CN105193678A - Sunscreen and after-sun repairing skin care composition - Google Patents
Sunscreen and after-sun repairing skin care composition Download PDFInfo
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- CN105193678A CN105193678A CN201510725054.9A CN201510725054A CN105193678A CN 105193678 A CN105193678 A CN 105193678A CN 201510725054 A CN201510725054 A CN 201510725054A CN 105193678 A CN105193678 A CN 105193678A
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- 230000000475 sunscreen effect Effects 0.000 title claims abstract description 29
- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 29
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- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 2
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
- 235000010234 sodium benzoate Nutrition 0.000 description 2
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
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- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 150000003180 prostaglandins Chemical class 0.000 description 1
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- 235000020712 soy bean extract Nutrition 0.000 description 1
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- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides sunscreen and after-sun repairing skin care composition and a cosmetic containing the same. The composition comprises a rhEGF (recombinant human epidermal growth factor), hydrolyzed soy protein, purslane herb extract, Chinese magnoliavine fruit extract and rhizoma kaempferiae extract. The weight content of the composition in the cosmetic is 1%-2%. The weight content of the rhEGF in the sunscreen cosmetic is only 1-10 mu g/ml and is far lower than the conventional addition amount, the rhEGF is compounded with the hydrolyzed soy protein, the purslane herb extract, the Chinese magnoliavine fruit extract and the rhizoma kaempferiae extract to realize synergistic effect, so that injured cells can be rapidly repaired, skin injury caused by ultraviolet radiation is relieved, further, abnormal increase of melanophores of a skin basal layer can be reduced, melanin synthesis is blocked, black spots growing on the after-sun skin are reduced, gene mutation factors of the injured cells are eliminated, light aging is prevented, and accordingly, the composition has an ultraviolet ray preventing function and an after-sun injury repairing function.
Description
Technical field
The invention belongs to cosmetic technical field, be specifically related to a kind of sun-proof and repair skin care compositions after shining.
Background technology
Epidermal growth factor (EGF) is a kind of multi-functional Growth of Cells promotive factor, there is Promote cell's growth widely active, accelerate human skin cell's speed of growth, promoting the new Growth of Cells breeding of skin, is the deciding factor affecting skin health.But with advancing age and the deterioration of environment, in human body, the content of EGF reduces gradually, causes skin health impaired.Natural EGF is extensively present in mammalian body, and its content is low, and extract difficulty large, cost is high, and people adopt rhEGF to substitute natural EGF usually.RhEGF can stimulate the various cells of outer embryo rhEGF layer and endodermal origin as cornea, epithelium etc., makes it breed.Its biological effect comprises: 1) promote that low molecular weight compound is initiatively transported in cell from extracellular, increase the nutrient substance of cell; 2) glycolysis is activated to increase respiratory metabolism, energy activating phosphatase fructokinase; 3) the outer macromolecular synthesis of irritation cell, as hyaluronic acid and glycoprotein.4) synthesis of RNA and protein is activated; 5) synthesis of DNA is promoted; 6) some materials of body are as the synthesis of fruit acid, prostaglandin to promote cell proliferation to promote.These biological effects show, rhEGF, by conducted signal, causes a series of Biochemical changes in cell, starts the gene relevant with cell division, makes akinete enter cell division phase, thus make cell proliferation.RhEGF can repair damaged cell rapidly, alleviate the injury of ultraviolet radiation to skin, and the exception that can reduce basal melanocyte increases, block B16 cell, reduce the black speck growth of skin after shining, eliminate the genetic mutational factors of damaged cell, prevention photoaging, thus has the repair of pre-anti-ultraviolet and damage after shining.There is the sunscreen product containing rhEGF in prior art, to aspects such as reparations after sun-proof and solarization, there is certain positive effect.Because external source rhEGF occurs Physical Loss or Damage and inactivation in the processes such as skin permeation, make the content of rhEGF in cosmetics will far beyond EGF concentration several times in human body even hundreds of times just can produce a desired effect, through skin verification experimental verification, when the concentration of rhEGF is 100 μ g/ml in cosmetics, just good sun-proof result can be reached.Formally because the addition of rhEGF in cosmetics is too high, considerably increase production cost.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of sun-proof and repair skin care compositions after shining and containing the cosmetics of said composition, in these cosmetics, rhEGF addition is little, and active high, sun-proof result is good.
