CN1792217A - Additives of fodder for improving intestines function of piglings - Google Patents
Additives of fodder for improving intestines function of piglings Download PDFInfo
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- 239000000654 additive Substances 0.000 title abstract description 4
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Abstract
本发明公开了一种增进仔猪肠道功能的饲料添加剂。它是将一种将谷氨酰胺、甘氨酰－L－谷氨酰胺、丁酸钠、维生素C和葡萄糖五种物质中的三种或三种以上物质按一定比例配伍加工成。在配合饲料的基础上添加0.05～2％本发明的增进仔猪肠道功能的饲料添加剂进行饲喂，可明显减少仔猪的腹泻率，提高日增重，提高饲料转化率。本发明的增进仔猪肠道功能的饲料添加剂可替代血浆蛋白粉，避免因应用血浆蛋白粉而引起的生物安全问题。经多项试验及实验室检测，本添加剂不但高效且安全无毒，所饲喂的动物产品符合食品卫生要求。The invention discloses a feed additive for improving intestinal function of piglets. It is made by processing three or more of the five substances glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a certain proportion. Adding 0.05-2% of the feed additive for improving intestinal function of piglets of the present invention on the basis of compound feed can obviously reduce the diarrhea rate of piglets, increase daily gain and feed conversion rate. The feed additive for improving intestinal function of piglets of the invention can replace plasma protein powder and avoid biological safety problems caused by the application of plasma protein powder. After a number of tests and laboratory tests, this additive is not only efficient but also safe and non-toxic, and the animal products fed meet the food hygiene requirements.
Description
技术领域technical field
本发明涉及一种增进仔猪肠道功能的饲料添加剂。The invention relates to a feed additive for improving intestinal function of piglets.
背景技术Background technique
养猪生产中，关键的环节是断奶仔猪生产，仔猪早期断奶是国内外集约化养猪生产中普遍关注的先进技术，早期断奶能提高母猪的繁殖率，可增加母猪的年产仔数，减少由母体向仔猪的疾病传播，并能提高生长猪的生产性能和胴体品质，同时可使产房等设备的利用率提高。目前养猪业发达的国家已经开始推广应用14日龄超早期断奶技术。但早期断奶带来的一个重要问题是如何提高断奶仔猪的生长性能，因为断奶仔猪的生长性能不仅关系到仔猪阶段的生产水平和经济效益，而且关系到猪的整个生长阶段的生产性能和经济效益，仔猪早期生长性能的提高会使后期的生长性能有较大的提高，并缩短肉猪的出栏时间，从而给养猪生产带来更大的经济效益。但断奶仔猪的生长性能的提高也是整个养猪环节中最难解决的一环。因为仔猪出生时，其消化道未能充分适应母乳的消化和利用(Rhoads，1990)，仔猪断奶后日粮的性质发生了重大变化，而仔猪消化道尚未发育完全、消化酶活性不足、免疫功能也尚未发育成熟(Aumaitre andCorring，1978)，而且断奶不仅关系到生理的变化、心理、环境和营养状况也发生了变化，因而常表现为食欲差、消化功能紊乱、腹泻、生长迟滞、饲料利用率低等所谓的“仔猪早期断奶综合症”。In pig production, the key link is the production of weaned piglets. Early weaning of piglets is an advanced technology that is widely concerned in intensive pig production at home and abroad. Early weaning can improve the reproductive rate of sows and increase the annual litter size of sows , reduce the disease transmission from the mother to the piglets, and can improve the production performance and carcass quality of the growing pigs, and at the same time can increase the utilization rate of equipment such as the farrowing room. At present, countries with developed pig farming industry have begun to promote the application of 14-day-old ultra-early weaning technology. However, an important issue brought about by early weaning is how to improve the growth performance of weaned piglets, because the growth performance of weaned piglets is not only related to the production level and economic benefits of piglets, but also related to the production performance and economic benefits of the whole growth stage of pigs , the improvement of the growth performance of piglets in the early stage will greatly improve the growth performance of piglets in the later stage, and shorten the slaughtering time of piglets, thus bringing greater economic benefits to pig production. However, the improvement of the growth performance of weaned piglets is also the most difficult part of the whole pig raising process. Because the digestive tract of piglets was not fully adapted to the digestion and utilization of mother's milk when they were born (Rhoads, 1990), the nature of the diet of piglets after weaning has undergone significant changes, and the digestive tract of piglets has not yet fully developed, the activity of digestive enzymes is insufficient, and the immune function It is also immature (Aumaitre and Corring, 1978), and weaning is not only related to physiological changes, but also changes in psychological, environmental and nutritional status, so it often manifests as poor appetite, digestive disorders, diarrhea, growth retardation, and feed utilization. Low so called "Piglet Weaning Syndrome".
