CN1568927A - Water soluble combination with elution preventing function and its application in cosmetics - Google Patents
Water soluble combination with elution preventing function and its application in cosmetics Download PDFInfo
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- CN1568927A CN1568927A CN 200410038215 CN200410038215A CN1568927A CN 1568927 A CN1568927 A CN 1568927A CN 200410038215 CN200410038215 CN 200410038215 CN 200410038215 A CN200410038215 A CN 200410038215A CN 1568927 A CN1568927 A CN 1568927A
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Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a water-soluble composition which comprises hyaluronic acid, protein, and proteolytic enzyme, the composition may also comprise one or more of ceramide, amino acid, vitamins, alpha-carboxylic acid, microelement.
Description
Technical field
Relate generally to cosmetic field of the present invention more particularly, the present invention relates to a kind of water-soluble composition with anti-eluting function that can be used as cosmetics additive, wherein comprise hyaluronic acid, protein and protolysate.The invention still further relates to the cosmetics that comprise this water-soluble composition.
Background technology
At present, the various hair products of washing of selling on the market are of a great variety, wherein comprise multiple functional factor usually, play nutrition, nursing, anti-dandruff, effect such as preserve moisture respectively.Common functional factor has all kinds of sized molecules such as aminoacid, vitamin, ceramide, fruit acid, collagen protein, Fructus Cucumidis sativi extract.
These functional factors must just can play functions such as corresponding nutrition nursing at human body surface effect certain hour.But these functional factors are easy to run off in washing process.Much wash hair products because the ability of these functional factors of set is relatively poor, cause a large amount of functional factors in water-washing process, just to be lost, too short with the action time of human body (for example hair, scalp); Simultaneously, a lot of functional factors run off totally after washing, can't be retained in human body surface, can not play the nourishing effect of nursing.Therefore these are washed hair products and in fact are difficult to play its nutrition of declaring, nursing, anti-dandruff, effect such as preserve moisture.
In order to solve the problem that functional factor runs off easily in washing process, the someone has adopted the method for adding the hydrophobicity additive.But various functional factors are normally water miscible, and relatively poor with the compatibility of hydrophobicity material, effect is not satisfactory.
Therefore, preferably can develop a kind of hydrophilic additive, can make various functional factors still can on hair and/or skin, keep a certain amount of existence after the washing, improve it and nourish effect of nursing with anti-eluting function.Wash the hair products except that various, need such as cleansing milk, body lotion, handwashing liquid are washed to protect and are also had similar problem in the articles for use through washing, and promptly various functional factors run off in water-washing process easily.In addition, for cosmetics such as protective skin cream, sunscreen cream, emulsion, facial film, the massage cream of preserving moisture, foundation cream, though they are not directly needing through washing in the use, but still might be owing to sweat stain, drench with rain, water logging (when for example swimming) etc. acts on the functional factor that runs off wherein.Therefore,, more effectively pin functional factor wherein, just might further improve its nutrition nursing role if can in these skin care item, add hydrophilic additive with good anti-eluting function.
Summary of the invention
The invention provides a kind of water-soluble composition, can comprise following component in the described compositions: (A) hyaluronic acid as the additive of all kinds of cosmetics; (B) protein; And (C) protolysate.
Can also comprise in ceramide, aminoacid, vitamin, 'alpha '-hydroxy acids, the trace element one or more in the described compositions.In a preferred embodiment, also comprise ceramide, aminoacid, vitamin, 'alpha '-hydroxy acids and trace element in the described compositions.
Component in the described compositions (B) is can be a kind of, two or more protein.Be applicable to that protein of the present invention includes but not limited to: keratin, elastin, collagen protein, sericin, Limax mucin, Snailase, zinc metallothionein, silk peptide, bovine serum albumin, epidermal growth factor, human acid fibroblast growth factor.In a preferred embodiment, component (B) is a collagen protein.
Component in the described compositions (B) can also be the protein mixture that comprises multiple proteins.Be applicable to that protein mixture of the present invention includes but not limited to: soybean protein, yeast protein, Limax bovine protein, egg membrane albumen.In a preferred embodiment, component (B) is a yeast protein; In a further advantageous embodiment, component (B) is a soybean protein; In another preferred embodiment, component (B) is the Limax bovine protein.
Component in the described compositions (C) can be various protolysates.Be applicable to that protolysate of the present invention includes but not limited to: soybean protein hydrolyate, yeast protein hydrolysate, Limax bovine protein hydrolysate, egg membrane protolysate.In a preferred embodiment, component (C) is the yeast protein hydrolysate; In a further advantageous embodiment, component (C) is a soybean protein hydrolyate; In another preferred embodiment, component (C) is a Limax bovine protein hydrolysate.
