CN1717183A

CN1717183A - Cosmetic composition for preventing and/or correcting the functional disorders of the pilo-sebaceous unit of mammals

Info

Publication number: CN1717183A
Application number: CNA2003801044825A
Authority: CN
Inventors: A·迪朗东; A·马尔诺
Original assignee: Nestec SA; LOreal SA
Current assignee: Nestec SA; LOreal SA
Priority date: 2002-10-16
Filing date: 2003-10-16
Publication date: 2006-01-04
Also published as: FR2845900B1; FR2845900A1

Abstract

The invention relates to a makeup compound, which is suitable to be ingested, and is designed to prevent and/or correct dysfunctions of mammalian hair follicle sebaceous gland units, in particular to resist skin activation of androgen with time. The compound comprises poly-unsaturated fatty acid, flavonoid and stilbene compound. The invention also provides a make-up method to use the compound, and the use of the compound in preparation and design of a foodstuff supplement used to prevent and/or correct dysfunctions of mammalian hair follicle sebaceous gland unit, in particular used to treat oily and/or highly seborrheic skin and/or scalp, thin hair, hirsutism and/or phalacrosis.

Description

Be used to prevent and/or proofread and correct the make-up composition of mammiferous pilosebaceous unit dysfunction

The invention belongs to the exploitation of new product and be used for the scope of methods of treatment of the cosmetic purpose of humans and animals.The invention particularly relates to the field of the cosmetics that can by oral route give, for example food supplement.

Therefore, the objective of the invention is to be suitable for the make-up composition that by oral route gives, and be used to prevent and/or proofread and correct the dysfunction of mammiferous pilosebaceous unit, especially in time resist androgenic epidermis and activate, described composition comprises poly-unrighted acid, flavone compound and stilbene compound.

The present invention also relates to utilize this composition prevention and/or proofread and correct the cosmetic method of the dysfunction of mammiferous pilosebaceous unit.

Common mammiferous hair, especially Ren Lei hair and hair are adjustable length cornified silks.

In the remaining part of this paper, term " hair " refers to the body hairs of humans and animals and people's hair.Therefore, adjective " hair " refers to this hair or hair or refers to both.In each case, being endowed this adjectival implication will occur from literary composition in clear and unambiguous mode.

In implication of the present invention, unless otherwise noted, term " people " refers to man and women.

Hair comprises fixing part or the root that is implanted in the caving in of epidermis, and hair follicle and free part or trunk are its end being tapered more or less.The root of hair is attached to mao shape folliculus and forms the bubble of hollow at its basal part, and this place has and has being rich in of trophic function papilla capillaceous.

Bases at each hair has pilosebaceous follicle.The latter secretes mixture, triglycerides, cholesterol, cholesterol derivative and the cell fragment (Stewart, M.E.Semin.Dermatol 11,100-105 (1992)) of semi liquid state lipid, sebum, aliphatic acid.For the mankind, for example, sebaceous glands covers the whole machine body except palm and vola.Except that scalp, these bodies of gland are around the nose, around the mouth, on the forehead, especially blazon on the upper and lower chin of cheek and the neck, can change between every square centimeter about 400 and 900 bodies of gland in these local their density.

Pass through sebum lubricated skin, hair and the hair surface of smegma in the hair follicle level.It constitutes slightly acidic panniculus, is used to protect outside invasion and attack and the dehydration of skin opposing, and this gives the credit to its antibacterial properties, and it keeps the ability of water towards " barrier " function of outside and its.

Yet when the sebum excessive secretion, skin, hair and hair show as and can hold itself out to be especially inaesthetic gloss and plunder the angle.Tell about the dysfunction of " damage ", " disorder ", " imbalance " or pilosebaceous unit then.

In this article, should be appreciated that term pilosebaceous follicle " unit ", " organ (organ) " are used interchangeably the integral body and relevant sebaceous glands that refers to by hair shape folliculus formation with " organ (apparatus) ".

It oneself is serious, simple hypersteatosis or seborrhagia that above-mentioned disorder can disclose them sometimes, can develop into the very alopecia of broad form.