解决“仔猪早期断奶综合症”的研究是目前养猪科技工作者的研究热点，例如，利用大型屠宰场健康的猪血资源，采用先进的分离、调质、喷雾干燥工艺生产的喷雾干燥血浆(球)蛋白粉，因其具有适口性好，蛋白含量高，氨基酸平衡且保留了血浆中的免疫球蛋白活性等特点而被用作解决“仔猪早期断奶综合症”的技术措施。但由于生物安全问题而被禁止使用。The research on solving the "early weaning syndrome of piglets" is currently a research hotspot for pig science and technology workers. For example, using healthy pig blood resources in large slaughterhouses, spray-dried plasma produced by advanced separation, conditioning, and spray drying processes ( Globular) protein powder, because of its good palatability, high protein content, amino acid balance and characteristics such as retaining the activity of immunoglobulin in plasma, is used as a technical measure to solve "piglet early weaning syndrome". But it was banned due to biosafety concerns.
大量研究表明谷氨酰胺(GLN)是肠道细胞的燃料，是合成细胞分化所必需的嘌呤和嘧啶核苷酸的前体，是肠系膜淋巴和上皮淋巴细胞和重要能量底物，是维持与肠道相关的淋巴组织的必需成份，也是合成肠道分泌免疫球蛋白质的必需物质，在维持肠道正常功能和提高肠道免疫力方面起着重要的作用(James，1998)。而且GLN是猪乳中含量最丰富的氨基酸，断奶后GLN供应量减少是仔猪早期断奶综合症产生的最根本的原因(Alverdy，1990)。GLN、葡萄糖、丁酸盐、丙酸盐和乙酸盐均是肠黏膜细胞的能量来源，其中GLN是最重要的肠黏膜细胞的能量来源，葡萄糖次之。GLN二肽(如Gly-L-Gln)在小肠内主要以二肽的形式吸收，吸收率高，吸收后被小肠等组织器官中的二肽酶分解为其组成的氨基酸，能克服GLN单体的热不稳定性以及低溶解度，也是一种GLN的有效添加方式。A large number of studies have shown that glutamine (GLN) is the fuel of intestinal cells, the precursor of purine and pyrimidine nucleotides necessary for the synthesis of cell differentiation, and an important energy substrate for mesenteric lymphoid and epithelial lymphocytes. It is an essential component of the intestinal tract-associated lymphoid tissue, and is also an essential substance for the synthesis of intestinal immunoglobulins, which plays an important role in maintaining normal intestinal function and improving intestinal immunity (James, 1998). Moreover, GLN is the most abundant amino acid in pig milk, and the reduction of GLN supply after weaning is the most fundamental cause of early weaning syndrome in piglets (Alverdy, 1990). GLN, glucose, butyrate, propionate and acetate are the energy sources of intestinal mucosal cells, among which GLN is the most important energy source of intestinal mucosal cells, followed by glucose. GLN dipeptide (such as Gly-L-Gln) is mainly absorbed in the form of dipeptide in the small intestine, and the absorption rate is high. After absorption, it is decomposed into amino acids by dipeptidase in tissues and organs such as the small intestine, which can overcome GLN monomer The thermal instability and low solubility are also an effective way to add GLN.
发明内容Contents of the invention
本发明提供一种增进仔猪肠道功能的饲料添加剂。The invention provides a feed additive for improving intestinal function of piglets.
增进仔猪肠道功能的饲料添加剂由谷氨酰胺、甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖五种物质中的三种或三种以上物质按比例配制而成。The feed additive for improving intestinal function of piglets is prepared by proportioning three or more of the five substances of glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and glucose.
增进仔猪肠道功能的饲料添加剂中各种物质配比如下：The ratio of various substances in the feed additives to improve the intestinal function of piglets is as follows:
1)谷氨酰胺∶丁酸钠∶维生素C比例为1∶0.05～10∶0.1～10。1) The ratio of glutamine: sodium butyrate: vitamin C is 1:0.05-10:0.1-10.