In a particularly preferred embodiment of the present invention, component (B) is a yeast protein, and component (C) is the yeast protein hydrolysate; Wherein can also further comprise ceramide, aminoacid, vitamin, 'alpha '-hydroxy acids and trace element.Wherein, be applicable to that 'alpha '-hydroxy acids of the present invention includes but not limited to: lactic acid, malic acid and citric acid.In a preferred embodiment, described 'alpha '-hydroxy acids is a lactic acid.
In another particularly preferred embodiment of the present invention, component (B) is a soybean protein, and component (C) is a soybean protein hydrolyate; Wherein can also further comprise ceramide, aminoacid, vitamin, 'alpha '-hydroxy acids and trace element.
The present invention also provides all kinds of cosmetics that comprise described compositions, for example washes and protects articles for use, skin care item etc.In preferred embodiments more of the present invention, described cosmetics are shampoo, hair conditioner, handwashing liquid, protective skin cream, emulsion, the massage cream of preserving moisture, skin-lightening cosmetic etc.
The present invention also provides the application of described compositions in all kinds of cosmetics of preparation.For example, described compositions is added in the described cosmetics, addition can be between 1%-50%.In a preferred embodiment, described cosmetics are shampoo or hair conditioner.
Test finds that the present composition has the good function that prevents the quick eluting of various functional factors quilts, and has functions such as good moisture preserving, nutrition simultaneously.
Description of drawings
Fig. 1 shows the result of present composition moisture retention test.It is the aqueous solution of 1%, 5%, 10% the present composition (abbreviating LBF among the figure as) that four pillars among the figure are from left to right represented water and concentration respectively, and vertical coordinate is an electrical conductivity.As can be seen from Figure 1, along with the raising of present composition concentration, the also corresponding increase of skin conductivity rate.This explanation present composition has tangible moisture-keeping function.
The specific embodiment
The specific embodiment of the present invention to be described the present invention in order explaining in further detail, wherein known method, material etc. not to be described in detail, in order to avoid a presumptuous guest usurps the role of the host, desalinated main contents of the present invention below in conjunction with accompanying drawing.
The implication of term " cosmetics " should be done to understand the most widely herein, comprise all kinds of cosmetics that protect articles for use, skin care item and other kinds of washing, the example includes but not limited to: shampoo, hair conditioner, cleansing milk, body lotion, handwashing liquid, protective skin cream, sunscreen cream, emulsion, facial film, the massage cream of preserving moisture, skin-lightening cosmetic, astringent, lipstick, foundation cream, eye shadow, rouge etc.
Can comprise multiple composition in the compositions of the present invention, they have various beneficial effects to human body.
Hyaluronic acid (Hyaluronic Acid, be called for short HA, claim glass acid or candy aldehydic acid again) be a kind of linear macromolecule mucopolysaccharide of uniqueness, alternately be formed by connecting repeatedly by the disaccharidase unit of glucuronic acid and N-acetylglucosamine, molecular weight hundreds thousand of between millions of.Hyaluronic acid is a kind of high viscosity substance, is present in widely in the various tissues of animal, and content is higher in vitreum, umbilical cord, skin, cartilage and synovial fluid.Hyaluronic acid is a macromolecular network structure, contains great amount of hydroxy group, can form hydrogen bond and combine a large amount of water with water, has superpower hydrophilic and water retention, is again the good transdermal absorption enhancer simultaneously.It is the best material of finding at present of occurring in nature moisture retention, be called as ideal nature moisturizing factor (Natural moisturizing factor, NMF).For example: 2% pure hyaluronic acid aqueous solution can keep 98% moisture securely.Hyaluronic acid acts on hair and skin surface, and the gas-pervious aquation elasticity of feasible one-tenth one deck mucosa increases the lubricious sense and the elasticity of hair and skin, keeps hair and skin is smooth, moisten.Hyaluronic acid can also promote the hair growth of fibroblasts, repairs damaged skin, increases the elasticity and the antiinflammatory action of skin.The cosmetics that contain HA are acknowledged as " bionical cosmetics " at present, many in recent years countries competitively research and develop the cosmetics that contain HA, as have preserve moisture, the high-grade cosmetics such as bright element, shampoo of hair washing and conditioning, cream frost, emulsion, astringent, lipstick, foundation cream and body lotion of effects such as defying age, sun-proof, Wound care, addition is generally 0.05-0.5%, can increase soft degree, moisture and the elasticity of skin.
