CN1849145A - Formulation for a cement preparation as bone substitute - Google Patents
Formulation for a cement preparation as bone substitute Download PDFInfo
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- CN1849145A CN1849145A CNA2003801049195A CN200380104919A CN1849145A CN 1849145 A CN1849145 A CN 1849145A CN A2003801049195 A CNA2003801049195 A CN A2003801049195A CN 200380104919 A CN200380104919 A CN 200380104919A CN 1849145 A CN1849145 A CN 1849145A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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Abstract
A bone cement comprises a powdery component including calcium phosphate and an aqueous liquid component. A radiopaque material is added to at least one of the powder and liquid components, and the components may be combined into a pasty substance for application to bone.
Description
Technical field
The present invention relates to a kind of formulation of cement article of bone substitute, it contains calcium phosphate as major constituent, and with water or liquid, aqueous the mixing, obtain sticking with paste or pastel.The invention still further relates to and a kind ofly prepare phosphate cement, the method for apatite and guanite cement especially by these formulations.
Background technology
Since 1970, calcium phosphate ceramic is sold as synthetic bone implant on market always.But such pottery has changeless size, is difficult to adapt to be generally erose bone defective.It also has a shortcoming to be: calcium phosphate ceramic can not be absorbed in the tissue fully again.Poor like this absorbability again comes from the sintering preparation method, and this mode forms very thick structure.
Since nineteen eighty, the appearance of calcium phosphate cement has obvious improvement than existing bone pottery.This is because they can fill up erose bone defective, and improves the load transfer between bone and the implant.Such calcium phosphate cement is powdered, and it and liquid mixing just form pastel, can easily add to the marrow in the defective.
In the solidification process of this calcium phosphate cement, calcium phosphate precipitates, because it is thermodynamically stable.Such precipitated calcium phosphate is aspect the soma degraded, and is more far better than sintered material, because the structure density of solidified cement is littler than sintered material.Such cement has description in United States Patent (USP) 4612053, United States Patent (USP) 5149368, United States Patent (USP) 4518430, WO96/14265, EP1296909A1 and EP0835668A1.Their content is in conjunction with being referred to this.For example BoneSource, Norian SRS, Biobon, Calcibon and Cementek sell such cement with trade name.
An object of the present invention is to provide a kind of harden and can resorbent bone or other cement article, they have improved safety, and when implanting required time shorter.Just increased the selection degree of freedom of operator when implanting or using cement article thus.Another object of the present invention is: cement article of the present invention has improved processing characteristics, and the sclerosis cement intensity of increase is provided.A further object of the present invention is that cement article has improved X ray contrast.
The description of background technology: described above United States Patent (USP) 4612053, United States Patent (USP) 5149368, United States Patent (USP) 4518430, PCT publication WO96/14265, EP publication EP 1296909A1 and EP0835668A1.Various calcium phosphate and other bone cements and in conjunction with the filler of radiopaque material at United States Patent (USP) 6641587,6599520,6075067,6375659 and WO02/32474 (corresponding to United States Patent (USP) 6599520) and WO02/17801 (corresponding to United States Patent (USP) 6641587).The full text of each patent and disclosed patent application is in conjunction with being referred to this.
Summary of the invention
In a first aspect of the present invention, a kind of cement article is provided, it is as bone substitute or filler, and it contains calcium phosphate as major constituent.This calcium phosphate component is typical powdery, and contains other materials.This powder is suitable for and water or liquid, aqueous the mixing, forms the pastel (viscosity) add defective to the marrow or other bone target locations.Before blending ingredients, with the additive and the cement article of a kind of raising X ray contrast (radiopaque), preferably phosphoric acid calcium dry powder component, but mix with aquo-compound in some cases.
In another aspect of this invention, provide a kind of method for preparing cement, this method comprises: the additive of phosphoric acid calcium powder, preferred apatite material and raising X ray contrast and water or moisture component are mixed; And make mixture cures.This sclerosis can form cement, preferred apatite cement, as product.
In an especially preferred embodiment of the present invention, cement article of the present invention contains and will and/or liquid, aqueously carry out blended calcium salt with water, magnesium salt, and/or the salt mixture of orthophosphate, the additive that wherein improves the X ray contrast contains at least a such material, and it is selected from: barium salt, metal and inorganic and organically metallic compound preferable alloy oxide (wherein said metal is selected from: ferrum, titanium, tantalum, gold, silver, rare earth element, yttrium, ytterbium, zirconium, niobium, molybdenum, ruthenium, rhodium, palladium and tungsten), the chemical compound of preferred gadolinium of rare earth element or cerium, inorganic or organic iodine compound, with agglomerating hydroxyapatite and agglomerating tricalcium phosphate.
