CN114099403A

CN114099403A - Skin-feel-improving nanostructured lipid carrier and preparation process and application thereof

Info

Publication number: CN114099403A
Application number: CN202111409060.5A
Authority: CN
Inventors: 黎晓燕; 林彤彤; 徐梦漪; 郑丹阳; 黄振宇; 黄小燕; 龚盛昭; 蔡丽华
Original assignee: Guangdong Industry Technical College
Current assignee: Guangdong Industry Technical College
Priority date: 2021-11-19
Filing date: 2021-11-19
Publication date: 2022-03-01

Abstract

The invention discloses a nanostructure lipid carrier for improving skin feel, as well as a preparation process and application. The nanostructure lipid carrier comprises the following components by weight: 4-26% of emulsifier, 9-28% of complex lipid material, 1-16% of lemongrass extract, 1-26% of phenethyl resorcinol, The rest is deionized water. The present invention utilizes nanostructured lipid carrier to load the active ingredient lemongrass extract, has controlled-release and sustained-release effects, can increase the bioavailability, improve the water solubility and stability of the fat-soluble ingredient, etc., and also has better sealing properties. and skin adhesion, can reduce the loss of water from the epidermis, thereby increasing skin hydration, and can regulate oil secretion, benefit oily skin and hair, promote blood circulation, and can provide skin care cosmetics with encapsulated functional ingredients. , moisturizing and other skin sensations, so that consumers can directly feel the skin's softness is better, so that the skin is full of moisture.

Description

Skin-feel-improving nanostructured lipid carrier and preparation process and application thereof

Technical Field

The invention relates to a nanostructured lipid carrier for improving skin feel, and also relates to a preparation process and application of the nanostructured lipid carrier, belonging to the technical field of cosmetic preparation.

Background

It is good for people to eat. The oriental women always pay attention to the skin problems, especially the aspects of whitening, acne removing, aging resistance and the like. Moreover, with the development of economy, consumers are more concerned about the components of the skin care cosmetics, and the consumers are more in need of safe and healthy products and are more inclined to the skin care cosmetics with efficacy in the consumption trend.

The functional components are the main reasons influencing the efficacy of the skin care product, and mainly comprise plant extracts and main active components thereof, biotechnology raw materials, raw materials modified and modified by certain technologies, and the like.

However, the traditional functional components can cause poor skin feel of the cosmetics, and when the skin care products without the coated functional raw materials are used, consumers can obviously perceive that the softness of the skin of the products is poor, and feel that the moisture on the surface of the skin is quickly lost, and the stability is poor, so that the products are easy to discolor when being directly added into a formula, and oil-water stratification occurs.

Disclosure of Invention

The invention aims to provide a nanostructured lipid carrier for improving skin feel, and aims to solve the problems of poor skin feel and poor stability in the application of functional components in the prior art.

Another technical problem to be solved by the present invention is to provide a preparation process and application of the above nanostructured lipid carrier.

In order to achieve the purpose, the invention adopts the following technical scheme:

according to a first aspect of embodiments of the present invention, there is provided a nanostructured lipid carrier for improving skin feel, comprising the following components in percentage by weight: 4-26% of an emulsifier, 9-28% of a composite lipid material, 1-16% of a lemon grass extract, 1-26% of phenethyl resorcinol, and the balance of deionized water.

Preferably, the nanostructured lipid carrier comprises the following components in percentage by weight: 26% of emulsifier, 28% of composite lipid material, 1% of lemon grass extract, 1% of phenethyl resorcinol, and the balance of deionized water.

Preferably, the nanostructured lipid carrier comprises the following components in percentage by weight: 26% of emulsifier, 28% of composite lipid material, 16% of lemon grass extract, 26% of phenethyl resorcinol, and the balance of deionized water.

