pressure lowering electuary of embodiment 1 is obvious
It is better than the therapeutic effect of comparative example 1.
Meanwhile select 3 groups of similar hyperpietics of background ill to experimental group 2-4 respectively as matched group 2-1,
3-1 and 4-1, is taken the blood pressure lowering electuary that comparative example 2-4 is made respectively, is found by Ureteral Calculus, matched group 2-1,3-1 and 4-
All there is the slow problem that takes effect in the patient of 1 compared with the patient of experimental group 2,3 and 4, blood pressure reduces speed slow respectively, headache,
Cardiopalmus, the symptom such as weak, irritated have been alleviated but have been got better the most completely, the therefore therapeutic effect of the blood pressure lowering electuary of embodiment 2-4
It is substantially better than the therapeutic effect of comparative example 2-4.
In summary, the blood pressure lowering electuary that the present invention provides has good blood pressure lowering effect, not only good drug efficacy, treatment week
Phase is short, be difficult to bounce-back, have no side effect, moreover it is possible to blood pressure complication contour to coronary heart disease, diabetes, arteriosclerosis and hepatopathy has very well
Therapeutic effect.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's
May be made that in the case of spirit and scope many other change and amendment.It is, therefore, intended that in the following claims
Including all such changes and modifications belonged in the scope of the invention.
Claims (10)
1. a blood pressure lowering electuary, it is characterised in that include the crude drug of following weight portion: Herba Apii graveolentis 30-45 part, lavandula angustifolia 20-
25 parts, Fructus Crataegi 10-15 part, Herba Medicaginis 5-10 part and Flos Chrysanthemi 10-15 part.
Blood pressure lowering electuary the most according to claim 1, it is characterised in that include the crude drug of following weight portion: Herba Apii graveolentis 32-
43 parts, lavandula angustifolia 21-24 part, Fructus Crataegi 11-14 part, Herba Medicaginis 6-9 part and Flos Chrysanthemi 11-14 part.
Blood pressure lowering electuary the most according to claim 1, it is characterised in that include the crude drug of following weight portion: Herba Apii graveolentis 33-
42 parts, lavandula angustifolia 22-23 part, Fructus Crataegi 12-13 part, Herba Medicaginis 7-8 part and Flos Chrysanthemi 12-13 part.
4. according to the blood pressure lowering electuary described in any one of claim 1-3, it is characterised in that described Herba Apii graveolentis is Herba Apii graveolentis, described west
Pluck when celery and lavandula angustifolia are to bloom in the fall.
5. according to the blood pressure lowering electuary described in any one of claim 1-3, it is characterised in that described crude drug also includes Semen Cassiae
In son, Spica Prunellae, Radix Rehmanniae Preparata, Bulbus Lilii, Folium Mori, Folium Nelumbinis, Stigma Maydis, Fructus Momordicae charantiae, Folium Ginkgo and Radix Puerariae any one or at least two
The mixture planted.
Blood pressure lowering electuary the most according to claim 5, it is characterised in that described crude drug also includes Semen Cassiae, Spica Prunellae
With the mixture of Radix Rehmanniae Preparata, wherein Semen Cassiae be 30-40 weight portion, Spica Prunellae be 10-15 weight portion, Radix Rehmanniae Preparata be 10-15 weight
Amount part；
Or, described crude drug also includes the mixture of Bulbus Lilii, Folium Mori and Folium Ginkgo, and wherein Bulbus Lilii is that 5-10 weight portion, Folium Mori are
5-15 weight portion, Folium Ginkgo are 5-10 weight portion.
Blood pressure lowering electuary the most according to claim 5, it is characterised in that described crude drug also include Semen Cassiae, Spica Prunellae,
The mixture of Radix Rehmanniae Preparata, Bulbus Lilii, Folium Mori, Folium Nelumbinis, Stigma Maydis, Fructus Momordicae charantiae, Folium Ginkgo and Radix Puerariae, counts by weight, wherein Semen Cassiae
Sub-30-40 part, Spica Prunellae 10-15 part, Radix Rehmanniae Preparata 10-15 part, Bulbus Lilii 5-10 part, Folium Mori 5-15 part, Folium Ginkgo 5-10 part, Folium Nelumbinis
5-15 part, Stigma Maydis 5-10 part, Radix Puerariae 5-15 part.
8. the preparation method of the blood pressure lowering electuary as described in any one of claim 1-7, it is characterised in that include following step
Rapid: to weigh the crude drug of formula ratio, respectively described crude drug is completed until being dried, then breaking cellular wall, finally sieving, it is described to obtain
Blood pressure lowering electuary.
The preparation method of blood pressure lowering electuary the most according to claim 8, it is characterised in that described in complete as microwave deactivation of enzyme,
The temperature that completes is 90-140 DEG C, and described breaking cellular wall uses wall-breaking machine to carry out, described in the sieve number sieved be 120-400 mesh.
10. the blood pressure lowering electuary as described in any one of claim 1-7 is in preparing the medicine for treating hypertension
Application.
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Application publication date: 20161026 |