Above-mentioned cement article especially can be used as bone substitute.Term " bone substitute " comprises substitute material, bone implant, bone filler, bone cement, bone cementum of bone etc.The disease that such bone substitute can be used for treating bone defective and fracture and skeletal system is osteoporosis or cancer for example.
The compositions and methods of the invention solve the following general issues of the cement of phosphoric acid calcium: owing to the similar chemical constitution of nature bone to the cement of the phosphoric acid calcium of using, can not provide qualified X ray contrast.In the present invention, a kind of additive that has enhancing or strengthen performance, with respect to the formulation or the compositions that lack this additive, its X ray contrast (radiopaque) improves the range estimation ability of the bony site of being treated that usually can not observe directly significantly, and makes doctor can estimate the process and the result of treatment on the X ray picture.The picture that obtains having higher X ray contrast can improve the safety of treatment.In addition, sclerosis cement of the present invention also has good absorption characteristic again.
Adopt choosing to improve the additive (the optional auxiliary additive of augmenting) of X ray contrast, the mixture of phosphoric acid calcium powder of the present invention and liquid, aqueous component just can provide a kind of like this material: it has pastel (paste) denseness, and this denseness has good flowable energy.In addition, this material forms the sclerosis cement that has minimum or do not lose product strength.Calcium phosphate compositions of the present invention does not preferably contain plastics, polymethyl methacrylate (PMMA) for example, so just can use the additive of multiple raising X ray contrast, because calcium phosphate cement can be owing to the chain reaction of polymer is hardened with wide range of concentrations.Many X ray additives, the additive of high concentration especially can disturb polyreaction in such PMMA cement, and can reduce the intensity of sclerosis PMMA cement.In addition, the bone cement goods at the hardened raising radiopacity of target site of the present invention usually have the absorption characteristic again of raising.Therefore, compositions of the present invention can be optimized according to desired application.According to the type of selected X ray contrast improving agent, said composition can be mixed with the high stability radiopaque performance that long-term observation arrives.In addition, in order to reduce the probability of the stimulation health that additive causes, can reduce the radiopaque performance after the operation.The combination property of the operation process range estimation property that generally speaking, the invention provides good machinability, hardening characteristics, increases.
Detailed description of the invention
Cement article of the present invention is based on the mixture of a kind of powdery component and liquid, aqueous component, and this powdery component contains main calcium phosphate, preferably at least about 50% weight percent phosphoric acid calcium, more preferably is at least about 65% weight, most preferably is at least about 75% weight; Described liquid, aqueous water or the common aqueous solution of containing is used to harden and prepare the cement product that generally is used as bone substitute.Basic powdery component preferably also contains other salt of tricalcium orthophosphate or magnesium and optional other metals except calcium phosphate.The tricalcium phosphate (TCP) of especially preferred α and/or beta type.Liquid components contains water and optional also contains other compositions, and preferred salt more preferably has the salt of buffering effect, specifically is sodium, potassium and/or the ammonium salt of a generation and/or secondary phosphoric acid, or corresponding carbonate.The pH value of liquid components is suitable for being adjusted to for example about 5-12, more preferably from about in the scope of 7-12.
For the cement article of the radiopaque performance with raising, improved mobile performance and improved mechanical property (especially improved hardening strength) is provided, cement article preferably contains the powdery component, and this powdery component comprises calcium, magnesium and orthophosphate.To describe the additive (being also referred to as radiopaque reinforcing agent or radiopaque material in this article) that improves the X ray contrast below in detail, it is preferably sneaked in the powdery component, and very advantageously hardening characteristics and/or mechanical property do not descend substantially.In addition, this sclerosis cement has especially good absorption characteristic again.In yet another preferred embodiment, basic cement article or in the powdery component or preferably in liquid, aqueous component also contains ammonium salt, especially ammonium phosphate salt form, for example (NH
4)
2HPO
4And/or (NH
4) H
2PO
4The mol ratio of calcium, magnesium and P is preferably 1.00＜Ca/P＜1.50 and O＜Mg/P＜0.50.The formulation of especially preferred cement article is the ammonium magnesium phosphate cement article that discloses among the EP-A-1296909.
For improving X ray contrast (radiopaque), in principle, can use atomic number in the periodic table of elements＞20 and be higher than all elements of calcium thus.Chemical compound according to employed element or element, should consider: by selecting the radiopaque element or the chemical compound of adequate types, and by using suitable amounts, concentration and/or the denseness of radiopaque additive, described cement article just can provide sufficiently high radiopaque performance.
