CN1857471A - Tribuloside composition preparing and its preparing process - Google Patents
Tribuloside composition preparing and its preparing process Download PDFInfo
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- CN1857471A CN1857471A CN 200610046080 CN200610046080A CN1857471A CN 1857471 A CN1857471 A CN 1857471A CN 200610046080 CN200610046080 CN 200610046080 CN 200610046080 A CN200610046080 A CN 200610046080A CN 1857471 A CN1857471 A CN 1857471A
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Abstract
The present invention relates to compound preparation with total tribuloside composition as main component for treating cardiac and cerebral vascular diseases. The total tribuloside composition contains total tribuloside in 1-99 wt% and ligustrazine, total erigeron braviscapus flavone, total haw stem and leaf phenolic acid, gingko leaf flavonid, sowthistle-leaf ixeris flavonid, safflower flavonid, pueraria flavonid, astragalus flavonid and total saponin, total salvianolic acid, total paeoniflorin or seabuckthorn flavonid in 1-99 wt%, and is compounded with pharmaceutically acceptable supplementary material to prepare pharmaceutically acceptable preparations. The medicine of the present invention is used in preventing and treating cardiac and cerebral vascular diseases, senile dementia, kidney deficiency disease and other diseases.
Description
Technical field:
The present invention relates to a kind of compound preparation of the treatment cardiovascular and cerebrovascular disease based on the Fructus Tribuli total saponins compositions.And the application of various preparations in pharmaceutical field that utilizes the inventive method to obtain, the particularly application in the medicine of preparation control cardiovascular and cerebrovascular disease, senile dementia, cerebral infarction, cerebral ischemia and other various diseases that causes by cerebral ischemia, the disease of suffering from a deficiency of the kidney etc.Make a distinction between the important and the lesser one in the full side of medicine of the present invention, compatibility is proper, and complementation is short mutually.
Background technology:
Fructus Tribuli, Rhizoma Chuanxiong, Herba Erigerontis, Fructus Crataegi, Semen Ginkgo, Herba Ixeritis Sonchifoliae, Radix Puerariae, Flos Carthami, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Fructus Hippophae all are China's conventional Chinese medicines, its medicine as the treatment cardiovascular and cerebrovascular disease has basis of clinical application widely and long clinical application history, and evident in efficacy.Modern pharmacology studies show that Fructus Tribuli except that having at cardio-cerebrovascular the important physical activity, also has to improve the masculinity and femininity sexual function, improve effect such as Woman climacteric; Rhizoma Chuanxiong, Herba Erigerontis have that to improve the breviscapine that contains in myocardial oxygen delivery and multiple important physical effects such as hemorheology, removing interior free yl, the ligustrazine that wherein contains in the Rhizoma Chuanxiong, the Herba Erigerontis be wherein main effective ingredient; Total phenolic acids of Caulis Crataegi and Folium Crataegi improves significantly to the blood ability of penetrating, the oxygen metabolism effect tool of heart, can significantly increase cardiac output and cardiac output, increases venous oxygen content, reduces myocardial oxygen consumption, improves the blood supply oxygen supply of cardiac muscle; Folium Ginkgo total flavones and Herba Ixeritis Sonchifoliae total flavones have effects such as blood vessel dilating, blood flow increasing, blood viscosity lowering, quickening blood flow rate, anti-hypoxia; Radix Puerariae total flavones (its main component is a puerarin) has promoting blood circulation and stopping pain, expansion is normal and the coronary vasodilator of spasm, lax vascular smooth muscle, improve ischemic region the cardiac muscle power supply, reduce the myocardium lactic acid that causes because of ischemia generation, reduce oxygen consumption, improve effect such as myocardial metabolism; Flos Carthami total flavone has effects such as coronary artery dilator, coronary blood flow increasing, microcirculation improvement, blood fat reducing, blood pressure lowering; Radix Astragali total flavones and total saponins thereof have the myocardium shrinkage function of improvement, dwindle myocardial infarction area, alleviate myocardial damage, improve myocardial ischemia, protect effects such as cardiovascular and cerebrovascular vessel, microcirculation improvement, antiviral property myocarditis; Effects such as salvianolic acid has the myocardium shrinkage function of improvement, blood vessel dilating, bring high blood pressure down, improve coronary artery and cerebral artery blood flow amount, anticoagulant, raising cell hypoxia-bearing capability; Peoniflorin have promote learning memory disorder due to learning and memory, the antagonism scopolamine, significantly improve learning memory disorder due to the cerebral ischemia re-pouring, improve effects such as body microcirculating state, blood viscosity lowering, the inductive platelet aggregation of inhibition ADP.Modern clinical research shows that Fructus Hippophae total flavones has curative effect preferably for angina pectoris, coronary heart disease.