In mammal, the development of sebaceous glands and function are the (Mercurio etc. that regulate by the complex mechanism that comprises internal system; J.Gend Specif Med 2000May-Jun; 3 (4): 59-64).

Internal system has been gathered incretory, and its secretory product-hormone is directly to be released in the blood.

The hormone of organic chemical messenger-therefore generation acts on organ or specified target tissue usually.

Hormone is not the chemical classes of homogeneous.In fact, under this generic term, gathered compound as the different structure of protein, peptide, steroids, aromatic and amine.

Especially sex hormone for example testosterone, estrogen or progesterone belong to steroids family, derived from the hormonal compounds of cholesterol.These especially comprise male sex hormones and androgen.

It is time dependent having observed mammiferous hair density.

About hair, the number of capillary trunk and diameter reduced with the age.Some male experimenter even develop into androgenetic alopecia.In addition, the unfavorable variation of these of hair is attended by the change of scalp state sometimes, for example the excessive generation of sebum.

For the women, the age can cause that to manifest crinosity unusual, for example the excess of hairs on leg, the arm or in the growth of beard or the horizontal hair of moustache.

Research has shown active hormones, especially sex steroid, is that the conversion by inactive precursor in the periphery target tissue forms, for example mammary gland, prostate, uterus, bone and skin.Therefore, androgen and estrogen produce active in these tissues.

Therefore, above-mentioned unfavorable variation in pilosebaceous unit comes down to because abnormal metabolism, the especially androgen (Labrie etc. of steroid hormone; Horm Res 2000; 54 (5-6): 218-29).More accurately, described unfavorable variation be in time androgen particularly the testosterone part be epidermis, the result of activation, (Labrie etc.; Horm Res 2000; 54 (5-6): 218-29;

After the embodiment 1).

At present, from cosmetic point, the dysfunction of mammiferous pilosebaceous follicle organ still is difficult to treat.On the one hand, local approach be proved to be difficult to adapt to major part normally big and needs at least every day therapeutic frequency the quilt surface for the treatment of.On the other hand, possible by oral route gives, and is that the product that can buy on market at present shows very important side effect, especially property aspect.Their application therefore need the medical science qualification personnel orderly control and pay close attention to.

Therefore, need anti-above-mentioned worried active product, described product needed is suitable for by oral route and gives and be free from side effects.

The objective of the invention is accurately to meet this demand.

In fact the present invention relates to the make-up composition that is used to prevent and/or proofread and correct the dysfunction of mammal hair follicle sebaceous glands unit, and described composition is designed by oral route and gives, and comprises poly-unrighted acid, flavone compound and stilbene compound.

This composition makes it can resist the androgenic skin that comprises testosterone and adrenaline (adrenalian) androgen in time course and activates.

Composition of the present invention is sparse especially for treatment people's oiliness and/or height-seborrheal skin and/or scalp, hair, hirsutism or hair and/or alopecia are excessive.

In preferred mode, composition of the present invention is food or nutritious supplementary pharmaceutical.

In the context of the present invention, term " mammal " must be understood that consistent with the meaning of a word that It is generally accepted usually.However, the advantageously targets domestic animals and/or the mankind of term " mammal " implication in the present invention.

In preferred mode, poly-unrighted acid that comprises in composition of the present invention and/or flavone compound and/or stilbene compound are natural origins.In preferred mode, these compounds of this group are natural origins." natural origin " refers to pure state or with the compound of variable concentrations in solution, described compound by for expert's various extraction processes known from for example plant or the initial acquisition of animal of natural key element.More preferably, all compounds are to extract from the compound that is often used as food.

Poly-unrighted acid comes down to polyolefin acid (polyethylenic acids), promptly comprises the two keys of at least two carbon.In fact, the poly-unrighted acid that does not almost comprise carbon carbon triple bond at occurring in nature.

According to first feature of the composition consistent with the present invention, its poly-unrighted acid that comprises is known as essential fatty acid.These aliphatic acid are though they can not be synthetic by mammal self, for described mammiferous eubolism (integrality of growth, growth and skin, reproductive function, especially gestation and lactation ...) be essential.This essential fatty acid must be with food intake.