2)谷氨酰胺∶丁酸钠∶葡萄糖比例为1∶0.05～10∶1～100。2) The ratio of glutamine: sodium butyrate: glucose is 1:0.05-10:1-100.
3)谷氨酰胺∶维生素C∶葡萄糖比例为1∶0.1～10∶1～100。3) The ratio of glutamine:vitamin C:glucose is 1:0.1-10:1-100.
4)谷氨酰胺∶丁酸钠∶维生素C∶葡萄糖比例为1∶0.05～10∶0.1～10∶1～100。4) The ratio of glutamine: sodium butyrate: vitamin C: glucose is 1:0.05-10:0.1-10:1-100.
5)甘氨酰-L-谷氨酰胺∶丁酸钠∶维生素C比例为1∶0.1～10∶0.1～10。5) The ratio of glycyl-L-glutamine: sodium butyrate: vitamin C is 1: 0.1-10: 0.1-10.
6)甘氨酰-L-谷氨酰胺∶丁酸钠∶葡萄糖比例为1∶0.1～10∶1～100。6) The ratio of glycyl-L-glutamine:sodium butyrate:glucose is 1:0.1-10:1-100.
7)甘氨酰-L-谷氨酰胺∶维生素C∶葡萄糖比例为1∶0.1～10∶1～100。7) The ratio of glycyl-L-glutamine:vitamin C:glucose is 1:0.1-10:1-100.
8)甘氨酰-L-谷氨酰胺∶丁酸钠∶维生素C∶葡萄糖比例为1∶0.1～10∶0.1～10∶1～100。8) The ratio of glycyl-L-glutamine: sodium butyrate: vitamin C: glucose is 1:0.1-10:0.1-10:1-100.
9)谷氨酰胺∶甘氨酰-L-谷氨酰胺∶丁酸钠∶维生素C∶葡萄糖比例为1∶0.1～10∶0.1～10∶0.1～10∶1～100。9) The ratio of glutamine: glycyl-L-glutamine: sodium butyrate: vitamin C: glucose is 1: 0.1-10: 0.1-10: 0.1-10: 1-100.
将上述复合物混合均匀，得到相应的增进仔猪肠道功能的饲料添加剂。The compound is uniformly mixed to obtain the corresponding feed additive for improving intestinal function of piglets.
本发明从仔猪的消化生理发育特点入手，应用营养与免疫调控手段，将多种具有提高肠道功能、增强消化酶活力和提高免疫力的活性物质进行合理配伍组合，成功研制了一种增进仔猪肠道功能的饲料添加剂。应用本发明的增进仔猪肠道功能的饲料添加剂，能防止仔猪断奶后1～7天肠黏膜绒毛过度萎缩和隐窝的加深，可显著提高断奶后8～14天肠黏膜绒毛高度，可显著提高断奶仔猪十二指肠内容物总蛋白酶活性，可显著提高断奶后14天断奶仔猪的淀粉酶活性。应用本发明的增进仔猪肠道功能的饲料添加剂，能显著提高断奶仔猪的平均日增重，降低仔猪断奶腹泻率，缩短腹泻周期。增进仔猪肠道功能的饲料添加剂能完全替代血浆蛋白粉，具有显著的经济效益和社会效益，市场前景广阔。The present invention starts from the digestive physiological development characteristics of piglets, applies nutritional and immune control means, and combines various active substances that can improve intestinal function, digestive enzyme activity and immunity, and successfully develops a piglet-enhancing Feed additive for intestinal function. The application of the feed additive for improving intestinal function of piglets of the present invention can prevent excessive atrophy of intestinal mucosal villi and deepening of crypts in piglets 1 to 7 days after weaning, can significantly increase the height of intestinal mucosal villi in 8 to 14 days after weaning, and can significantly improve Total protease activity in duodenal contents of weaned piglets significantly increased amylase activity in weaned piglets 14 days after weaning. The application of the feed additive for improving intestinal function of piglets of the invention can significantly increase the average daily gain of weaned piglets, reduce the rate of weaned diarrhea in piglets, and shorten the period of diarrhea. The feed additive for improving intestinal function of piglets can completely replace plasma protein powder, has significant economic and social benefits, and has a broad market prospect.