The additive that improves X ray contrast (radiopaque performance) can mix with the powdery component of cement article or liquid components or both.The sclerous reaction product that is obtained by formulation of the present invention or compositions can advantageously contain crystalline compounds, especially monocrystalline phosphate compounds, apatite structure, hydroxyapatite structure, guanite cement or tricresyl phosphate barium.
Radiopaque effect according to the sclerosis cement of the type of radiopaque reinforcing agent and phosphoric acid calcium, the amount ranges of radiopaque reinforcing agent is suitably certainly at least about in 0.5% weight to 25% weight range, preferably certainly at least about 3% to 20% weight, more preferably certainly at least about 5% to 15% weight, most preferably certainly at least about 10% weight.The upper limit can be selected according to the type and predetermined should being used for of radiopaque additive suitably.The upper limit of consumption can for example be about 50% weight, more preferably 25% weight.The preferred upper limit of above-mentioned radiopaque reinforcing agent consumption and lower limit specifically are to consider to select from such angle: have the combination property of favourable following performance, the radiopaque performance that promptly significantly improves, maintenance simultaneously or even the flowable energy of raising cement article when intra-operative is administered to predeterminated target.Above-mentioned weight % is a benchmark with the weight of powdery component.Liquid, aqueous component mixes with the powdery component with such consumption: with respect to every mg powder, and about 0.1-1.5ml, preferably about 0.2-0.65ml liquid.
In a preferred embodiment of the present invention, when keeping and preferably improving the flowable of the cement article that is mixed into pastel, use additive.The example of such additive is strontium salt, especially barium salt, and they are used singly or in combination.For example be selected from the chemical compound of strontium carbonate, strontium phosphate and barium sulfate.By using the mixture of such chemical compound, can improve the machinability of the cement article of phosphoric acid calcium extraly, especially syringeability is because the mixture of these chemical compounds improves the flowable of the cement article when mixing with liquid components significantly.In addition, the required pressure of injection cement article also reduces thus greatly.Reduce injection pressure for for operator, not only more comfortable, and also more convenient.So-called " filter pressing effect " also minimizes thus.This effect is understood that: therefrom extrude liquid when exerting pressure on the cement mixture of making paste (cement paste).This effect is very bad, because it is caused the initial engagement agent to stick with paste the defective curing of mixture by fluid loss.In an especially improved embodiment, do not use or not merely use strontium salt for example strontium carbonate or strontium phosphate, all or part of with barium salt for example barium sulfate replace because barium salt also advantageously influences the intensity of the sclerosis cement of formed phosphoric acid calcium.
The mixture of the barium salt of the application of the invention can obtain better adhesion when ensureing suitable hardening characteristics.In addition, when the calcium phosphate in barium salt and the cement article with when preferably also making up with magnesium phosphate, the mechanical property that can also improve curing adhesive significantly is intensity especially.Thus, by adding barium salt especially barium sulfate, tricresyl phosphate barium, barium iodide, barium zirconate and barium tungstate, just can obtain the combination property of following performance: significantly improve radiopaque performance, raising machinability especially mobile performance, suitable hardening characteristics and mechanical property.
The additive that can be used for other especially suitable raising radiopaque performances of the present invention comprises and is selected from following material: metal, inorganic metal compound is metal-oxide for example, metal nitride, metal carbides, metal silicide, metal halide, metal phosphate, the metal gluconate, metal citrate, the metal fumarate, and metal sulfate, metallo-organic compound, based on ferrum, titanium, tantalum, gold, silver, rare earth element, yttrium, ytterbium, zirconium, niobium, molybdenum, ruthenium, rhodium, palladium and tungsten are as metallic element.Preferred metallic element is ferrum and rare earth element (lanthanide series), cerium and especially gadolinium be selected rare earth element.Especially preferred such material is an iron compound, especially iron phosphate, ferrum oxide, hydrated ferric oxide., or ferrum and organic acid chemical compound for example ferric citrate (because they can be incorporated in the hardened cement article with stable manner, and it is especially effective aspect the mechanical property that does not reduce the sclerosis goods), also have salicylic acid tungsten and water solublity lanthanum or rare-earth compound, for example lanthanum acetate, Lanthanum (III) nitrate, lanthanum sulfate, the ammonium nitrate lanthanum, cerium citrate, cerous nitrate, cerium chloride, the ammonium sulfate cerium, especially gadolinium compound (having been found that they are favourable) gadolinium fluoride for example, Gadolinium trichloride, gadolinium sequestration thing (for example divinyl triamido pentaacetic acid gadolinium), Gadoteridol (available from Bristol-Myers Squibb).
