CN1613462A - Longhedan pills and their preparation - Google Patents
Longhedan pills and their preparation Download PDFInfo
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- CN1613462A CN1613462A CN 200310103526 CN200310103526A CN1613462A CN 1613462 A CN1613462 A CN 1613462A CN 200310103526 CN200310103526 CN 200310103526 CN 200310103526 A CN200310103526 A CN 200310103526A CN 1613462 A CN1613462 A CN 1613462A
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- rhizoma curcumae
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Abstract
A Chinese medicine in the form of particles tablet, capsule, pills, or oral liquid for auxiliary therapy of cervix cancer is prepared from 12 Chinese-medicinal materials including red sage root, musk, peach kernel, safflower, etc.
Description
[invention field]
The present invention relates to a kind of Chinese medicine composition, is a kind of Chinese medicine composition of auxiliary treatment of cervical carcinoma specifically, the invention still further relates to the preparation method of this Chinese medicine composition.
[background technology]
Cervical cancer is the malignant tumor that occurs in women's uterine cervix, sees women more than 40 years old more, and with age, its sickness rate also increases.Accounting for the first place of women's genital malignant tumor, is the commonly encountered diseases of serious harm WomanHealth.Its method of treatment mainly is operation, radiation and chemotherapy at present, and other also have immunomodulating and treatment by Chinese herbs.But all undesirable because of the curative effect of the whole bag of tricks, and tend to the cooperation of various therapies, take Comprehensive Treatment.Can alleviate patient's slight illness like this, improve the quality of living, life-saving etc.The Chinese traditional treatment cervical cancer is to control by differential diagnosis of diseases and dialectical executing, and also can cooperate the chemicotherapy method sometimes, and the improvement of part patient symptom, pain kitchen range remission rate are improved.
In view of the medicine and the method for the treatment malignant tumor that does not have better curative effect at present, so a kind of Chinese medicine for oral administration of demand still in conjunction with the better auxiliary treatment of cervical carcinoma of chemotherapy.The inventor is through animal experiment and clinical verification repeatedly for many years, develops a kind ofly effectively to treat the Chinese medicine composition of cervical cancer in conjunction with chemotherapy, thereby finished the present invention.
[summary of the invention]
Goal of the invention
Purpose of the present invention just provide a kind of can be in conjunction with the Chinese medicine composition of the effective auxiliary treatment of cervical carcinoma of chemotherapy.This medicine has the effect of heat-clearing and toxic substances removing, dissolving blood stasis and detoxication, can be used for that malicious heresy is pented up, the cervical cancer operation due to the blood-stasis internal-depression and the auxiliary treatment after the radiotherapy.
Another object of the present invention just provides the preparation method of this Chinese medicine composition.
Technical scheme
The object of the present invention is achieved like this:
The present invention treats the Chinese medicine composition of cervical cancer, it is characterized in that the preparation raw material (in weight portion) of the contained active component of this Chinese medicine composition is as follows:
Herba Solani Nigri 166-234 part Pseudobulbus Cremastrae Seu Pleiones 166-234 part Rhizoma Curcumae 100-167 part
Herba Agrimoniae 166-234 part Radix Salviae Miltiorrhizae 100-167 part Herba Lycopi 100-167 part
Moschus 3-9 part Semen Vaccariae 100-167 part Semen Persicae 66-117 part
Flos Carthami 66-117 part Radix Astragali 166-234 part Radix Angelicae Sinensis 100-167 part
Preferably, medicine material consumption of the present invention is as follows in weight portion:
Herba Solani Nigri 183-217 part Pseudobulbus Cremastrae Seu Pleiones 183-217 part Rhizoma Curcumae 116-151 part
Herba Agrimoniae 183-217 part Radix Salviae Miltiorrhizae 116-151 part Herba Lycopi 116-151 part
Moschus 3-7 part Semen Vaccariae 116-151 part Semen Persicae 66-101 part
Flos Carthami 66-101 part Radix Astragali 183-217 part Radix Angelicae Sinensis 116-151 part
More preferably, medicine material consumption of the present invention is as follows by weight:
133 parts of 208 parts of Rhizoma Curcumae of 208 parts of Pseudobulbus Cremastrae Seu Pleioness of Herba Solani Nigri
133 parts of 133 parts of Herba Lycopi of 208 parts of Radix Salviae Miltiorrhizaes of Herba Agrimoniae
83 parts in 133 parts of Semen Persicaes of 5 parts of Semen Vaccariae of Moschus
133 parts of 208 parts of Radix Angelicae Sinensis of 83 parts of Radixs Astragali of Flos Carthami
The source and the effect thereof of the Chinese crude drug that technique scheme is mentioned are as follows:
Herba Solani Nigri: the herb for Solanaceae annual herb plant black nightshade has heat-clearing and toxic substances removing, eliminating stagnation diuretic effect.