Preferably, the preparation method of the lemon grass extract comprises the following steps:

(1) selecting dried lemon grass, cutting, adding purified water with the weight 4-9 times of that of the raw materials, soaking for 0.5-1 hour, heating to 90-100 ℃, decocting for 0.5-2 hours, and filtering to obtain a first filtrate;

(2) adding purified water with the weight 0.5-2 times that of the medicinal materials into the filter residue again, covering, heating to 90-100 ℃, and decocting for 0.5-1 hour; filtering for the second time to obtain a second filtrate;

(3) and pouring the first filtrate and the second filtrate into a container together, heating and concentrating until the total liquid amount is 25-50%, and then cooling and sterilizing to obtain the lemon grass extract.

(4) Taking 10 parts by weight of lemon grass extract, adding 1 part of tween 80, 1 part of poloxamer 184, 1 part of cetyl alcohol (Novel A), 1 part of emulsifier SSE-2, 1 part of caprylic capric glycerin and 10 parts of water, mixing and stirring for 30 minutes, and preparing to finish; preparing the pretreated lemongrass extract.

Preferably, the composite lipid material comprises solid lipid and liquid lipid.

Preferably, the solid lipid is selected from five or more than five of the following compounds: lauric acid, stearic acid, palmitic acid, myristic acid, palmitic alcohol, myristyl alcohol, stearyl alcohol, cetylstearic acid, glyceryl tristearate and glyceryl trimyristate; the liquid lipid material is selected from one or a mixture of several of the following compounds: isopropyl palmitate, caprylic capric triglyceride, olive oil, soybean oil, oleic acid and 2-octyllauryl alcohol.

Preferably, the emulsifier is selected from one or more of the following compounds: tween 80, tween 40, tween 60, poloxamer 184, poloxamer 188, soya bean curd, cetyl alcohol (Novel a) emulsifier SS and emulsifier SSE-20.

According to a second aspect of embodiments of the present invention, there is provided a process for preparing a skin-feel enhancing nanostructured lipid carrier, comprising the steps of:

step 1, weighing an emulsifier and deionized water according to a proportion, mixing the deionized water and the emulsifier, heating and stirring to obtain a water phase with a specified temperature;

step 2, weighing solid lipid and liquid lipid according to a preset proportion, and heating and mixing the lipid materials to obtain an oil phase at a specified temperature;

step 3, weighing the lemongrass extract and the phenethyl resorcinol according to the proportion, and then heating and mixing to obtain a mixed solution;

step 4, adding a water phase with a specified temperature into the oil phase with a specified temperature, homogenizing and mixing uniformly at a low speed, then adding a mixed solution with a specified temperature, and then adding the mixed solution into a preheated high-pressure homogenizer for homogenizing for 3-6 times to obtain a high-temperature emulsion;

and 5, rapidly cooling the high-temperature emulsion to room temperature to obtain the skin-feel-improving nano-structure lipid carrier.

Preferably, the specified temperature in the process is within the range of 50-80 ℃, and the high pressure is within the range of 100-1000 bar.

According to a second aspect of embodiments of the present invention, there is provided the use of the above-described skin feel enhancing nanostructured lipid carrier in the preparation of a skin care cosmetic.

Compared with the prior art, the invention has the beneficial effects that:

the invention utilizes the nano-structured lipid carrier to load the lemongrass extract which is an active ingredient, has the controlled release and slow release effects, can increase the bioavailability, improve the water solubility and stability of fat-soluble ingredients, has better sealing property and skin adhesion, can reduce the water loss on the skin surface, further increase the skin hydration, adjust the grease secretion, be beneficial to oily skin and hair, promote the blood circulation, provide various skin feels such as softness and moisture of skin care cosmetics applying the wrapped active ingredients, enable consumers to directly feel better skin softness and fully fill the skin with water, form a water emulsion structure by matching and mixing the lemongrass extract and phenethyl resorcinol, then form stable water emulsion micro-particles, use the nano-structured lipid carrier as the carrier of the lemongrass extract, and further enable the nano-structured lipid carrier to have good stability, can be stored for a long time, has good water solubility, and makes the preparation of effective components in cosmetics simpler and more convenient.

Drawings

Fig. 1 is a process flow diagram of a skin-feel-enhancing nanostructured lipid carrier prepared according to the present invention.

Detailed Description

The technical contents of the invention are described in detail below with reference to the accompanying drawings and specific embodiments.

