CN102626508A - Traditional Chinese medicine composite for curing liver cancer - Google Patents
Traditional Chinese medicine composite for curing liver cancer Download PDFInfo
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Abstract
本发明涉及一种治疗肝癌的中药组合物，属中药领域。该中药组合物由云芝、五味子、茯苓、黄芪、八月扎、柴胡、麝香、皂角刺、壁虎、茵陈、莪术、川芎、当归、乳香和没药15种原料药制成，具有补气固表、舒肝理气、活络散结的作用，提高机体免疫力，保肝抗癌，用于治疗肝癌疗效确切，有效率高，且无明显毒副作用。The invention relates to a traditional Chinese medicine composition for treating liver cancer, which belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is made of 15 kinds of raw materials such as Yunzhi, Schisandra, Poria, Astragalus, August Zha, Bupleurum, Musk, Saponaria, Gecko, Capillary, Curcuma, Chuanxiong, Angelica, Frankincense and Myrrh. It has the functions of invigorating qi and consolidating the surface, soothing the liver and regulating qi, activating collaterals and dispelling stagnation, improving the body's immunity, protecting the liver and fighting cancer. It has a definite curative effect and high efficiency in the treatment of liver cancer, and has no obvious side effects.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition of treating hepatocarcinoma.
Background technology
Hepatocarcinoma is meant the malignant tumor that betides liver, comprises two kinds of primary hepatocarcinoma and secondary liver cancers, and the hepatocarcinoma of daily theory refers to primary hepatocarcinoma more.Primary hepatocarcinoma is one of modal malignant tumor clinically, and according to recent statistics, the annual New Development liver cancer patient in the whole world is about 600,000, occupies the 5th of malignant tumor.Primary hepatocarcinoma belongs to high morbidity in China, and China's number of the infected accounts for 55% of global hepatocarcinoma patient, serious threat China people's health and lives at present.The means of treatment hepatocarcinoma mainly contain operation, radiotherapy, chemotherapy and medicine at present, because the early stage performance of hepatocarcinoma is not obvious, the patient is easy to miss the best opportunity of performing an operation, and radiotherapy and chemotherapy produce injury to the human normal cell in kill cancer cell.In the Drug therapy, the Western medicine side effect is big, expensive, and the side effect of treatment by Chinese herbs hepatocarcinoma is little, and expense is relatively low, but eutherapeutic this type of Chinese medicine lacks.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of treating hepatocarcinoma, this Drug therapy hepatocarcinoma determined curative effect, effective percentage is high.
The present invention realizes through following technical scheme; A kind of Chinese medicine composition of treating hepatocarcinoma; It is characterized in that, process: Coriolous Dersicolor (Fr.) Quel 40-55, Fructus Schisandrae Chinensis 40-55, Poria 35-50, Radix Astragali 35-50, Fructus Akebiae 35-45, Radix Bupleuri 20-30, Moschus 20-30, Spina Gleditsiae 45-55, Gekko Swinhonis 25-35, Herba Artemisiae Scopariae 25-35, Rhizoma Curcumae 30-40, Rhizoma Chuanxiong 20-30, Radix Angelicae Sinensis 30-40, Olibanum 15-25, Myrrha 15-25 by following raw medicaments in portion by weight.
The present invention treats the Chinese medicine composition of hepatocarcinoma; Preferably, process by following raw medicaments in portion by weight: Coriolous Dersicolor (Fr.) Quel 50, Fructus Schisandrae Chinensis 50, Poria 45, the Radix Astragali 40, Fructus Akebiae 40, Radix Bupleuri 25, Moschus 25, Spina Gleditsiae 50, Gekko Swinhonis 30, Herba Artemisiae Scopariae 30, Rhizoma Curcumae 35, Rhizoma Chuanxiong 25, Radix Angelicae Sinensis 35, Olibanum 20, Myrrha 20.
