CN1559613A - Medicinal invert sugar injection - Google Patents
Medicinal invert sugar injection Download PDFInfo
- Publication number
- CN1559613A CN1559613A CNA2004100081607A CN200410008160A CN1559613A CN 1559613 A CN1559613 A CN 1559613A CN A2004100081607 A CNA2004100081607 A CN A2004100081607A CN 200410008160 A CN200410008160 A CN 200410008160A CN 1559613 A CN1559613 A CN 1559613A
- Authority
- CN
- China
- Prior art keywords
- medicine
- injection
- glucose
- fructose
- invert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007924 injection Substances 0.000 title claims abstract description 32
- 238000002347 injection Methods 0.000 title claims abstract description 32
- 229960004903 invert sugar Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 48
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 33
- 239000008103 glucose Substances 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000000654 additive Substances 0.000 claims abstract description 12
- -1 pectose Substances 0.000 claims abstract description 10
- 150000003839 salts Chemical class 0.000 claims abstract description 4
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 23
- 239000005715 Fructose Substances 0.000 claims description 22
- 229930091371 Fructose Natural products 0.000 claims description 22
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 13
- FINHMKGKINIASC-UHFFFAOYSA-N Tetramethylpyrazine Chemical compound CC1=NC(C)=C(C)N=C1C FINHMKGKINIASC-UHFFFAOYSA-N 0.000 claims description 12
- IPWKIXLWTCNBKN-UHFFFAOYSA-N Madelen Chemical compound CC1=NC=C([N+]([O-])=O)N1CC(O)CCl IPWKIXLWTCNBKN-UHFFFAOYSA-N 0.000 claims description 7
- 229960002313 ornidazole Drugs 0.000 claims description 7
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- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 5
- GSDSWSVVBLHKDQ-JTQLQIEISA-N Levofloxacin Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-JTQLQIEISA-N 0.000 claims description 4
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- 239000002904 solvent Substances 0.000 claims description 3
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- QBDBUKJBJJWZMG-VIFPVBQESA-N 1-cyclopropyl-8-(difluoromethoxy)-6-fluoro-7-[(3s)-3-methylpiperazin-1-yl]-4-oxoquinoline-3-carboxylic acid Chemical compound C1CN[C@@H](C)CN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN(C3CC3)C2=C1OC(F)F QBDBUKJBJJWZMG-VIFPVBQESA-N 0.000 claims description 2
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- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims description 2
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- 239000002126 C01EB10 - Adenosine Substances 0.000 claims description 2
- JRWZLRBJNMZMFE-UHFFFAOYSA-N Dobutamine Chemical compound C=1C=C(O)C(O)=CC=1CCNC(C)CCC1=CC=C(O)C=C1 JRWZLRBJNMZMFE-UHFFFAOYSA-N 0.000 claims description 2
- HBGOLJKPSFNJSD-UHFFFAOYSA-N Etamsylate Chemical compound CC[NH2+]CC.OC1=CC=C(O)C(S([O-])(=O)=O)=C1 HBGOLJKPSFNJSD-UHFFFAOYSA-N 0.000 claims description 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 2
- 235000011201 Ginkgo Nutrition 0.000 claims description 2
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 2
- 229930010555 Inosine Natural products 0.000 claims description 2
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims description 2
- ZSBXGIUJOOQZMP-UHFFFAOYSA-N Isomatrine Natural products C1CCC2CN3C(=O)CCCC3C3C2N1CCC3 ZSBXGIUJOOQZMP-UHFFFAOYSA-N 0.000 claims description 2
- OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 claims description 2
- ZSBXGIUJOOQZMP-JLNYLFASSA-N Matrine Chemical compound C1CC[C@H]2CN3C(=O)CCC[C@@H]3[C@@H]3[C@H]2N1CCC3 ZSBXGIUJOOQZMP-JLNYLFASSA-N 0.000 claims description 2
- KSMRODHGGIIXDV-YFKPBYRVSA-N N-acetyl-L-glutamine Chemical compound CC(=O)N[C@H](C(O)=O)CCC(N)=O KSMRODHGGIIXDV-YFKPBYRVSA-N 0.000 claims description 2
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 2
- ZBBHBTPTTSWHBA-UHFFFAOYSA-N Nicardipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZBBHBTPTTSWHBA-UHFFFAOYSA-N 0.000 claims description 2