Pseudobulbus Cremastrae Seu Pleiones: the dry pseudobulb for orchid Cremastra appendiculata, pleione bulbocodioides has heat-clearing and toxic substances removing, the effect of dissipating phlegm and resolving masses.
Rhizoma Curcumae: be the dry rhizome of zingiberaceous plant Rhizoma Curcumae, have the circulation of qi promoting removing blood stasis, removing food stagnancy analgesic effect.
Herba Agrimoniae: the dry aerial parts for the rosaceous plant Radix Agrimoniae have astringing to arrest bleeding, preventing the attack (or recurrence) of malaria antidotal effect.
Radix Salviae Miltiorrhizae: be herbaceos perennial, be used as medicine to have the effect of blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, promoting tissue regeneration by removing blood stasis with root.
The Herba Lycopi: the dry aerial parts for lip type section vegetable hair leaf lycopus lucidus have activating blood circulation to dissipate blood stasis, the effect of line water detumescence.
Moschus: the dry secretions in the ripe male body note capsule of animal in deer family woods Moschus moschiferous has the refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, the effect of reducing swelling and alleviating pain.
Semen Vaccariae: be the dry mature seed of pinkwort Vaccaria segetalis, have the effect of promoting blood circulation to restore menstrual flow.
Semen Persicae: the dry mature seed for the rosaceous plant peach has blood circulation promoting and blood stasis dispelling, the effect of loosening bowel to relieve constipation.
Flos Carthami: the dried floral for the feverfew Flos Carthami has promoting blood circulation to restore menstrual flow, the effect of eliminating stasis to stop pain.
The Radix Astragali: be the dry root of leguminous plant Radix Astagali, have the effect of invigorating QI to consolidate the body surface resistance.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica, having enriches blood invigorates blood circulation, the effect of loosening bowel to relieve constipation.
The effective ingredient of Chinese medicine composition of the present invention is according to comprising that the method for following each processing step obtains:
(a) Moschus powder is broken into fine powder, Herba Agrimoniae and Radix Salviae Miltiorrhizae powder are broken into coarse powder, extract twice, each 1-3 hour with 60-95 volume % ethanol water, merge extractive liquid, also filters, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol;
(b) Rhizoma Curcumae and Radix Angelicae Sinensis are extracted volatile oil, the aqueous solution after distillation device is in addition collected, and volatile oil is carried out inclusion with cyclodextrin and water, stirs 1-3 hour at 60 ℃, puts cold filtration, is ground into fine powder after the cold drying;
(c) with all the other Herba Solani Nigris, Pseudobulbus Cremastrae Seu Pleiones, the Herba Lycopi, Semen Vaccariae, Semen Persicae, Flos Carthami, the Radix Astragali decocts with water three times, each 1 hour, collecting decoction, filter and with the aqueous solution merging after filtrate and above-mentioned Rhizoma Curcumae and the Radix Angelicae Sinensis distillation, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, rotating speed centrifugalize with 2000-3000 rev/min, the clear paste of getting supernatant and above-mentioned Herba Agrimoniae and Radix Salviae Miltiorrhizae merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃ then, through vacuum drying, resulting dry thing is crushed to fine powder, again with above-mentioned steps (a) in the Moschus fine powder and (b) in the fine powder of Rhizoma Curcumae volatile oil inclusion complex mixed evenly, make various dosage forms with pharmaceutically acceptable carrier or excipient then, promptly obtain medicine of the present invention.
The described concentration of alcohol of step in the above-mentioned preparation method (a) is preferably 80%, preferably make a living by weight 6 times of dose of alcoholic solution consumption.The rotating speed of the described centrifugalize of step (c) is 2500 rev/mins.