Suitable metal and inorganic metal compound for example oxide, nitride, carbide, silicide and halogenide can preferably add with the fine particle form.Consider machinability, especially mobile, the mean diameter (d of metal or inorganic metal compound particle
50) be positioned at the scope of 0.1nm-10 micron suitably.Mean diameter (d
50) the preferably about 5nm of lower limit, preferably about 1 micron of the upper limit, 500nm more preferably from about, preferably about again 100nm.The fine particle material preferably joins in the powdery component of binder compositions.
Suitable material also has bromine compounds and iodine compound especially, preferred organic bromine and/or iodine compound.As more preferred example, according to the present invention, use the water soluble compound of ion or nonionic type, for example amidotrizoic acid ester (diatricoates), two iodine column rummy esters (dioxitalamates), iodine amidol (iopamidol), iohexol and Ioxaglic Acid ester (ioxaglate) etc.Suitable example in these iodine compounds can find in ECV-Editio Cantor Verlag (Aulendorf, 2003) " Rote Liste " (red catalogue) 35.2.2 part.
In addition, sintered material also can be used as radiopaque additive (one or more).The agglomerating material of preferred heights.As the preferred example of such additive, preferred agglomerating hydroxyapatite and agglomerating tricalcium phosphate.Described sintered material is the fine particle form suitably, can preferably join in the powdery component of binder compositions, as top about as described in the part of metal and inorganic metal compound.
The additive (one or more) of above-mentioned raising radiopaque performance can join in the powdery component of cement article or in the liquid component.Dried or fine particle material preferably joins in the cement powdery component, and water-soluble chemical compound is suitable for joining in the liquid components of cement article.Also can use the mixture of multiple additives.
In addition, according to purposes and predetermined purposes, the additive that improves the radiopaque performance can also stably be incorporated in the product of cement article, for example chemical compound such as oxide, sulfate or the phosphate of the metallic element of iron compound or other raising radiopaque performances.In addition, the additive that improves the radiopaque performance can also add by loosely, but after being applied to desired target, removing from hardened cement article or leak out, purpose is to improve bio-compatible, and the tissue stimulation of target site is minimized.For example, the water-soluble additives that improves the radiopaque performance can be selected as water-soluble iodine compound.
The formulation of cement article of the present invention can contain other suitable additives.For example, cement article of the present invention is particularly suited for the carrier material as biology and/or active constituents of medicine.For this purpose, cement article can also contain biology and/or pharmaceutically active substance in powdery and/or liquid components, for example antibiotics, cytostatic agent, analgesic, disinfectant, antiseptic, auxin, proliferin, protein or peptide, biopolymer etc., or the mixture of above-mentioned active substance.Especially preferred activating agent is selected from: gentamycin, Ethyl Biscoumacetate mycin (trombamycine), clindamycin, Vancomycin (vancomycine), β-TGF or its analog, bone morphogenic protein-2 white matter (BMP) series compound etc. or their compositions.
Other additive comprises the material of particulate forms, and they join in the powdery component of cement article of the present invention, and wherein particle-like substance has water-soluble performance in the liquid components of cement article.The example of these additives comprises salt, carbohydrate or sugar and polymer that can the water degraded.These with suitable particle diameter for example the 10-300 micron be present in particle in the powdery component, mixing and between hardening period, producing porous system, increase surface area, and promote the absorbent properties again of product.
The cement article that contains calcium phosphate of the present invention be mainly used in expansion (filling) in the bone defective.Aspect this, under the vertebra shaping situation or under the compression fracture situation of osteoporotic vertebral bodies, fill preternatural depressed fracture and also have vertebral body to stablize, be even more important.
Filling under the situation of vertebral body with the cement that contains calcium phosphate, if range estimation control is not enough, risk is especially high.When adding or use the cement paste, material can overflow from vertebral body, for example can enter spinal canal, and may cause oppressing spinal cord.Consequence can be very serious for the patient, because can paralyse.
For fear of this result, the operation in vertebra tagma is implemented under image transfer control (X ray control).Because the cortex sclerotin is equal substantially with the X-ray density of the cement that contains calcium phosphate, if use conventional cement mixture, picture contrast is very bad.Also usually receive the interference of other bone structures.In front/rear ray channel especially like this.
Of the present invention have the formulation that improves the X ray contrast when implanting the cement that contains calcium phosphate of the present invention, brings very big improvement, under the situation of vertebra tagma operation, especially like this.Operator can undergo surgery quickly, and patient's operation risk also reduces greatly.In addition, also obtain good machinability and product strength easily.Yet above-mentioned advantage equally also is applicable to operation or the treatment of carrying out at other positions of bone or skeleton.