Instructions of taking is: single dose 260g, be decocted in water for oral dose, and potion divided sooner or later and took for twice every day, and 20 days is a course of treatment.
The pharmacological action of each crude drug is in the compositions:
Coriolous Dersicolor (Fr.) Quel: nature and flavor are sweet, light, be slightly cold, and return liver, spleen, lung meridian, have heat clearing away, detoxifcation, antiinflammatory, anticancer, effect such as protect the liver.Main active is a krestin in the Coriolous Dersicolor (Fr.) Quel, and krestin has immunoloregulation function, is good immunostimulant, has enhance immunity cell function and identification ability; Krestin has liver protection function simultaneously, and significantly transaminase lowering has tangible repair to liver tissue lesions and hepatic necrosis.
Fructus Schisandrae Chinensis: temperature, acid, sweet, return lung, the heart, kidney channel; Herbal function is the power of strengthening by means of tonics, and medical value is high.Fructus Schisandrae Chinensis can be protected human five internal organs-heart, liver, spleen, lung, kidney, promotes detoxification processes, the liver protecting of liver to avoid poisoning, and can regenerate because of the impaired liver organization of abuse of alcohol, medicine or hepatitis.Fructus Schisandrae Chinensis contains rich organic acid, vitamin, flavonoid, phytosterol and the lignan of strong effect reactivation is arranged, and it also is one of minority medical material that has concurrently essence, gas, refreshing three big tonifications, the strong liver of ability QI invigorating, the efficient of promoting the cells exclude refuse.
Poria: sweet in the mouth, light, property are flat.Go into the heart, lung, spleen channel.Function with promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria ability enhancing human body immunity function, pachyman has tangible antitumor and protects the liver dirty effect.
The Radix Astragali: sweet in the mouth, tepor.Return lung, spleen, liver, kidney channel.Have effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The enhancing human body immunity function arranged, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Fructus Akebiae: bitter in the mouth, cold in nature.Return liver, spleen channel.Has liver-smoothing, qi-regulating, the effect of removing obstruction for relieving pain.Cure mainly: tumor and cancerous pain such as hepatocarcinoma, gastric cancer, pulmonary carcinoma, breast carcinoma.
Radix Bupleuri: have analgesic, analgesia, antiinflammatory and dispersing the stagnated live-QI to relieve the stagnation of QI effect, the effect that also has enhancing human body immunity power.
Moschus: Moschus property is hot, warm, nontoxic, bitter in the mouth.Go into the heart, spleen, Liver Channel, the function of having one's ideas straightened out, warding off dirty, collateral dredging, loosing silt is arranged.
Spina Gleditsiae: nature and flavor are hot, temperature, detumescence and apocenosis, tcm clinical practice are used for swollen ulcer drug all has better therapeutic effect, generally show as pus not Cheng Zheke disappear, the formed pus person can make it speed and burst.Modern anticancer pharmacological research shows that Spina Gleditsiae has anticancer tumor-suppression activity.
Gekko Swinhonis: salty, cold, slightly poisonous, function cures mainly dispels the wind, active, eliminating stagnation.
Herba Artemisiae Scopariae: have hepatic cholagogic, antiinflammatory, analgesia, analgesic, diuresis, excited smooth muscle, suppress effect such as tumor; Wherein anti-tumor active ingredient is a capillarisin.
Rhizoma Curcumae: hot, bitter, temperature.Return liver, spleen channel, have the effect of eliminating stagnation, removing blood stasis, promoting the circulation of QI to relieve pain, also have protect the liver, antiinflammatory, antitumor action.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Effect: blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.
Radix Angelicae Sinensis: warm in nature, sweet in the mouth, suffering.Return liver, the heart, spleen channel.Function cures mainly to enrich blood and invigorates blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Olibanum: property is hot, bitter, warm.Go into the heart, liver, spleen channel.Invigorate blood circulation circulation of qi promoting, pain relieving.
Myrrha: effects such as pain relieving, promoting blood circulation to remove blood stasis, circulation of qi promoting Shujin, detumescence and promoting granulation are arranged.