Prescription of the present invention is through the above-mentioned steps preparation, can make various pharmaceutical formulations such as granule, capsule, tablet, pill, oral liquid or the like with pharmaceutically acceptable carrier or excipient composition.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.These used carriers or excipient all are easy to determine for the those of ordinary skill of pharmaceutical field, also are conspicuous.
Beneficial effect
Chinese medicine composition of the present invention has the effect of heat-clearing and toxic substances removing, dissolving blood stasis and detoxication, can be used for that malicious heresy is pented up, the cervical cancer operation due to the blood-stasis internal-depression and the auxiliary treatment after the radiotherapy, and has no side effect, and is suitable for taking for a long time.Medicine of the present invention is easy to take, evident in efficacy, be a kind of medicine of ideal treatment cervical cancer.
[specific embodiment]
Below in conjunction with specific embodiment the present invention is elaborated.
Embodiment 1:The preparation of granule of the present invention
Herba Solani Nigri 208 weight portion Pseudobulbus Cremastrae Seu Pleioness 208 weight portion Rhizoma Curcumae 133 weight portions
Herba Agrimoniae 208 weight portion Radix Salviae Miltiorrhizaes 133 weight portion Herba Lycopi 133 weight portions
Moschus 5 weight portion Semen Vaccariae 133 weight portion Semen Persicaes 83 weight portions
The Flos Carthami 83 weight portion Radixs Astragali 208 weight portion Radix Angelicae Sinensis 133 weight portions
Take by weighing raw material according to above-mentioned consumption, Moschus powder is broken into fine powder, Herba Agrimoniae and Radix Salviae Miltiorrhizae powder are broken into coarse powder, extract twice with 70 volume % ethanol waters, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Rhizoma Curcumae and Radix Angelicae Sinensis are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is carried out inclusion with cyclodextrin and water, stirs 2 hours at 60 ℃, puts cold filtration, is ground into fine powder after the cold drying; With all the other Herba Solani Nigris, Pseudobulbus Cremastrae Seu Pleiones, the Herba Lycopi, Semen Vaccariae, Semen Persicae, Flos Carthami, the Radix Astragali decocts with water three times, each 1 hour, collecting decoction, filter and with the aqueous solution merging after filtrate and above-mentioned Rhizoma Curcumae and the Radix Angelicae Sinensis distillation, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, rotating speed centrifugalize with 2500 rev/mins, the clear paste of getting supernatant and above-mentioned Herba Agrimoniae and Radix Salviae Miltiorrhizae merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃ then, through vacuum drying, resulting dry thing is crushed to fine powder, granulates with the above-mentioned Moschus fine powder and the mixed evenly back of fine powder of Rhizoma Curcumae volatile oil inclusion complex again, with the particle drying of preparation, packing.
Embodiment 2:The preparation of granule of the present invention
Herba Solani Nigri 166 weight portion Pseudobulbus Cremastrae Seu Pleioness 166 weight portion Rhizoma Curcumae 100 weight portions
Herba Agrimoniae 166 weight portion Radix Salviae Miltiorrhizaes 100 weight portion Herba Lycopi 100 weight portions
Moschus 3 weight portion Semen Vaccariae 100 weight portion Semen Persicaes 66 weight portions
The Flos Carthami 66 weight portion Radixs Astragali 166 weight portion Radix Angelicae Sinensis 100 weight portions
Take by weighing raw material according to above-mentioned consumption, Moschus powder is broken into fine powder, Herba Agrimoniae and Radix Salviae Miltiorrhizae powder are broken into coarse powder, extract twice with 70 volume % ethanol waters, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Rhizoma Curcumae and Radix Angelicae Sinensis are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is carried out inclusion with cyclodextrin and water, stirs 2 hours at 60 ℃, puts cold filtration, is ground into fine powder after the cold drying; With all the other Herba Solani Nigris, Pseudobulbus Cremastrae Seu Pleiones, the Herba Lycopi, Semen Vaccariae, Semen Persicae, Flos Carthami, the Radix Astragali decocts with water three times, each 1 hour, collecting decoction, filter and with the aqueous solution merging after filtrate and above-mentioned Rhizoma Curcumae and the Radix Angelicae Sinensis distillation, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, rotating speed centrifugalize with 2500 rev/mins, the clear paste of getting supernatant and above-mentioned Herba Agrimoniae and Radix Salviae Miltiorrhizae merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃ then, through vacuum drying, resulting dry thing is crushed to fine powder, granulates with the above-mentioned Moschus fine powder and the mixed evenly back of fine powder of Rhizoma Curcumae volatile oil inclusion complex again, with the particle drying of preparation, packing.