Technical scheme provided by the invention is a kind of sun-proof and repair skin care compositions after shining, and it is made up of rhEGF, hydrolyzed soybean protein, Herba portulacae extract, Fructus Schisandrae Chinensis extrat and Rhizoma Kaempferiae extract.
Hydrolyzed soybean protein is soybean extract, is rich in the peptide with respiratory chain protein similar, can significantly promote skin vision and sensory effect.Parameter is: outward appearance is transparency liquid, yellow, PH (20 DEG C): 4.0 ~ 5.0; Refractive index (20 DEG C): 1.365 ~ 1.385; Density (20 DEG C): 1.06 ~ 1.09g/cm
3; Protein content (Lowry method) 1.5 ~ 3.5g/kg; Potassium sorbate content %0.10 ~ 0.16; Sodium benzoate content %0.240 ~ 0.30.
Herba portulacae extract is the extract of stem and leaf through water extraction of the aerial parts of the annual succulent plant Herba Portulacae of Portulaca.Quality standard: light brown liquid, pH value (20 DEG C) 4.0 ~ 6.0, proportion (20 DEG C) 0.90 ~ 1.10.
Fructus Schisandrae Chinensis extrat is by Fructus Schisandrae Chinensis, adds 95v% ethanol in the ratio of 1g:5 ~ 10ml, heating and refluxing extraction 2 times, each 2 ~ 3h, merge extractive liquid, and decompression recycling ethanol is condensed into extractum, and paste-forming rate is 10 ~ 40mg/g crude drug.
Rhizoma Kaempferiae extract is by Rhizoma Kaempferiae, and to add water reflux, extract, in the ratio of 1g:10 ~ 20ml, be concentrated into extractum, paste-forming rate is 10 ~ 20mg/g crude drug.
With the total restatement of above-mentioned composition, the percentage by weight of each component is respectively: rhEGF0.01 ~ 0.05%, hydrolyzed soybean protein 35 ~ 50%, Herba portulacae extract 20 ~ 30%, Fructus Schisandrae Chinensis extrat 10 ~ 20%, Rhizoma Kaempferiae extract 10 ~ 20%.
As preferably, the percentage by weight of said components is respectively: rhEGF0.03%, hydrolyzed soybean protein 40%, Herba portulacae extract 29.97%, Fructus Schisandrae Chinensis extrat 15%, Rhizoma Kaempferiae extract 15%.
Present invention also offers a kind of cosmetics, containing above-mentioned composition.The weight content of described compositions in these cosmetics is 1 ~ 2%, is preferably 1.5%.
Compared with prior art, the present invention has following beneficial effect:
1) hydrolyzed soybean protein and Herba portulacae extract are similar to rhEGF with the peptide bond structure of protein contained in Rhizoma Kaempferiae extract; very easily intersect between peptide bond, coil, the reaction of the space displacement such as compositions; the peptide molecule key ring-type that rhEGF is hydrolyzed soybean protein and Herba portulacae extract and Rhizoma Kaempferiae extract is surrounded; protect rhEGF space structure; avoid rhEGF inactivation, greatly raise the efficiency.
2) Herba portulacae extract, Rhizoma Kaempferiae extract, Fructus Schisandrae Chinensis extrat can combine with cell, before cell damage, in ultraviolet, skin will be produced to the ingredient draws of injury, reach sun-proof object, and damaged cell can also be repaired rapidly, block B16 cell, reduce the black speck growth of skin after shining, there is the effect of repairing after shining.