The preparation method of the lemon grass extract comprises the following steps:

(1) selecting dry lemon grass, cutting, adding purified water with the weight 5 times of that of the raw materials, soaking for 1 hour, heating to 100 ℃, decocting for 1.5 hours, and filtering to obtain a first filtrate;

(2) adding purified water with the weight 1.5 times of that of the medicinal materials into the filter residue again, covering the filter residue, heating to 100 ℃, and decocting for 1 hour; filtering for the second time to obtain a second filtrate;

(3) pouring the first filtrate and the second filtrate into a container, heating and concentrating to 25% of the total liquid amount, and cooling and sterilizing to obtain the lemongrass extract.

(4) Taking 10 parts by weight of lemon grass extract, adding 4 parts of compound emulsifier (containing 1 part of Tween 80, 1 part of poloxamer 184, 1 part of cetyl alcohol (Novel A) and 1 part of emulsifier SSE-2), 1 part of caprylic/capric glycerin (liquid oil) and 10 parts of water, mixing and stirring for 30 minutes, and thus preparing.

The lemongrass extract is subjected to pretreatment in the step (4), so that the rich essential oil aromatic hydrocarbon and other effective substances in the lemongrass extract are conveniently mixed and melted in water emulsion with multiple O/W, and the lemongrass extract can be ensured to be substantially reacted in the subsequent liposome preparation.

A skin-feel-improving nanostructured lipid carrier comprises the following components in percentage by weight: 4-26% of an emulsifier, 9-28% of a composite lipid material (comprising solid lipid and liquid lipid), 1-16% of a lemon grass extract, 1-26% of phenethyl resorcinol, and the balance of deionized water.

The solid lipid is selected from five or more than five of the following compounds: lauric acid, stearic acid, palmitic acid, myristic acid, palmitic alcohol, myristyl alcohol, stearyl alcohol, cetylstearic acid, glyceryl tristearate and glyceryl trimyristate.

The liquid lipid material is selected from one or a mixture of several of the following compounds: isopropyl palmitate, caprylic capric triglyceride, olive oil, soybean oil, oleic acid and 2-octyllauryl alcohol.

The emulsifier is selected from one or a mixture of several of the following compounds: tween 80, tween 40, tween 60, poloxamer 184, poloxamer 188, soya bean curd, cetyl alcohol (Novel a) emulsifier SS and emulsifier SSE-20.

Example 1:

a skin-feel-improving nanostructured lipid carrier comprises the following components in percentage by weight: tween 604%, poloxamer 1843%, soybean curd 3%, lauric acid 2%, stearic acid 2%, palmitic acid 2%, myristic acid 2%, palmitic alcohol 2%, caprylic/capric triglyceride 2%, lemon grass extract 1%, phenylethyl resorcinol 1%, and deionized water 76%.

The preparation method of the nanostructured lipid carrier for improving the skin feeling comprises the following steps:

step 1, weighing an emulsifier and deionized water according to a proportion, mixing the deionized water and the emulsifier, heating and stirring to obtain a water phase at 80 ℃;

step 2, weighing solid lipid and liquid lipid according to a preset proportion, and heating and mixing the lipid materials to obtain an oil phase at 80 ℃;

step 3, weighing the pretreated lemongrass extract and phenethyl resorcinol in proportion, and then heating and mixing to obtain a mixed solution;

step 4, adding a water phase with a specified temperature into the oil phase at the temperature of 80 ℃, homogenizing and mixing uniformly at a low speed, then adding the mixed solution at the temperature of 80 ℃, and then adding the mixed solution into a preheated high-pressure homogenizer for homogenizing for 3-6 times to obtain a high-temperature emulsion;

Example 2:

a skin-feel-improving nanostructured lipid carrier comprises the following components in percentage by weight: tween 602%, poloxamer 1842%, soybean curd 2%, lauric acid 2%, stearic acid 2%, palmitic acid 2%, myristic acid 2%, palmitic alcohol 2%, caprylic/capric triglyceride 2%, lemon grass extract 7%, phenylethyl resorcinol 11%, and deionized water 64%.

