CN1524540A - Chinese medicine preparation for treating fatty liver and its preparation method - Google Patents
Chinese medicine preparation for treating fatty liver and its preparation method Download PDFInfo
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- CN1524540A CN1524540A CNA031047483A CN03104748A CN1524540A CN 1524540 A CN1524540 A CN 1524540A CN A031047483 A CNA031047483 A CN A031047483A CN 03104748 A CN03104748 A CN 03104748A CN 1524540 A CN1524540 A CN 1524540A
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Abstract
The invention relates to a traditional Chinese preparation for treating fatty liver and process for preparation, characterized by that, the constituent percentage by weight of the raw material are, alisol 12-30%, radix salvia miltiorrhiza 10-25%, haw 12-30%, cassia seed 10-25%, prepared fleece-flower root 5-20%, bupleurum root 5-20%. And the making process comprises the steps of, (1) extracting by ethanol backflow, (2) combination of extract, filtering, depression reclaiming, condensation into clear plaster, (3) watering and immersing, vacuum drying, (4) filling starch into plaster powder, blending, then filling ethanol to obtain the finished product. Clinical application of the invention has proved its substantial curative effect and no side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of hepatopathy, particularly treat the Chinese medicine preparation and the manufacture method of fatty liver.
Background technology
Along with improving constantly of living standard, the sickness rate of fatty liver is also more and more higher, and the Chinese medicine medicine of treatment fatty liver is generally selected the Radix Salviae Miltiorrhizae blood fat reducing for use, and single Radix Salviae Miltiorrhizae blood fat reducing therapeutic effect is not remarkable, the relapse rate height.Prevent the Chinese medicine compound medicine that does not also have at present to treat fatty liver merely to occur.
Summary of the invention
The object of the present invention is to provide and a kind ofly form, the Chinese medicine preparation and the manufacture method of the treatment fatty liver of manufacturing according to certain production technology by six kinds of raw material of Chinese medicine.
The object of the present invention is achieved like this: its raw material and weight percent content are Rhizoma Alismatis 12-30%, Radix Salviae Miltiorrhizae 10-25%, Fructus Crataegi 12-30%, Semen Cassiae 10-25%, Radix Polygoni Multiflori Preparata 5-20%, Radix Bupleuri 5-20%.
Its manufacture method is undertaken by following step,
A, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Fructus Crataegi are added the alcohol reflux 2 times that concentration is 60-80%, each 2 hours respectively at first in proportion;
B, the extracting solution of Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Fructus Crataegi is merged, filter, decompression recycling ethanol is condensed into the clear paste of certain relative density when not having the alcohol flavor, and clear paste is standby;
C, the medicinal residues after Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Fructus Crataegi filtered were soaked 2 hours with the Semen Cassiae, Radix Polygoni Multiflori Preparata, the Radix Bupleuri that take by weighing in proportion, and soak the back and decoct twice, collecting decoction, and with its filtration, filtrate for later use;
D, will be concentrated into the clear paste of certain relative density the merging of above-mentioned clear paste and filtrate, with the clear paste vacuum drying, it is standby to become dry extract;
Add starch in e, the past cream powder, mixing adds an amount of general ball of ethanol then, makes finished product.
The pharmacological action of various medicines of the present invention is: Rhizoma Alismatis has diuresis, the function of clearing away damp-heat.Be used for dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipidemia.The Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea amenorrhea, sick abdominal mass is gathered, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia, hepatosplenomegaly, angina pectoris.Hawthorn digesting is built stomach, the circulation of qi promoting dissipating blood stasis.Be used for meat stagnation, gastralgia, dysentery stomachache, blood stasis amenorrhea, hernia pain, hyperlipemia.The Radix Bupleuri reconciling superficies and interior, soothing the liver yang invigorating.Be used for cold, fever, alternate attack of chill and fever, sternal rib pain, menoxenia, uterine prolapse, proctoptosis.The Semen Cassiae clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Be used for the puckery pain of conjunctival congestion, the many tears of photophobia, it is dizzy to have a headache, poor vision, constipation.The Radix Polygoni Multiflori Preparata invigorating the liver and kidney, benefiting essence-blood, black beard and hair bone and muscle strengthening.Be used for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void, hyperlipemia.