3) hydrolyzed soybean protein and Herba portulacae extract and Rhizoma Kaempferiae extract are easily absorbed by the skin, and rhEGF is combined with hydrolyzed soybean protein, Herba portulacae extract and Rhizoma Kaempferiae extract and is very easily absorbed by the skin, and reduces the rhEGF loss in process of osmosis.
4) in cosmetics of the present invention, the weight content of rhEGF is only 1 ~ 10 μ g/ml, well below conventional addition, synergism is produced with Hamamelis virginiana extracting solution, hydrolyzed soybean protein and Herba portulacae extract, damaged cell can be repaired rapidly, alleviate the injury of ultraviolet radiation to skin, and the exception that can reduce basal melanocyte increases, block B16 cell, reduce the black speck growth of skin after shining, eliminate the genetic mutational factors of damaged cell, prevention photoaging, thus has the repair of pre-anti-ultraviolet and damage after shining.
Detailed description of the invention
The present invention is further elaborated for following specific embodiment, but not as a limitation of the invention.
Design parameter raw materials used in various embodiments of the present invention or preparation method as follows:
The mass parameter of hydrolyzed soybean protein is: outward appearance is transparency liquid, yellow, PH (20 DEG C): 4.0 ~ 5.0; Refractive index (20 DEG C): 1.365 ~ 1.385; Density (20 DEG C): 1.06 ~ 1.09g/cm
3; Protein content (Lowry method) 1.5 ~ 3.5g/kg; Potassium sorbate content %0.10 ~ 0.16; Sodium benzoate content %0.240 ~ 0.30.
The quality standard of Herba portulacae extract: light brown liquid, pH value (20 DEG C) 4.0 ~ 6.0, proportion (20 DEG C) 0.90 ~ 1.10.
Fructus Schisandrae Chinensis extrat is pulverized by Fructus Schisandrae Chinensis, and add 95v% ethanol in the ratio of 1g:10ml, heating and refluxing extraction 2 times, each 3h, merge extractive liquid, decompression recycling ethanol is condensed into extractum, and paste-forming rate is 40mg/g crude drug.
Rhizoma Kaempferiae extract is by Rhizoma Kaempferiae, and to add water reflux, extract, in the ratio of 1g:20ml, be concentrated into extractum, paste-forming rate is 20mg/g crude drug.
Embodiment 1
Sunscreen composition: rhEGF0.01%, hydrolyzed soybean protein 49.99%, Herba portulacae extract 20%, Fructus Schisandrae Chinensis extrat 10%, Rhizoma Kaempferiae extract 10%.
Sunscreen cream:
Glycerol: 4%
Emulsifying agent: 3%
Carbomer: 0.3%
Titanium dioxide: 1.5%
Sunscreen composition: 1.5%
Oils and fats: 5%
Antiseptic: 0.3%
Essence: 0.2%
Deionized water: surplus.
Embodiment 2
Sunscreen composition: rhEGF0.05%, hydrolyzed soybean protein 35%, Herba portulacae extract 24.95%, Fructus Schisandrae Chinensis extrat 20%, Rhizoma Kaempferiae extract 20%.
Sunscreen cream: formula is identical with embodiment 1, only sunscreen composition is the sunscreen composition of embodiment 2.
Embodiment 3
Sunscreen composition: rhEGF0.03%, hydrolyzed soybean protein 40%, Herba portulacae extract 29.97%, Fructus Schisandrae Chinensis extrat 15%, Rhizoma Kaempferiae extract 15%.
Sunscreen cream: formula is identical with embodiment 1, only sunscreen composition is the sunscreen composition of embodiment 3.
Reference examples 1
Glycerol: 4%
Emulsifying agent: 3%
Carbomer: 0.3%
Titanium dioxide: 1.5%
rhEGF：0.00015％；
Oils and fats: 5%
Antiseptic: 0.3%
Essence: 0.2%
Deionized water: surplus.