The cement article that contains calcium phosphate also can be used for filling because the formed recessed or space of bow-backed shaping.Bow-backed shaping is the percutaneous technology, relates to adopting distensible structure, and for example balloon catheter is proofreaied and correct the bow-backed deformity relevant with the vertebral body compression fractures.The method and the instrument that are suitable for treatment like this have description: № 4969888,5108404,5827289,5972015 in following United States Patent (USP), 6048346,6066154,6235043,6241734,6248110,6280456,6423083,6440138,6468279,6575919,6607544,6613054,6623505,6641587 and 6645213, each is all in conjunction with being referred to this.The optimized of the cement article of phosphoric acid calcium is to be used for bow-backed shaping, wherein can form the known space of size or recessed in the bone, and the cement article of the phosphoric acid calcium of respective amount is added in the described space.
Embodiment
Embodiment 1
Cement with following component powder composition is provided, then, with 3.5M (NH
4)
2HPO
4Aqueous solution (liquid components) fully mixes, and forms pastel, makes its sclerosis subsequently:
65g TCP (tricalcium phosphate)
12g?Mg
3(PO
4)
2
4g?MgHPO
4
3g?SrCO
3
2g?BaSO
4
The radiopaque performance of the resulting hardened calcium phosphate cement of visual assessment on X-ray film.Obtain can clear identification qualified X ray contrast.
Embodiment 2
Repeat embodiment 1, difference is to improve BaSO
4Measure to 8g, as described below:
65g TCP (tricalcium phosphate)
12g?Mg
3(PO
4)
2
4g?MgHPO
4
3g?SrCO
3
8g?BaSO
4
Because BaSO
4Consumption increase, obtain the radiopaque performance that improves.The sclerosis cement after 2 hour incubation period in 37 ℃, the NaCl aqueous solution of 0.9% weight, measured intensity.Recording intensity is 24.11MPa.
Embodiment 3
Repeat embodiment 1, difference is to use the Ioxaglic Acid available from Guerbet GmbH (Sulzbach-Taunus of Germany), and a kind of ionic organoiodine compound replaces radiopaque reinforcing agent:
65g TCP (tricalcium phosphate)
12g?Mg
3(PO
4)
2
4g?MgHPO
4
3g?SrCO
3
The 2g Ioxaglic Acid
Embodiment 4
Repeat embodiment 3, difference is to use the iobitridol (iobitridol) available from Guerbet GmbH (Sulzbach-Taunus of Germany), and a kind of organoiodine compound of nonionic replaces radiopaque reinforcing agent Ioxaglic Acid:
65g?TCP
12g?Mg
3(PO
4)
2
4g?MgHPO
4
3g?SrCO
3
The 2g iobitridol
The result: the radiopaque performance of acquisition is similar to embodiment 3.Under the contrast, iobitridol provides a kind of and has the binder compositions of improving machinability, because this chemical compound mixes with other components in a kind of favourable, more uniform mode.BaSO with the adding same amount of embodiment 2
4Compare, the X ray contrast is improved.
Embodiment 5
Repeat embodiment 4, difference is to increase measuring to 8g of iobitridol, and is as described below:
65g?TCP
12g?Mg
3(PO
4)
2
4g?MgHPO
4
3g?SrCO
3
The 8g iobitridol
The result: the X ray contrast significantly increases (the darker grade of development radioscopic image) than adding 8g barium sulfate.The sclerosis cement after 2 hour incubation period in 37 ℃, the NaCl aqueous solution of 0.9% weight, measured intensity.Recording intensity is 17.5MPa.
Embodiment 6-7
Repeat embodiment 3-4, difference is that the consumption of Ioxaglic Acid or iobitridol is 6g, and is as described below:
65g?TCP 65g?TCP
12g?Mg
3(PO
4)
2 12g?Mg
3(PO
4)
2
4g?MgHPO
4 4g?MgHPO
4
3g?SrCO
3 3g?SrCO
3
6g Ioxaglic Acid 6g iobitridol
The result: when adding iobitridol, the powdery component of binder compositions and blended liquid components (3.5M (NH
4)
2HPO
4Solution) wettability, better during than the adding Ioxaglic Acid.
Embodiment 8
Repeat embodiment 1, difference is to replace barium sulfate with another kind of radiopaque reinforcing agent two hydration ammonium sulfate ceriums (IV), and is as described below:
65g?TCP
12g?Mg
3(PO
4)
2
4g?MgHPO
4
3g?SrCO
3
5g two hydration ammonium sulfate ceriums (IV)
The result: contrast is equivalent to add 9g barium sulfate.
Embodiment 9
Implemented another experiment by this way: the barium sulfate or the SrCO that in the cement powder, add various consumptions
3By adding about 10-15% weight percent sulfuric acid barium, obtained best following performance: the intensity of uniformity, more effective mixed performance and hardened product.
