CN1907345A - Chinese traditional medicine composition for treating cerebral apoplexy - Google Patents
Chinese traditional medicine composition for treating cerebral apoplexy Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition and use in treating cerebral apoplexy, wherein the medicinal composition is prepared from rhubarb horsetails, notopterygium root, leeches, baras camphor and musk.
Description
Technical field
The invention belongs to the pharmaceutical technology field, be specifically related to a kind of Chinese medicine composition and the application aspect the treatment apoplexy thereof, said composition basis prescription is made up of Moschus, Borneolum Syntheticum, Radix Et Rhizoma Rhei, Hirudo and Rhizoma Et Radix Notopterygii.
Background technology
Apoplexy is with its high incidence, high mortality, high relapse rate and high disability rate serious harm human health.And present that sickness rate rises year by year, age of onset is tending towards rejuvenation.But still neither one can be used for the kind that " apoplexy " urgent prevention is given treatment to as " fast-acting heart disease curing drop pill " in the market.
The present invention is intended to provide when the morbidity tendency is arranged for " apoplexy " patient a kind of kind of emergency aid and treatment, reduces the generation of apoplexy acute attack and sequela.
The apoplexy that is meant premonitory apoplexy took place preceding 1～3 year, be interrupted occur light, moderate is dizzy, limbs fiber crops order, or occur one the disadvantageous disease of language.Modern medicine is called the prodrome of cerebral infarction.Premonitory apoplexy to be to mark real factor, wherein especially with the pathomechanism of " internal organs is real " for outstanding.
The present invention is directed to the basic pathogenesis of apoplexy morbidity, adopt clearing away heat and relieving the wind syndrome, promote blood circulation and have one's ideas straightened out, the method for promoting blood circulation to remove blood stasis, under traditional Basic Theories of Chinese Medicine instructs, with Radix Et Rhizoma Rhei, Rhizoma Et Radix Notopterygii, Hirudo, Borneolum Syntheticum and Moschus is basis side, and wherein monarch gets its removing heat by catharsis expells the pathogenic heat with Radix Et Rhizoma Rhei, fluent mechanism of qi, the power of promoting tissue regeneration by removing blood stasis, minister is with Rhizoma Et Radix Notopterygii, Hirudo, blood circulation promoting and blood stasis dispelling, dispels the wind and stimulates the menstrual flow; Make with Moschus, Borneolum Syntheticum the refreshment of having one's ideas straightened out.The side's of system main points are that compatibility is promoted blood circulation and had one's ideas straightened out based on removing heat by catharsis expells the pathogenic heat, the product of promoting blood circulation to remove blood stasis, and all medicine 5 usefulness are precise and appropriate, and giving consideration to both the incidental and fundamental is dispelled the logical heat of internal organs, and key is opened ruton, and the blood stasis of blood alive is loose, and for controlling the key medicine of apoplexy.
Summary of the invention
It is basis side and in the application aspect the apoplexy that the present invention discloses with Radix Et Rhizoma Rhei, Rhizoma Et Radix Notopterygii, Hirudo, Borneolum Syntheticum and Moschus first.
The basis side of the present composition is made up of the medical material of following weight parts
Radix Et Rhizoma Rhei 3-30
Rhizoma Et Radix Notopterygii 3-20
Hirudo 3-12
Borneolum Syntheticum 0.1-2
Moschus 0.01-0.5
The basis side of the present composition is made up of the medical material of following weight parts
Radix Et Rhizoma Rhei 3-20
Rhizoma Et Radix Notopterygii 3-10
Hirudo 3-9
Borneolum Syntheticum 0.1-1
Moschus 0.01-0.2
The basis side of the present composition is made up of the medical material of following weight parts
Radix Et Rhizoma Rhei 9-18
Rhizoma Et Radix Notopterygii 6-12
Hirudo 3-6
Borneolum Syntheticum 0.1-1
Moschus 0.05-0.2
The function of Chinese medicine composition of the present invention cures mainly: clearing away heat and relieving the wind syndrome, promote blood circulation have one's ideas straightened out, the kidney invigorating dissipating blood stasis; Control is stopped up Sheng into pathogenic heat, and channels is obstructed, stagnation of blood stasis, the card of hepatic and renal YIN deficiency; Disease is seen numbness of the skin, numb hand and foot, and it is obstructed etc. that suddenly hemiplegia, crooked mouth and tongue, hemianesthesia, slobbering, headache and dizziness, stool close knot.