Total saponins in the Fructus Tribuli has two big classes, and wherein a class has haemolysis, and another kind of then do not have a haemolysis.How to overcome the shortcoming of taking single medicinal material, reasonable compatibility, short complementary mutually, make it to become effective good recipe of the treatment diseases of cardiovascular and cerebrovascular systems and the disease of suffering from a deficiency of the kidney, make it improving cardio-cerebrovascular function and control aging of brain, raise immunity, slow down aging, the kidney invigorating bone strengthening, aspect performance the best use of such as improve the quality of living are its maximum difficult points.
Summary of the invention:
The objective of the invention is defective and deficiency at above-mentioned prior art existence, provide a kind of and can overcome the shortcoming of taking single medicinal material, reasonable compatibility, short complementary mutually, make it to become effective good recipe of the treatment diseases of cardiovascular and cerebrovascular systems and the disease of suffering from a deficiency of the kidney, make it improving cardio-cerebrovascular function and control aging of brain, raise immunity, slow down aging the kidney invigorating bone strengthening, aspect performance the best use of such as improve the quality of living.
Another object of the present invention is to solve the hemolytic method of Fructus Tribuli total saponins.
Further aim of the present invention provides the total saponins of tribulus compositions (compositions of Fructus Tribuli total saponins and ligustrazine and salt thereof, the compositions of Fructus Tribuli total saponins and Herba Erigerontis total flavones, the compositions of Fructus Tribuli total saponins and total phenolic acids of Caulis Crataegi and Folium Crataegi, the compositions of Fructus Tribuli total saponins and Folium Ginkgo total flavones, the compositions of Fructus Tribuli total saponins and Herba Ixeritis Sonchifoliae total flavones, Fructus Tribuli total saponins and total safflower flavone composition, Fructus Tribuli total saponins and pueraria flavonid composition, Fructus Tribuli total saponins and Radix Astragali total flavones and total astragalin composition, Fructus Tribuli total saponins and salvianolic acid compositions, the compositions of Fructus Tribuli total saponins and Radix Paeoniae Alba total glycosides, the compositions of Fructus Tribuli total saponins and Fructus Hippophae total flavones) and the application of preparation in pharmaceutical field, particularly be used to prevent and treat cardiovascular and cerebrovascular disease in preparation, senile dementia, other dysfunction that cerebral ischemia causes, the medicine of the disease of suffering from a deficiency of the kidney and the anti-ageing disease of waiting for a long time.The present invention is implemented by following technical proposals.