The cement formulation that contains barium sulfate, its strength characteristics measurement result favorable reproducibility, because described material is in process of lapping, the trend of solidifying is lower.
Embodiment 10
Do not contain SrCO at formulation
3Situation under, implemented the test of all the foregoing descriptions again, that is: use the goods and the liquid components of following cement powder:
65g TCP, 12g Mg
3(PO
4)
2, 4g MgHPO
4, wherein add the radiopaque reinforcing agent that embodiment of the invention 1-9 is arranged.
Aspect the radiopaque performance, do not see effect.
Embodiment 11
Repeat embodiment 1, difference is to replace the radiopaque reinforcing agent with bronze, and bronze adds with the form of metallic fine particle:
65g?TCP
12g?Mg
3(PO
4)
2
4g?MgHPO
4
3g?SrCO
3
The 2g bronze
Result: can ensure good and uniform mixed performance.The X ray contrast equals to add 15g barium sulfate and replaces the 2g bronze in same cement article.
Embodiment 12-13
Repeat embodiment 1, except replacing the radiopaque reinforcing agent with Fe (II) or Fe (III) oxide, they add with the form of metal-oxide, and are as described below:
65g?TCP 65g?TCP
12g?Mg
3(PO
4)
2 12g?Mg
3(PO
4)
2
4g?MgHPO
4 4g?MgHPO
4
3g?SrCO
3 3g?SrCO
3
5g?FeO 5g?Fe
2O
3
Result: add 5g Fe
2O
3Produce especially high X ray contrast, the final strength of sclerosis cement does not descend.
Though described above preferred embodiment and with embodiment the present invention has been described, note: feature of the present invention, embodiment and embodiment are not limited to this, but comprise its equivalent, improvement thing and combination thereof.The present invention especially can not be interpreted as narrower than the scope and spirit of claims.
Claims (29)
1. cement article as bone substitute, it comprise can with the phosphoric acid calcium powder of liquid, aqueous combination, wherein said powder or liquid, aqueous at least aly before being combined into cement, mix with radio-opaque material.
2. goods as claimed in claim 1, it also comprises and flow to strengthen additive, with described liquid combination after, be used to improve the flowable of cement article.
3. goods as claimed in claim 1, the powder composition of wherein said additive of sneaking into and phosphoric acid calcium makes up, and the mechanical property of the hardening characteristics of cement article and/or sclerosis goods does not descend substantially thus.
4. goods as claimed in claim 1, wherein said radio-opaque material comprises barium salt.
5. goods as claimed in claim 4, wherein said barium salt are selected from barium sulfate, tricresyl phosphate barium, barium iodide, barium zirconate and barium tungstate.
6. goods as claimed in claim 1, wherein at least a in metal, inorganic metal compound and the metallo-organic compound sneaked into as additive, and described metal or metallic compound are selected from following metallic element based on any: ferrum, titanium, tantalum, gold, silver, rare earth element, yttrium, ytterbium, zirconium, niobium, molybdenum, ruthenium, rhodium, palladium and tungsten.
7. goods as claimed in claim 6, wherein said metallic compound are selected from iron phosphate, ferrum oxide, hydrated ferric oxide. and ferrum and organic acid chemical compound.
8. goods as claimed in claim 1, wherein said additive contains the chemical compound that is selected from the element in the rare earth element.
9. goods as claimed in claim 1, wherein said iodine compound is sneaked into as additive.
10. goods as claimed in claim 9, wherein said iodine compound are the organoiodine compounds of ion-type or nonionic, preferred amidotrizoic acid ester, two iodine column rummy esters, iodine amidol, iohexol or Ioxaglic Acid ester or their mixture.
11. goods as claimed in claim 1, wherein said additive of sneaking into is a water soluble compound, mixes with liquid, aqueous component.
12. goods as claimed in claim 11, wherein said metal or metal-oxide mix as the additive of fine particle form.
13. goods as claimed in claim 1, wherein said sintered material, preferred agglomerating hydroxyapatite and/or agglomerating tricalcium phosphate mix as additive.
14. goods as claimed in claim 1, the mixed volume of the additive of wherein said raising X ray contrast is about 2.5-50% weight, is benchmark with the total amount of cement article.
15. goods as claimed in claim 1, described cement article contain calcium, magnesium and orthophosphate and choose the component of ortho-phosphoric other salt as compositions wantonly.
16. goods as claimed in claim 15, described cement article also contains ammonium salt, and preferably the form with ammonium phosphate and/or ammonium hydrogen phosphate exists in liquid, aqueous component.
17. goods as claimed in claim 1, describedly contain liquid, aqueous cement article a kind of such sclerosis cement can be provided, it contains at least a following constituent that is selected from: apatite structure, hydroxyapatite structure, guanite structure and tricresyl phosphate barium structure.