Chinese medicine composition of the present invention can also specifically refer to Rhizoma Chuanxiong, Olibanum, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Paeoniae Rubra by the compatibility promoting blood flow and remove blood stasis drug; Qi-restoratives medicine specifically refers to the Radix Astragali, Herba Epimedii, Radix Angelicae Sinensis, Radix Polygoni Multiflori.Wherein dosage is conventional amount used: Rhizoma Chuanxiong 3-10g, Olibanum 3-10g, Rhizoma Corydalis 3-10g, Radix Salviae Miltiorrhizae 5-15g, Flos Carthami 3-9g, Radix Achyranthis Bidentatae 5-15g, Radix Paeoniae Rubra 5-10g; Qi-restoratives medicine specifically refers to Radix Astragali 10-15g, Herba Epimedii 3-15, Radix Angelicae Sinensis 5-15g, Radix Polygoni Multiflori 10-20g, and each medical material of distinguishing the flavor of is prepared into extract according to the disclosed conventional method of document.
Chinese medicine composition of the present invention, through can making the various dosage forms on the medicament book after extracting, its administering mode is oral, injection or topical.
Each medical material preparation method is as follows:
1, Radix Et Rhizoma Rhei
Radix Et Rhizoma Rhei is a polygonum rheum palmatum, the dry root and rhizome of Rheum tanguticum or Rheum officinale.Main product in Qinghai, province such as Gansu, Sichuan.Radix Et Rhizoma Rhei is used for a long time in China's traditional medicine, and the beginning is stated from the existing pharmacy monograph Shennong's Herbal the earliest of China, because of its yellow skin, so name.The successive dynasties book on Chinese herbal medicine all records: " prescriptions worth thousand gold " claims that Radix Et Rhizoma Rhei is bright and beautiful civilian Radix Et Rhizoma Rhei; " WU Pu Bencao " claim Radix Et Rhizoma Rhei be yellow good, fire is joined, skin as; Lee is called general when it " medicine record "; " the Chinese crude drug handbook then is referred to as Radix Et Rhizoma Rhei.The Pharmacopoeia of the People's Republic of China one one of version in 2005 is recorded.Radix Et Rhizoma Rhei has heat and toxic materials clearing away, clearing away heat-fire, the detoxifcation hemostasis, activating blood circulation to dissipate blood stasis, the function of eliminating damp-heat is widely used in control that constipation, carbuncle, furuncle, conjunctival congestion and swelling pain, mumps, sore throat, gingival swelling and pain, bleeding due to blood-heat cause various hemorrhage, congestion amenorrhea, puerperal abdonimal pain, traumatic injury, damp and hotly lets out dysentery, jaundice, edema, middle wind-phlegm fan etc., and the gastrointestinal of cleansing is arranged, push away Chen Zhixin, the merit of peace and the five internal organs.Its property bitter cold of Radix Et Rhizoma Rhei is gone into the conscience blood system, both kindly lets out excess-heat fire-toxin in the blood and the cooling blood for hemostasis detoxifcation, again can promoting blood circulation and activating blood circulation to dissipate blood stasis.Modern study shows, Radix Et Rhizoma Rhei is given birth to abnormal smells from the patient deep, walks and do not keep, the through part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, discharge function is high strong, and gas easily injures one's stomach, it is slow slightly that wine is processed its power of back, and the property of borrowing the wine ascending, and priming is up, can improve plasma osmotic pressure, short extracellular fluid shifts in blood vessel, makes blood further diluted, and blood viscosity reduces, thereby strengthen the flowability of blood, microcirculation improvement; Put forth energy effect because Radix et Rhizoma Rhei (stir-fried with wine) is the tangible heart to large intestine again, strengthen colon movement and can dispel congestion, rush down excess-heat down, make the not absurd row of blood, strengthened the effect of blood circulation promoting and blood stasis dispelling.So this prescription adopts Radix Et Rhizoma Rhei (processed), determines the Radix Et Rhizoma Rhei (processed) preparation method of extract:
Get Radix et Rhizoma Rhei (processed with wine), with 50%-70% ethanol reflux, extract, 3 hours under 70 ℃ of conditions, the extracting solution concentrating under reduced pressure adds concentrated hydrochloric acid, stir, place, filter, it is 9 that filtrate is transferred pH with 2%-5%KOH, filters the macroporous resin of handling well on the filtrate, with ethanol-KOH eluting, collect eluent, reclaim ethanol, transferring PH with concentrated hydrochloric acid is 2-3, produce yellow mercury oxide, washing is neutral, the dry Radix Et Rhizoma Rhei extract that gets.