The present invention proves through clinical use, is raw material with the said medicine, and through the Chinese medicine preparation that the processing technique of exquisiteness makes, therapeutic effect is remarkable, has no side effect.Its raw material is easy to get, and production technology is simple, processing ease.Especially take the present invention and can effect a radical cure fatty liver up hill and dale, accelerate metabolism, relapse rate is almost nil.
The specific embodiment
The weight percent content embodiment such as the following table of raw material of the present invention:
Table 1
| Material name | Weight percent content (%) | |||||
| Rhizoma Alismatis | 15 | ?20 | ?25 | ?12 | 30 | ?18 |
| Radix Salviae Miltiorrhizae | 10 | ?20 | ?25 | ?15 | ?18 | ?10 |
| Fructus Crataegi | 20 | ?20 | ?12 | ?23 | ?15 | ?30 |
| Semen Cassiae | 15 | ?25 | ?10 | ?20 | ?22 | ?18 |
| Radix Polygoni Multiflori Preparata | 20 | ?5 | ?18 | ?15 | ?10 | ?12 |
| Radix Bupleuri | 20 | ?10 | ?10 | ?15 | ?5 | ?12 |
| Add up to | 100 | ?100 | ?100 | ?100 | ?100 | ?100 |
Manufacture method embodiment of the present invention:
1, take by weighing Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Fructus Crataegi according to the above ratio, respectively with Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Fructus Crataegi, the ethanol that adds concentration and be 60-85% was multi-function extractor internal reflux 2 times, each 2 hours.
2, then the reflux extracting liquid of three kinds of medicines is combined, with 60 purpose screen filtrations, filtered liquid medicine is put into ethanol recycling can reduced-pressure backflow do not end to there being the alcohol flavor, putting into vacuum concentration pot then, to be condensed into relative density be that the clear paste of 0.8-1.5 is standby.
3, the medicinal residues after Rhizoma Alismatis, Radix Salviae Miltiorrhizae, the Fructus Crataegi filtration and the Semen Cassiae that takes by weighing in proportion, Radix Polygoni Multiflori Preparata, Radix Bupleuri mixing and water adding (every 1kg adds water 8kg) were soaked 2 hours, soak 2 hours after-filtration of back decoction, filtrate for later use.And then decoct with water medicinal residues and the Semen Cassiae, Radix Polygoni Multiflori Preparata, the Radix Bupleuri that take by weighing in proportion 1.5 hours after Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Fructus Crataegi are filtered, and decocting liquid is filtered filtrate for later use; The filtrate of twice decoction is merged, filter filtrate for later use once more.
4, above-mentioned clear paste and filtrate merging are concentrated into the clear paste that relative density is 08-15, the clear paste of relative density is put into the spray dryer vacuum drying, it is standby to become dry extract;
5, add starch in the cream powder, the fine powder of every 42g adds starch 8g, and it is the ethanol of 60-85% that mixed evenly back adds concentration, the per kilogram mixing fine powders adds the general ball of an amount of ethanol, and the addition of the general ball of ethanol is stared at according to the character of season and cream powder, if cream powder tide, then add less, on the contrary also anti-.Make the pack of finished product solid preparation, every bag 5 gram.
Instructions of taking of the present invention: oral every day three times, each 5 grams.
The present invention has used for many years clinically as the preparation of treatment fatty liver and hyperlipidemia, and curative effect is preferably arranged.Clinical observation obese fatty liver 30 examples, 3 months courses of treatment, the result shows that total obvious effective rate is 70%, total effective rate 93.3%.To stopping in the turbid damp, total obvious effective rate of stagnation of liver-QI Blood stasis is 73.5%, and total effective rate is 96.7%.The present invention can obviously improve the patient to be coerced costalgia and expands, distension and fullness in the abdomen, and inappetence, the cardinal symptom signs such as not well and hepatomegaly of defecating are improved effect comparatively significantly to unusually also having of blood fat ACT.Do not find obvious adverse reaction in the observation process.