18. cement article, it contains the powdery component, this component comprises the mixture that will carry out blended calcium salt, magnesium salt and orthophosphate with liquid, aqueous component, and wherein said cement article also contains at least a additive that is selected from following raising X ray contrast:
Barium salt;
Metal and inorganic and organic metallic compound, the preferable alloy oxide, wherein said metal is selected from: ferrum, titanium, tantalum, gold, silver, rare earth element, yttrium, ytterbium, zirconium, niobium, molybdenum, ruthenium, rhodium, palladium and tungsten;
Rare-earth compound, the chemical compound of preferred gadolinium or cerium;
Inorganic or organic iodine compound; With
Agglomerating hydroxyapatite and agglomerating tricalcium phosphate.
19. cement article as claimed in claim 18, wherein said additive is sneaked in the powdery component of cement article as the fine particle form.
20. cement article as claimed in claim 18, wherein said additive is a water soluble compound, and sneaks in the water or liquid, aqueous component of cement article.
21. cement article as claimed in claim 18, it also contains strontium salt in the powdery component.
22. goods as claimed in claim 18, wherein said additive are to be selected from following barium salt: barium sulfate, tricresyl phosphate barium, barium iodide, barium zirconate and barium tungstate; And/or be selected from following metallic compound: iron phosphate, ferrum oxide, hydrated ferric oxide. and ferrum and organic acid chemical compound.
23. as claim 1 or 18 described cement article, it has also sneaked into pharmaceutically active and/or bioactive substance.
24. a hardened bone substitute material, it is obtained by claim 1 or 18 described cement article.
25. hardened bone substitute material as claimed in claim 24, wherein said hardened cement contain at least a following constituent that is selected from: apatite structure, hydroxyapatite structure, guanite structure and tricresyl phosphate barium structure.
26. the purposes of the described hardened bone substitute material of claim 24, it is as bone implant, bone filler, bone cement or bone cementum or as treatment bone defective or osteoporotic therapeutic agent.
27. a method for the treatment of bone defective or treatment skeletal system disease, it comprises such step: according to the needs of this treatment, claim 1 or 18 described cement article are administered on the part of patient's bone rejected region or patient's skeleton.
28. method as claimed in claim 27, wherein said bone defective is applicable to patient's vertebral body.
29. a method that forms the cement of phosphoric acid calcium, it comprises such step:
Hybrid right requires the powdery component and the liquid components of 1 or 18 described cement article;
Make the mixture cures that obtains.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE20218668.7 | 2002-12-03 | ||
| DE20218668U DE20218668U1 (en) | 2002-12-03 | 2002-12-03 | Recipes for cement preparations as a bone substitute |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1849145A true CN1849145A (en) | 2006-10-18 |
| CN100540068C CN100540068C (en) | 2009-09-16 |
Family
ID=7977548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003801049195A Expired - Fee Related CN100540068C (en) | 2002-12-03 | 2003-12-03 | Cement formulation, bone substitute material and the method that forms the cement formulation |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1560609A1 (en) |
| JP (1) | JP2006524058A (en) |
| KR (1) | KR20050084094A (en) |
| CN (1) | CN100540068C (en) |
| AU (1) | AU2003302607A1 (en) |
| DE (1) | DE20218668U1 (en) |
| HK (1) | HK1097778A1 (en) |
| WO (1) | WO2004050131A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107737367A (en) * | 2008-04-15 | 2018-02-27 | 生命科学企业股份有限公司 | The vertebrae minimally-invasive of the bone cement combined using calcium phosphate is treated |
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| DE10032220A1 (en) | 2000-07-03 | 2002-01-24 | Sanatis Gmbh | Magnesium ammonium phosphate cements, their manufacture and use |
| US7273523B2 (en) | 2002-06-07 | 2007-09-25 | Kyphon Inc. | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof |
| DE20218668U1 (en) * | 2002-12-03 | 2003-03-06 | Sanatis GmbH, 61191 Rosbach | Recipes for cement preparations as a bone substitute |
