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CN1720263A - 三聚细胞因子的三聚结合蛋白 - Google Patents

三聚细胞因子的三聚结合蛋白 Download PDF

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Publication number
CN1720263A
CN1720263A CNA2003801046587A CN200380104658A CN1720263A CN 1720263 A CN1720263 A CN 1720263A CN A2003801046587 A CNA2003801046587 A CN A2003801046587A CN 200380104658 A CN200380104658 A CN 200380104658A CN 1720263 A CN1720263 A CN 1720263A
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CN
China
Prior art keywords
seq
trimerization
tnfrsf1b
polypeptide
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2003801046587A
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English (en)
Chinese (zh)
Inventor
T·L·霍尔帝特
M·H·安德森
H·K·奥托
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yimunuoniuke Denmark Corp
Bird Rock Bio Inc
Original Assignee
Roche Bio Denmark AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Bio Denmark AS filed Critical Roche Bio Denmark AS
Publication of CN1720263A publication Critical patent/CN1720263A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CNA2003801046587A 2002-10-29 2003-10-29 三聚细胞因子的三聚结合蛋白 Pending CN1720263A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200201634 2002-10-29
DKPA200201634 2002-10-29
US60/421,807 2002-10-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2010101352531A Division CN101899106A (zh) 2002-10-29 2003-10-29 三聚细胞因子的三聚结合蛋白

Publications (1)

Publication Number Publication Date
CN1720263A true CN1720263A (zh) 2006-01-11

Family

ID=35931707

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2003801046587A Pending CN1720263A (zh) 2002-10-29 2003-10-29 三聚细胞因子的三聚结合蛋白

Country Status (6)

Country Link
JP (1) JP4690044B2 (es)
CN (1) CN1720263A (es)
AT (1) ATE505484T1 (es)
DE (1) DE60336746D1 (es)
DK (1) DK1558640T3 (es)
ES (1) ES2367749T3 (es)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103172746A (zh) * 2011-12-26 2013-06-26 财团法人工业技术研究院 三聚体Fc融合蛋白及其用途
CN103172748A (zh) * 2013-01-29 2013-06-26 中国人民解放军第三军医大学 一种抗恶性淋巴瘤融合蛋白及其制备方法
CN111819186A (zh) * 2018-01-10 2020-10-23 综合医院公司 表达嵌合抗原受体的免疫细胞
WO2022089426A1 (zh) * 2020-10-27 2022-05-05 细胞图谱有限公司 外周血样本分析方法和试剂盒

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8039437B2 (en) * 2008-06-30 2011-10-18 The Trustees Of The University Of Pennsylvania Fn14/TRAIL fusion proteins
EP3243836A1 (en) * 2016-05-11 2017-11-15 F. Hoffmann-La Roche AG C-terminally fused tnf family ligand trimer-containing antigen binding molecules

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2146559A1 (en) * 1992-10-23 1994-05-11 Melanie K. Spriggs Methods of preparing soluble, oligomeric proteins
ES2231991T3 (es) * 1997-06-11 2005-05-16 Borean Pharma A/S Modulo de trimerizacion.
US10183986B2 (en) * 2005-12-15 2019-01-22 Industrial Technology Research Institute Trimeric collagen scaffold antibodies

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103172746A (zh) * 2011-12-26 2013-06-26 财团法人工业技术研究院 三聚体Fc融合蛋白及其用途
CN103172746B (zh) * 2011-12-26 2016-09-21 财团法人工业技术研究院 三聚体Fc融合蛋白及其用途
CN103172748A (zh) * 2013-01-29 2013-06-26 中国人民解放军第三军医大学 一种抗恶性淋巴瘤融合蛋白及其制备方法
CN103172748B (zh) * 2013-01-29 2014-11-05 中国人民解放军第三军医大学 一种抗恶性淋巴瘤融合蛋白及其制备方法
CN111819186A (zh) * 2018-01-10 2020-10-23 综合医院公司 表达嵌合抗原受体的免疫细胞
WO2022089426A1 (zh) * 2020-10-27 2022-05-05 细胞图谱有限公司 外周血样本分析方法和试剂盒

Also Published As

Publication number Publication date
DE60336746D1 (de) 2011-05-26
ES2367749T3 (es) 2011-11-08
ATE505484T1 (de) 2011-04-15
JP4690044B2 (ja) 2011-06-01
DK1558640T3 (da) 2011-07-25
JP2006520318A (ja) 2006-09-07

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Open date: 20060111