2, Rhizoma Et Radix Notopterygii
The Chinese medicine Rhizoma Et Radix Notopterygii is the dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii or Radix et Rhizoma Notopterygii.Mainly be distributed in provinces and regions such as Qinghai, Sichuan, Yunnan, Gansu.Rhizoma Et Radix Notopterygii is used for a long time in China's traditional medicine, and the beginning is stated from Shennong's Herbal.The Pharmacopoeia of the People's Republic of China one one of version in 2005 is recorded.The little hardship of Rhizoma Et Radix Notopterygii acrid in the mouth temperature is returned bladder, kidney channel.Has diffusing exterior cold, wind-damp dispelling, the function in sharp joint.In addition, Rhizoma Et Radix Notopterygii has longer history at the treatment cardiovascular and cerebrovascular disease, and " property of medicine opinion " is all on the books in " doctor is the six scripts slightly ".Modern pharmacological research shows that Rhizoma Et Radix Notopterygii has the QI and blood of passing unimpeded, regulating functional activities of qi, expelling pathogenic wind from the body surface, priming return through, the effect of through sick institute forms at antithrombotic, resist myocardial ischemia, the treatment cardiovascular and cerebrovascular disease, the opposing antibacterial, aspects such as virus have all obtained application widely.
The Rhizoma Et Radix Notopterygii main chemical compositions is volatile oil and furocoumarin class, and the volatile oil main component has australene, nopinene; The Coumarins composition mainly contains Notopterol, so adopt supercritical extraction to prepare Rhizoma Et Radix Notopterygii effective site.
Get Rhizoma Et Radix Notopterygii, use supercritical carbon dioxide extraction, first pass extracting pressure 20Mpa, 50 ℃-60 ℃ of extraction temperature, the extraction time is 3h.Resolving pressure 5.0Mpa, under 30 ℃ of the resolution temperatures, resolving time 3h and collect, the Rhizoma Et Radix Notopterygii volatile oil crude extract, crude extract with molecular distillation refining Rhizoma Et Radix Notopterygii volatile oil; Medicinal residues continue to make entrainer with 95% ethanol, carry out reextraction, 60 ℃-70 ℃ of extraction temperature, and the extraction time is 5h.Resolving pressure 5.0Mpa, under 30 ℃ of the resolution temperatures, resolving time 4h and collect, the Rhizoma Et Radix Notopterygii total coumarins.