| DE10340800A1 (en) * | 2002-12-20 | 2004-07-01 | Merck Patent Gmbh | Production of acrylic bone cement, e.g. for anchoring prostheses in bone, involves using X-ray contrast medium which has been functionalised with (meth)acrylate after coating with melamine-formaldehyde resin |
| US7306786B2 (en) * | 2003-07-28 | 2007-12-11 | Skeletal Kinetics, Llc | Calcium phosphate cements comprising a water-soluble contrast agent |
| ES2396133T3 (en) | 2004-04-27 | 2013-02-19 | Kyphon SÀRl | Bone replacement compositions and method of use |
| US20050257714A1 (en) * | 2004-05-20 | 2005-11-24 | Constantz Brent R | Orthopedic cements comprising a barium apatite contrast agent |
| US7651701B2 (en) | 2005-08-29 | 2010-01-26 | Sanatis Gmbh | Bone cement composition and method of making the same |
| US7754005B2 (en) | 2006-05-02 | 2010-07-13 | Kyphon Sarl | Bone cement compositions comprising an indicator agent and related methods thereof |
| GB2442000A (en) | 2006-06-07 | 2008-03-26 | Apatech Ltd | Biomedical materials containing gadolinium |
| US7507286B2 (en) | 2006-06-08 | 2009-03-24 | Sanatis Gmbh | Self-foaming cement for void filling and/or delivery systems |
| CA2661195A1 (en) * | 2006-08-21 | 2008-02-28 | Next21 K.K. | Bone model, bone filler and process for producing bone filler |
| DE102007052116B4 (en) * | 2007-10-22 | 2013-02-21 | Heraeus Medical Gmbh | One-component bone cement pastes, their use and methods of curing them |
| DE102008010210A1 (en) * | 2008-02-20 | 2009-08-27 | Innotere Gmbh | Preparation for magnesium ammonium phosphate cements |
| US7968616B2 (en) | 2008-04-22 | 2011-06-28 | Kyphon Sarl | Bone cement composition and method |
| US9180137B2 (en) | 2010-02-09 | 2015-11-10 | Bone Support Ab | Preparation of bone cement compositions |
| KR101357673B1 (en) * | 2012-09-03 | 2014-02-04 | 한국기계연구원 | The scaffold composition for regeneration of hard tissue having magnesium phosphate, scaffold for regeneration of hard tissue comprising the same and preparation methods thereof |
| CN105120908B (en) | 2013-02-20 | 2018-04-27 | 骨支撑股份公司 | The improved solidification of hardenable bone substitute |
| JPWO2016137013A1 (en) * | 2015-02-26 | 2017-12-14 | 国立大学法人北海道大学 | Lesion identification marker for radiotherapy and lesion identification marker kit for radiotherapy |
| US20190201557A1 (en) * | 2016-08-25 | 2019-07-04 | National University Corporation Hokkaido University | Lesion identification marker utilizing bone cement for use in radiation therapy, and lesion identification marker kit for use in radiation therapy |
| RU2643337C1 (en) * | 2017-06-06 | 2018-01-31 | Федеральное государственное бюджетное учреждение науки Институт химии Дальневосточного отделения Российской академии наук (ИХ ДВО РАН) | Resorbable radioopaque cross-calcium-phosphate cement for bone plastics |
| CN116194162A (en) * | 2020-07-17 | 2023-05-30 | 泽特金疗法公司 | Methods and compositions for bone grafting using iron excipients |
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| DE10032220A1 (en) * | 2000-07-03 | 2002-01-24 | Sanatis Gmbh | Magnesium ammonium phosphate cements, their manufacture and use |
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| DE20218668U1 (en) * | 2002-12-03 | 2003-03-06 | Sanatis GmbH, 61191 Rosbach | Recipes for cement preparations as a bone substitute |
-
2002
- 2002-12-03 DE DE20218668U patent/DE20218668U1/en not_active Expired - Lifetime
-
2003
- 2003-12-03 KR KR1020057009928A patent/KR20050084094A/en not_active Application Discontinuation
- 2003-12-03 JP JP2004557582A patent/JP2006524058A/en active Pending
- 2003-12-03 EP EP03808436A patent/EP1560609A1/en not_active Ceased
- 2003-12-03 AU AU2003302607A patent/AU2003302607A1/en not_active Abandoned
- 2003-12-03 WO PCT/US2003/038580 patent/WO2004050131A1/en active Application Filing
- 2003-12-03 CN CNB2003801049195A patent/CN100540068C/en not_active Expired - Fee Related
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2007
- 2007-02-28 HK HK07102226.5A patent/HK1097778A1/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107737367A (en) * | 2008-04-15 | 2018-02-27 | 生命科学企业股份有限公司 | The vertebrae minimally-invasive of the bone cement combined using calcium phosphate is treated |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004050131A1 (en) | 2004-06-17 |
| KR20050084094A (en) | 2005-08-26 |
| HK1097778A1 (en) | 2007-07-06 |
| DE20218668U1 (en) | 2003-03-06 |
| JP2006524058A (en) | 2006-10-26 |
| CN100540068C (en) | 2009-09-16 |
| AU2003302607A1 (en) | 2004-06-23 |
| EP1560609A1 (en) | 2005-08-10 |
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