The procedure for preparing the above skin feel enhancing nanostructured lipid carrier is the same as in example 1.

Example 3:

a skin-feel-improving nanostructured lipid carrier comprises the following components in percentage by weight: tween 602%, poloxamer 1842%, soybean curd 2%, lauric acid 2%, stearic acid 2%, palmitic acid 2%, myristic acid 2%, palmitic alcohol 2%, caprylic/capric triglyceride 2%, lemon grass extract 12%, phenylethyl resorcinol 21%, and deionized water 49%.

Example 4:

a skin-feel-improving nanostructured lipid carrier comprises the following components in percentage by weight: tween 602%, poloxamer 1842%, soybean curd 2%, lauric acid 2%, stearic acid 2%, palmitic acid 2%, myristic acid 2%, palmitic alcohol 2%, caprylic/capric triglyceride 2%, lemon grass extract 16%, phenylethyl resorcinol 26%, deionized water 40%.

Test examples

1. Examples 1-4 describe a skin feel enhancing nanostructured lipid carrier stability test.

The skin-feel-improving nanostructured lipid carriers described in examples 1 to 4 were prepared into essences, the stability of the essences was examined under 45 ℃, 4 ℃, room temperature and light conditions, the separation and delamination of the products were observed at 1 week, 3 weeks, 5 weeks, 7 weeks, 9 weeks and 11 weeks, and no delamination was observed.

2. Evaluation of the comprehensive Effect of the skin-feeling-improving nanostructured lipid Carriers described in examples 1-4

The skin-feel-improving nanostructured lipid carrier described in embodiments 1 to 4 is prepared into an emulsion, and the addition amount is 5%.

The subject claims: 60 healthy skin volunteers were selected, and a group consisting of male and female, and 10 persons was selected, wherein five groups were test groups (corresponding to the skin-feeling-enhancing nanostructured lipid carriers of examples 1 to 4), and all volunteers were filled with informed consent before the test, and the age was 18 to 45 years. The emulsion prepared by the skin-feeling-improving nanostructured lipid carrier is used by a test subject continuously every day, the effect of the emulsion is scored 28 days after the test period, the average score is recorded, the score range is 1-5, the higher the score is, the higher the degree is, and the test results are as shown in the following table.

Content of test	Example 1	Example 2	Example 3	Example 4
					Flexibility	4.3	5	5	4.7
Moistening sensation	4.2	5	5	4.3
					Spreadability	4.7	4.8	4.7	3.9
Elasticity	4.3	5	4.8	4.2
					Smooth and comfortable	4.2	4.8	4.3	4.4

By combining the above embodiments, when the added lemongrass extract is 7% and the phenylethyl resorcinol is 11%, the emulsion prepared by the skin-feel-improving nanostructured lipid carrier has the best comprehensive effect, the active ingredient lemongrass extract is loaded by the nanostructured lipid carrier, so that the emulsion has the effects of controlled release and slow release, can increase the bioavailability, improve the water solubility and stability of fat-soluble ingredients, has better sealing property and skin adhesion, can reduce the loss of skin surface water, further increase the skin hydration, can adjust the grease secretion, is beneficial to oily skin and hair, promotes blood circulation, can provide the skin care cosmetic using the coated active ingredients, has various skin feels such as softness and moistening, and enables consumers to directly feel better skin softness.

The skin-feel-improving nanostructured lipid carrier provided by the invention, and the preparation process and application thereof are explained in detail above. It will be apparent to those skilled in the art that any obvious modifications thereof can be made without departing from the spirit of the invention, which infringes the patent right of the invention and bears the corresponding legal responsibility.

Claims

1. a nanostructure lipid carrier for improving skin feel is characterized in that it comprises the following compositions by weight: 4-26% of emulsifier, 9-28% of composite lipid material, 1-16% of lemongrass extract, benzene Ethyl resorcinol 1-26%, the rest is deionized water.

2. The nanostructured lipid carrier for enhancing skin feel as claimed in claim 1, characterized in that it comprises the following components by weight: 26% of emulsifier, 28% of complex lipid material, 1% of lemongrass extract, phenylethyl ether Resorcinol 1%, the rest is deionized water.