The present invention relates to a kind of is the method that main preparation prevents and treats the compound preparation of cardiovascular and cerebrovascular disease, senile dementia, cerebral ischemia and other various diseases that is caused by cerebral ischemia, the disease of suffering from a deficiency of the kidney etc. by the Fructus Tribuli total saponins compositions, it is characterized in that this method comprises following content:
(1) calculates according to composition by weight and get 1～99 part of Fructus Tribuli total saponins (content of its total saponins should be 20%～100%) respectively and ligustrazine (comprises various mineral acids and acylates such as hydrochlorate, sulfate, its content is 20%～100%) 99～1 parts, respectively or mix the back and add suitable adjuvant such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(2) calculate according to composition by weight and get 1～99 part of Fructus Tribuli total saponins (content of its total saponins should be 20%～100%) and Herba Erigerontis total flavones respectively (content of flavone is 20%～100% in the Herba Erigerontis total flavones, comprise that also content reaches the breviscapine more than 90%) 99～1 parts, respectively or mix the back and add suitable adjuvant such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(3) calculate according to composition by weight and get 99～1 parts of 1～99 part of Fructus Tribuli total saponins (content of its total saponins should be 20%～100%) and total phenolic acids of Caulis Crataegi and Folium Crataegi (content of total phenolic acid is 20%～100% in the total phenolic acids of Caulis Crataegi and Folium Crataegi) respectively, respectively or mix the suitable adjuvant of back adding such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(4) calculate according to composition by weight and get 99～1 parts of 1～99 part of Fructus Tribuli total saponins (content of its total saponins should be 20%～100%) and Folium Ginkgo total flavoness (content of total flavone is 20%～100% in the Folium Ginkgo total flavones) respectively, respectively or mix the suitable adjuvant of back adding such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(5) calculate according to composition by weight and get 99～1 parts of 1～99 part of Fructus Tribuli total saponins (content of its total saponins should be 20%～100%) and Herba Ixeritis Sonchifoliae total flavoness (content of total flavone is 20%～100% in the Herba Ixeritis Sonchifoliae total flavones) respectively, respectively or mix the suitable adjuvant of back adding such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(6) calculate according to composition by weight and get 99～1 parts of 1～99 part of and Flos Carthami total flavones of Fructus Tribuli total saponins (content of its total saponins should be 20%～100%) (content of total flavone is 20%～100% in the total flavones) respectively, respectively or mix the back and add suitable adjuvant such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(7) calculate according to composition by weight and get 1～99 part of Fructus Tribuli total saponins (content of its total saponins should be 20%～100%) and Radix Puerariae total flavones respectively (content of total flavone is 20%～100% in the Radix Puerariae total flavones, also can be that content is at the puerarin more than 80%) 99～1 parts, respectively or mix the back and add suitable adjuvant such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(8) calculate according to composition by weight and get 1～99 part of Fructus Tribuli total saponins (content of its total saponins should be 20%～100%) and Radix Astragali total flavones and total saponins respectively (content of total flavone is 20%～90% in the Radix Astragali total flavones, the content of total saponins is 10%～90%) 99～1 parts, respectively or mix the back and add suitable adjuvant such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(9) calculate according to composition by weight and get 99～1 parts of 1～99 part of Fructus Tribuli total saponins (content of its total saponins should be 20%～100%) and Radix Salviae Miltiorrhizae total phenolic acidss (content of total phenolic acid is 20%～100% in the Radix Salviae Miltiorrhizae total phenolic acids) respectively, respectively or mix the suitable adjuvant of back adding such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(10) calculate according to composition by weight and get 1～99 part of Fructus Tribuli total saponins (content of its total saponins should be 20%～100%) respectively and Radix Paeoniae Alba total glycosides (comprises Radix Paeoniae Rubra total glycosides and Radix Paeoniae Alba total glucosides, wherein the content of Radix Paeoniae Alba total glycosides is 20%～100%) 99～1 parts, respectively or mix the back and add suitable adjuvant such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(11) calculate according to composition by weight and get 99～1 parts of 1～99 part of Fructus Tribuli total saponins (content of its total saponins should be 20%～100%) and Fructus Hippophae total flavoness (content of total flavone is 20%～100% in the Fructus Hippophae total flavones) respectively, respectively or mix the suitable adjuvant of back adding such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
The specific embodiment
The following examples can help those skilled in the art more fully to understand the present invention.But do not limit the present invention in any way.