Food-based poly-unrighted acid is the location definition of length by carbochain and two keys.Therefore, they are divided into two groups, do not have metabolic conversion or can not function replacement mutually, and described group by distinguishing near the unsaturated bond position of terminal methyl group.These groups are known as n-3 (or ω 3 or " Omega-3 ") and n-6 (or ω 6 or " Omega-6 ") by convention.For example, the aliphatic acid of n-3 group is alpha-linolenic acid [18 (carbon numbers): 3 (unsaturated number) n-3] and parinaric acid (stearidonic acid) (18:4n-3).The aliphatic acid of N-6 group, for example, linoleic acid (18:2n-6) and gamma-Linolenic acid (18:3n-6).

Be suitable for preparing in the essential fatty acid of the present composition, the expert will preferably select to belong to the poly-unrighted acid of n-6 group.Especially advantageously select gamma-Linolenic acid.

As noted above, be included in the corresponding to composition of the present invention in aliphatic acid be preferably the extract of animal or plant natural origin.At this on the one hand, currant seed (black currantpip) oil, evening primrose oil; Common Borage and hemp can be mentioned as the oil of plant origin, and spirulina (spirulin) especially Spirula maxima and S.Platensis extract and fish oil and those derives from the oil of the oil of marine product as animal origin.These oil obviously can use separately or use with form of mixtures.Preferably, the expert will select the source of black currant pip oil as poly-unrighted acid.

According to another feature of the corresponding to composition of the present invention, the latter comprises flavone compound, especially isoflavonoid.

Flavone compound is a Polyphenols, depends on their structure and their oxidized degree, and they are divided into flavonols, flavones, catechin, proanthocyanidin and their analog and derivative.

The natural origin of flavone compound mainly is a plant, is representative with Umbelliferae, the rose family, pulse family and other compound especially.In from the product of vine and tea, also found flavone compound.

Isoflavonoid has constituted the subclass of flavone compound.They are formed by the 3-phenyl look alkane skeleton that can have different substituents in different oxidation level.Opposite with flavone compound, isoflavonoid exists only in very a limited number of plant.

In fact, term " isoflavonoid " refers to one group of classes of compounds, comprises isoflavones, isoflavanones, rotenoid, pterocarpan, isoflavan, isoflavan-3-alkene, 3-aryl-coumarin, 3-aryl-4-hydroxy cumarin, coumestanes, coumaronochromones, Alpha-Methyl deoxybenzoin or 2-aryl coumarone.Complete summary for isoflavonoid, their analytical method and their source, the expert can be the monograph " flavone compound " (Dewick, P.M.HarboneEd.pp.125-157 (1988)) of " isoflavonoid " with reference to the 5th chapter title.

Especially the isoflavonoid that is suitable for the context of the invention for example is daidzein, 7 hydroxyls-4 '-methoxy-isoflavone, cuneatin, genistein, different prunetin and prunetin, cajanin (cajanin), orobol, pratensein, santal, junipegenin A, Glycitein, afromosin, retusine, tectorigenin, purpleking iris (Iris germanica var upright flavine, jamaicin and their analog and derivative.

In the isoflavonoid that in the context of the invention, uses, preferred isoflavones, and even more preferably the simplest aglycon form, comprise daidzein, genistein and their mixture.These two kinds of compounds especially are present in the extract of soja Glycina max.

According to another specific embodiments of the present invention, use the extract of two kinds of separate sources being rich in flavone compound, a kind ofly be rich in OPC and another kind is rich in isoflavonoid.

According to another feature of the corresponding to composition of the present invention, the latter comprises stilbene compound, especially hydroxystilbenes.

Stilbene compound may be glycosylated, is that seed plant produces basically by plant, and belongs to the antibiotic molecule class that is called phytoalexin.Centrally can make resveratrol or 3,5,4 '-resveratrol what mention.

Resveratrol is produced by multiple fruit and plant, with simple (resveratrol) or glycosylated form (for example piceid, polygonin or 4 ', 5-pinosylvin-3-O-β-list-D-glucoside).Resveratrol simple and the glycosylation form especially is present in the Grape Skin Am J Enol Vitic 48 (2) (1997) such as () Vrhovsek, perhaps also be present in the in vitro culture thing supernatant of Vitis vinifera (J Nat Prod 61 such as Teguo, 655-657 (1998)).