3, Hirudo
Hirudo is an Annelida Hirudinidae animal Hirudo, the dry body of whitmania acranulata Whitman or Hirudo.Mainly be distributed in Hebei, Anhui, Jiangsu, Fujian, provinces and regions such as Hubei.Hirudo all has important medical value since ancient times in China, and China and foreign countries' medical science all has the ancient tradition of using Hirudo.Shennong's Herbal before more than 2000 years is just clearly put down in writing Hirudo " moon closes for the main stagnant blood that pursues, blood stasis, and removing blood stasis gathers, dredging water passages ", classifies low-grades as.The Pharmacopoeia of the People's Republic of China one one of version in 2005 is recorded, Hirudo salty in the mouth hardship, and property is flat, has removing blood stasis, removing blood stasis, effect such as stimulate the menstrual flow.Modern pharmacology studies show that Hirudo has anticoagulant, antithrombotic, and blood fat reducing, antitumor, antiinflammatory, significantly effects such as microcirculation improvement and increase myocardial flow, treatment hypertension and cerebrovascular circulatory disturbance, coronary heart disease and cerebral thrombosis etc. is received obvious curative effects.So determine the preparation method of Hirudo extract:
The water intaking trematodiasis is pulverized, and adds the fractional normal saline of equivalent weight, fully stirs, refrigerator is placed 24h, and inclining supernatant, extracts three times with method, merge extractive liquid, is transferred pH value 4.4, cold preservation 12h with phosphoric acid, get supernatant and transfer pH value 6 with hydrochloric acid, add ethanol then and make ethanol content reach 61%, placement is spent the night, and carefully inclining supernatant, precipitation is with 61% washing with alcohol 3 times, and that drains must crude product.Crude product is dissolved in an amount of distilled water, and with bag filter dialysis, water-bath concentrating under reduced pressure, vacuum drying gets Hirudo extract.
4, Moschus
Moschus is the dry product of the ripe male body note capsule secretions of animal in deer family woods Moschus moschiferous, horse Moschus moschiferous and former Moschus moschiferous.Moschus is great fame special product precious Chinese medicine both domestic and external and spice, and evident in efficacy, the fragrance virtue is strong, at the applicating history in existing more than 2,000 year of China.Shennong's Herbal is classified as top grade, and Compendium of Material Medica is listed in beastly portion the 51 volume, and the successive dynasties medical literature is all on the books.First one of the Pharmacopoeia of the People's Republic of China records.Moschus have have one's ideas straightened out, the effect of refreshment, promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain, cure mainly calentura coma, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors stupor, amenorrhea, trusted subordinate's sudden pain, carbuncle scrofula, arthralgia pain numbness, treat all deficient malignant diseases.Modern study shows that Moschus central nervous system, cardio-cerebrovascular etc. all have influence significantly.Because the natural Moschus belongs to the medical material that restriction is used,, determine the preparation method of Moschus extract so adopted the artificial Moschus to substitute:
Get the artificial Moschus of recipe quantity, use supercritical carbon dioxide extraction, extracting pressure 15-30Mpa, 40 ℃-70 ℃ of extraction temperature, the extraction time is 3-5h.Resolving pressure 5.0-10Mpa, under resolution temperature 20-50 ℃, resolving time 2-5h and collect, Moschus extract.
5, Borneolum Syntheticum
Directly add.
Embodiment:
Prescription 1: oil and extract that Radix Et Rhizoma Rhei 30g, Rhizoma Et Radix Notopterygii 20g, Hirudo 12g, Borneolum Syntheticum 2g, Moschus 0.5g, Olibanum 10g, Radix Polygoni Multiflori 20g make according to preparation method of the present invention, add Olibanum and Radix Polygoni Multiflori extract, mix homogeneously, add base oil and stabilizing agent, be pressed into soft capsule according to a conventional method.
Prescription 2: oil and extract that Radix Et Rhizoma Rhei 20g, Rhizoma Et Radix Notopterygii 10g, Hirudo 6g, Borneolum Syntheticum 1g, Moschus 0.1g, Rhizoma Chuanxiong 10g, Radix Angelicae Sinensis 10g make according to preparation method of the present invention, with Rhizoma Chuanxiong, Radix Angelicae Sinensis supercritical extract mix homogeneously, add base oil and stabilizing agent, be pressed into soft capsule according to a conventional method.