Embodiment 1 Fructus Tribuli Rhizoma Chuanxiong freeze-dried powder
Get Fructus Tribuli total saponins 2g respectively, ligustrazine hydrochloride 0.3g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 2 Fructus Tribuli Herba Erigerontis freeze-dried powders
Get Fructus Tribuli total saponins 1g respectively, breviscapine 1.0g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 3 Fructus Tribuli Fructus Crataegi freeze-dried powders
Get Fructus Tribuli total saponins 2g respectively, total phenolic acids of Caulis Crataegi and Folium Crataegi 1.4g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 4 Fructus Tribuli Folium Ginkgo lyophilized powder pins
Get Fructus Tribuli total saponins 1g respectively, Folium Ginkgo total flavones 1.0g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 5 Fructus Tribuli Ixers sonchifolia freeze-dried powders
Get Fructus Tribuli total saponins 2g respectively, Herba Ixeritis Sonchifoliae total flavones 1.0g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 6 Fructus Tribuli Radix Paeoniae freeze-dried powders
Get Fructus Tribuli total saponins 2g respectively, Radix Paeoniae Alba total glycosides 0.8g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 7 Fructus Tribuli Flos Carthami freeze-dried powders
Get Fructus Tribuli total saponins 2g respectively, Flos Carthami total flavone 0.5g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 8 Fructus Tribuli Radix Puerariae freeze-dried powders
Get Fructus Tribuli total saponins 2g respectively, Radix Puerariae total flavones 1.5g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 9 Fructus Tribuli Radix Astragali freeze-dried powders
Get Fructus Tribuli total saponins 2g respectively, Radix Astragali total flavones and total saponins 2.5g mix the back with an amount of water for injection dissolving, add 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 10 Fructus Tribuli Radix Salviae Miltiorrhizae freeze-dried powders
Get Fructus Tribuli total saponins 1g respectively, Radix Salviae Miltiorrhizae total phenolic acids 1.5g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 11 Fructus Tribuli Fructus Hippophae freeze-dried powders
Get Fructus Tribuli total saponins 2g respectively, Fructus Hippophae total flavones 1.0g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 12 Fructus Tribuli Rhizoma Chuanxiong capsules
Get Fructus Tribuli total saponins 30g respectively, ligustrazine hydrochloride 5g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 13 Fructus Tribuli Herba Erigerontis capsules
Get Fructus Tribuli total saponins 20g respectively, breviscapine 10g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 14 Fructus Tribuli Folium Ginkgo capsule
Get Fructus Tribuli total saponins 20g respectively, Folium Ginkgo total flavones 5g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 15 Fructus Tribuli Fructus Crataegi capsules
Get Fructus Tribuli total saponins 20g respectively, total phenolic acids of Caulis Crataegi and Folium Crataegi 10g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 16 Fructus Tribuli Herba Ixeritis Sonchifoliae capsules
Get Fructus Tribuli total saponins 10g respectively, Herba Ixeritis Sonchifoliae total flavones 20g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 17 Fructus Tribuli Radix Paeoniae capsules
Get Fructus Tribuli total saponins 10g respectively, Radix Paeoniae Alba total glycosides 8g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 18 Fructus Tribuli safflower capsules
Get Fructus Tribuli total saponins 10g respectively, Flos Carthami total flavone 10g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 19 Fructus Tribuli radix puerariae capsules
Get Fructus Tribuli total saponins 20g respectively, Radix Puerariae total flavones 15g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 20 Fructus Tribuli Radix Astragali capsules
Get Fructus Tribuli total saponins 20g respectively, Radix Astragali total flavones and total saponins 10g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 21 Fructus Tribuli capsule of red sage root
Get Fructus Tribuli total saponins 10g respectively, Radix Salviae Miltiorrhizae total phenolic acids 18g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 22 Fructus Tribuli Fructus Hippophae capsules
Get Fructus Tribuli total saponins 20g respectively, Fructus Hippophae total flavones 15g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
The extraction of embodiment 23 Herba Erigerontis total flavones, total phenolic acids of Caulis Crataegi and Folium Crataegi, Folium Ginkgo total flavones, Herba Ixeritis Sonchifoliae total flavones, Flos Carthami total flavone, Radix Puerariae total flavones, Fructus Hippophae total flavones, Radix Astragali total flavones
(1) takes by weighing Herba Erigerontis or hawthorn stem and leaf or Semen Ginkgo stem and leaf or Herba Ixeritis Sonchifoliae or Flos Carthami or Radix Puerariae or Fructus Hippophae or Radix Astragali 1Kg, water or variable concentrations alcohol (comprising ethanol, methanol etc.) extract 1～3 time, and (the solvent consumption is 15Kg～30Kg), be evaporated to 0.5～1L, add 1～4L ethanol, filter, reclaim ethanol to there not being the alcohol flavor.Concentrate with suitable quantity of water dissolving (100～1000ml), with organic solvent degreasing (comprise petroleum ether, chloroform, etc., hyposynchronization also can save), extractions such as ethyl acetate or n-butyl alcohol or n-amyl alcohol, get final product behind the recovery organic solvent the total flavones crude product.