Ceramide is one of important composition composition of biological intravital biological membrane lipid, extensively is present in yeast, plant, the mammalian cell.The structure of ceramide can be divided into two parts: long-chain base and fatty acid.Ceramide is the main component of keratinocyte lipid; account for the 40-50% of its total lipid; also be a kind of efficient moisture-retention factor, it is present in the uppermost one deck of cell, can help to keep moisture; the skin histology that protection is positioned under it avoids drying out fast; increase the water content of keratodermatitis, help repairing and the maintenance cuticular layer, help to keep skin health; avoid skin dehydration and protection skin to escape injury, thereby reach the purpose of preserving moisture, removing the wrinkle on the skin.Ceramide acts on hair and skin surface, can form protective layer, is widely used in cosmetics and pharmaceuticals industry in recent years.
The protein that is applicable to the present composition can be a kind of protein, also can be to comprise two or more proteinic mixture.Protein is to the nutritious effect of human body, can repair the internal structure of hair and skin, replenish the nutrition of running off, the close timepiece cortex, make hair and skin recover elasticity, for example keratin, elastin, collagen protein, sericin, Limax mucin, Snailase, zinc metallothionein, silk peptide, bovine serum albumin etc.; Also having some protein is the necessary somatomedin of hair and skin growth, can promote the growth of cell, avoids the generation of wrinkle, as human acid fibroblast growth factor (rh-aFGF), epidermal growth factor etc.In addition, comprise multiple proteins in the protein mixtures such as soybean protein, yeast protein, Limax bovine protein, egg membrane albumen, nutrient substance is horn of plenty more, and is easy to preparation, also is the protein source of using always therefore.Yeast protein comparatively preferably wherein, its nutritive validity is good, and is easy to preparation, and is with low cost.The preparation method of above-mentioned protein or protein mixture all is known to those skilled in the art.
Protolysate is an additive commonly used in this area, typically refer to the molecular weight that proteolysis becomes less, can be by the intermediate product of semipermeable membrane, it also is one of raw material of forming hair and skin protein, hair and skin desired nutritional composition can be provided, work to preserve moisture, nourish skin and hair.Wherein comprise polypeptide, peptone, aminoacid of various molecular weight etc. usually.Nearest discovers, human body also wants fast to the absorptance aminoacid of some polypeptide, and utilization rate is higher, and has the various biological activity.The polypeptide that molecular weight is bigger, good film-forming property can be given the hair natural gloss, increases hair elasticity, makes hair be easy to molding; Low-molecular-weight polypeptide, its water solublity is better, more easily is skin absorbs, and can infiltrates skin inside, for its homergy provides essential nutrient, can also repair the skin of damage.Yeast protein hydrolysate comparatively preferably, its nutritive validity is better, and is easy to preparation, and is with low cost.Other protolysates such as hydrolyzed animal protein, soybean protein hydrolyate, Limax bovine protein hydrolysate, egg membrane protolysate etc. also have similar effect.The preparation method of above-mentioned protolysate all is known to those skilled in the art.
Aminoacid is the basis of constitutive protein matter, is the necessary nutritional labeling of hair and skin growth, can replenish the required primary amino acid of cortical layer, and extraordinary writs damaged hair and skin recover flexibility and elasticity, and promotes cell regeneration.
Vitamin is the cofactor of enzyme catalysis, is widely used in the cosmetic skin or hair care.Vitamin A is to regulate Skin Cell to grow up and active important component, and it can make skin increase elasticity and help epidermis and corium increase thickness; Provitamin B5 can promote the regeneration of fibroblast, helps the reparation of tissue; Vitamin C can promote the synthetic of collagen, makes skin fuller, prevents the formation of wrinkle; Vitamin E can accumulate in the horny layer of skin, helps keratodermatitis to repair its waterproof barrier, reaches the evaporation of horny layer moisture in the prevention skin and scatters and disappears; Vitamin A, vitamin B1, vitamin B2, vitamin E and beta-carotene etc. can stop the oxidation and the decomposition of the unsaturated fatty acid in the human body cell, prevent xerosis cutis.
Fruit acid is called 'alpha '-hydroxy acids again, is usually used in making the cosmetics that change the skin removing spots and whitening, also is the primary raw material of the present fruit acid cosmetics that prevail.Lactic acid is a kind of pure natural organic fruit acid, has the characteristic of horny layer softening, and the lactic acid of 2% concentration can be applicable in the maintenance and hair care product of hair, and function is a convergence skin, makes it to tighten, and also can strengthen humidification, the moisture-keeping efficacy of cream.