Prescription 3: Radix Et Rhizoma Rhei 12g, Rhizoma Et Radix Notopterygii 3g, Hirudo 3g, Borneolum Syntheticum 1g, Moschus 0.05g, Rhizoma Corydalis 6g, Radix Salviae Miltiorrhizae 9g, Herba Epimedii 9g
Oil and extract according to preparation method of the present invention makes mix with Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Herba Epimedii extract, add solubilizing agent and correctives, make oral liquid according to a conventional method.
Prescription 4: Radix Et Rhizoma Rhei 9g, Rhizoma Et Radix Notopterygii 6g, Hirudo 3g, Borneolum Syntheticum 0.5g, Moschus 0.1g, Rhizoma Corydalis 6g, Flos Carthami 9g, Radix Achyranthis Bidentatae 9g, Radix Salviae Miltiorrhizae 9g, Radix Astragali 9g
Oil and extract according to preparation method of the present invention makes add solubilizing agent and correctives with Rhizoma Corydalis, Flos Carthami, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Radix Astragali extract, make oral liquid according to a conventional method.
Prescription 5: Radix Et Rhizoma Rhei 12g, Rhizoma Et Radix Notopterygii 9g, Hirudo 6g, Borneolum Syntheticum 0.6g, Moschus 0.1g, Radix Polygoni Multiflori 9g
Oil and extract according to preparation method of the present invention makes mix with Radix Polygoni Multiflori extract, add solubilizing agent and correctives, make oral liquid according to a conventional method.
The preliminary test of pesticide effectiveness-focal cerebral ischemia in rats the model of preparation of the present invention
In order to inquire into the therapeutical effect of preparation of the present invention, we utilize photochemically-induced focal cerebral ischemia in rats model, and paired observation preparation of the present invention is to effect of ischemic treatment of cerebral and dose-effect relationship.
1 materials and methods
1.1 animal grouping
Male 3 monthly age SD rats, body weight 200～250g is provided by the PLA General Hospital Experimental Animal Center, is divided into model group, the present invention's 5 prescriptions preparation group and BUCHANG NAOXINTONG JIAONANG matched group at random, and 8 every group, totally 56.
1.2 experimental drug
Preparation of the present invention, the Beijing Jinfanghua Pharmaceutical Technology Co., Ltd provides middle test agent, is divided into 5 prescriptions, is respectively prescription one, prescription two, prescription three, prescription four, prescription five; BUCHANG NAOXINTONG JIAONANG, step-length pharmaceutical Co. Ltd in Xianyang produces, the 0.4g/ grain.
((annotate: dA is the kg body weight dosage of known person to the rat dosage in dB=dA * kB/kA) [1] than formula with the body weight conversion factor by adult's dosage, dB desires to ask the kilogram dosage of calculating rat, kA is people's a conversion factor, kB is the conversion factor of rat) dosage that calculates preparation group of the present invention is 3.2g/kg, the dosage of BUCHANG NAOXINTONG matched group is 3.2g/kg.Be mixed with the medicinal liquid of variable concentrations respectively by the filling stomach dosage of 3ml/200g body weight, each was organized postoperative 3h administration 1 time, later every day 1 time, continuous 4d, and model group waits the drinking water of capacity, natural diet.
1.3 experimental technique
10% chloral hydrate is pressed 0.35ml/100g body weight intraperitoneal injection of anesthesia, in a medisection scalp, separates left top periosteum, exposes left top skull; Vena femoralis injection 2% rose red b 25mg/kg; Shine left top 10min with cold light source behind the 5min, cold light source covers surrounding cranial bone apart from skull 5mm with the black adhesive plaster, exposes the about 5 * 8mm2 of range of exposures, irradiation temperature: 22 ℃.
1.4 body weight determination and function of nervous system's scoring
Irritate every day before the stomach and before putting to death and all survey body weight, and adopt behavioristics's point system of Bederson and Zea Longa to carry out function of nervous system's scoring.0 minute, impassivity damage symptom; 1 minute, can not full extension offside fore paw; 2 minutes, turn-take to offside; 3 minutes, topple over to offside; 4 minutes, can not spontaneously walk loss of consciousness.