(2) take by weighing Herba Erigerontis or hawthorn stem and leaf or Semen Ginkgo stem and leaf or Herba Ixeritis Sonchifoliae or Flos Carthami or Radix Puerariae or Fructus Hippophae or Radix Astragali 1Kg, add 6～10 times of water gagings, regulate pH to 8～9, decocted 0.5～3 hour, filter, extract so repeatedly 1～3 time with lime cream.Merge extractive liquid, is chilled to below 70 ℃, regulates pH to 3～5 with acid (comprising mineral acid and organic acid such as acetic acid, trichloroacetic acid such as hydrochloric acid, sulphuric acid), and is static, filter get final product the total flavones crude product.
(3) take by weighing Herba Erigerontis or hawthorn stem and leaf or Semen Ginkgo stem and leaf or Herba Ixeritis Sonchifoliae or Flos Carthami or Radix Puerariae or Fructus Hippophae or Radix Astragali 1Kg, water or different concentration ethanol are extracted 1～3 time, and (the solvent consumption is 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filter, reclaim ethanol to there not being the alcohol flavor.With suitable quantity of water dissolving (100～1000ml), (comprise polarity, middle polarity and nonpolar macroporous adsorption resin through the separation of macroporous adsorbent resin chromatography post, the ratio of the consumption of resin and crude drug is 1: 0.2～5), water, different concentration ethanol or methanol-eluted fractions successively, collect different concentration ethanol or methanol-eluted fractions fraction, reclaim get final product behind the solvent the different total flavones elaboration of purity.The total flavones crude product that obtains in above-mentioned (1 and 2) also can be by macroporous adsorbent resin chromatography post refining (method be the same).
(4) take by weighing Herba Erigerontis or hawthorn stem and leaf or Semen Ginkgo stem and leaf or Herba Ixeritis Sonchifoliae or Flos Carthami or Radix Puerariae or Fructus Hippophae or Radix Astragali 1Kg, water or different concentration ethanol are extracted 1～3 time, and (the solvent consumption is 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filter, reclaim ethanol to there not being the alcohol flavor.With suitable quantity of water dissolving (100～1000ml), separate through the polyamide chromatographic column, water, different concentration ethanol or methanol-eluted fractions are collected different concentration ethanol or methanol-eluted fractions fraction successively, reclaim get final product behind the solvent the different total flavones elaboration of purity.The total flavones crude product that obtains in above-mentioned (1 and 2) also can be by polyamide chromatographic column refining (method be the same).
The extraction of embodiment 24 Fructus Tribuli total saponins, Radix Paeoniae Alba total glycosides
(1) take by weighing Fructus Tribuli or Radix Paeoniae 1Kg, water or variable concentrations alcohol (comprising ethanol, methanol etc.) extract 1～3 time (the solvent consumption are 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filters, and reclaims ethanol to there not being the alcohol flavor.Concentrate with suitable quantity of water dissolving (100～1000ml), with organic solvent degreasing (comprise petroleum ether, chloroform, ethyl acetate etc., hyposynchronization also can save), n-butanol extraction (comprising n-amyl alcohol etc.), reclaim get final product behind the n-butyl alcohol slightly total glycosides or total saponins.
(2) take by weighing Fructus Tribuli or Radix Paeoniae 1Kg, water or different concentration ethanol are extracted 1～3 time (the solvent consumption are 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filters, and reclaims ethanol to there not being the alcohol flavor.With suitable quantity of water dissolving (100～1000ml), (comprise polarity, middle polarity and nonpolar macroporous adsorption resin through the separation of macroporous adsorbent resin chromatography post, the ratio of the consumption of resin and crude drug is 1: 0.2～5), water, different concentration ethanol eluting successively, collect the different concentration ethanol eluting fraction, get final product different total glycosides or the total saponins elaboration of purity.Thick total saponins that obtains in above-mentioned (1) or total glycosides also can be by macroporous adsorbent resin chromatography post refining (method be the same).
The extraction of embodiment 25 Radix Salviae Miltiorrhizae total phenolic acidss
Take by weighing Radix Salviae Miltiorrhizae 1Kg, water or different concentration ethanol are extracted 1～3 time (the solvent consumption are 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filters, and reclaims ethanol and can not get the salvianolic acid crude product to there being pure flavor.The salvianolic acid crude product is soluble in water, (comprise polarity, middle polarity and nonpolar macroporous adsorption resin with the separation of macroporous adsorbent resin chromatography post, the ratio of the consumption of resin and crude drug is 1: 0.2～5), water, different concentration ethanol eluting successively, collect different eluting fractions, can get the different salvianolic acid of purity.