Reference examples 2
Glycerol: 4%
Emulsifying agent: 3%
Carbomer: 0.3%
Titanium dioxide: 1.5%
rhEGF：0.01％；
Oils and fats: 5%
Antiseptic: 0.3%
Essence: 0.2%
Deionized water: surplus.
Reference examples 3
Glycerol: 4%
Emulsifying agent: 3%
Carbomer: 0.3%
Titanium dioxide: 1.5%
Herba portulacae extract: 0.3%;
Oils and fats: 5%
Antiseptic: 0.3%
Essence: 0.2%
Deionized water: surplus.
Reference examples 4
Glycerol: 4%
Emulsifying agent: 3%
Carbomer: 0.3%
Titanium dioxide: 1.5%
Fructus Schisandrae Chinensis extrat: 0.15%;
Oils and fats: 5%
Antiseptic: 0.3%
Essence: 0.2%
Deionized water: surplus.
Reference examples 5
Glycerol: 4%
Emulsifying agent: 3%
Carbomer: 0.3%
Titanium dioxide: 1.5%
Rhizoma Kaempferiae extract: 0.15%;
Oils and fats: 5%
Antiseptic: 0.3%
Essence: 0.2%
Deionized water: surplus.
Embodiment 4
Sunscreen composition: rhEGF0.03%, hydrolyzed soybean protein 40%, Herba portulacae extract 29.97%, Fructus Schisandrae Chinensis extrat 15%, Rhizoma Kaempferiae extract 15%.
Sunscreen cream:
Glycerol: 4%
Emulsifying agent: 3%
Carbomer: 0.3%
Titanium dioxide: 1.5%
Sunscreen composition: 1%
Oils and fats: 5%
Antiseptic: 0.3%
Essence: 0.2%
Deionized water: surplus.
Embodiment 5
Sunscreen composition: rhEGF0.03%, hydrolyzed soybean protein 40%, Herba portulacae extract 29.97%, Fructus Schisandrae Chinensis extrat 15%, Rhizoma Kaempferiae extract 15%.
Sunscreen cream:
Glycerol: 4%
Emulsifying agent: 3%
Carbomer: 0.3%
Titanium dioxide: 1.5%
Sunscreen composition: 3%
Oils and fats: 5%
Antiseptic: 0.3%
Essence: 0.2%
Deionized water: surplus.
Choose men and women 160, IV type skin (namely seldom tan severely, but easily tanned), unglazed allergies, are divided into 8 groups at random, often organize 20 people, are respectively experimental group 1 ~ 3 and matched group 1 ~ 5.Wherein experimental group 1 ~ 3 uses the sunscreen cream of embodiment 1 ~ 3 respectively, and matched group 1 ~ 5 uses the sunscreen cream of reference examples 1 ~ 5 respectively.Measure each group every experimenter's minimum erythema dose (MED) respectively.Concrete grammar is as follows:
1) with self-control 6 hole biological dosimetry instrument, aperture is 1cm, and pitch of holes is 1cm, horizontal direction is fixed on back central authorities, and the UVB of various dose is irradiated in every hole respectively, and dosage increases progressively with 25%, observed result after 24h, to occur that the dosage in the minimum hole of visible erythema amounts of reactants is as MED.
2) there is the cardboard of 2 × 12.5cm rectangular opening to be horizontally fixed on back part by one, in limited range, evenly embrocate sunscreen cream 50mg, average out to 2mg/cm
2as a test tape.Between every bar test tape, spacing is 1cm, according to circumstances can establish 2 test tapes, establishes 1 blank tape in contrast simultaneously, marks the position of each band with marking pen.
3) after xenon lamp preheating 5min, measure light intensity, after stable luminescence, start test.