Embodiment 3:The preparation of granule of the present invention
Herba Solani Nigri 234 weight portion Pseudobulbus Cremastrae Seu Pleioness 234 weight portion Rhizoma Curcumae 167 weight portions
Herba Agrimoniae 234 weight portion Radix Salviae Miltiorrhizaes 167 weight portion Herba Lycopi 167 weight portions
Moschus 9 weight portion Semen Vaccariae 167 weight portion Semen Persicaes 117 weight portions
The Flos Carthami 117 weight portion Radixs Astragali 234 weight portion Radix Angelicae Sinensis 167 weight portions
Take by weighing raw material according to above-mentioned consumption, Moschus powder is broken into fine powder, Herba Agrimoniae and Radix Salviae Miltiorrhizae powder are broken into coarse powder, extract twice with 70 volume % ethanol waters, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Rhizoma Curcumae and Radix Angelicae Sinensis are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is carried out inclusion with cyclodextrin and water, stirs 2 hours at 60 ℃, puts cold filtration, is ground into fine powder after the cold drying; With all the other Herba Solani Nigris, Pseudobulbus Cremastrae Seu Pleiones, the Herba Lycopi, Semen Vaccariae, Semen Persicae, Flos Carthami, the Radix Astragali decocts with water three times, each 1 hour, collecting decoction, filter and with the aqueous solution merging after filtrate and above-mentioned Rhizoma Curcumae and the Radix Angelicae Sinensis distillation, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, rotating speed centrifugalize with 2500 rev/mins, the clear paste of getting supernatant and above-mentioned Herba Agrimoniae and Radix Salviae Miltiorrhizae merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃ then, through vacuum drying, resulting dry thing is crushed to fine powder, granulates with the above-mentioned Moschus fine powder and the mixed evenly back of fine powder of Rhizoma Curcumae volatile oil inclusion complex again, with the particle drying of preparation, packing.
Embodiment 4:The preparation of capsule of the present invention
Herba Solani Nigri 208 weight portion Pseudobulbus Cremastrae Seu Pleioness 208 weight portion Rhizoma Curcumae 133 weight portions
Herba Agrimoniae 208 weight portion Radix Salviae Miltiorrhizaes 133 weight portion Herba Lycopi 133 weight portions
Moschus 5 weight portion Semen Vaccariae 133 weight portion Semen Persicaes 83 weight portions
The Flos Carthami 83 weight portion Radixs Astragali 208 weight portion Radix Angelicae Sinensis 133 weight portions
Take by weighing raw material according to above-mentioned consumption, Moschus powder is broken into fine powder, Herba Agrimoniae and Radix Salviae Miltiorrhizae powder are broken into coarse powder, extract twice with 85 volume % ethanol waters, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Rhizoma Curcumae and Radix Angelicae Sinensis are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is carried out inclusion with cyclodextrin and water, stirs 2 hours at 60 ℃, puts cold filtration, is ground into fine powder after the cold drying; With all the other Herba Solani Nigris, Pseudobulbus Cremastrae Seu Pleiones, the Herba Lycopi, Semen Vaccariae, Semen Persicae, Flos Carthami, the Radix Astragali decocts with water three times, each 1 hour, collecting decoction, filter and with the aqueous solution merging after filtrate and above-mentioned Rhizoma Curcumae and the Radix Angelicae Sinensis distillation, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, rotating speed centrifugalize with 2500 rev/mins, the clear paste of getting supernatant and above-mentioned Herba Agrimoniae and Radix Salviae Miltiorrhizae merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃ then, through vacuum drying, resulting dry thing is crushed to fine powder, and is evenly mixed with the fine powder of above-mentioned Moschus fine powder and Rhizoma Curcumae volatile oil inclusion complex again, incapsulates then.