Claims (10)
1, a kind of Fructus Tribuli total saponins compositions, it is characterized in that being grouped into (percentage by weight) by following one-tenth: Fructus Tribuli total saponins 1%～99%, ligustrazine (comprises hydrochlorate, various mineral acids such as sulfate and acylate) 99%～1% or Herba Erigerontis total flavones 99%～1% or total phenolic acids of Caulis Crataegi and Folium Crataegi 99%～1% or Folium Ginkgo total flavones 99%～1% or Herba Ixeritis Sonchifoliae total flavones and saponin 99%～1% or Flos Carthami total flavone 99%～1% or Radix Puerariae total flavones 99%～1% or Radix Astragali total flavones and total saponins 99%～1% or salvianolic acid 99%～1% or Radix Paeoniae Alba total glycosides (comprising Radix Paeoniae Rubra total glycosides and Radix Paeoniae Alba total glucosides) 99%～1% or Fructus Hippophae total flavones 99%～1%.More particularly, be meant in Fructus Tribuli total saponins and the said medicine combination of any one or two or more medicines, be equipped with suitable pharmaceutic adjuvant and make the pharmaceutically various preparations of acceptable.
2, according to right 1 described preparation, it is characterized in that: in the described composition in the Fructus Tribuli total saponins content of total saponins should be 20%～100%.
3, according to right 1 described preparation, it is characterized in that: the ligustrazine in the described composition comprises various mineral acids and acylates such as the hydrochlorate, phosphate of ligustrazine, and its content is 20%～100%.
4, according to right 1 described preparation, it is characterized in that: the content of flavone is 20%～100% in the Herba Erigerontis total flavones in the described composition, comprises that also content reaches the breviscapine more than 90%.
5, according to right 1 described preparation, it is characterized in that: the content of total phenolic acid is 20%～100% in the total phenolic acids of Caulis Crataegi and Folium Crataegi in the described composition; Content of total flavone is 20%～100% in the Folium Ginkgo total flavones; Content of total flavone is 20%～100% in the Herba Ixeritis Sonchifoliae total flavones; Content of total flavone is 20%～100% in the Flos Carthami total flavone; Content of total flavone is 20%～100% in the Fructus Hippophae total flavones; The content of the Radix Paeoniae Alba total glycosides in the Radix Paeoniae Alba total glycosides (comprising Radix Paeoniae Rubra total glycosides and Radix Paeoniae Alba total glucosides) is 20%～100%, and content of total flavone is 20%～100% in the Radix Puerariae total flavones, comprises that also content reaches the puerarin more than 80%.
6, according to right 1 described preparation, it is characterized in that: content of total flavone is 20%～90% in Radix Astragali total flavones in the described composition and the total saponins, and the content of total saponins is 10%～90%.
7, according to right 1 described preparation, it is characterized in that: the salvianolic acid in the described composition is by the phenolic acid compound that extracts in the Radix Salviae Miltiorrhizae, and the phenolic acid compound wherein such as the content of phenolic acid compounds such as danshensu, salvianolic acid B are 20%～100%.
8, according to right 1 described preparation of compositions method, it is characterized in that: it is the characteristics according to various compositionss, and the modern preparation technique that allows on the employing pharmaceutics is realized.
9, all kinds of preparations of making according to right 1 described compositions, it is characterized in that: it comprises injection type, peroral dosage form, percutaneous dosing dosage form, mucosa absorption dosage form.
10, all kinds of preparations of making according to right 1 described compositions is characterized in that: be mainly used in other dysfunction, the disease of suffering from a deficiency of the kidney and the anti-ageing disease of waiting for a long time that control cardiovascular and cerebrovascular disease, senile dementia, cerebral infarction, cerebral ischemia cause.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101288705B (en) * | 2007-04-18 | 2010-12-22 | 北京本草天源药物研究院 | Medicine composition mainly for adjusting blood fat and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101288705B (en) * | 2007-04-18 | 2010-12-22 | 北京本草天源药物研究院 | Medicine composition mainly for adjusting blood fat and its preparation method |
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