3. The nanostructured lipid carrier for enhancing skin feel as claimed in claim 1, characterized in that it comprises the following components by weight: 26% of emulsifier, 28% of complex lipid material, 16% of lemongrass extract, styrene ethyl Resorcinol 26%, the rest is deionized water.

4. the nanostructure lipid carrier of improving skin feel as claimed in claim 1, is characterized in that the preparation method of described lemongrass extract is as follows:

(1) Select dried lemongrass to be chopped, add 4 to 9 times the weight of the raw material and soak it in purified water for 0.5 to 1 hour, then heat to 90 to 100 ° C, decoct for 0.5 to 2 hours, and then filter to obtain the first time filtrate;

(2) Add purified water of 0.5 to 2 times the weight of the medicinal material to the filter residue again, cover it, then heat it to 90 to 100 ° C, and decoct for 0.5 to 1 hour; filter the second time to obtain the second filtrate;

(3) pouring the first filtrate and the second filtrate into the container together, heating and concentrating to 25%～50% of the total liquid volume, then cooling and sterilizing to obtain the lemongrass extract;

(4) Take 10 parts of lemongrass extract by weight, add 1 part of Tween 80, 1 part of Poloxamer 184, 1 part of cetyl alcohol (Novel A), 1 part of emulsifier SSE-2, 1 part of caprylic acid caprylic acid Acid glycerin and 10 parts of water are mixed and stirred for 30 minutes, and the preparation is completed; the pretreated lemongrass extract is prepared.

5. the nanostructure lipid carrier of improving skin feel as claimed in claim 1, is characterized in that:

The complex lipid material includes solid lipids and liquid lipids.

6. the nanostructure lipid carrier of lifting skin feel as claimed in claim 5, is characterized in that described solid lipid is selected from five kinds or more than five kinds of mixing of following compound:

lauric acid, stearic acid, palmitic acid, myristic acid, palmityl alcohol, myristyl alcohol, stearyl alcohol, cetearyl acid, glyceryl tristearate and glyceryl trimyristate; the liquid lipids The material is selected from one or a mixture of the following compounds: isopropyl palmitate, caprylic capric triglyceride, olive oil, soybean oil, oleic acid and 2-octyl lauryl alcohol.

7. the nanostructure lipid carrier of lifting skin feel as claimed in claim 1, is characterized in that described emulsifying agent is selected from the mixing of one or more of following compounds:

Tween 80, Tween 40, Tween 60, Poloxamer 184, Poloxamer 188, Soy Curd, Cetyl Alcohol (Novel A) Emulsifier SS and Emulsifier SSE-20.

8. the preparation technology of the nanostructure lipid carrier of improving skin feel as described in any one of claim 1～7, is characterized in that comprising the following steps:

Step 1. Weigh the emulsifier and deionized water in proportion, and heat and stir after mixing the deionized water and the emulsifier to obtain the water phase of the specified temperature;

Step 2, taking by weighing solid lipid and liquid lipid by preset ratio, heating and mixing the lipid material to obtain the oil phase of the specified temperature;

Step 3, weigh the pretreated lemongrass extract and phenethyl resorcinol in proportion, then heat and mix to obtain a mixed solution;

Step 4. Add the water phase of the specified temperature to the oil phase of the specified temperature, homogenize and mix at a low speed, then add the mixture of the specified temperature, and then add it to the preheated high-pressure homogenizer and homogenize it for 3 to 6 times to obtain high temperature emulsion;

Step 5. The high temperature emulsion is rapidly cooled to room temperature to obtain a nanostructured lipid carrier that enhances skin feel.

9 . The preparation process of the nanostructured lipid carrier for enhancing skin feel according to claim 8 , wherein the specified temperature in the preparation process is within the range of 50-80° C. and the high-pressure range is within the range of 100-1000 bar. 10 .

10 . The application of the nanostructured lipid carrier for enhancing skin feel as claimed in claim 1 in the preparation of skin care cosmetics. 11 .