Trace element also is the basis of hair and skin, and as the active center of enzyme, its trace meter that contains is identical with other parts of human body with mineral.Hair and skin also need to absorb enough mineral and trace element, can prevent and treat coming off of hair as trace element such as copper, ferrum, zinc, calcium.The trace element that is applicable to the present composition can be one or more; The solution that contains suitable trace element can be prepared at an easy rate and be used by those skilled in the art.
Hydrophilic compositions with anti-eluting function provided by the present invention mainly is a characteristic of having utilized hyaluronic acid highly viscous.Hyaluronic acid can be combined closely with the become fibre structure and the Skin Cell of hair, is difficult for washed away at short notice.Simultaneously, the hydrate structure that hyaluronic acid itself forms, polypeptide with protein molecule and all size, further form a commissure network structure more closely, the aqueous solution that contains micromolecule functional factor such as ceramide, aminoacid, vitamin, 'alpha '-hydroxy acids and/or trace element closely is wrapped in the netted hydrate structure of this commissure, and attached on skin and/or the hair, make it to be difficult for washed away, the nutrition retention time is long, thereby has solved functional factor by the problem of quick eluting.
Experiment is found, with only comprise hyaluronic acid and proteinic compositions and only comprise hyaluronic acid and the compositions of protolysate is compared, the compositions viscosity that comprises these three kinds of components of hyaluronic acid, protein and protolysate simultaneously is bigger, pins micromolecular better effects if.This may be because the molecular weight of protein molecule is bigger, and structure is complicated, may play the effect of skeleton in compositions; And comprising polypeptide, peptone of all size etc. in the protolysate, molecular weight is lower, helps forming with it network more closely, thereby wraps various functional factors.
Meanwhile, protein in the present composition and protolysate, except can playing anti-eluting effect, itself also has good trophic function.In a preferred embodiment of the invention, comprise yeast protein and yeast protein hydrolysate in the compositions; In another preferred embodiment, comprise soybean protein and soybean protein hydrolyate in the compositions.These compositions itself are exactly good nutrient substance, have higher nutritive value.
In compositions of the present invention, can also add other functional factor, for example ceramide, aminoacid, vitamin, 'alpha '-hydroxy acids and trace element etc. are so that further strengthen its nutrition nursing efficacy.Be specially adapted to 'alpha '-hydroxy acids of the present invention and include but not limited to lactic acid, malic acid and citric acid.
Possible interaction in the present composition between each component is as follows: trace element, vitamin and aminoacid provide the nutrition of cell, trace element (nickel, cobalt, zinc, manganese, vitriol, arsenic, magnesium, ferrum etc.) is catalyst---the active center of enzyme that constitutes biochemical reaction, vitamin is the cofactor of enzyme catalysis a---coenzyme, aminoacid is the assembly that constitutes the structural protein of life, there are not trace element and vitamin, enzyme can not be realized the catalysis of its biochemical reaction, do not have amino acid whose supply, protein and enzyme all can not generate; Hyaluronic acid, protein and polypeptide have preserves moisture and anti-eluting effect, hyaluronic acid is preserved moisture to skin and hair, simultaneously the skin of breakage and the fibrin that becomes of hair there is the effect of reparation, the healthy color and luster that keeps skin also there is important effect, but hyaluronic moisture-keeping function is shorter, and protein and polypeptide be with respect to hyaluronic acid, and structure is more stable, and its moisture-keeping function is also more permanent simultaneously; Ceramide and 'alpha '-hydroxy acids have the effect of skin or hair care, ceramide has certain moisture-keeping function, but bigger acting body is now to the reparation of damaged hair quality, promote the growth of hair and prevent dermatitis and the generation of dandruff, 'alpha '-hydroxy acids can tighten up skin, promote hair to generate simultaneously, prevent alopecia.Above factor interphase interaction, can effectively promote skin microcirculation and metabolism, increase the blood flow of capillary of skin and the supply of nutrient substance, nourish hair fiber and Skin Cell more for a long time, so hair and skin are had good moisture preserving and Nutrition, can give hair and skin gloss, smooth and flexibility.
Each component of the present composition is adjusted a little, added the conventional adjuvant of various cosmetics again, can be used for developing various cosmetics.Cosmetics are according to using object, dosage form and function can divide a lot of classes.By using the object classification to be divided into: shampoo, hair conditioner, a film, cleansing cream, cosmetic water, protective skin cream, eye cream, health moistening breast and hand cream etc.; By dosage form can be divided into transparence, paste, emulsion, gel is Powdered and aerosol-type etc.; By function can be divided into the maintenance essence, the day cream of preserving moisture, the late frost of preserving moisture, the massage cream of preserving moisture, moisture saver mask etc.For example, in some preferred embodiments, the present composition adds in the various cosmetics with the ratio of 1-50%.