- 241001597008 Nomeidae Species 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 claims description 2
- GMZVRMREEHBGGF-UHFFFAOYSA-N Piracetam Chemical compound NC(=O)CN1CCCC1=O GMZVRMREEHBGGF-UHFFFAOYSA-N 0.000 claims description 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 2
- NJCJBUHJQLFDSW-UHFFFAOYSA-N Rufloxacin Chemical compound C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 NJCJBUHJQLFDSW-UHFFFAOYSA-N 0.000 claims description 2
- HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 claims description 2
- DJSISFGPUUYILV-UHFFFAOYSA-N UNPD161792 Natural products O1C(C(O)=O)C(O)C(O)C(O)C1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC(O)=CC=1)O2 DJSISFGPUUYILV-UHFFFAOYSA-N 0.000 claims description 2
- DDNCQMVWWZOMLN-IRLDBZIGSA-N Vinpocetine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C=C(C(=O)OCC)N5C2=C1 DDNCQMVWWZOMLN-IRLDBZIGSA-N 0.000 claims description 2
- 229960005488 aceglutamide Drugs 0.000 claims description 2
- 229960004150 aciclovir Drugs 0.000 claims description 2
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 2
- 229960005305 adenosine Drugs 0.000 claims description 2
- JBDGDEWWOUBZPM-XYPYZODXSA-N ambroxol Chemical compound NC1=C(Br)C=C(Br)C=C1CN[C@@H]1CC[C@@H](O)CC1 JBDGDEWWOUBZPM-XYPYZODXSA-N 0.000 claims description 2
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- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 claims description 2
- 230000000202 analgesic effect Effects 0.000 claims description 2
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 claims description 2
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- SPPIIOPGDLITJE-VLQRKCJKSA-N diazanium;(2s,3s,4s,5r,6s)-6-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-5-[(2r,3r,4s,5s,6s)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-3,4-dihy Chemical compound N.N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O SPPIIOPGDLITJE-VLQRKCJKSA-N 0.000 claims description 2
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- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 claims description 2
- DJSISFGPUUYILV-ZFORQUDYSA-N scutellarin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC(O)=CC=1)O2 DJSISFGPUUYILV-ZFORQUDYSA-N 0.000 claims description 2
- NCTHNHPAQAVBEB-WGCWOXMQSA-M sodium ferulate Chemical compound [Na+].COC1=CC(\C=C\C([O-])=O)=CC=C1O NCTHNHPAQAVBEB-WGCWOXMQSA-M 0.000 claims description 2
- NCNYJCOBUTXCBR-IPZCTEOASA-M sodium;(e)-3-[4-(imidazol-1-ylmethyl)phenyl]prop-2-enoate Chemical compound [Na+].C1=CC(/C=C/C(=O)[O-])=CC=C1CN1C=NC=C1 NCNYJCOBUTXCBR-IPZCTEOASA-M 0.000 claims description 2
- 229960004954 sparfloxacin Drugs 0.000 claims description 2
- DZZWHBIBMUVIIW-DTORHVGOSA-N sparfloxacin Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=C(F)C(N)=C2C(=O)C(C(O)=O)=CN(C3CC3)C2=C1F DZZWHBIBMUVIIW-DTORHVGOSA-N 0.000 claims description 2
- WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 claims description 2
- 229960001674 tegafur Drugs 0.000 claims description 2
- LJVAJPDWBABPEJ-PNUFFHFMSA-N telithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]([C@]2(OC(=O)N(CCCCN3C=C(N=C3)C=3C=NC=CC=3)[C@@H]2[C@@H](C)C(=O)[C@H](C)C[C@@]1(C)OC)C)CC)[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O LJVAJPDWBABPEJ-PNUFFHFMSA-N 0.000 claims description 2
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 24
- 229960002737 fructose Drugs 0.000 description 21
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- 239000000243 solution Substances 0.000 description 7
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- RQKFOGXUTRDQPB-UHFFFAOYSA-N hydron;2,3,5,6-tetramethylpyrazine;chloride Chemical compound Cl.CC1=NC(C)=C(C)N=C1C RQKFOGXUTRDQPB-UHFFFAOYSA-N 0.000 description 5
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
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- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 208000002705 Glucose Intolerance Diseases 0.000 description 2