1.5 the cerebral infarction kitchen range is measured
Give normal saline 60ml lavation from heart behind the rat anesthesia, open cranium and get brain, freezing cerebral tissue 30min, brain is cut in crown position at the optic chiasma place, thereafter 2mm does 6 crown sections continuously at interval, put into TTC liquid after 37 ℃ of water baths dye 20min (turn-over behind the 10min), filtering TTC liquid, place the fixing preservation of 10% formalin, graphical analysis is carried out with the digital camera shooting in the back, calculate each aspect infarction kitchen range area, infarction kitchen range area be multiply by bed thickness (2mm), and the infarction stove that draws each aspect is long-pending, and the long-pending infarction stove that promptly draws whole cerebral tissue of the infarction stove of each aspect of addition amasss.
1.6 pathological examination
Brain tissue slice is dewatered, does HE dyeing behind transparent, the waxdip, embedding, section by common paraffin section method.
1.7 statistical method
Calculate through image analyzer and respectively to organize the focus of infarct volume, represent with mean ± standard deviation, utilization SPSS10.0 statistical software carries out one factor analysis of variance.
1.8 result
1.8.1 general situation is observed
Matched group and treatment group all in postoperative 2～3d the appearance activity reduce, lose weight, weight increase behind the 3d, fur gloss and brightness gradually take a turn for the better, the mental status also has clear improvement, autonomic activities increases, and the treatment group than model group and matched group recover very fast.
1.8.2 function of nervous system's evaluation
Rat reduces in photochemical induction postoperative 3h, 1d, 2d autonomic activities, but major part is not seen quadriplegia.Model group has 2 focus offside fore paw flexing to the inside to occur in postoperative 24h, limitation of activity, and scoring is 1 minute, the BUCHANG NAOXINTONG matched group has an analogue, and preparation for treating group neurological deficit of the present invention is not obvious, and all in 72h, alleviate.The treatment group is compared with matched group, function of nervous system's scoring statistics zero difference (P＞0.05).
1.8.3 focus of infarct volume
Rat cerebral tissue all sharpness of border, the constant pale focus of infarct of scope occur at the irradiated region cerebral cortex after TTC dyeing.The treatment component is five prescriptions, is converted to rat experiment dosage by the human recommended dose respectively.
Each treatment group of table 1 and BUCHANG NAOXINTONG group focus of infarct volume (mean ± standard deviation)
| Grouping | Number of animals (n) | Dosage (g/kg)/day | Infarct volume (mm 3) |
| Two prescriptions three of writing out a prescription are write out a prescription everywhere, and side's five step-length brain hearts lead to the group model group | 8 8 8 8 8 8 8 | 3.2×5 3.2×5 3.2×5 3.2×5 3.2×5 3.2×5 0×5 | 16.13±1.27 *** 12.98±1.43 *** 15.21±1.80 ** 16.90±1.50 ** 17.39±3.20 ** 22.20±3.89 * 33.23±6.30 |
Annotate: compare with model group
*P＜0.05
*P＜0.01
* *P＜0.001
The result shows: each prescription of the present invention is compared than model group with matched group, and focus of infarct obviously reduces, and has statistical significance (P＜0.05); The treatment group is compared with matched group, and each prescription comparison of the present invention obviously reduces according to group, and statistics has significant difference (P＜0.01).
1.8.4 pathological change
The visible large stretch of cerebral tissue necrosis of matched group cerebral cortex ischemic region, neuron takes off mistake, and necrosis region peripheral glia cell hypertrophy is remarkable, and regional area is seen hemorrhagic focus, and vessel lumen increases, the erythrocyte of visible bunchiness in the tube chamber.Neuron is ischemic change in various degree, and light the dying of neuron endochylema of swelling is rounded or oval, and the neuron dyeing of shrinkage is dark, and cell space is little, and is triangular in shape.Neurocyte, the broadening of neurogliocyte peripheral clearance, the neuron pyknosis.The ischemia scope of treatment group rat is little, and infarction edge tissues structure is not destroyed fully, and the remaining neuron of ischemic region is more, is dispersed in glial cells hyperplasia on every side, and the quantity of glial cells hyperplasia obviously reduces than matched group.Ischemic change alleviates than matched group is obvious, and the ischemia marginal zone is not seen hemorrhagic focus.