Added the cosmetic skin or hair care of the present composition, have than other like products: moisturizing and nourishing, increase the blood flow of capillary of skin and the supply of nutrient substance, effectively promote skin microcirculation and metabolism, when stimulating hair and skin growth impaired hair and skin are had repair; And, the netted macromole of hyaluronic acid with high viscosity characteristic can be difficult for being rinsed with the net of the tight commissure of above all trophic factors together, so can nourish hair fiber and Skin Cell more for a long time, reach the purpose of bringing into play cosmetics moisture retention and trophism more longer.
Various components contents can be determined as the case may be by those skilled in the art in the present composition.In some preferred embodiments, the preferred composition that comprises the compositions of hyaluronic acid, ceramide, protein, polypeptide, aminoacid, vitamin, 'alpha '-hydroxy acids and trace element of the present invention is: hyaluronic content range is 0.1-10g/l; The content range of ceramide is 0.05-5g/l; The Protein content scope is 0.1-5g/l; The content range of polypeptide is 0.1-5g/l; Amino acid whose content range is 0.05-5g/l; The content range of vitamin is that the content range of 0.01-5g/l 'alpha '-hydroxy acids is 1-100g/l; The content of elements scope is 0.01-2g/l.
For the ease of understanding the present invention better, will provide the preferred embodiments of the present invention below.Should be appreciated that because length is limit, below given embodiment only be comparatively preferred a part of in a large amount of tests that the inventor carried out, be not the Total Test data.Providing these embodiment only is for explaining and illustrative purposes, should not utilizing these embodiment that the scope of claim is limited.
The moisture retention and the viscosity test of embodiment 1 present composition
According to a kind of nutrition of the present invention of the formulation of table 1 and care composition (hereinafter referred to as composition I), form uniform aqueous solution.
Choose 15 ages the volunteer of 18-62 between year, choosing everywhere in the inboard of its arm, area is 3 * 3cm
2Skin, be the above-mentioned skin everywhere of 1%, 5% or 10% composition I diluent coating with 5ml water and 5ml concentration respectively.After the coating, (Electric Conductivity Ohm/S), the results are shown in Figure 1 to the electrical conductivity of test skin for three days on end.As can be seen from Figure 1, along with the raising of composition I concentration, the also corresponding increase of skin conductivity rate.This explanation composition I has tangible moisture-keeping function.
The prescription of table 1 composition I
Component content (g/l)
Hyaluronic acid 4.5
Yeast protein
(1)2.0
The yeast protein hydrolysate
(2)1.0
Ceramide 1.0
Aminoacid 0.5
Vitamin 0.3
Citric acid
(3)1-100
Trace element 0.1
(1) but the manufacturing process list of references 1 and 2 of yeast protein; (2) but the manufacturing process list of references 3 of yeast protein hydrolysate; (3) citric acid also is used to regulate pH value simultaneously, so its content can change within the specific limits.
Prescription shown in the his-and-hers watches 1 is adjusted as follows, thereby forms reference composition I ' and I ": remove the yeast protein hydrolysate, obtain reference composition I '; Remove yeast protein, obtain reference composition I ".
Adopt said method to composition I and reference composition I ' and I " carry out the moisture retention test.The result shows that the moistening effect of composition I is best.
Methods such as utilization is toppled over, stirring are assessed the viscosity of each compositions.With reference composition I ' and I " to compare, the viscosity of composition I is bigger, pins micromolecular better effects if.
Embodiment 2 contains the nutrition nursing shampoo of the present composition
Production technology: be lower than the present composition that in the shampoo mother solution, adds various prescriptions under 50 ℃ the condition respectively (its prescription respectively as table 2-1 to showing shown in the 2-7) with the addition (being preferably 2.5%-10%) of 1%-15% (volume).Comprise in this shampoo mother solution: surfactant, as ammonium lauryl sulfate, hydroxyethyl-cellulose alkyl trimethyl ammonium chloride, dodecyl polyoxyethylene ether ammonium sulfate, cocoyl glutamic acid triethanol ammonium or cocos nucifera oil both sexes sodium acetate etc.; Foam stabilizer and thickening agent are as fatty alkanol amide, ethylene glycol bis (list) stearate etc.; Conditioner is as polyquaternary ammonium salt Q-10 etc.; Other additives are as EDTA, essence and antiseptic etc.Add an amount of citric acid at last, pH value is adjusted to 6.5, be cooled to room temperature, and the adding appropriate amount of deionized water gets final product.A kind of optimization formula of this nutrition nursing shampoo is as shown in table 3.