- 229920002527 Glycogen Polymers 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 201000009104 prediabetes syndrome Diseases 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000008354 sodium chloride injection Substances 0.000 description 2
- 235000010265 sodium sulphite Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
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- 239000003643 water by type Substances 0.000 description 2
- 239000008215 water for injection Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- ZDPACSAHMZADFZ-UHFFFAOYSA-N 1-[3-(2,4,6-Trimethoxybenzoyl)propyl]pyrrolidinium chloride Chemical compound [Cl-].COC1=CC(OC)=CC(OC)=C1C(=O)CCC[NH+]1CCCC1 ZDPACSAHMZADFZ-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- ONDRRTIAGBDDKP-PPHPATTJSA-N 294662-18-3 Chemical compound CC(O)C(O)=O.C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 ONDRRTIAGBDDKP-PPHPATTJSA-N 0.000 description 1
- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- HCBIBCJNVBAKAB-UHFFFAOYSA-N Procaine hydrochloride Chemical compound Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 HCBIBCJNVBAKAB-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- UFUVLHLTWXBHGZ-MGZQPHGTSA-N [(2r,3r,4s,5r,6r)-6-[(1s,2s)-2-chloro-1-[[(2s,4r)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1 UFUVLHLTWXBHGZ-MGZQPHGTSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229960002113 buflomedil hydrochloride Drugs 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 229960004926 chlorobutanol Drugs 0.000 description 1
- 229960002291 clindamycin phosphate Drugs 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
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- 235000019800 disodium phosphate Nutrition 0.000 description 1
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- CAOOISJXWZMLBN-PPHPATTJSA-N htn0d03vrz Chemical compound Cl.C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 CAOOISJXWZMLBN-PPHPATTJSA-N 0.000 description 1
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An investose injection of 65 medicines and their addition salts, esterified substances and derivatives for treating diabetes, heart disease and hepatism is prepared from a medicine, glucose, pectose, water and additive.
Description
Technical fieldThe invention belongs to medical technical field, relate to the invert srgar inj injection medicine of some medicines.
Background technologyInjection is a class I liquid I injection, and medicine directly enters in human vas, tissue or the organ with liquid form, has to absorb soon, and effect is rapid, and being very suitable for rescuing critical patient and patient should not use under the case of oral administration.
In the process of healing with medicine, especially in the Therapeutic Method with injection, usually together inject use as a kind of carrier and medicine, as Gatifloxacin glucose injection, ligustrazine hydrochloride glucose injection, C14H25N4NaO11P2 sodium chloride injection etc. with glucose or sodium chloride solution.Glucose in the injection and sodium chloride can also be corrected the disorder that the interior power and water of body is separated matter except having the effect of regulating osmotic pressure, regulate the acid-base balance of body fluid, and glucose can also replenish necessary nutrition, heat and moisture content.
For the medicine that uses with injection system, especially glucose injection medicine, glucose solution is as a kind of pharmaceutical carrier, be oxidized to carbon dioxide and water in vivo, and energize simultaneously, or store the effect that detoxifcation is arranged, protects the liver with the form of glycogen, this is a kind of good rehabilitation support for the patient, helps the recovery of body function and the toxic and side effects of minimizing medicine; But since glucose in vivo metabolism need consume insulin, should not use for diabetics and impaired glucose tolerance person, reduced the scope of application of glucose injection medicine to a great extent.