Claims (4)
1, a kind of Chinese medicine preparation for the treatment of fatty liver is characterized in that, its raw material and weight percent content are Rhizoma Alismatis 12-30%, Radix Salviae Miltiorrhizae 10-25%, Fructus Crataegi 12-30%, Semen Cassiae 10-25%, Radix Polygoni Multiflori Preparata 5-20%, Radix Bupleuri 5-20%.
2 one kinds of manufacture methods for the treatment of the Chinese medicine preparation of fatty liver is characterized in that it is undertaken by following step,
A, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Fructus Crataegi are added the alcohol reflux 2 times that concentration is 60-80%, each 2 hours respectively at first in proportion;
B, the extracting solution of Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Fructus Crataegi is merged, filter, decompression recycling ethanol is condensed into the clear paste of certain relative density when not having the alcohol flavor, and clear paste is standby;
C, the medicinal residues after Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Fructus Crataegi filtered were soaked 2 hours with the Semen Cassiae, Radix Polygoni Multiflori Preparata, the Radix Bupleuri that take by weighing in proportion, and soak the back and decoct twice, collecting decoction, and with its filtration, filtrate for later use;
D, will be concentrated into the clear paste of certain relative density the merging of above-mentioned clear paste and filtrate, with the clear paste vacuum drying, it is standby to become dry extract;
Add starch in e, the past cream powder, mixing adds an amount of general ball of ethanol then, makes finished product.
3, the manufacture method of the Chinese medicine preparation of treatment fatty liver according to claim 2, it is characterized in that, medicinal residues after Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Fructus Crataegi are filtered are soaked the back with the Semen Cassiae, Radix Polygoni Multiflori Preparata, the Radix Bupleuri that take by weighing in proportion and were decocted 2 hours for the first time, decoct 1.5 hours for the second time.
4, the Chinese medicine preparation of treatment fatty liver according to claim 1 and 2 and manufacture method, the relative density that it is characterized in that described clear paste is 0.8-1.5, general ball concentration of ethanol is 70-90%.
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| CN 03104748 CN1220506C (en) | 2003-02-28 | 2003-02-28 | Chinese medicine preparation for treating fatty liver and its preparation method |
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| CN 03104748 CN1220506C (en) | 2003-02-28 | 2003-02-28 | Chinese medicine preparation for treating fatty liver and its preparation method |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1566169A1 (en) * | 2004-02-10 | 2005-08-24 | ABOCA S.p.A. | Cosmetic compositions containing combinations of Bupleurum species extracts and Salvia miltiorrhiza extracts for the treatment and reduction of blemishes caused by cellulite |
| CN1299715C (en) * | 2004-12-31 | 2007-02-14 | 闫自力 | Preparing tablets of reducing blood fat |
| CN1299733C (en) * | 2005-03-15 | 2007-02-14 | 青岛浩普医药研究有限公司 | Chinese medicine and its preparing method and use |
| CN1313113C (en) * | 2005-07-13 | 2007-05-02 | 张惠云 | 'Wudan Xinggan' granular for treating fatty liver, and its prepn. method |
| CN1330346C (en) * | 2005-05-22 | 2007-08-08 | 崔秀芝 | Chinese proprietary medicine for treating hypertension and hyperlipemia and preparation process thereof |
| CN100393334C (en) * | 2006-04-26 | 2008-06-11 | 闫聿逊 | A method for preparing fat-reducing medicine |
| CN102106992A (en) * | 2011-01-30 | 2011-06-29 | 河南中医学院 | Chinese medicinal granules for treating non-alcoholic steatohepatitis |
| CN102125676A (en) * | 2010-10-27 | 2011-07-20 | 宋爱民 | Traditional Chinese medicine preparation for treating fatty liver |