Practical probation result shows, added the present composition shampoo preserve moisture and trophic function all better.
The prescription of table 2-1 composition I I-1
Component content (g/l)
Hyaluronic acid 4.5
Yeast protein 4.0
Yeast protein hydrolysate 0.5
Ceramide 0.5
Aminoacid 3.0
Vitamin 1.0
Citric acid 50
Trace element 0.1
The prescription of table 2-2 composition I I-2
Component content (g/l)
Hyaluronic acid 2.5
Yeast protein 4.2
Yeast protein hydrolysate 1.7
Aminoacid 3.0
Lactic acid 50
Trace element 0.9
The prescription of table 2-3 composition I I-3
Component content (g/l)
Hyaluronic acid 4.1
Yeast protein 3.0
Yeast protein hydrolysate 2.1
The prescription of table 2-4 composition I I-4
Component content (g/l)
Hyaluronic acid 0.8
Yeast protein 1.3
Yeast protein hydrolysate 4.5
The prescription of table 2-5 composition I I-5
Component content (g/l)
Hyaluronic acid 2.0
Soybean protein 2.0
Soybean protein hydrolyate 2.0
The prescription of table 2-6 composition I I-6
Component content (g/l)
Hyaluronic acid 4.5
Collagen protein 3.0
Limax bovine protein hydrolysate 0.7
Ceramide 0.2
Aminoacid 2.0
Vitamin 1.0
Lactic acid 20
Trace element 0.4
The prescription of table 2-7 composition I I-7
Component content (g/l)
Hyaluronic acid 3.5
Collagen protein 2.0
Yeast protein hydrolysate 1.1
Ceramide 0.8
Malic acid 30
Trace element 0.2
Table 3 contains the shampoo prescription of the present composition
Component content (weight %)
Hydroxyethyl-cellulose alkyl trimethyl ammonium chloride 21
Dodecyl polyoxyethylene ether ammonium sulfate 9.0
Ammonium lauryl sulfate 4.0
Cocoyl glutamic acid triethanol ammonium 4.0
Betanin 2.0
Cocoyl both sexes carboxyl glycine disodium 5.0
Ethylene glycol bis (list) stearate 2.0
Citric acid (20%) about 0.3
EDTA 0.1
Triumphant loose 0.1
Essence 0.9
Polyquaternary ammonium salt Q-10 0.8
Oleum Cocois diethanol acyl ammonium 1.0
Anti-dandruff dose 0.3
Present composition 10-50
Deionized water complements to 100
Embodiment 3 contains the skin care item of the present composition
Production technology: after liquid paraffin, squalane, the carboxyl ethylene polymer of formula ratio be heated to molten condition in the lump, be cooled to 50 ℃ again, after dissolving in the lump with the deionized water of formula ratio, glycyrrhizic acid dipotassium, potassium hydroxide, ethanol and as Nepal's gold ester of antiseptic, both are mixed, behind stirring and evenly mixing, the composition I II (its prescription is as shown in table 4) that adds the 10%-50% addition, mix homogeneously.Through suitably handling, can make skin care item such as nutrition nursing preserving moisture and protecting skin emulsion or protective skin cream respectively then.A kind of optimization formula of these type of skin care item is as shown in table 5.
The prescription of table 4 composition I II
Component content (g/l)
Hyaluronic acid 5.0
Yeast protein 2.0
Yeast protein hydrolysate 1.0
Ceramide 1.0
Aminoacid 0.8
Vitamin 0.8
Lactic acid or malic acid 70
Trace element 0.7
Table 5 contains the skin care item prescription of the present composition
Component content (weight %)
Liquid paraffin 10.0
Squalane 3.0
Glycyrrhizic acid dipotassium 0.1
Carboxyl ethylene polymer 0.1
Potassium hydroxide 0.1
Composition I II 10-50
Ethanol 5.0
Nepal's gold ester 0.3
Deionized water complements to 100
Embodiment 4 contains the massage cream of preserving moisture of the present composition
Production technology: oil phase (comprising dimethyl polysiloxane, vaseline, stearic acid, Nepal's tortoise beetle ester etc.) and water (comprise deionized water, contract two glycerol, triacetamide, Polymeric sodium metaphosphate. etc.) are heated to 80 ℃, the even matter of mixing and emulsifying 15 minutes, cool again to 40 ℃, add the spice of formula ratio and the composition I V (its prescription is as shown in table 6) of 20%-50% addition, mix homogeneously.Through suitable subsequent treatment, promptly can be made into the massage cream of preserving moisture then.A kind of optimization formula of this type of massage cream of preserving moisture is as shown in table 7.