Embodiment 5:The preparation of tablet of the present invention
Herba Solani Nigri 208 weight portion Pseudobulbus Cremastrae Seu Pleioness 208 weight portion Rhizoma Curcumae 133 weight portions
Herba Agrimoniae 208 weight portion Radix Salviae Miltiorrhizaes 133 weight portion Herba Lycopi 133 weight portions
Moschus 5 weight portion Semen Vaccariae 133 weight portion Semen Persicaes 83 weight portions
The Flos Carthami 83 weight portion Radixs Astragali 208 weight portion Radix Angelicae Sinensis 133 weight portions
Take by weighing raw material according to above-mentioned consumption, Moschus powder is broken into fine powder, Herba Agrimoniae and Radix Salviae Miltiorrhizae powder are broken into coarse powder, extract twice with 85 volume % ethanol waters, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Rhizoma Curcumae and Radix Angelicae Sinensis are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is carried out inclusion with cyclodextrin and water, stirs 2 hours at 60 ℃, puts cold filtration, is ground into fine powder after the cold drying; With all the other Herba Solani Nigris, Pseudobulbus Cremastrae Seu Pleiones, the Herba Lycopi, Semen Vaccariae, Semen Persicae, Flos Carthami, the Radix Astragali decocts with water three times, each 1 hour, collecting decoction, filter and with the aqueous solution merging after filtrate and above-mentioned Rhizoma Curcumae and the Radix Angelicae Sinensis distillation, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, rotating speed centrifugalize with 2500 rev/mins, the clear paste of getting supernatant and above-mentioned Herba Agrimoniae and Radix Salviae Miltiorrhizae merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃ then, through vacuum drying, resulting dry thing is crushed to fine powder, evenly mixed with the fine powder of above-mentioned Moschus fine powder and Rhizoma Curcumae volatile oil inclusion complex again, make wet granular, tabletting with commonly used excipient of preparation tablet such as starch etc.
Embodiment 6:The preparation of pill of the present invention
Herba Solani Nigri 208 weight portion Pseudobulbus Cremastrae Seu Pleioness 208 weight portion Rhizoma Curcumae 133 weight portions
Herba Agrimoniae 208 weight portion Radix Salviae Miltiorrhizaes 133 weight portion Herba Lycopi 133 weight portions
Moschus 5 weight portion Semen Vaccariae 133 weight portion Semen Persicaes 83 weight portions
The Flos Carthami 83 weight portion Radixs Astragali 208 weight portion Radix Angelicae Sinensis 133 weight portions
Take by weighing raw material according to above-mentioned consumption, Moschus powder is broken into fine powder, Herba Agrimoniae and Radix Salviae Miltiorrhizae powder are broken into coarse powder, extract twice with 85 volume % ethanol waters, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Rhizoma Curcumae and Radix Angelicae Sinensis are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is carried out inclusion with cyclodextrin and water, stirs 2 hours at 60 ℃, puts cold filtration, is ground into fine powder after the cold drying; With all the other Herba Solani Nigris, Pseudobulbus Cremastrae Seu Pleiones, the Herba Lycopi, Semen Vaccariae, Semen Persicae, Flos Carthami, the Radix Astragali decocts with water three times, each 1 hour, collecting decoction, filter and with the aqueous solution merging after filtrate and above-mentioned Rhizoma Curcumae and the Radix Angelicae Sinensis distillation, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, rotating speed centrifugalize with 2500 rev/mins, the clear paste of getting supernatant and above-mentioned Herba Agrimoniae and Radix Salviae Miltiorrhizae merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃ then, through vacuum drying, resulting dry thing is crushed to fine powder, and is evenly mixed with the fine powder of above-mentioned Moschus fine powder and Rhizoma Curcumae volatile oil inclusion complex again, adds refined honey and makes small honey pill or big honeyed pills.