The injection medicine that the purpose of this invention is to provide some medicines makes the carrier composition that wherein is used to regulate osmotic pressure have pharmacological effect as glucose, and type ii diabetes patient and impaired glucose tolerance person all can use safely.
Summary of the inventionIn order to achieve the above object, the present invention adopts that medicine is made with Nulomoline solution is the injection of carrier.
Nulomoline is the equal amount of mixture of glucose and fructose, fructose is the isomer of glucose, has the optics levorotation, is called levulose again, its pharmacological action is identical substantially with glucose, the fructose metabolism does not rely on the regulation and control of insulin, and its accretion rate is fast than glucose, can metabolism be glycogen under the situation of no insulin, effectively blood sugar lowering fluctuation, glucose metabolism speed is slow than fructose, sustainable energy supply, but glucose can cause the fluctuation of blood sugar level.The less dependence insulin of the compound preparation----invert srgar inj that fructose and glucose are formed participates in metabolism, and energy utilization rate can the influence to the blood sugar level fluctuation be significantly less than glucose significantly greater than monosaccharide when fully providing energy fast.
The invert srgar inj of medicine of the present invention is the medicine of the liquid dosage form of injection use, is to be the injection medicine of carrier with Nulomoline solution, and it is formed and comprises medicine, glucose, fructose and four kinds of compositions of water at least.Medicine is its principal agent composition; Glucose and fructose exist in injection with the content that equates, are to be used for regulating the osmotic pressure of injection and to have the heat of providing and complementary pharmacological action such as nutrition; Water has compositions such as dissolved substance, glucose and fructose as solvent, keeps the effect of liquid dosage form.
Medicine of the present invention is a total notion title, and it comprises the medicine of following 65 kinds of clinical uses: Gatifloxacin, levofloxacin, ofloxacin, ciprofloxacin, Pazufloxacin, fleroxacin, Sparfloxacin, Moxifloxacin, pefloxacin, rufloxacin, lomefloxacin, norfloxacin, cadrofloxacin, azithromycin, Ketek, ornidazole, Saikexiaozuo, tinidazole, metronidazole, clindamycin, lincomycin, fluconazol, etimicin, netilmicin, amikacin, ligustrazine, sorbide nitrate, isosorbide mononitrate, C14H25N4NaO11P2, pentoxifylline, nicardipine, sodium ozagrel, Retilian Simplex, breviscapine, Radix Salviae Miltiorrhizae extract, Folium Ginkgo extract, ilexonin A, dipyridamole, pyritinol, vinpocetine, troxerutin, aceglutamide, piracetam, milrinone, meglumine adenosine cycle phosphate, buflomedil, sodium ferulate, etamsylate, dobutamine, ribavirin, acyclovir, Oleum Curcumae, Andrographolide, kurarinone, matrine, oxymatrine, diammonium glycyrrhizinate, inosine, fluorouracil, ftorafur, doxifluridine, ondansetron, granisetron, tropisetron, ambroxol.
More than these medicines relate to antibiotics, cardiovascular and cerebrovascular vessel medication, antiviral class medicine, antitumor class medicine etc., should be noted that, above medicine also comprise their separately pharmaceutically acceptable acid addition salts, carboxylate, derivant etc., for example levofloxacin just has various forms of addition hydrochlorates, as levofloxacin lactate, levofloxacin hydrochloride, Levofloxacin M. S. A or the like; The addition salts Pazufloxacin Mesilate of Pazufloxacin its methanesulfonic acid commonly used; For example clindamycin has forms such as clindamycin phosphate, Clindamycin Hydrochloride, clindamycin hydrochloride palmitate again; Zitromax have forms such as lactobionic acid azithromycin, Azithromycin Sulfate; For example ligustrazine just has various forms of addition hydrochlorates, example hydrochloric acid ligustrazine, ligustrazine phosphate etc. again; Addition of acid the salt form----divalvon-D and the Buflomedil Hydrochloride of pyritinol and buflomedil its hydrochloric acid commonly used.These all are that those skilled in the art are familiar with, and give unnecessary details no longer one by one at this.