The prescription of table 6 composition I V
Component content (g/l)
Hyaluronic acid 2.0
Yeast protein 1.0
Yeast protein hydrolysate 0.8
Ceramide 0.8
Aminoacid 2.0
Vitamin 0.8
Citric acid 30
Trace element 0.5
Table 7 contains the massage cream prescription of preserving moisture of the present composition
Component content (weight %)
Dimethyl polysiloxane 10.0
Vaseline 5.0
Stearic acid 1.0
One two glycerol 7.0 that contract
Triacetamide 0.6
Composition I V 10-50
Polymeric sodium metaphosphate. 0.1
Nepal's tortoise beetle ester 0.3
Deionized water complements to 100
Embodiment 5 contains the skin-lightening cosmetic of the present composition
Production technology: oil phase (comprising stearic acid, polyethylene glycol oxide cetyl ether, American Avocado Tree oil, almond oil, Nepal's tortoise beetle ester etc.) and water (comprising deionized water, a borono phenylalanine, PEG-400, pyrrolidone sodium carboxylate, EDTA disodium etc.) are heated to 70 ℃, the even matter of mixing and emulsifying 15 minutes, cool again to 40 ℃, add the spice of formula ratio and the compositions V (its prescription is as shown in table 8) of 2-10% addition, mix homogeneously.Through suitable subsequent treatment, promptly can be made into skin-lightening cosmetic then.A kind of optimization formula of this type of skin-lightening cosmetic is as shown in table 9.
The prescription of table 8 compositions V
Component content (g/l)
Hyaluronic acid 5.0
Yeast protein 1.0
Yeast protein hydrolysate 1.0
Ceramide 1.0
Aminoacid 0.8
Vitamin 0.8
'alpha '-hydroxy acids 70
Table 9 contains the skin-lightening cosmetic prescription of the present composition
Component content (weight %)
Borono phenylalanine 1
Compositions V 2-10
PEG-400 3
Stearic acid 1
Polyethylene glycol oxide cetyl ether 5
American Avocado Tree oil 1
Almond oil 10
Pyrrolidone sodium carboxylate 5
EDTA disodium 0.01
Nepal's tortoise beetle ester 0.3
Deionized water complements to 100
Related herein list of references comprises patent document, scientific paper, publication etc., all by reference its full content is included in herein.
Among the related herein various experimental articles (including but not limited to various chemical reagent, biological product, instrument etc.), special or be difficult for obtaining for those, Wen Zhongjun has indicated manufacturer or detailed preparation method; Without what specify, be the normal experiment articles for use, in the application submits to, can pass through variety of way (for example buy, preparation etc.) voluntarily acquisition easily.
Though the present invention is described in conjunction with the above-mentioned specific embodiment, the present invention also can be implemented in other mode.Should be appreciated that under situation without departing from the spirit and scope of the present invention those of ordinary skill in the art can make various changes and improvements to it in form and details, and these all are considered to fall into protection scope of the present invention.
List of references
1 ring dawn, Yuan Xinhua, Xu Rou, Zhang Kechang. the preparation technology of beer waste yeast protolysate. Wuxi Light Industry Univ.'s journal, 20 (2001): 48-54.
2 Chen Ting step on, and Liu Xianjun is quiet. and induce the beer yeast cells dissolving to discharge protein. Wuxi Light Industry Univ.'s journal, 19 (2000): 19-22.
3 Zou Far East. with the preparation method and the purposes of papain enzymolysis whole protein protein isolate powder product. Chinese invention patent application 01124102.0.
Claims (10)
1. water-soluble composition can comprise following component as the additive of all kinds of cosmetics in the described compositions:
(A) hyaluronic acid;
(B) protein; And
(C) protolysate.
2. according to the compositions of claim 1, wherein also comprise in ceramide, aminoacid, vitamin, 'alpha '-hydroxy acids, the trace element one or more.
3. according to the compositions of claim 1, wherein component (B) is selected from the group that is made of following member: keratin, elastin, collagen protein, sericin, Limax mucin, Snailase, zinc metallothionein, silk peptide, bovine serum albumin, epidermal growth factor, human acid fibroblast growth factor, soybean protein, yeast protein, Limax bovine protein, egg membrane albumen.
4. according to the compositions of claim 1, wherein component (C) is selected from the group that is made of following member: soybean protein hydrolyate, yeast protein hydrolysate, Limax bovine protein hydrolysate, egg membrane protolysate.
5. according to the compositions of claim 3, wherein component (B) is a yeast protein, and component (C) is the yeast protein hydrolysate.
6. according to the compositions of claim 5, wherein also comprise in ceramide, aminoacid, vitamin, 'alpha '-hydroxy acids, the trace element one or more.