Embodiment 7:Oral liquid of the present invention
Herba Solani Nigri 208 weight portion Pseudobulbus Cremastrae Seu Pleioness 208 weight portion Rhizoma Curcumae 133 weight portions
Herba Agrimoniae 208 weight portion Radix Salviae Miltiorrhizaes 133 weight portion Herba Lycopi 133 weight portions
Moschus 5 weight portion Semen Vaccariae 133 weight portion Semen Persicaes 83 weight portions
The Flos Carthami 83 weight portion Radixs Astragali 208 weight portion Radix Angelicae Sinensis 133 weight portions
Take by weighing raw material according to above-mentioned consumption, Moschus powder is broken into fine powder, Herba Agrimoniae and Radix Salviae Miltiorrhizae powder are broken into coarse powder, extract twice with 85 volume % ethanol waters, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Rhizoma Curcumae and Radix Angelicae Sinensis are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is carried out inclusion with cyclodextrin and water, stirs 2 hours at 60 ℃, puts cold filtration, is ground into fine powder after the cold drying; With all the other Herba Solani Nigris, Pseudobulbus Cremastrae Seu Pleiones, the Herba Lycopi, Semen Vaccariae, Semen Persicae, Flos Carthami, the Radix Astragali decocts with water three times, each 1 hour, collecting decoction, filter and with the aqueous solution merging after filtrate and above-mentioned Rhizoma Curcumae and the Radix Angelicae Sinensis distillation, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, rotating speed centrifugalize with 2500 rev/mins, the clear paste of getting supernatant and above-mentioned Herba Agrimoniae and Radix Salviae Miltiorrhizae merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃ then, through vacuum drying, resulting dry thing is crushed to fine powder, evenly mixed with the fine powder of above-mentioned Moschus fine powder and Rhizoma Curcumae volatile oil inclusion complex again, add correctives Mel and diluent water and make oral liquid.
Below further specify the effect of this Chinese medicine composition by clinical trial.
Test example 1: granule clinical trial of the present invention
Case is selected:
1, meets cervical cancer diagnostic criteria and tcm syndrome diagnostic criteria and suitable radiotherapy person, can include case in.
2, experimenter muscle power situation is fair, estimation 3 months persons of surviving.
3, cervical cancer II phase, III phase and IV phase person.
4, the age is at 18-65 between year, non-gestation or women breast-feeding their children, non-allergic constitution.
Get rid of the case standard:
1, non-constitutional cervical cancer, stopping of cervical cancer, two months patients of radiotherapy less than.
2, be associated with serious primary disease such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system, psychotic.
Test method:
1, adopts randomized blocks
2, observe 43 examples
3, medication: use medicinal granule of the present invention, each 10 grams, every day 3 times, warm boiled water, and combined with chemotherapy.
Chemotherapy medication ADM 40MG intravenous injection, first day
CDDP 50MG intravenous injection, first day
AT1258 40MG intravenous injection, first and third, five day
Per three weeks are one-period.
4, the course of treatment: 2 months was 1 course of treatment, 1 course of treatment of medication, did not use other treatment relevant with primary disease during the clinical verification.
Curative effect determinate standard:
1, clinical recovery: cardinal symptom and foci disappearance, vaginal exfoliated check continuous 3 times all negative, infiltrating carcinoma gets 2 biopsies under colposcope or iodine test and cervical canal erasion pathological examination is all negative; Drug withdrawal was recurrence in 1 year.
2, produce effects: cardinal symptom is obviously improved or is disappeared, and focus is dwindled more than 1/2, and continues more than 1 month.
3, effective: cardinal symptom makes moderate progress or obviously improves, and focus is dwindled more than 1/3, and continues more than 1 month.
4, invalid: cardinal symptom does not have improvement or increases the weight of focus no change or development.
Result of the test:
Table 1 tumor efficiency analytical table
| The example number | Clinical recovery | Produce effects | Effectively | Invalid | Effective percentage (%) | |
| Medicine+chemotherapy of the present invention | ???43 | ????3 | ???14 | ???14 | ??12 | ???39.53％ |
Above-mentioned result of the test shows, medicine of the present invention has the effect of heat-clearing and toxic substances removing, dissolving blood stasis and detoxication, can be used for that malicious heresy is pented up, the cervical cancer operation due to the blood-stasis internal-depression and the auxiliary treatment after the radiotherapy, and has no side effect, evident in efficacy, be a kind of medicine of ideal treatment cervical cancer.
Claims (7)
1. the Chinese medicine composition of an auxiliary treatment of cervical carcinoma, it is made up of effective ingredient or effective ingredient and pharmaceutically acceptable carrier, it is characterized in that its contained effective ingredient made by following bulk drugs:
Herba Solani Nigri 166-234 weight portion Pseudobulbus Cremastrae Seu Pleiones 166-234 weight portion
Rhizoma Curcumae 100-167 weight portion Herba Agrimoniae 166-234 weight portion
Radix Salviae Miltiorrhizae 100-167 weight portion Herba Lycopi 100-167 weight portion
Moschus 3-9 weight portion Semen Vaccariae 100-167 weight portion
Semen Persicae 66-117 weight portion Flos Carthami 66-117 weight portion
Radix Astragali 166-234 weight portion Radix Angelicae Sinensis 100-167 weight portion.