What those skilled in the art were appreciated that is, because the different in kind of each medicine, in its Nulomoline injection, safe, effectively and each component stable in order to ensure injection, character according to different pharmaceutical, can also add other suitable material, these materials are referred to as " additives ", and additives can be divided into following a few class:
The pH value regulator: the pH value that is used for regulating injection is for example often selected hydrochloric acid, citric acid, potassium hydroxide (sodium), sodium dihydrogen phosphate, sodium hydrogen phosphate etc. for use with stability that increases medicine and the absorption of accelerating medicinal liquid;
Solubilizing agent and cosolvent: the purpose of interpolation is in order to increase the dissolubility of principal agent in aqueous solvent, and reaching the required purpose of treatment, for example commonly used have Tween-80, glycerol, an ethanol etc.;
Antioxidant: the Reducing agent that is the easy oxidation of a class, when antioxidant and medicine existed simultaneously, antioxidant at first reacted with oxygen, thereby the protection medicine exempts from oxidation, guaranteeing the stable of medicine, for example commonly used have sodium sulfite, sodium sulfite, vitamin C, sodium pyrosulfite, a thiourea etc.;
Metal chelating agent: be used for medicinal liquid in trace metal ion generate stable complex, avoid the catalytic action of metal ion to the pharmaceutical compositions oxidation, for example often select ethylenediaminetetraacetic acid, disodiumedetate etc. for use;
Noble gas: be used for replacing the air in medicinal liquid and the packing container, avoid the principal agent oxidation, for example often select nitrogen, carbon dioxide for use;
Suspensoid and emulsifying agent: the purpose of interpolation is dispersibility and the stability that height is arranged for the principal agent composition that makes injection, and for example commonly used have soybean phosphatide, lecithin, a Tween-80 etc.;
Analgesic: the purpose of interpolation be for alleviate when using injection owing to medicine itself to the pain that stimulation or other reason of body generation causes, for example often select lidocaine hydrochloride, procaine hydrochloride, chlorobutanol etc. for use.
More than these additives be not the composition that must use, but select to use according to the character of the invert srgar inj of drug prepared, its select for use with using method all be that those skilled in the art know and understand.
Preparation technology's flow process of the invert srgar inj about medicine of the present invention is similar to glucose injection of the prior art or sodium chloride injection, basic operating procedure is that glucose and the fructose of getting equivalent earlier are prepared into the Nulomoline aqueous solution, use activated carbon adsorption thermal source, decolouring after regulating pH value and adding other additives, add principal agent and additives behind the filtering active carbon, dissolving, fine straining, filling and sealing, sterilization gets final product.For various medicine; the preparation process of its invert srgar inj can be different; but the medicine invert srgar inj of producing with any preparation method, technological process no matter; as long as contain the specified medicine of the present invention, glucose, fructose, water and additives in its finished product, all belong to the protection domain of the technology of the present invention.
Medicine is made as invert srgar inj, except easy to use, rapid-action advantage, compares the injection of glucose, be more suitable for type ii diabetes, heart disease, hepatopath and middle-older patient and use, enlarged its scope of application with injection.
The specific embodimentThree embodiment with following further illustrate the composition of medicine invert srgar inj of the present invention by its preparation process, but do not represent the embodiment limitation of the present invention.
Embodiment 1. ornidazole invert srgar injs
After taking by weighing the about 900ml dissolving of ornidazole 5 gram adding waters for injection, add 25 gram glucoses and 25 gram fructose, whisk to CL, transfer about pH value to 4.5 with dilute hydrochloric acid, add 0.05% needle-use activated carbon, insulation is 15 minutes about 50 ℃, decarbonization filtering while hot, add the injection water to 1000ml, after the content of mensuration solution and pH value are qualified, reuse microporous filter membrane fine straining, embedding is in the 100ml infusion bottle, through 115 ℃ of pressure sterilizings 30 minutes, promptly get every bottle and contain the 0.5g ornidazole, 2.5 gram glucoses and 2.5 restrain the injection of fructose.