The traditional Chinese medical science is thought: forming an integral part for liver and gallbladder, has one's ideas straightened out in order liver storing blood, main catharsis, the function that storage is arranged and regulate blood.The present invention is according to theory of Chinese medical science monarch prescription, have protect the liver, the Coriolous Dersicolor (Fr.) Quel of immunomodulating effect, Fructus Schisandrae Chinensis, Poria is monarch drug, the Radix Astragali, Fructus Akebiae, Radix Bupleuri with invigorating QI to consolidate the body surface resistance, liver-smoothing, qi-regulating effect are ministerial drug; Moschus, Spina Gleditsiae, Gekko Swinhonis and Herba Artemisiae Scopariae with active eliminating stagnation, detumescence and apocenosis effect are adjuvant drug, and having enriches blood invigorates blood circulation, Rhizoma Curcumae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Olibanum and the Myrrha of promoting the circulation of QI to relieve pain effect are messenger drug, each medicine synergism in the side; Play the effect of invigorating QI to consolidate the body surface resistance, liver-smoothing, qi-regulating, active eliminating stagnation altogether; Human body immunity improving power, liver-protecting and cancer-resisting, and do not have obvious toxic-side effects; Be used to treat the hepatocarcinoma determined curative effect, effective percentage is high.
The specific embodiment
Embodiment 1
A kind of Chinese medicine composition of treating hepatocarcinoma is processed by following raw medicaments in portion by weight: Coriolous Dersicolor (Fr.) Quel 50, Fructus Schisandrae Chinensis 50, Poria 45, the Radix Astragali 40, Fructus Akebiae 40, Radix Bupleuri 25, Moschus 25, Spina Gleditsiae 50, Gekko Swinhonis 30, Herba Artemisiae Scopariae 30, Rhizoma Curcumae 35, Rhizoma Chuanxiong 25, Radix Angelicae Sinensis 35, Olibanum 20, Myrrha 20.
Embodiment 2
A kind of Chinese medicine composition of treating hepatocarcinoma is processed by following raw medicaments in portion by weight: Coriolous Dersicolor (Fr.) Quel 40, Fructus Schisandrae Chinensis 40, Poria 50, the Radix Astragali 50, Fructus Akebiae 45, Radix Bupleuri 25, Moschus 25, Spina Gleditsiae 45, Gekko Swinhonis 25, Herba Artemisiae Scopariae 25, Rhizoma Curcumae 30, Rhizoma Chuanxiong 20, Radix Angelicae Sinensis 35, Olibanum 15, Myrrha 20.
Embodiment 3
A kind of Chinese medicine composition of treating hepatocarcinoma is processed by following raw medicaments in portion by weight: Coriolous Dersicolor (Fr.) Quel 55, Fructus Schisandrae Chinensis 55, Poria 35, the Radix Astragali 35, Fructus Akebiae 35, Radix Bupleuri 20, Moschus 20, Spina Gleditsiae 55, Gekko Swinhonis 35, Herba Artemisiae Scopariae 35, Rhizoma Curcumae 40, Rhizoma Chuanxiong 30, Radix Angelicae Sinensis 40, Olibanum 25, Myrrha 15.
Embodiment 4
A kind of Chinese medicine composition of treating hepatocarcinoma is processed by following raw medicaments in portion by weight: Coriolous Dersicolor (Fr.) Quel 50, Fructus Schisandrae Chinensis 50, Poria 40, the Radix Astragali 35, Fructus Akebiae 45, Radix Bupleuri 30, Moschus 30, Spina Gleditsiae 45, Gekko Swinhonis 25, Herba Artemisiae Scopariae 35, Rhizoma Curcumae 40, Rhizoma Chuanxiong 30, Radix Angelicae Sinensis 30, Olibanum 15, Myrrha 25.