在配合饲料的基础上添加0.05～2％本发明的增进仔猪肠道功能的饲料添加剂进行饲喂，可明显减少仔猪的腹泻率，提高日增重，提高饲料转化率。本发明的增进仔猪肠道功能的饲料添加剂可替代血浆蛋白粉，避免因应用血浆蛋白粉而引起的生物安全问题。经多项试验及实验室检测，本添加剂不但高效且安全无毒，所饲喂的动物产品符合食品卫生要求。Adding 0.05-2% of the feed additive for improving intestinal function of piglets of the present invention on the basis of compound feed can obviously reduce the diarrhea rate of piglets, increase daily gain and feed conversion rate. The feed additive for improving intestinal function of piglets of the invention can replace plasma protein powder and avoid biological safety problems caused by the application of plasma protein powder. After a number of tests and laboratory tests, this additive is not only efficient but also safe and non-toxic, and the animal products fed meet the food hygiene requirements.
具体实施方式Detailed ways
增进仔猪肠道功能的饲料添加剂为粉末状，应用时是将该粉状的复合物添加到配合饲料、浓缩饲料、预混料或添加剂中，并进行均匀混合，其添加量折合配合饲料中含量计为0.05～2％。The feed additive for improving the intestinal function of piglets is in powder form. When it is applied, the powdery compound is added to the compound feed, concentrated feed, premix or additive, and mixed evenly. The added amount is equivalent to the content in the compound feed. Calculated as 0.05 to 2%.
实施例1Example 1
将谷氨酰胺、丁酸钠和维生素C三种物质以1∶0.05∶10比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, sodium butyrate and vitamin C at a ratio of 1:0.05:10, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例2Example 2
将谷氨酰胺、丁酸钠和维生素C三种物质以1∶10∶0.1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, sodium butyrate and vitamin C at a ratio of 1:10:0.1, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例3Example 3
将谷氨酰胺、丁酸钠和维生素C三种物质以1∶5∶5.05比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, sodium butyrate and vitamin C at a ratio of 1:5:5.05, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例4Example 4
将谷氨酰胺、丁酸钠和葡萄糖三种物质以1∶0.05∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, sodium butyrate and glucose at a ratio of 1:0.05:100, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例5Example 5
将谷氨酰胺、丁酸钠和葡萄糖三种物质以1∶10∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, sodium butyrate and glucose at a ratio of 1:10:1, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例6Example 6
将谷氨酰胺、丁酸钠和葡萄糖三种物质以1∶5.03∶50.5比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, sodium butyrate and glucose at a ratio of 1:5.03:50.5, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例7Example 7
将谷氨酰胺、维生素C和葡萄糖三种物质以1∶0.1∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, vitamin C and glucose in a ratio of 1:0.1:100, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例8Example 8
将谷氨酰胺、维生素C和葡萄糖三种物质以1∶10∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, vitamin C and glucose in a ratio of 1:10:1, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例9Example 9
将谷氨酰胺、维生素C和葡萄糖三种物质以1∶5.05∶50.5比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, vitamin C and glucose at a ratio of 1:5.05:50.5, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例10Example 10
将谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶0.05∶10∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:0.05:10:100, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例11Example 11
将谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶10∶0.1∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:10:0.1:1, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例12Example 12
将谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶5.03∶5.05∶50.5比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:5.03:5.05:50.5, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例13Example 13
将谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶10∶0.1∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:10:0.1:100, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例14Example 14
将谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶0.05∶10∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:0.05:10:1, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例15Example 15
将谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶10∶10∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:10:10:1, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例16Example 16
将谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶0.05∶0.1∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glutamine, sodium butyrate, vitamin C and glucose at a ratio of 1:0.05:0.1:100, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例17Example 17
将甘氨酰-L-谷氨酰胺、丁酸钠和维生素C三种物质以1∶0.1∶10比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, sodium butyrate and vitamin C at a ratio of 1:0.1:10, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例18Example 18
将甘氨酰-L-谷氨酰胺、丁酸钠和维生素C三种物质以1∶10∶0.1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, sodium butyrate and vitamin C at a ratio of 1:10:0.1, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例19Example 19
将甘氨酰-L-谷氨酰胺、丁酸钠和维生素C三种物质以1∶5.05∶5.05比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, sodium butyrate and vitamin C at a ratio of 1:5.05:5.05, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例20Example 20
将甘氨酰-L-谷氨酰胺、丁酸钠和葡萄糖三种物质以1∶0.1∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, sodium butyrate and glucose at a ratio of 1:0.1:100, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例21Example 21
将甘氨酰-L-谷氨酰胺、丁酸钠和葡萄糖三种物质以1∶10∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, sodium butyrate and glucose at a ratio of 1:10:1, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例22Example 22
将甘氨酰-L-谷氨酰胺、丁酸钠和葡萄糖三种物质以1∶5.05∶50.5比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, sodium butyrate and glucose at a ratio of 1:5.05:50.5, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例23Example 23
将甘氨酰-L-谷氨酰胺、维生素C和葡萄糖三种物质以1∶0.1∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, vitamin C and glucose at a ratio of 1:0.1:100, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例24Example 24
将甘氨酰-L-谷氨酰胺、维生素C和葡萄糖三种物质以1∶10∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, vitamin C and glucose at a ratio of 1:10:1, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例25Example 25
将甘氨酰-L-谷氨酰胺、维生素C和葡萄糖三种物质以1∶5.05∶50.5比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, vitamin C and glucose at a ratio of 1:5.05:50.5, and mixing the above compounds evenly, obtains a feed additive for improving intestinal function of piglets.