(WO 99/04747, and name is Unilever, N.V.) to have described the make-up composition that comprises resveratrol in the literary composition of control skin senescence sign.Similarly, the step of the ester derivant that obtains resveratrol and use the precursor (WO 99/03816, name be Caudalie) of these latter as resveratrol in make-up composition has been described.At last, the applicant has described glycosylated hydroxystilbenes derivative and has been used to prepare the cosmetic that is designed for topical application, favourable application dermatology or pharmaceutical composition as these latter's precursor, than the more stable and easier dissolving of corresponding hydroxystilbenes (french patent application was submitted on July 28th, 0010008,2000).

Hydroxystilbenes can be plant or the extract that comprises their plant material, it comprises following plant section, only quotes as an illustration: Vitaceae, Ombelliferae, Myrtaceae, Dipterocarpaceae, yperaceae, Gnetaceae, pulse family, Grami naeae, Sericeae, Haemodoraceae, Muaceae, polygonaceae, Pinaceae, Crupressaceae, Cesalpiniaceae, Poaceae, Solanaceae.They especially can separate the tissue from V.vinifera or Polygonum cuspidatum.The product that the expert will select Grape Skin or derive from grape for example grape wine as the preferred source of hydroxystilbenes.For example grape extract can obtain from residue, seed and/or the seed adventitia of grape and/or obtain from the grape stem possibly.

Therefore, in this article, can advantageously adopt the polyphenol compound and the claret of proanthocyanidin or the extract of grape seed that are rich in resveratrol type.

According to an embodiment of the corresponding to composition of the present invention, the latter is being suitable for presented in unit dosage form packing that by oral route gives, described give give every day 1-6 dosage or the frequency of unit carry out.Preferably, every days 3 unit dosage recommend.

And the daily dose of the corresponding to recommendation of the present invention comprises between 0.5-2600mg every day and gather unrighted acid between the 5-1200mg preferred every day, stilbene compound between the flavone compound between the every day 0.5-1000mg and between the preferred every day 20-300mg, every day 0.5-1000mg and between the preferred every day 10-200mg.

The present composition can be taken a couple of days, several weeks or several months.Treatment cycle can repeat for several times and even can be continued in 1 year.The activity extract that uses in said composition derives from human or animal's common food source really, and can not cause risk of toxicity.

The daily dose of these recommendations is like this, and promptly the every 1g dosage device of the present composition comprises following amount:

-0.1%-99%, preferably 5-60% and the more preferably poly-unrighted acid of 10-40%;

-0.1%-99%, preferably 5-60% and the more preferably flavone compound of 10-30%; And more preferably 20-30%;

-0.1%-99%, preferably 5-40% and the more preferably stilbene compound of 10-25%.

Composition of the present invention can with the galenica form that might imagine exist, condition is that these latter are suitable for by oral route and give.The limiting examples that therefore can be mentioned have drinkable solution, syrup, tablet, coated tablet, gelatine capsule or or even the food that concentrates for example biscuit, nutrition bar or powder, may be compacting.Powder for example can be diluted in water, soda, dairy products or the soybean derivatives or be added in rod or the biscuit.Preferably, composition of the present invention is a solid composite, and for example be tablet, coated tablet, gelatine capsule or or even the food that concentrates for example biscuit, nutrition bar or powder, may be compacting.

According to corresponding to another embodiment of the present invention, the latter also comprises at least a excipient that is suitable for orally give except that poly-unrighted acid, flavone compound and stilbene compound.In a specific embodiments, composition of the present invention is made up of poly-unrighted acid, flavone compound, stilbene compound and the excipient that is suitable for orally give.At this on the one hand, being used for Orally administered composition is known in particular for preparation, assistant agent and the excipient of food supplement for the expert.In the middle of other and in pure illustrative mode, the lubricant that is useful on the food aspect that can mention is dolomol for example, be used for instant product, gelling agent, thickener, wetting agent, fat and/or aquo-compound, anticorrisive agent, texturizing agent, flavor enhancement and/or glazing agent, antioxidant and colouring agent.