4), after wear sunscreen 15min, above-mentioned biological dosimetry instrument is fixed on test tape, according to the spf value that med value and the product of experimenter are estimated, dosage in the middle of determining one, then each dosage before and after calculating with 25% increasing or decreasing.From low to high, irradiation reaches the stipulated time successively.At once observe dermoreaction, observe erythema after 24h and occur situation.Same to occur that the dosage in the minimum hole of visible Erythema Dose is as MED.
MED/ during SPF=use sunscreen cream does not use MED during sunscreen cream
As seen from the above table, the far super matched group of sunscreen cream effect of experimental group, and with the best results of experimental group 3.
Claims (7)
1. sun-proof and shine after repair skin care compositions, it is characterized in that: it is made up of rhEGF, hydrolyzed soybean protein, Herba portulacae extract, Fructus Schisandrae Chinensis extrat and Rhizoma Kaempferiae extract.
2. according to claim 1 sun-proof and shine after repair skin care compositions, it is characterized in that: with the total restatement of said composition, the percentage by weight of each component is respectively: rhEGF0.01 ~ 0.05%, hydrolyzed soybean protein 35 ~ 50%, Herba portulacae extract 20 ~ 30%, Fructus Schisandrae Chinensis extrat 10 ~ 20%, Rhizoma Kaempferiae extract 10 ~ 20%.
3. according to claim 2 sun-proof and shine after repair skin care compositions, it is characterized in that: the percentage by weight of each component is respectively: rhEGF0.03%, hydrolyzed soybean protein 40%, Herba portulacae extract 29.97%, Fructus Schisandrae Chinensis extrat 15%, Rhizoma Kaempferiae extract 15%.
4. cosmetics, is characterized in that: containing the compositions according to any one of claims 1 to 3.
5. cosmetics according to claim 4, is characterized in that: the weight content of described compositions in these cosmetics is 1 ~ 2%.
6. cosmetics according to claim 5, is characterized in that: the weight content of described compositions in these cosmetics is 1.5%.
7. the cosmetics according to any one of claim 4 ~ 6, is characterized in that: it is sunscreen cream or ultra light sun block lotion.
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| CN201510725054.9A CN105193678A (en) | 2015-10-29 | 2015-10-29 | Sunscreen and after-sun repairing skin care composition |
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| CN201510725054.9A CN105193678A (en) | 2015-10-29 | 2015-10-29 | Sunscreen and after-sun repairing skin care composition |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1568927A (en) * | 2004-05-13 | 2005-01-26 | 陈国强 | Water soluble combination with elution preventing function and its application in cosmetics |
| CN101606898A (en) * | 2009-07-21 | 2009-12-23 | 中国人民武装警察部队医学院 | The application of Fructus Schisandrae Chinensis extrat in the preparation sunlight screening skin-protecting product |
| CN101933892A (en) * | 2010-08-24 | 2011-01-05 | 唯美度生物科技(深圳)有限公司 | New application of kaempferum extract and sunscreen cosmetics containing kaempferum extract |
| CN104334157A (en) * | 2012-03-13 | 2015-02-04 | 詹姆士·E·哈森 | A natural sunscreen ingredient |
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2015
- 2015-10-29 CN CN201510725054.9A patent/CN105193678A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1568927A (en) * | 2004-05-13 | 2005-01-26 | 陈国强 | Water soluble combination with elution preventing function and its application in cosmetics |
| CN101606898A (en) * | 2009-07-21 | 2009-12-23 | 中国人民武装警察部队医学院 | The application of Fructus Schisandrae Chinensis extrat in the preparation sunlight screening skin-protecting product |
| CN101933892A (en) * | 2010-08-24 | 2011-01-05 | 唯美度生物科技(深圳)有限公司 | New application of kaempferum extract and sunscreen cosmetics containing kaempferum extract |
| CN104334157A (en) * | 2012-03-13 | 2015-02-04 | 詹姆士·E·哈森 | A natural sunscreen ingredient |
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