实施例26Example 26
将甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶0.1∶10∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:0.1:10:100, and mixing the above compounds evenly, to obtain a formula for improving intestinal function of piglets Feed additives.
实施例27Example 27
将甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶10∶0.1∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:10:0.1:1, and mixing the above compounds evenly, to obtain a formula for improving intestinal function of piglets Feed additives.
实施例28Example 28
将甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶10∶0.1∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:10:0.1:100, and mixing the above compounds evenly, to obtain a formula for improving intestinal function of piglets Feed additives.
实施例29Example 29
将甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶0.1∶10∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:0.1:10:1, and mixing the above compounds evenly, to obtain a formula for improving intestinal function of piglets Feed additives.
实施例30Example 30
将甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶10∶10∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:10:10:1, and mixing the above compounds evenly, to obtain a formula for improving intestinal function of piglets Feed additives.
实施例31Example 31
将甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶0.1∶0.1∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:0.1:0.1:100, and mixing the above compounds evenly, to obtain a formula for improving intestinal function of piglets Feed additives.
实施例32Example 32
将甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖四种物质以1∶5.05∶5.05∶50.5比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combining glycyl-L-glutamine, sodium butyrate, vitamin C and glucose at a ratio of 1:5.05:5.05:50.5, and mixing the above compounds evenly, to obtain a formula for improving intestinal function of piglets Feed additives.
实施例33Example 33
将GLN、甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖五种物质以1∶0.1∶10∶10∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combine GLN, glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:0.1:10:10:100, and mix the above compounds evenly to obtain an improved piglet Feed additive for intestinal function.
实施例34Example 34
将谷氨酰胺、甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖五种物质以1∶10∶0.1∶0.1∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combine glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:10:0.1:0.1:1, and mix the above compounds evenly to obtain a Feed additives for improving intestinal function in piglets.
实施例35Example 35
将谷氨酰胺、甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖五种物质以1∶10∶0.1∶10∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combine glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:10:0.1:10:100, and mix the above compounds evenly to obtain a Feed additives for improving intestinal function in piglets.
实施例36Example 36
将谷氨酰胺、甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖五种物质以1∶0.1∶10∶0.1∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combine glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:0.1:10:0.1:1, and mix the above compounds evenly to obtain a Feed additives for improving intestinal function in piglets.
实施例37Example 37
将谷氨酰胺、甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖五种物质以1∶10∶10∶0.1∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combine glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:10:10:0.1:100, and mix the above compounds evenly to obtain a Feed additives for improving intestinal function in piglets.
实施例38Example 38
将谷氨酰胺、甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖五种物质以1∶0.1∶0.1∶10∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combine glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:0.1:0.1:10:1, and mix the above compounds evenly to obtain a Feed additives for improving intestinal function in piglets.
实施例39Example 39
将谷氨酰胺、甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖五种物质以1∶10∶10∶10∶1比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combine glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:10:10:10:1, and mix the above compounds evenly to obtain a Feed additives for improving intestinal function in piglets.