Claims (6)
1, a kind of Chinese medicine composition for the treatment of apoplexy, it is characterized in that said composition by Radix Et Rhizoma Rhei, Rhizoma Et Radix Notopterygii, Hirudo, Borneolum Syntheticum and Moschus as basis side, each medical material parts by weight is:
Radix Et Rhizoma Rhei 3-30
Rhizoma Et Radix Notopterygii 3-20
Hirudo 3-12
Borneolum Syntheticum 0.1-2
Moschus 0.01-0.5.
2,, it is characterized in that said composition is made up of the medical material of following weight parts according to the Chinese medicine composition of claim 1:
Radix Et Rhizoma Rhei 3-20
Rhizoma Et Radix Notopterygii 3-10
Hirudo 3-9
Borneolum Syntheticum 0.1-1
Moschus 0.01-0.2,
3,, it is characterized in that said composition is made up of the medical material of following weight parts according to the Chinese medicine composition of claim 1:
Radix Et Rhizoma Rhei 9-18
Rhizoma Et Radix Notopterygii 6-12
Hirudo 3-6
Borneolum Syntheticum 0.1-1
Moschus 0.05-0.2.
4,, it is characterized in that and specifically to refer to Rhizoma Chuanxiong, Olibanum, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Paeoniae Rubra by the compatibility promoting blood flow and remove blood stasis drug according to the Chinese medicine composition of claim 1-3; Qi-restoratives medicine specifically refers to the Radix Astragali, Herba Epimedii, Radix Angelicae Sinensis, Radix Polygoni Multiflori.Wherein dosage is conventional amount used: Rhizoma Chuanxiong 3-10g, Olibanum 3-10g, Rhizoma Corydalis 3-10g, Radix Salviae Miltiorrhizae 5-15g, Flos Carthami 3-9g, Radix Achyranthis Bidentatae 5-15g, Radix Paeoniae Rubra 5-10g, Radix Astragali 10-15g, Herba Epimedii 3-15, Radix Angelicae Sinensis 5-15g, Radix Polygoni Multiflori 10-20g.
5, according to the Chinese medicine composition of claim 1-4, the medical material that it is characterized in that respectively distinguishing the flavor of can be made the various dosage forms on the medicament book through after extracting, and its administering mode is oral, injection or topical.
6,, it is characterized in that said composition is used for the treatment of apoplexy according to the Chinese medicine composition of claim 1-4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101113322A CN1907345A (en) | 2006-08-23 | 2006-08-23 | Chinese traditional medicine composition for treating cerebral apoplexy |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2006101113322A CN1907345A (en) | 2006-08-23 | 2006-08-23 | Chinese traditional medicine composition for treating cerebral apoplexy |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406670B (en) * | 2008-11-19 | 2011-03-23 | 张合林 | Chinese patent medicine for treating brain injury coma |
| CN102973678A (en) * | 2012-12-26 | 2013-03-20 | 房守和 | Chinese medicinal formulae for treating cerebral apoplexy and method of application thereof |
| CN107496647A (en) * | 2017-08-29 | 2017-12-22 | 杨金龙 | A kind of Chinese medicine liniment for external application for treating rheumatism bone disease |
-
2006
- 2006-08-23 CN CNA2006101113322A patent/CN1907345A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406670B (en) * | 2008-11-19 | 2011-03-23 | 张合林 | Chinese patent medicine for treating brain injury coma |
| CN102973678A (en) * | 2012-12-26 | 2013-03-20 | 房守和 | Chinese medicinal formulae for treating cerebral apoplexy and method of application thereof |
| CN107496647A (en) * | 2017-08-29 | 2017-12-22 | 杨金龙 | A kind of Chinese medicine liniment for external application for treating rheumatism bone disease |
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Application publication date: 20070207 |