Embodiment 5: the clinical trial result of traditional Chinese medicine composition for treating hepatocarcinoma of the present invention.Selecting 332 routine liver cancer patients is example.
1, diagnostic criteria
1.1, the Western medicine diagnose standard
Primary hepatocarcinoma diagnostic criteria with in " the Chinese common cancer diagnosis and treatment standard " of China's Ministry of Public Health volume is a foundation.
1.2, the tcm diagnosis standard
With reference to " new drug (Chinese medicine) treatment primary hepatocarcinoma clinical guidance principle " differentiation of symptoms and signs for classification of syndrome standard, distinguish to be the blood stasis TCM liver depression.
2, case is included standard in
2.1, clarifying a diagnosis is the patient of primary hepatocarcinoma;
2.2, Chinese medical discrimination is the patient of blood stasis stagnation of liver-QI pattern of syndrome;
2.3, Karnofsky marks more than 40 minutes, estimates the life cycle of person more than 2 months;
2.4, the age is the 25-65 patient in year;
3, Therapeutic Method
According to the foregoing description 1 prescription, single dose 260g is decocted in water for oral dose, and potion divided sooner or later and took for twice every day, and 20 days is a course of treatment.
4, efficacy assessment standard
4.1, the tumor size variation
According to primary hepatocarcinoma efficacy assessment standard in the Ministry of Public Health " Chinese common cancer diagnosis and treatment standard "; To compare with treatment back B ultrasonic or CT before the patient treatment, carry out efficacy evaluation with alleviation (CR) fully, part alleviation (PR), stable (SD), progress (PD).
4.2, tcm syndrome (treatment before and after respectively observation once, compare)
Produce effects: symptom, sign are obviously improved, and the syndrome integration reduces >=70%;
Effectively: symptom, sign all take a favorable turn, and the syndrome integration reduces >=30%;
Invalid: symptom, sign do not have obvious improvement, and the syndrome integration reduces less than 30%;
Computing formula: [integration before (integration before the treatment-treatment back integration)/treatment] * 100%
5, interpretation of result
5.1, the treatment before and after tumor size variation (seeing table 1)
Tumor size evaluation result before and after table 1 treatment
| Efficacy evaluation | CR | PR | SD | PD | Add up to |
| Number | 36 | 165 | 88 | 43 | 332 |
| Percentage rate (%) | 10.8 | 49.7 | 26.5 | 13.0 | 100 |
Visible by last table, traditional Chinese medicine composition for treating hepatocarcinoma effective percentage of the present invention is 60.5% (CR+PR), and coefficient of stabilization accounts for 87% (CR+PR+SD), explains that treatment by Chinese herbs hepatocarcinoma effective percentage of the present invention is high, has the development of the hepatocarcinoma of inhibition, the effect of stablizing the tumor body.
5.2, the doing well,improving situation
According to tcm syndrome observed result before and after the treatment relatively, doing well,improving effective percentage 82%.
5.3, the toxic and side effects analysis
Among the 332 routine patients that observe, only have 5 examples low grade fever, 3 routine laxativeness to occur after taking Chinese medicine of the present invention, the probability that side reaction occurs is merely 2.4%, disappears through disposing side reaction to the ill, and all the other are without any side effects.
In sum, the present invention is used to treat the Chinese medicine composition of hepatocarcinoma, through clinical trial, shows that it can effectively suppress the hepatocarcinoma development, improves patient's symptom, sign, and does not have obvious toxic-side effects.
Model case
Case 1: Zhang, the man, 45 years old, patient diagnosis was hepatocarcinoma mid-term, appetite is poor; Become thin, fatigue and weakness, abdominal distention, hepatalgia is according to the foregoing description 1 prescription; Single dose 260g is decocted in water for oral dose, and potion divided sooner or later and took for twice every day, and 20 days is a course of treatment; After taking 2 courses of treatment, patient's spirit and appetite take a turn for the better, and physical ability strengthens, and hepatalgia obviously alleviates.