| CN102488798A (en) * | 2011-12-13 | 2012-06-13 | 广州中医药大学 | Medicine for treating non-alcoholic fatty liver |
| CN103230486A (en) * | 2013-04-17 | 2013-08-07 | 苏州深久医药生物技术有限公司 | Traditional Chinese medicine composition, preparation method thereof, and application thereof in preparing medicines used for treating fatty liver |
| CN103301267A (en) * | 2013-07-07 | 2013-09-18 | 崔新明 | Traditional Chinese medicine composition for treating hypertension and/or atherosclerosis and application thereof |
| CN103989995A (en) * | 2014-05-22 | 2014-08-20 | 李晓杰 | Pharmaceutical composition for treating fatty liver |
| CN104189631A (en) * | 2014-07-28 | 2014-12-10 | 王永远 | Traditional Chinese medicine composition with effect of reducing weight and lowering lipid and preparation method thereof |
| CN109620937A (en) * | 2019-02-20 | 2019-04-16 | 江西省人民医院 | A kind of rouge that disappears answers the drug and preparation method of liver |
-
2003
- 2003-02-28 CN CN 03104748 patent/CN1220506C/en not_active Expired - Fee Related
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1566169A1 (en) * | 2004-02-10 | 2005-08-24 | ABOCA S.p.A. | Cosmetic compositions containing combinations of Bupleurum species extracts and Salvia miltiorrhiza extracts for the treatment and reduction of blemishes caused by cellulite |
| CN1299715C (en) * | 2004-12-31 | 2007-02-14 | 闫自力 | Preparing tablets of reducing blood fat |
| CN1299733C (en) * | 2005-03-15 | 2007-02-14 | 青岛浩普医药研究有限公司 | Chinese medicine and its preparing method and use |
| CN1330346C (en) * | 2005-05-22 | 2007-08-08 | 崔秀芝 | Chinese proprietary medicine for treating hypertension and hyperlipemia and preparation process thereof |
| CN1313113C (en) * | 2005-07-13 | 2007-05-02 | 张惠云 | 'Wudan Xinggan' granular for treating fatty liver, and its prepn. method |
| CN100393334C (en) * | 2006-04-26 | 2008-06-11 | 闫聿逊 | A method for preparing fat-reducing medicine |
| CN102125676B (en) * | 2010-10-27 | 2012-05-30 | 宋爱民 | Traditional Chinese medicine preparation for treating fatty liver |
| CN102125676A (en) * | 2010-10-27 | 2011-07-20 | 宋爱民 | Traditional Chinese medicine preparation for treating fatty liver |
| CN102106992A (en) * | 2011-01-30 | 2011-06-29 | 河南中医学院 | Chinese medicinal granules for treating non-alcoholic steatohepatitis |
| CN102106992B (en) * | 2011-01-30 | 2012-06-06 | 河南中医学院 | Chinese medicinal granules for treating non-alcoholic steatohepatitis |
| CN102488798A (en) * | 2011-12-13 | 2012-06-13 | 广州中医药大学 | Medicine for treating non-alcoholic fatty liver |
| CN102488798B (en) * | 2011-12-13 | 2014-03-05 | 广州中医药大学 | A drug for treating non-alcoholic fatty liver disease |
| CN103230486A (en) * | 2013-04-17 | 2013-08-07 | 苏州深久医药生物技术有限公司 | Traditional Chinese medicine composition, preparation method thereof, and application thereof in preparing medicines used for treating fatty liver |
| CN103230486B (en) * | 2013-04-17 | 2014-11-05 | 苏州深久医药生物技术有限公司 | Traditional Chinese medicine composition, preparation method thereof, and application thereof in preparing medicines used for treating fatty liver |
| CN103301267A (en) * | 2013-07-07 | 2013-09-18 | 崔新明 | Traditional Chinese medicine composition for treating hypertension and/or atherosclerosis and application thereof |
| CN103301267B (en) * | 2013-07-07 | 2014-11-05 | 崔新明 | Traditional Chinese medicine composition for treating hypertension and/or atherosclerosis and application thereof |
| CN103989995A (en) * | 2014-05-22 | 2014-08-20 | 李晓杰 | Pharmaceutical composition for treating fatty liver |
| CN104189631A (en) * | 2014-07-28 | 2014-12-10 | 王永远 | Traditional Chinese medicine composition with effect of reducing weight and lowering lipid and preparation method thereof |
| CN109620937A (en) * | 2019-02-20 | 2019-04-16 | 江西省人民医院 | A kind of rouge that disappears answers the drug and preparation method of liver |
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| CN1220506C (en) | 2005-09-28 |
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