The composition of this ornidazole invert srgar inj is: ornidazole, and glucose and fructose, hydrochloric acid and water, wherein hydrochloric acid is additives, in order to regulate the pH value of injection.
Embodiment 2. ligustrazine hydrochloride invert srgar injs
Glucose and the fructose of getting equivalent add dissolving fully in an amount of water for injection, add the needle-use activated carbon of appropriate amount again, stir evenly, and regulate pH value 3.5～4.5 with hydrochloric acid solution, and 90 ℃ are incubated 30 minutes, filter while hot and remove active carbon; Other gets the appropriate hydrochloric acid ligustrazine and adds in the above-mentioned Nulomoline filtrate, adds to the full amount of water for injection, and stirs evenly, and the fine straining potting in 115 ℃ of pressure sterilizings 30 minutes, detects check, and packing gets final product.
In above-mentioned preparation process, active carbon is used for adsorbing pyrogen and decolouring, and active carbon is not the composition of injection; In addition, the inventory of control ligustrazine hydrochloride, glucose and fructose can make the injection of variable concentrations, for example can be made into the injection that every 100ml contains each 2.5 gram of ligustrazine 0.1 gram, glucose and fructose.
The composition of this ligustrazine hydrochloride invert srgar inj is: ligustrazine hydrochloride, glucose and fructose, hydrochloric acid and water, wherein hydrochloric acid is additives, plays the effect of regulating pH value.
Embodiment 3. C14H25N4NaO11P2 invert srgar injs
After taking by weighing the about 900ml dissolving of C14H25N4NaO11P2 2.5 gram adding waters for injection, add 25 gram glucoses and 25 gram fructose, whisk to CL, transfer about pH value to 4.5 with dilute hydrochloric acid, add 0.05% needle-use activated carbon, insulation is 20 minutes about 50 ℃, decarbonization filtering while hot, add the injection water to 1000ml, after the content of mensuration solution and pH value are qualified, reuse microporous filter membrane fine straining, the inflated with nitrogen embedding is in the 100ml infusion bottle, through 115 ℃ of pressure sterilizings 30 minutes, promptly get every bottle and contain the 0.25g C14H25N4NaO11P2,2.5 gram glucoses and 2.5 restrain the injection of fructose.
The composition of this C14H25N4NaO11P2 invert srgar inj is: C14H25N4NaO11P2, and glucose, fructose, hydrochloric acid, the nitrogen G﹠W, wherein hydrochloric acid and nitrogen are additives, are respectively pH value regulator and protective gas.
Claims (5)
1. the invert srgar inj of medicine is characterized in that it is made up of a kind of medicine, glucose, fructose and water, can also contain suitable additives.
2. the invert srgar inj of medicine according to claim 1 is characterized in that medicine comprises: Gatifloxacin, levofloxacin, ofloxacin, ciprofloxacin, Pazufloxacin, fleroxacin, Sparfloxacin, Moxifloxacin, pefloxacin, rufloxacin, lomefloxacin, norfloxacin, cadrofloxacin, azithromycin, Ketek, ornidazole, Saikexiaozuo, tinidazole, metronidazole, clindamycin, lincomycin, fluconazol, etimicin, netilmicin, amikacin, ligustrazine, sorbide nitrate, isosorbide mononitrate, C14H25N4NaO11P2, pentoxifylline, nicardipine, sodium ozagrel, Retilian Simplex, breviscapine, Radix Salviae Miltiorrhizae extract, Folium Ginkgo extract, ilexonin A, dipyridamole, pyritinol, vinpocetine, troxerutin, aceglutamide, piracetam, milrinone, meglumine adenosine cycle phosphate, buflomedil, sodium ferulate, etamsylate, dobutamine, ribavirin, acyclovir, Oleum Curcumae, Andrographolide, kurarinone, matrine, oxymatrine, diammonium glycyrrhizinate, inosine, fluorouracil, ftorafur, doxifluridine, ondansetron, granisetron, tropisetron, ambroxol.