The present composition can comprise one or more vitamins and/or trace element in addition.As guidance, following reactive compound for example can be used singly or in combination: zinc and comprise its salt of zinc sulfate and zinc gluconate, vitamin B5, B6, B8, C, E or PP, beta carotene and carotenoid, garlic P.E is allyl sulfides or ajoene form especially, selenium, curcurmine, curcuminoid, nicotinic acid, alkannic acid and adenosine.Should be appreciated that the expert will select this class reactive compound and, if essential, will merge them, and avoid suppressing or weakening interested ideal activity so that improve the character of the expection of composition.

In a specific embodiments, said composition does not comprise any Lotus (Nelumbo) extract, and especially, said composition does not comprise the active material of any Lotus, selects in transmethylase, ascorbic acid, gluthatione and dopamine agonist.

In another embodiment, said composition does not comprise any DHEA or its analog.

In another embodiment, composition of the present invention does not comprise panthetin.

In another particular, composition of the present invention does not comprise milk or extracts from the compound of suckling.

Target of the present invention also is to be used to prevent and/or to proofread and correct the especially cosmetic method of the dysfunction of the pilosebaceous unit of people and domestic animal of mammal, and more is used in particular for treating oiliness and/or height seborrhagia skin and/or scalp, and is fine; Excessive and/or the alopecia of hirsutism or hair, described method give above-mentioned composition by by oral route and form.More preferably, this cosmetic method is applied to the people.

At last, the composition that comprises poly-unrighted acid, flavone compound and stilbene compound that the present invention relates to as noted above is designed for prevention and/or proofreaies and correct the especially purposes in the food supplement of the mankind and the dysfunction of domestic animal pilosebaceous unit of mammal in preparation.

Therefore, the present invention relates to purposes, be used to increase the density of keratin fiber and especially hair, and/or reduce the inhomogeneities of their diameter as the composition that in above-mentioned cosmetic method, defines, and/or improve their growths, and/or prevention and/or reduce and/or postpone their forfeiture.

The term " inhomogeneities of hair diameter " that this paper adopts refers to the marked change of hair diameter in the concrete zone of scalp; Some hairs have the physiology diameter in 100 mu m ranges, and other is immediate with those hairs, has the diameter (fine) of minimizing.Therefore, " reduce the inhomogeneities of diameter " and refer to increase fine diameter.

" increase density " refers to increase keratin fiber, hair or the ciliary number of every square centimeter of skin or scalp.

By following accompanying drawing the present invention is described without limitation:

Fig. 1:Under the influence of topical application testosterone, the growth (" testosterone effect " is described) of the rib vertebra organ (hereinafter CVO) of hamster size

D50 is corresponding to right CVO being begun applications of testosterone every day.

Fig. 2: suppress " testosterone effect " alone or in combination by poly-unrighted acid, flavone compound and stilbene compound.

Contrast

-◆-Hei gooseberry seed

-▲-concentrates the extract of soybean of the isoflavone compounds that 40% content is arranged

-■-grape wine concentrate

-Φ-combination

Above mentioned feature of the present invention and the further feature of not mentioning in detail hereinbefore, embodiment is partly clear below manifests.These embodiment are used to illustrate purpose of the present invention, and do not limit its scope.

Embodiment

Embodiment 1: to the proof-in vitro test of the effect of pilosebaceous unit topical application testosterone:

1-A- The principle of CVO test

The CVO of hamster is the skin area that is rich in pilosebaceous unit.

CVO test comprises measures different compounds anti--androgenic effect to CVO, promptly measures the effect whether described compound stop testosterone Arch Dermatol Res 293 (4) such as (, 200-205 (2001)) Liao S.

1-B- The result of control experiment: observe " testosterone effect "

Fig. 1 is presented under the situation of topical testosterone application, does not accept the variation of CVO size in the control-animal of any dietary supplement ingredient.More accurately, Fig. 1 is presented at the right CVO that accepted testosterone and the difference in surface areas between the left CVO (negative control).Therefore, this figure has illustrated " testosterone effect ".

From the 50 day (dotted arrow), testosterone is applied to right CVO every day.