Case 2: Jiang, the man, 60 years old, patient's symptom was that abdominal part is vexed bloated, dyspepsia; Sometimes feel sick, vomit, the heating of unknown cause, the hepatic region rest pain is diagnosed as hepatocarcinoma; Find that through the abdominal CT inspection tumor size is 3cm * 4cm, according to the foregoing description 3 prescriptions, single dose 260g is decocted in water for oral dose; Potion divided sooner or later and took for twice every day, and 20 days is a course of treatment, take 3 courses of treatment after; Patient's abdominal part is vexed to expand, heating, the symptom of feeling sick obviously alleviate, and appetite increases, and tumor is reduced into 2cm * 3cm on inspection, and sb.'s illness took a favorable turn.
Claims (2)
1. Chinese medicine composition of treating hepatocarcinoma; It is characterized in that, process: Coriolous Dersicolor (Fr.) Quel 40-55, Fructus Schisandrae Chinensis 40-55, Poria 35-50, Radix Astragali 35-50, Fructus Akebiae 35-45, Radix Bupleuri 20-30, Moschus 20-30, Spina Gleditsiae 45-55, Gekko Swinhonis 25-35, Herba Artemisiae Scopariae 25-35, Rhizoma Curcumae 30-40, Rhizoma Chuanxiong 20-30, Radix Angelicae Sinensis 30-40, Olibanum 15-25, Myrrha 15-25 by following raw medicaments in portion by weight.
2. the Chinese medicine composition of treatment hepatocarcinoma according to claim 1; It is characterized in that, process: Coriolous Dersicolor (Fr.) Quel 50, Fructus Schisandrae Chinensis 50, Poria 45, the Radix Astragali 40, Fructus Akebiae 40, Radix Bupleuri 25, Moschus 25, Spina Gleditsiae 50, Gekko Swinhonis 30, Herba Artemisiae Scopariae 30, Rhizoma Curcumae 35, Rhizoma Chuanxiong 25, Radix Angelicae Sinensis 35, Olibanum 20, Myrrha 20 by following raw medicaments in portion by weight.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920977A (en) * | 2012-10-12 | 2013-02-13 | 河南科技大学 | Traditional Chinese medicine composition for treating liver cancer |
| CN104800766A (en) * | 2015-05-06 | 2015-07-29 | 李桂香 | Liver soothing and qi regulating preparation for liver cancer patients and preparing method |
| CN105596589A (en) * | 2016-01-07 | 2016-05-25 | 甘肃省中医院 | Traditional Chinese medicine composition for treating liver cancer and preparing method and application thereof |
| CN106177660A (en) * | 2016-07-27 | 2016-12-07 | 朱华亭 | A kind of Chinese medicine preparation for treating hepatocarcinoma and preparation method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772262A (en) * | 2005-10-27 | 2006-05-17 | 吴军杰 | Broad-spectrum cancer-treating Chinese medicine prepn and its prepn process |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1772262A (en) * | 2005-10-27 | 2006-05-17 | 吴军杰 | Broad-spectrum cancer-treating Chinese medicine prepn and its prepn process |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920977A (en) * | 2012-10-12 | 2013-02-13 | 河南科技大学 | Traditional Chinese medicine composition for treating liver cancer |
| CN102920977B (en) * | 2012-10-12 | 2013-12-18 | 河南科技大学 | Traditional Chinese medicine composition for treating liver cancer |
| CN104800766A (en) * | 2015-05-06 | 2015-07-29 | 李桂香 | Liver soothing and qi regulating preparation for liver cancer patients and preparing method |
| CN105596589A (en) * | 2016-01-07 | 2016-05-25 | 甘肃省中医院 | Traditional Chinese medicine composition for treating liver cancer and preparing method and application thereof |
| CN106177660A (en) * | 2016-07-27 | 2016-12-07 | 朱华亭 | A kind of Chinese medicine preparation for treating hepatocarcinoma and preparation method |
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| CN102626508B (en) | 2013-07-10 |
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