3. the invert srgar inj of medicine according to claim 1 is characterized in that additives comprise pH value regulator, solubilizing agent and cosolvent, antioxidant, metal chelating agent, noble gas, suspensoid and emulsifying agent, analgesic.
4. the invert srgar inj of medicine according to claim 1 is characterized in that the glucose in the injection and the content of fructose equate.
5. the invert srgar inj of medicine according to claim 2 is characterized in that medicine comprises its pharmaceutically acceptable acid addition salts, carboxylate, derivant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100081607A CN1559613A (en) | 2004-03-10 | 2004-03-10 | Medicinal invert sugar injection |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100081607A CN1559613A (en) | 2004-03-10 | 2004-03-10 | Medicinal invert sugar injection |
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| CN1559613A true CN1559613A (en) | 2005-01-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2004100081607A Pending CN1559613A (en) | 2004-03-10 | 2004-03-10 | Medicinal invert sugar injection |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101836950A (en) * | 2010-03-12 | 2010-09-22 | 陕西合成药业有限公司 | Moxifloxacin hydrochloride glucose injection and preparation method and use thereof |
| CN102462659A (en) * | 2010-11-17 | 2012-05-23 | 华北制药股份有限公司 | Citicoline sodium injection and preparation method thereof |
| CN102525890A (en) * | 2010-12-17 | 2012-07-04 | 北大方正集团有限公司 | Milrinone injection and preparation method thereof |
| CN102552115A (en) * | 2010-12-17 | 2012-07-11 | 北大方正集团有限公司 | Milrinone injection and preparation method thereof |
| CN102793730A (en) * | 2012-08-31 | 2012-11-28 | 山西普德药业股份有限公司 | Ginkgo-damole medicinal composition and preparation method thereof |
| CN102144963B (en) * | 2010-02-05 | 2013-04-10 | 四川科伦药物研究有限公司 | Citicoline sodium glucose injecta and preparation process thereof |
| CN108113990A (en) * | 2018-01-30 | 2018-06-05 | 牡丹江医学院 | A kind of pharmaceutical composition for treating urinary tract infections |
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2004
- 2004-03-10 CN CNA2004100081607A patent/CN1559613A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102144963B (en) * | 2010-02-05 | 2013-04-10 | 四川科伦药物研究有限公司 | Citicoline sodium glucose injecta and preparation process thereof |
| CN101836950A (en) * | 2010-03-12 | 2010-09-22 | 陕西合成药业有限公司 | Moxifloxacin hydrochloride glucose injection and preparation method and use thereof |
| CN102462659A (en) * | 2010-11-17 | 2012-05-23 | 华北制药股份有限公司 | Citicoline sodium injection and preparation method thereof |
| CN102462659B (en) * | 2010-11-17 | 2013-04-24 | 华北制药股份有限公司 | Citicoline sodium injection and preparation method thereof |
| CN102525890A (en) * | 2010-12-17 | 2012-07-04 | 北大方正集团有限公司 | Milrinone injection and preparation method thereof |
| CN102552115A (en) * | 2010-12-17 | 2012-07-11 | 北大方正集团有限公司 | Milrinone injection and preparation method thereof |
| CN102793730A (en) * | 2012-08-31 | 2012-11-28 | 山西普德药业股份有限公司 | Ginkgo-damole medicinal composition and preparation method thereof |
| CN102793730B (en) * | 2012-08-31 | 2013-11-06 | 山西普德药业股份有限公司 | Ginkgo-damole medicinal composition and preparation method thereof |
| CN108113990A (en) * | 2018-01-30 | 2018-06-05 | 牡丹江医学院 | A kind of pharmaceutical composition for treating urinary tract infections |
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