Show that as Fig. 1 compare with the size of left CVO, testosterone is induced the increase of right CVO size in time.

Embodiment 2: suppress the proof that " testosterone " acts on the corresponding to composition of the present invention:

2-A- The product of test:

Following product is used in the scope of CVO test in the body, for example as defined above.These products by test sheet solely or in combination as food supplement.

(a) be rich in the natural perfume material of the claret of resveratrol (stilbene compound) and proanthocyanidin (flavone compound), ratio is for there being 0.11g (18% Polyphenols) in 43g food;

(b) comprise the extract of soybean of 40% isoflavonoid, ratio is for there being 0.02g extract (40% isoflavonoid) in 44g food;

(c) be rich in the black currant pip oil (poly-unrighted acid 18:3n-6) of gamma-Linolenic acid, ratio is for having 10% by weight in food;

(d) above-mentioned three kinds of product combination.

2-B- The result:

Product (b)-the be called extract of soybean that is rich in isoflavonoid does not stop " testosterone " effect, when in control experiment (embodiment 1-B) scope, observing, as by " contrast " curve and " the concentrated isoflavonoid that 40% content is arranged " illustrated in fig. 2.

On the other hand, show among Fig. 2 and product (a) and (c) and product (a) and (b) and (c) combination reduce the difference in size between right CVO and the left CVO significantly.

Yet, with the inclination that the observed curve of natural perfume material (product (a)) of claret keeps up, hint " testosterone effect " though advantageously descended, still the variation opposite with predictive role can be arranged in time.

With the observed curve of product (c)-corresponding to the oil that comprises poly-unrighted acid, when especially strong from giving to show in about 20 days, or even suddenly, to the inhibition activity of " testosterone effect ".The shortcoming relevant with independent application product (c) derives from the fact, promptly during about first five days of treatment, and (" contrast " curve) compared with the control, the difference in size increase between right and left CVOs.

At last, only have product (a) and (b) and (c) combination-corresponding to the corresponding to composition that comprises poly-unrighted acid, flavone compound and stilbene compound of the present invention, the feasible inhibition figure that may observe expection, promptly when beginning a large amount of minimizings of " testosterone effect " from treatment, be attended by the gradual slow decline of described effect, act on so that finally trend towards zero in time or be actually zero.

In addition, individually verified or in combination the different tests compound for the not influence of the sexual organ of buck.In fact, observe the different trial products that is subjected to and to influence seminal vesicle and prostatic weight (result does not show) sharply.These observed results show with the corresponding to make-up composition of the present invention should not show undesirable side effect for known composition.

Embodiment 3: the preparation-example of formulations of the present composition:

3-A-sugar-coat type preparation

The amount of each compound is to indicate at the mg of each sugar coated tablet number

The excipient of dressing nuclear

-microcrystalline cellulose 70

-Encompress ^TM 60

-dolomol 3

-colloidal silica anhydrous 1

Coating agent:

-rubber resin (gum-lac) 5

-talcum 61

-sucrose 250

-PVP 6

-titanium dioxide 0.3

-colouring agent 5

Active component:

-black currant pip oil 0.5

-comprise the claret extract 2 of 18% Polyphenols

-concentrated the extract of soybean 2 that the isoflavonoid of 40% content is arranged

Dosage device implication in the present invention is corresponding to a sugar coated tablet.

3-B- The preparation of plant or animal gelatin capsule type:

Excipient:

-starch 128

-dolomol 2.5

Active component:

-black currant pip oil 200

-comprise the claret extract 100 of 18% Polyphenols

-concentrated the extract of soybean 50 that the isoflavonoid of 40% content is arranged

The dosage device that defines in the specification is corresponding to a capsule in front.

3-C- The preparation of single dose gel type:

Following content is represented with the percentage in the final products gross weight.