2. according to the Chinese medicine composition described in the claim 1, it is characterized in that preparing raw materials of effective components medicine and consumption thereof and be:
Herba Solani Nigri 183-217 weight portion Pseudobulbus Cremastrae Seu Pleiones 183-217 weight portion
Rhizoma Curcumae 116-151 weight portion Herba Agrimoniae 183-217 weight portion
Radix Salviae Miltiorrhizae 116-151 weight portion Herba Lycopi 116-151 weight portion
Moschus 3-7 weight portion Semen Vaccariae 116-151 weight portion
Semen Persicae 66-101 weight portion Flos Carthami 66-101 weight portion
Radix Astragali 183-217 weight portion Radix Angelicae Sinensis 116-151 weight portion.
3. according to the Chinese medicine composition described in the claim 1, wherein prepare raw materials of effective components medicine and consumption thereof and be:
Herba Solani Nigri 208 weight portion Pseudobulbus Cremastrae Seu Pleioness 208 weight portion Rhizoma Curcumae 133 weight portions
Herba Agrimoniae 208 weight portion Radix Salviae Miltiorrhizaes 133 weight portion Herba Lycopi 133 weight portions
Moschus 5 weight portion Semen Vaccariae 133 weight portion Semen Persicaes 83 weight portions
The Flos Carthami 83 weight portion Radixs Astragali 208 weight portion Radix Angelicae Sinensis 133 weight portions.
4. according to any one described Chinese medicine composition among the claim 1-3, it is granule, capsule, tablet, pill or oral liquid.
5. according to the preparation method of any one described Chinese medicine composition among the claim 1-4, it comprises:
(a) Moschus powder is broken into fine powder, Herba Agrimoniae and Radix Salviae Miltiorrhizae are extracted twice with 60-95 volume % ethanol water, each 1-3 hour, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol;
(b) Rhizoma Curcumae and Radix Angelicae Sinensis are extracted volatile oil, the aqueous solution after distillation device is in addition collected, and volatile oil is carried out inclusion with cyclodextrin and water, stirs 1-3 hour at 60 ℃, puts cold filtration, is ground into fine powder after the cold drying;
(c) with all the other Herba Solani Nigris, Pseudobulbus Cremastrae Seu Pleiones, the Herba Lycopi, Semen Vaccariae, Semen Persicae, Flos Carthami, the Radix Astragali decocts with water three times, each 1 hour, collecting decoction, filter and with the aqueous solution merging after filtrate and above-mentioned Rhizoma Curcumae and the Radix Angelicae Sinensis distillation, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, rotating speed centrifugalize with 2000-3000 rev/min, the clear paste of getting supernatant and above-mentioned Herba Agrimoniae and Radix Salviae Miltiorrhizae merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃ then, through vacuum drying, resulting dry thing is crushed to fine powder, again with above-mentioned steps (a) in the Moschus fine powder and (b) in the fine powder of Rhizoma Curcumae volatile oil inclusion complex mixed evenly, make various dosage forms with pharmaceutically acceptable carrier or excipient then, promptly obtain medicine of the present invention.
6. preparation method according to claim 5 is characterized in that the described concentration of alcohol of step (a) is 80%, make a living by weight 6 times of dose of alcoholic solution consumption.
7. the preparation method of medicine according to claim 5 is characterized in that the rotating speed of the described centrifugalize of step (c) is 2500 rev/mins.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNB2003101035264A CN1304043C (en) | 2003-11-06 | 2003-11-06 | Longhedan pills and their preparation |
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| CNB2003101035264A CN1304043C (en) | 2003-11-06 | 2003-11-06 | Longhedan pills and their preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101095923B (en) * | 2007-07-17 | 2011-01-19 | 宋雅丽 | Chinese traditional medicine for treating ectopic pregnancy |
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| CN1061854C (en) * | 1993-05-24 | 2001-02-14 | 潘世庆 | Medicinal preparation for treatment and prevention of gynopathy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101095923B (en) * | 2007-07-17 | 2011-01-19 | 宋雅丽 | Chinese traditional medicine for treating ectopic pregnancy |
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