7. according to the compositions of claim 6, wherein said 'alpha '-hydroxy acids is lactic acid, malic acid or citric acid.
8. comprise each the cosmetics of compositions according to claim 1-7.
9. cosmetics according to Claim 8, wherein said cosmetics are selected from the group that is made of following member: shampoo, hair conditioner, cleansing milk, body lotion, handwashing liquid, protective skin cream, sunscreen cream, emulsion, facial film, the massage cream of preserving moisture, skin-lightening cosmetic.
According to each the compositions of claim 1-7 in the application of preparation in all kinds of cosmetics.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410038215 CN1568927A (en) | 2004-05-13 | 2004-05-13 | Water soluble combination with elution preventing function and its application in cosmetics |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410038215 CN1568927A (en) | 2004-05-13 | 2004-05-13 | Water soluble combination with elution preventing function and its application in cosmetics |
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| CN1568927A true CN1568927A (en) | 2005-01-26 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102178617A (en) * | 2011-05-09 | 2011-09-14 | 刘佩华 | Protein skin care products having function of skin repair and care |
| CN102908304A (en) * | 2012-11-19 | 2013-02-06 | 浙江省林业科学研究院 | Anti-ageing wrinkle reduction toning lotion enriched with active peptide, and preparation method thereof |
| CN104173256A (en) * | 2014-08-11 | 2014-12-03 | 杨磊 | Nourishing and water-supplementing moisturizing emulsion |
| CN104814884A (en) * | 2015-04-21 | 2015-08-05 | 山东福瑞达生物科技有限公司 | Liquid shampoo capable of preventing hair loss and promoting hair growth and preparation method thereof |
| CN104983630A (en) * | 2015-06-30 | 2015-10-21 | 江苏奇力康皮肤药业有限公司 | Whitening softening lotion and preparation method thereof |
| CN105193679A (en) * | 2015-10-29 | 2015-12-30 | 桂林华诺威基因药业有限公司 | Sunscreen composition |
| CN105193678A (en) * | 2015-10-29 | 2015-12-30 | 桂林华诺威基因药业有限公司 | Sunscreen and after-sun repairing skin care composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102178617A (en) * | 2011-05-09 | 2011-09-14 | 刘佩华 | Protein skin care products having function of skin repair and care |
| CN102178617B (en) * | 2011-05-09 | 2012-10-10 | 刘佩华 | Protein skin care products having function of skin repair and care |
| CN102908304A (en) * | 2012-11-19 | 2013-02-06 | 浙江省林业科学研究院 | Anti-ageing wrinkle reduction toning lotion enriched with active peptide, and preparation method thereof |
| CN104173256A (en) * | 2014-08-11 | 2014-12-03 | 杨磊 | Nourishing and water-supplementing moisturizing emulsion |
| CN104173256B (en) * | 2014-08-11 | 2016-08-31 | 杨磊 | Compose and support replenishing water and preserving moisture emulsion |
| WO2016065688A1 (en) * | 2014-10-27 | 2016-05-06 | 彭海英 | Essence capable of activating skin vitality and being anti-aging |
| CN104814884A (en) * | 2015-04-21 | 2015-08-05 | 山东福瑞达生物科技有限公司 | Liquid shampoo capable of preventing hair loss and promoting hair growth and preparation method thereof |
| CN104814884B (en) * | 2015-04-21 | 2017-09-01 | 山东福瑞达生物科技有限公司 | A kind of pre-Anti-hair loss and trichogenous shampoo and preparation method thereof |
| CN104983630A (en) * | 2015-06-30 | 2015-10-21 | 江苏奇力康皮肤药业有限公司 | Whitening softening lotion and preparation method thereof |
| CN105193679A (en) * | 2015-10-29 | 2015-12-30 | 桂林华诺威基因药业有限公司 | Sunscreen composition |
| CN105193678A (en) * | 2015-10-29 | 2015-12-30 | 桂林华诺威基因药业有限公司 | Sunscreen and after-sun repairing skin care composition |
| CN105213269A (en) * | 2015-10-29 | 2016-01-06 | 桂林华诺威基因药业有限公司 | A kind of sunscreen cream |
| KR20200097058A (en) * | 2019-02-07 | 2020-08-18 | 오성음 | Cosmetic composition for anti-aging or anti-wrinkle comprising epidermal growth factor, sericin, Foeniculum vulgare extract and Eugenia caryophyllus extract |
| CN110522698A (en) * | 2019-09-30 | 2019-12-03 | 广州香枝化妆品有限公司 | A kind of scalp injury repairs Essence and preparation method thereof |
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