According to said preparation, dosage unit equals 200ml and approximates 200g

A) Single dose gel 1:

Excipient:

-syrup 30

-maltodextrin 17

-xanthans 0.8

-Sodium Benzoate 0.2

-water qsp 100

Active component:

-black currant pip oil 20

-comprise the claret extract 10 of 18% Polyphenols

-concentrated the extract of soybean 20 that the isoflavonoid of 40% content is arranged

A) Single dose gel 2:

Excipient:

-syrup 50

-maltodextrin 17

-xanthans 0.8

-Sodium Benzoate 0.2

-water qsp 100

Vitamin and trace element:

-antioxidant composition *

Active component:

-Hei gooseberry seed oil 10

-comprise the claret extract 12 of 18% Polyphenols

-concentrated the extract of soybean 24 that the isoflavonoid of 40% content is arranged

* be included in the antioxidant composition in the 200ml gel

-vitamin C 120mg

-selenium 100 μ g

-vitamin E 30mg

-zinc 20mg

-beta carotene 6mg

3-D- The preparation of capsule type:

Following amount is represented with the mg/ capsule.

According to said preparation, a dosage device is corresponding to a capsule.

A) Capsule 1:

Excipient

-glycerine 150

-dolomol 0.02

-water qsp 900

Trace element:

-zinc gluconate 160

Active component:

-black currant pip oil 300

-comprise the claret extract 200 of 18% Polyphenols

-concentrated the extract of soybean 200 that the isoflavonoid of 40% content is arranged

B) Capsule 2:

Excipient:

-glycerine 150

-dolomol 0.02

-water qsp 900

Vitamin and trace element:

-vitamin compound *

-zinc gluconate 160

Active component:

-black currant pip oil 400

-comprise the claret extract 100 of 18% Polyphenols

-concentrated the extract of soybean 300 that the isoflavonoid of 40% content is arranged

* the vitamin compound that comprises of each capsule:

-vitamin C 60mg

-selenium 50 μ g

-vitamin E 15mg

-zinc 10mg

-lycopene 3mg

3-E- The preparation of soft capsule type:

Following amount is represented with the mg/ soft capsule.

Excipient:

-soybean oil 40

-wheat-germ oil 85

-soybean lecithin 25

Vitamin:

-natural VE 3

-vitamin C 60

Active component:

-black currant pip oil 200

-comprise the claret extract 100 of 18% Polyphenols

-concentrated the extract of soybean 100 that the isoflavonoid of 40% content is arranged

In such, a dosage device equals a soft capsule.

Claims

1. the make-up composition that is used to prevent and/or proofread and correct the sebaceous glands unit's dysfunction of mammal hair follicle and specifies by oral route to give is characterized in that it comprises poly-unrighted acid, flavone compound and stilbene compound.

2. according to the composition of claim 1, it is characterized in that it is designed to resist androgenic skin and activates, skin especially in time activates.

3. according to the composition of claim 1, it is characterized in that it is a food supplement.

4. according to the composition of claim 1, it is characterized in that described mammal is domestic.

5. according to the composition of claim 1, it is characterized in that described mammal is the people.

6. according to each composition among the claim 1-3, it is characterized in that described poly-unrighted acid and/or described flavone compound and/or described stilbene compound are natural origins.

7. according to each composition among the claim 1-3, it is characterized in that described poly-unrighted acid, described flavone compound and described stilbene compound are natural origins.

8. according to the composition of claim 6 or 7, it is characterized in that described poly-unrighted acid is the n-6 group.

9. composition according to Claim 8 is characterized in that described poly-unrighted acid is corresponding to gamma-Linolenic acid.

10. according to Claim 8 or 9 composition, it is characterized in that described poly-unrighted acid is contained in oil or is selected from the extract of black currant pip oil, or even evening primrose oil, borage oil, cannabis oil, spirulina extract, especially Spirula maxima and S.Platensis extract, derive from the oil of marine product with fish oil and those, and preferably black gooseberry seed oil.

11. according to the composition of claim 6 or 7, it is characterized in that described flavone compound is an isoflavonoid, preferred isoflavones.

12., it is characterized in that described isoflavonoid is selected from daidzein, genistein and their mixture according to the composition of claim 11.

13. according to the composition of claim 11 or claim 12, it is characterized in that described flavone compound is contained in the plant extracts, for example vine, tea, fruit, soybean and preferred soybean.

14., it is characterized in that described stilbene compound is a hydroxystilbenes according to the composition of claim 6 or 7.