实施例40Example 40
将谷氨酰胺、甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖五种物质以1∶0.1∶0.1∶0.1∶100比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combine glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:0.1:0.1:0.1:100, and mix the above compounds evenly to obtain a Feed additives for improving intestinal function in piglets.
实施例41Example 41
将谷氨酰胺、甘氨酰-L-谷氨酰胺、丁酸钠、维生素C和葡萄糖五种物质以1∶5.05∶5.05∶5.0.5∶50.5比例组合，并将上述复合物混合均匀，得到一种增进仔猪肠道功能的饲料添加剂。Combine glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and glucose in a ratio of 1:5.05:5.05:5.0.5:50.5, and mix the above compounds evenly to obtain A feed additive for improving intestinal function of piglets.
应用实施例1Application Example 1
在28日龄断奶仔猪日粮中添加0.5％本发明的增进仔猪肠道功能的饲料添加剂，对断奶仔猪腹泻率的影响见表-1。Add 0.5% of the feed additive for improving intestinal function of piglets of the present invention to the diet of 28-day-old weaned piglets, and the effect on the diarrhea rate of weaned piglets is shown in Table-1.
表-1肠道功能调节剂对腹泻率的影响
日粮中添加0.5％本发明的增进仔猪肠道功能的饲料添加剂，仔猪28～35日龄阶段腹泻率比对照组低70.98％(P＜0.01)；仔猪35～42日龄阶段腹泻率比对照组低73.28％(P＜0.01)；仔猪42～49日龄阶段腹泻率比对照组低87.54％(P＜0.01)。Add 0.5% of the feed additive of the present invention to improve intestinal function of piglets in the diet, and the diarrhea rate of piglets at the age of 28 to 35 days is 70.98% lower than that of the control group (P<0.01); the diarrhea rate of piglets at the age of 35 to 42 days is lower than that of the control group The group was 73.28% lower (P<0.01); the diarrhea rate of piglets at the age of 42 to 49 days was 87.54% lower than that of the control group (P<0.01).
应用实施例2Application Example 2
在28日龄断奶仔猪日粮中添加0.75％本发明的增进仔猪肠道功能的饲料添加剂，28～42日龄阶段对断奶仔猪日增重、料重比的影响见表-2。Add 0.75% of the feed additive for improving intestinal function of piglets of the present invention to the diet of 28-day-old weaned piglets, and the effects of 28-42-day-old piglets on daily gain and feed-to-weight ratio of weaned piglets are shown in Table-2.
表-2肠道功能调节剂对断奶仔猪日增重、料重比的影响
在28日龄断奶仔猪日粮中添加0.75％本发明的增进仔猪肠道功能的饲料添加剂，28～42日龄阶段对断奶仔猪日增重提高28.25％(P＜0.01)，料重比12.66％(P＜0.05)。Adding 0.75% of the feed additive for improving intestinal function of piglets of the present invention to the diet of 28-day-old weaned piglets can increase the daily gain of weaned piglets by 28.25% (P<0.01) at the age of 28-42 days, and the ratio of feed to weight is 12.66%. (P<0.05).
应用实施例3Application Example 3
在21日龄断奶仔猪日粮中添加1％本发明的增进仔猪肠道功能的饲料添加剂对断奶后血清木糖浓度的影响见表-3。The effect of adding 1% of the feed additive for improving intestinal function of piglets of the present invention to the diet of 21-day-old weaned piglets on post-weaning serum xylose concentration is shown in Table-3.
表-3 肠道功能调节剂对血清木糖浓度的影响(mmol/L)
在21日龄断奶仔猪日粮中添加1％本发明的增进仔猪肠道功能的饲料添加剂，断奶后1周血清木糖浓度比对照组高125.49％(P＜0.01)，断奶后2周血清木糖浓度比对照组高102.43％(P＜0.01)，断奶后3周血清木糖浓度比对照组高108.05％(P＜0.01)。Add 1% of the feed additive for improving piglet intestinal function of the present invention in the diet of 21-day-old weaned piglets, and the serum xylose concentration in 1 week after weaning is higher than that of the control group by 125.49% (P＜0.01), and the serum xylose concentration in 2 weeks after weaning The sugar concentration was 102.43% higher than the control group (P<0.01), and the serum xylose concentration 3 weeks after weaning was 108.05% higher than the control group (P<0.01).
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