15., it is characterized in that described hydroxystilbenes is selected from resveratrol and derivative thereof, especially the latter's ester and glycosylated derivative according to the composition of claim 14.

16. according to each composition of claim 14-15, it is characterized in that described stilbene compound is a grape extract, especially Grape Skin and/or derived from extract, the especially grape wine of the product of grape.

17. according to claim 1-3, each composition among the 6-7 is characterized in that it is packaged with dosage unit form, give every day 1-6 unit and preferred every day 3 unit.

18. according to the composition of claim 17, it comprises the poly-unrighted acid of 0.1 weight %-99 weight % to it is characterized in that every dosage unit.

19. according to the composition of claim 18, it comprises 5-60 weight % to it is characterized in that every dosage unit, and the poly-unrighted acid of preferred 10-40 weight %.

20. according to the composition of claim 17, it comprises the flavone compound of 0.1 weight %-99 weight % to it is characterized in that every dosage unit.

21. according to the composition of claim 20, it comprises 5 weight %-60 weight % to it is characterized in that every dosage unit, and the polyunsaturated fatty acid of preferred 10-30 weight %.

22. according to the composition of claim 17, it comprises the stilbene compound of 0.1 weight %-99 weight % to it is characterized in that every dosage unit.

23. according to the composition of claim 22, it comprises 5 weight %-40 weight % to it is characterized in that every dosage unit, and the stilbene compound of preferred 10-25 weight %.

24., it is characterized in that it comprises at least a excipient that is suitable for orally give in addition according to each composition of claim 1-23.

25., it is characterized in that it comprises one or more vitamins and/or trace element in addition according to each composition of claim 1-24.

26. prevention and/or proofread and correct the especially cosmetic method of the pilosebaceous unit dysfunction of people and domestic animal of mammal is given to form according to each composition of claim 1-25 by by oral route.

27. according to the method for claim 26, it is characterized in that described composition packs with presented in unit dosage form, with 1-6 unit every day, and preferred every day 3 unit speed give.

28. the composition that comprises poly-unrighted acid, flavone compound and stilbene compound is designed for prevention and/or proofreaies and correct the especially purposes in the food supplement of the pilosebaceous unit dysfunction of people and domestic animal of mammal in preparation.

29., it is characterized in that described poly-unrighted acid and/or described flavone compound and/or described stilbene compound are natural origins according to the purposes of claim 28.

30., it is characterized in that described poly-unrighted acid according to the purposes of claim 28; Described flavone compound and described stilbene compound are natural origins.

31., it is characterized in that described poly-unrighted acid is n-6 group, for example gamma-Linolenic acid according to the purposes of claim 29 or 30.

32. according to the purposes of claim 29 or 30, it is characterized in that described flavone compound is an isoflavonoid, preferred isoflavones for example is selected from the isoflavone compounds of daidzein, genistein and their mixture.

33. according to the purposes of claim 29 or 30, it is characterized in that described stilbene compound is a hydroxystilbenes, be selected from resveratrol and derivative thereof, especially the latter's ester and glycosylated derivative.

34. according to the purposes of claim 28, it is characterized in that described composition is packaged with dosage unit form, by oral route give every day 1-6 unit and preferred every day 3 unit.

35., it is characterized in that the described composition of every dosage unit comprises the poly-unrighted acid of 0.1 weight %-99 weight % according to the purposes of claim 34.

36., it is characterized in that the described composition of every dosage unit comprises 5%-60%, and the poly-unrighted acid of preferred 10-40% according to the purposes of claim 35.

37., it is characterized in that the described composition of every dosage unit comprises the flavone compound of 0.1 weight %-99 weight % according to the purposes of claim 34.

38., it is characterized in that the described composition of every dosage unit comprises 5-60 weight %, and the flavone compound of preferred 10-30 weight % according to the purposes of claim 37.

39., it is characterized in that the described composition of every dosage unit comprises the stilbene compound of 0.1 weight %-99 weight % according to the purposes of claim 34.

40., it is characterized in that the described composition of every dosage unit comprises 5-40 weight %, and the stilbene compound of preferred 10-25 weight % according to the purposes of claim 39.